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Protein

Zinc finger protein SNAI2

Gene

Snai2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri129 – 151C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri160 – 182C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri186 – 208C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri214 – 236C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 265C2H2-type 5; atypicalPROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein SNAI2
Alternative name(s):
Neural crest transcription factor Slug
Protein snail homolog 2
Gene namesi
Name:Snai2
Synonyms:Slug, Slugh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1096393 Snai2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000470331 – 269Zinc finger protein SNAI2Add BLAST269

Post-translational modificationi

GSK3B-mediated phosphorylation results in cytoplasmic localization and degradation.By similarity

Proteomic databases

PaxDbiP97469
PRIDEiP97469

PTM databases

iPTMnetiP97469
PhosphoSitePlusiP97469

Expressioni

Gene expression databases

BgeeiENSMUSG00000022676 Expressed in 294 organ(s), highest expression level in lung
CleanExiMM_SNAI2
ExpressionAtlasiP97469 baseline and differential
GenevisibleiP97469 MM

Interactioni

Subunit structurei

Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains). Interacts (via zinc fingers) with KPNA2, KPNB1, and TNPO1. May interact (via zinc fingers) with IPO7 (By similarity).By similarity

Protein-protein interaction databases

DIPiDIP-29680N
IntActiP97469, 1 interactor
STRINGi10090.ENSMUSP00000023356

Structurei

3D structure databases

ProteinModelPortaliP97469
SMRiP97469
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 20SNAG domainBy similarityAdd BLAST20

Domaini

Repression activity depends on the C-terminal DNA-binding zinc fingers and on the N-terminal repression domain.By similarity

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri129 – 151C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri160 – 182C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri186 – 208C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri214 – 236C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 265C2H2-type 5; atypicalPROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2462 Eukaryota
ENOG41106JS LUCA
GeneTreeiENSGT00390000011027
HOGENOMiHOG000261665
HOVERGENiHBG007477
InParanoidiP97469
KOiK05706
OMAiYSPITMW
OrthoDBiEOG091G0Q0V
PhylomeDBiP97469
TreeFamiTF315515

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequencei

Sequence statusi: Complete.

P97469-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRSFLVKKH FNASKKPNYS ELDTHTVIIS PYLYESYPIP VIPKPEILTS
60 70 80 90 100
GAYSPITVWT SSAAPLHSPL PSGLSPLTGY SSSLGRVSPP PSSDTSSKDH
110 120 130 140 150
SGSESPISDE EERLQPKLSD PHAIEAEKFQ CNLCNKTYST FSGLAKHKQL
160 170 180 190 200
HCDAQSRKSF SCKYCDKEYV SLGALKMHIR THTLPCVCKI CGKAFSRPWL
210 220 230 240 250
LQGHIRTHTG EKPFSCPHCN RAFADRSNLR AHLQTHSDVK KYQCKNCSKT
260
FSRMSLLHKH EESGCCVAH
Length:269
Mass (Da):30,003
Last modified:May 1, 1997 - v1
Checksum:iC61F57779251BEB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U97059 mRNA Translation: AAB58704.1
U79550 mRNA Translation: AAB38365.1
AF079305 Genomic DNA Translation: AAD23913.1
BC062164 mRNA Translation: AAH62164.1
CCDSiCCDS27974.1
RefSeqiNP_035545.1, NM_011415.2
UniGeneiMm.4272

Genome annotation databases

EnsembliENSMUST00000023356; ENSMUSP00000023356; ENSMUSG00000022676
GeneIDi20583
KEGGimmu:20583
UCSCiuc007yhm.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U97059 mRNA Translation: AAB58704.1
U79550 mRNA Translation: AAB38365.1
AF079305 Genomic DNA Translation: AAD23913.1
BC062164 mRNA Translation: AAH62164.1
CCDSiCCDS27974.1
RefSeqiNP_035545.1, NM_011415.2
UniGeneiMm.4272

3D structure databases

ProteinModelPortaliP97469
SMRiP97469
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29680N
IntActiP97469, 1 interactor
STRINGi10090.ENSMUSP00000023356

PTM databases

iPTMnetiP97469
PhosphoSitePlusiP97469

Proteomic databases

PaxDbiP97469
PRIDEiP97469

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023356; ENSMUSP00000023356; ENSMUSG00000022676
GeneIDi20583
KEGGimmu:20583
UCSCiuc007yhm.1 mouse

Organism-specific databases

CTDi6591
MGIiMGI:1096393 Snai2

Phylogenomic databases

eggNOGiKOG2462 Eukaryota
ENOG41106JS LUCA
GeneTreeiENSGT00390000011027
HOGENOMiHOG000261665
HOVERGENiHBG007477
InParanoidiP97469
KOiK05706
OMAiYSPITMW
OrthoDBiEOG091G0Q0V
PhylomeDBiP97469
TreeFamiTF315515

Miscellaneous databases

ChiTaRSiSnai2 mouse
PROiPR:P97469
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022676 Expressed in 294 organ(s), highest expression level in lung
CleanExiMM_SNAI2
ExpressionAtlasiP97469 baseline and differential
GenevisibleiP97469 MM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSNAI2_MOUSE
AccessioniPrimary (citable) accession number: P97469
Secondary accession number(s): O09096, Q9R211
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1997
Last modified: November 7, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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