UniProtKB - P97460 (NPAS2_MOUSE)

BLAST

>sp|P97460|NPAS2_MOUSE Neuronal PAS domain-containing protein 2 OS=Mus musculus OX=10090 GN=Npas2 PE=1 SV=1
MDEDEKDRAKRASRNKSEKKRRDQFNVLIKELSSMLPGNTRKMDKTTVLEKVIGFLQKHN
EVSAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFVIVVTTDGSIIYVSDSITPLLGHL
PADVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEFLKSDNDLEFYCHLLRGSLNPK
EFPTYEYIKFVGNFRSYNNVPSPSCNGFDNTLSRPCHVPLGKDVCFIATVRLATPQFLKE
MCVADEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYNYYHIDDLELLARCH
QHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSVVSYADVRVER
RQELALEDPPTEAMHPSAVKEKDSSLEPPQPFNALDMGASGLPSSPSPSASSRSSHKSSH
TAMSEPTSTPTKLMAENSTTALPRPATLPQELPVQGLSQAATMPTALHSSASCDLTKQLL
LQSLPQTGLQSPPAPVTQFSAQFSMFQTIKDQLEQRTRILQANIRWQQEELHKIQEQLCL
VQDSNVQMFLQQPAVSLSFSSTQRPAAQQQLQQRPAAPSQPQLVVNTPLQGQITSTQVTN
QHLLRESNVISAQGPKPMRSSQLLPASGRSLSSLPSQFSSTASVLPPGLSLTTIAPTPQD
DSQCQPSPDFGHDRQLRLLLSQPIQPMMPGSCDARQPSEVSRTGRQVKYAQSQVMFPSPD
SHPTNSSASTPVLLMGQAVLHPSFPASRPSPLQPAQAQQQPPPYLQAPTSLHSEQPDSLL
LSTFSQQPGTLGYAATQSTPPQPPRPSRRVSRLSES

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History
Entry version 149 (07 Nov 2018)
Sequence version 1 (01 May 1997)
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Protein

Neuronal PAS domain-containing protein 2

Gene

Npas2

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. The NPAS2-ARNTL/BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. NPAS2 plays an important role in sleep homeostasis and in maintaining circadian behaviors in normal light/dark and feeding conditions and in the effective synchronization of feeding behavior with scheduled food availability. Regulates the gene transcription of key metabolic pathways in the liver and is involved in DNA damage response by regulating several cell cycle and DNA repair genes.10 Publications

Cofactorⁱ

Activity regulationⁱ

Carbon monoxide (CO) and the redox state of the cell can modulate the transcriptional activity of the NPAS2-ARNTL/BMAL1 heterodimer. NADH and NADPH enhance the DNA-binding activity of the heterodimer whereas CO binds the heme group in NPAS2 and inhibits the DNA-binding activity of the heterodimer.2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Metal bindingⁱ	119	Iron (heme B axial ligand)2 Publications		1
Metal bindingⁱ	171	Iron (heme B axial ligand)2 Publications		1

GO - Molecular functionⁱ

DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 23831463
DNA-binding transcription factor activity Source: InterPro
Hsp90 protein binding Source: MGI
metal ion binding Source: UniProtKB-KW
protein dimerization activity Source: InterPro
RNA polymerase II distal enhancer sequence-specific DNA binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to DNA damage stimulus Source: UniProtKB-KW
circadian regulation of gene expression
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18316400
- 24048828
circadian rhythm
Source: UniProtKB
Inferred from expression patternⁱ
- 14645221
circadian sleep/wake cycle
Source: MGI
Inferred from mutant phenotypeⁱ
- 12843397
locomotor rhythm
Source: MGI
Inferred from mutant phenotypeⁱ
- 12843397
negative regulation of cell death Source: UniProtKB
positive regulation of DNA repair Source: UniProtKB
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 18316400
- 24048828
positive regulation of transcription by RNA polymerase II Source: MGI
regulation of circadian rhythm
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24048828
regulation of response to DNA damage stimulus Source: UniProtKB
response to redox state
Source: UniProtKB
Inferred from direct assayⁱ
- 23831463

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Biological rhythms, DNA damage, Transcription, Transcription regulation
Ligand	Heme, Iron, Metal-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Neuronal PAS domain-containing protein 2 Short name: Neuronal PAS2
Gene namesⁱ	Name:Npas2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Unplaced

Organism-specific databases

MGIⁱ	MGI:109232 Npas2

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Mice exhibit altered sleep and locomotor activity. Show alterations in sleep homeostasis, altering the electrophysiological properties of neurons after sleep deprivation. Display normal patterns of sleep throughout the light period, however during the active, nocturnal period, they remain awake nearly continuously for the first 8 to 9 hours of darkness and tend to fast rather than readapt to eating in daylight. Exhibit a dysregulation in the lipid and fatty acid metabolism pathways and a significant reduction in daytime contrast sensitivity.5 Publications

