UniProtKB - P97459 (NPAS1_MOUSE)

BLAST

>sp|P97459|NPAS1_MOUSE Neuronal PAS domain-containing protein 1 OS=Mus musculus OX=10090 GN=Npas1 PE=1 SV=1
MATPYPRSGGRGEVKCGGGRGAGVPWDFLPGLMVKAPPGPCLQAQRKEKSRNAARWRRGK
ENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAPPWGLRAVGPPAGLA
PGRRGPVALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGS
SVFDYIHPGDHSEVLEQLGLRAASIGPPTPPSVSSSSSSSSSSLVDTPEIEASPTEASPA
FRAQERSFFVRMKSTLTKRGLNVKASGYKVIHVTGRLRARALGLVALGHTLPPAPLAELP
LHGHMIVFRLSLGLTILACESRVSDHMDMGPSELVGRSCYQFVHGQDATRIRQSHLDLLD
KGQVVTGYYRWLQRAGGFVWLQSVATVAGNGKSTGEHHVLWVSHVLSNAEGSQTPLDAFQ
LPAIVSQEEPSRPGPEPTEEEPPVDGKQAVPADQDKDKDPQARGKRIKVEASPKEARGSE
DSGEEELSDPPAPPRPEFTSVIRAGALKHDPVLPWGLTTPGDPSPALLHAGFLPPVVRGL
CTPGTIRYGPAELSLMYPHLHRLGAGPSLPEAFYPTLGLPYPGPTGTRVQRKGD

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History
Entry version 145 (07 Nov 2018)
Sequence version 1 (01 May 1997)
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Protein

Neuronal PAS domain-containing protein 1

Gene

Npas1

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level. Forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) leading to transcriptional repression on its target gene TH (PubMed:27782878).3 Publications

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
DNA-binding transcription factor activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein heterodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 27782878

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

maternal behavior
Source: MGI
Inferred from genetic interactionⁱ
- 15347806
negative regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 27782878
negative regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 15635607
positive regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
startle response
Source: MGI
Inferred from genetic interactionⁱ
- 15347806

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Neuronal PAS domain-containing protein 1 Short name: Neuronal PAS1
Gene namesⁱ	Name:Npas1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:109205 Npas1

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	249	F → D: Destabilizes heterodimerization with ARNT. Compromises the transcriptional repression activity of heterodimer ARNT:NPAS1. 1 Publication	1
Mutagenesisⁱ	251	R → A: Destabilizes heterodimerization with ARNT. Compromises the transcriptional repression activity of heterodimer ARNT:NPAS1. 1 Publication	1
Mutagenesisⁱ	270	V → D: Destabilizes heterodimerization with ARNT. Compromises the transcriptional repression activity of heterodimer ARNT:NPAS1. 1 Publication	1
Mutagenesisⁱ	272	H → A: Destabilizes heterodimerization with ARNT. Compromises the transcriptional repression activity of heterodimer ARNT:NPAS1. 1 Publication	1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000127405	1 – 594	Neuronal PAS domain-containing protein 1Add BLAST		594

Proteomic databases

PaxDbⁱ	P97459
PRIDEⁱ	P97459

PTM databases

PhosphoSitePlusⁱ	P97459

PhosphoSitePlusⁱ

P97459

Expressionⁱ

Tissue specificityⁱ

Expressed in brain in inhibitory interneurons. Also found in spinal cord.1 Publication

Developmental stageⁱ

First detected between embryonic day 15 and day 16.

Gene expression databases

Bgeeⁱ	ENSMUSG00000001988 Expressed in 58 organ(s), highest expression level in head
CleanExⁱ	MM_NPAS1
ExpressionAtlasⁱ	P97459 baseline and differential
Genevisibleⁱ	P97459 MM

Interactionⁱ

Subunit structureⁱ

Efficient DNA binding requires dimerization with another bHLH protein. Interacts with ARNT; forms a heterodimer that binds core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) leading to a transcriptional repressor on its target gene TH.2 Publications