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	119	H → A: Significant decrease in DNA binding affinity resulting in a loss of the transcriptional activity. 1 Publication		1
Mutagenesisⁱ	171	H → A: Significant decrease in DNA binding affinity resulting in a loss of the transcriptional activity. 1 Publication		1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000127407	1 – 816	Neuronal PAS domain-containing protein 2Add BLAST		816

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P97460
PaxDbⁱ	P97460
PRIDEⁱ	P97460

PTM databases

PhosphoSitePlusⁱ	P97460

PhosphoSitePlusⁱ

P97460

Expressionⁱ

Tissue specificityⁱ

Expressed in the retinal ganglion cells (at protein level). Expressed in the hypothalamic suprachiasmatic CC nuclei (SCN) of the brain. Also found in spinal cord, and to a lesser extent in colon, small intestine and uterus.3 Publications

Developmental stageⁱ

First detected 3 days after birth.1 Publication

Inductionⁱ

Gene expression databases

CleanExⁱ	MM_NPAS2

CleanExⁱ

MM_NPAS2

Interactionⁱ

Subunit structureⁱ

Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, ARNTL/BMAL1 or ARNTL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Efficient DNA binding requires dimerization with another bHLH protein. Interacts with NCOA3, KAT2B and CREBBP (By similarity). Forms a heterodimer with ARNTL/BMAL1 and this heterodimerization is required for E-box-dependent transactivation. Interacts with EP300.By similarity2 Publications

GO - Molecular functionⁱ

Hsp90 protein binding Source: MGI
protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	P97460, 1 interactor
Molecular INTeraction database More...MINTⁱ	P97460
STRINGⁱ	10090.ENSMUSP00000054719

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P97460
SMRⁱ	P97460
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	9 – 59	bHLHPROSITE-ProRule annotationAdd BLAST	51
Domainⁱ	82 – 152	PAS 1PROSITE-ProRule annotationAdd BLAST	71
Domainⁱ	237 – 307	PAS 2PROSITE-ProRule annotationAdd BLAST	71
Domainⁱ	311 – 354	PACAdd BLAST	44

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 61	Sufficient for heterodimer formation with ARNTL/BMAL1, E-box binding and for the effect of NADPH1 PublicationAdd BLAST		61

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IQ5V Eukaryota ENOG410Y7Z8 LUCA
HOGENOMⁱ	HOG000234382
HOVERGENⁱ	HBG050997
InParanoidⁱ	P97460
KEGG Orthology (KO) More...KOⁱ	K09026
PhylomeDBⁱ	P97460

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit cd00130 PAS, 2 hits
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR001067 Nuc_translocat IPR001610 PAC IPR000014 PAS IPR035965 PAS-like_dom_sf IPR013767 PAS_fold
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit PF00989 PAS, 1 hit
PRINTSⁱ	PR00785 NCTRNSLOCATR
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit SM00086 PAC, 1 hit SM00091 PAS, 2 hits
SUPFAMⁱ	SSF47459 SSF47459, 1 hit SSF55785 SSF55785, 2 hits
TIGRFAMsⁱ	TIGR00229 sensory_box, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit PS50112 PAS, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

P97460-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDEDEKDRAK RASRNKSEKK RRDQFNVLIK ELSSMLPGNT RKMDKTTVLE 
        60         70         80         90        100
KVIGFLQKHN EVSAQTEICD IQQDWKPSFL SNEEFTQLML EALDGFVIVV 
       110        120        130        140        150
TTDGSIIYVS DSITPLLGHL PADVMDQNLL NFLPEQEHSE VYKILSSHML 
       160        170        180        190        200
VTDSPSPEFL KSDNDLEFYC HLLRGSLNPK EFPTYEYIKF VGNFRSYNNV 
       210        220        230        240        250
PSPSCNGFDN TLSRPCHVPL GKDVCFIATV RLATPQFLKE MCVADEPLEE 
       260        270        280        290        300
FTSRHSLEWK FLFLDHRAPP IIGYLPFEVL GTSGYNYYHI DDLELLARCH 
       310        320        330        340        350
QHLMQFGKGK SCCYRFLTKG QQWIWLQTHY YITYHQWNSK PEFIVCTHSV 
       360        370        380        390        400
VSYADVRVER RQELALEDPP TEAMHPSAVK EKDSSLEPPQ PFNALDMGAS 
       410        420        430        440        450
GLPSSPSPSA SSRSSHKSSH TAMSEPTSTP TKLMAENSTT ALPRPATLPQ 
       460        470        480        490        500
ELPVQGLSQA ATMPTALHSS ASCDLTKQLL LQSLPQTGLQ SPPAPVTQFS 
       510        520        530        540        550
AQFSMFQTIK DQLEQRTRIL QANIRWQQEE LHKIQEQLCL VQDSNVQMFL 
       560        570        580        590        600
QQPAVSLSFS STQRPAAQQQ LQQRPAAPSQ PQLVVNTPLQ GQITSTQVTN 
       610        620        630        640        650
QHLLRESNVI SAQGPKPMRS SQLLPASGRS LSSLPSQFSS TASVLPPGLS 
       660        670        680        690        700
LTTIAPTPQD DSQCQPSPDF GHDRQLRLLL SQPIQPMMPG SCDARQPSEV 
       710        720        730        740        750
SRTGRQVKYA QSQVMFPSPD SHPTNSSAST PVLLMGQAVL HPSFPASRPS 
       760        770        780        790        800
PLQPAQAQQQ PPPYLQAPTS LHSEQPDSLL LSTFSQQPGT LGYAATQSTP 
       810 
PQPPRPSRRV SRLSES

Length:816

Mass (Da):90,916

Last modified:May 1, 1997 - v1

Checksum:ⁱ7E5CF0641CFDC1DD

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

G3X9B7	G3X9B7_MOUSE	Neuronal PAS domain protein 2 Neuronal PAS domain protein 2 (Neuronal PAS domain-containing protein 2)	Npas2 mCG_8437	816	Annotation score:
G3UYV8	G3UYV8_MOUSE	Neuronal PAS domain-containing prot... Neuronal PAS domain-containing protein 2	Npas2	60	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U77969 mRNA Translation: AAB47249.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS48244.1
NCBI Reference Sequences More...RefSeqⁱ	NP_032745.2, NM_008719.2
UniGeneⁱ	Mm.2380

Genome annotation databases

GeneIDⁱ	18143
KEGGⁱ	mmu:18143

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P97460	Uncharacterized protein		MOUSE		82	UniRef100_P97460

Protein	Similar proteins		Species	Score	Length	Source
P97460	Uncharacterized protein		MOUSE		82	UniRef90_P97460
Neuronal PAS domain protein 2		RAT		816
neuronal PAS domain-containing protein 2		MESAU		813
UPI00042ACB54		PERMB		822
UPI000A3121F5		MUSPA		816
+4

Protein	Similar proteins		Species	Score	Length	Source
P97460	Uncharacterized protein		MOUSE		82	UniRef50_P97460
Neuronal PAS domain protein 2		RAT		816
neuronal PAS domain-containing protein 2		MESAU		813
Neuronal PAS domain protein 2		NOTFU		855
Neuronal PAS domain-containing protein 2		LARCR		818
+318

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U77969 mRNA Translation: AAB47249.1
CCDSⁱ	CCDS48244.1
RefSeqⁱ	NP_032745.2, NM_008719.2
UniGeneⁱ	Mm.2380

3D structure databases

ProteinModelPortalⁱ	P97460
SMRⁱ	P97460
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	P97460, 1 interactor
MINTⁱ	P97460
STRINGⁱ	10090.ENSMUSP00000054719

PTM databases

PhosphoSitePlusⁱ	P97460

PhosphoSitePlusⁱ

P97460

Proteomic databases

MaxQBⁱ	P97460
PaxDbⁱ	P97460
PRIDEⁱ	P97460

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	18143
KEGGⁱ	mmu:18143

Organism-specific databases

CTDⁱ	4862
MGIⁱ	MGI:109232 Npas2

Phylogenomic databases

eggNOGⁱ	ENOG410IQ5V Eukaryota ENOG410Y7Z8 LUCA
HOGENOMⁱ	HOG000234382
HOVERGENⁱ	HBG050997
InParanoidⁱ	P97460
KOⁱ	K09026
PhylomeDBⁱ	P97460

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P97460
SOURCEⁱ	Search...

Gene expression databases

CleanExⁱ	MM_NPAS2

CleanExⁱ

MM_NPAS2

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit cd00130 PAS, 2 hits
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR001067 Nuc_translocat IPR001610 PAC IPR000014 PAS IPR035965 PAS-like_dom_sf IPR013767 PAS_fold
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit PF00989 PAS, 1 hit
PRINTSⁱ	PR00785 NCTRNSLOCATR
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit SM00086 PAC, 1 hit SM00091 PAS, 2 hits
SUPFAMⁱ	SSF47459 SSF47459, 1 hit SSF55785 SSF55785, 2 hits
TIGRFAMsⁱ	TIGR00229 sensory_box, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit PS50112 PAS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NPAS2_MOUSE
Accessionⁱ	P97460Primary (citable) accession number: P97460
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	May 1, 1997
	Last modified:	November 7, 2018
	This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P97460 (NPAS2_MOUSE)

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Neuronal PAS domain-containing protein 2

Npas2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