GO - Molecular functionⁱ

protein heterodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 27782878

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000002053

STRINGⁱ

10090.ENSMUSP00000002053

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	53 – 71	Combined sources	19
Beta strandⁱ	72 – 74	Combined sources	3
Helixⁱ	76 – 79	Combined sources	4
Helixⁱ	84 – 102	Combined sources	19
Beta strandⁱ	103 – 106	Combined sources	4
Turnⁱ	130 – 134	Combined sources	5
Helixⁱ	138 – 145	Combined sources	8
Beta strandⁱ	146 – 153	Combined sources	8
Beta strandⁱ	158 – 162	Combined sources	5
Helixⁱ	166 – 169	Combined sources	4
Helixⁱ	174 – 177	Combined sources	4
Helixⁱ	182 – 184	Combined sources	3
Helixⁱ	191 – 198	Combined sources	8
Beta strandⁱ	245 – 253	Combined sources	9
Beta strandⁱ	268 – 276	Combined sources	9
Beta strandⁱ	285 – 290	Combined sources	6
Beta strandⁱ	305 – 310	Combined sources	6
Beta strandⁱ	315 – 319	Combined sources	5
Helixⁱ	321 – 325	Combined sources	5
Helixⁱ	331 – 334	Combined sources	4
Helixⁱ	339 – 342	Combined sources	4
Turnⁱ	345 – 347	Combined sources	3
Helixⁱ	348 – 361	Combined sources	14
Beta strandⁱ	362 – 365	Combined sources	4
Beta strandⁱ	368 – 372	Combined sources	5
Beta strandⁱ	374 – 376	Combined sources	3
Beta strandⁱ	378 – 387	Combined sources	10
Beta strandⁱ	399 – 405	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	P97459
SMRⁱ	P97459
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	45 – 98	bHLHPROSITE-ProRule annotationAdd BLAST	54
Domainⁱ	135 – 205	PAS 1PROSITE-ProRule annotationAdd BLAST	71
Domainⁱ	294 – 360	PAS 2PROSITE-ProRule annotationAdd BLAST	67
Domainⁱ	366 – 409	PACAdd BLAST	44

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	212 – 223	Poly-SerAdd BLAST		12

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG3558 Eukaryota ENOG410YK57 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118788
HOGENOMⁱ	HOG000236298
HOVERGENⁱ	HBG052655
InParanoidⁱ	P97459
KEGG Orthology (KO) More...KOⁱ	K09098
OMAⁱ	VPWDFLP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02J4
PhylomeDBⁱ	P97459
TreeFamⁱ	TF317772

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit cd00130 PAS, 2 hits
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR000014 PAS IPR035965 PAS-like_dom_sf IPR013767 PAS_fold IPR013655 PAS_fold_3
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit PF00989 PAS, 1 hit PF08447 PAS_3, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit SM00091 PAS, 2 hits
SUPFAMⁱ	SSF47459 SSF47459, 1 hit SSF55785 SSF55785, 2 hits
TIGRFAMsⁱ	TIGR00229 sensory_box, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit PS50112 PAS, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P97459-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MATPYPRSGG RGEVKCGGGR GAGVPWDFLP GLMVKAPPGP CLQAQRKEKS 
        60         70         80         90        100
RNAARWRRGK ENLEFFELAK LLPLPGAISS QLDKASIVRL SVTYLRLRRF 
       110        120        130        140        150
AALGAPPWGL RAVGPPAGLA PGRRGPVALV SEVFEQHLGG HILQSLDGFV 
       160        170        180        190        200
FALNQEGKFL YISETVSIYL GLSQVELTGS SVFDYIHPGD HSEVLEQLGL 
       210        220        230        240        250
RAASIGPPTP PSVSSSSSSS SSSLVDTPEI EASPTEASPA FRAQERSFFV 
       260        270        280        290        300
RMKSTLTKRG LNVKASGYKV IHVTGRLRAR ALGLVALGHT LPPAPLAELP 
       310        320        330        340        350
LHGHMIVFRL SLGLTILACE SRVSDHMDMG PSELVGRSCY QFVHGQDATR 
       360        370        380        390        400
IRQSHLDLLD KGQVVTGYYR WLQRAGGFVW LQSVATVAGN GKSTGEHHVL 
       410        420        430        440        450
WVSHVLSNAE GSQTPLDAFQ LPAIVSQEEP SRPGPEPTEE EPPVDGKQAV 
       460        470        480        490        500
PADQDKDKDP QARGKRIKVE ASPKEARGSE DSGEEELSDP PAPPRPEFTS 
       510        520        530        540        550
VIRAGALKHD PVLPWGLTTP GDPSPALLHA GFLPPVVRGL CTPGTIRYGP 
       560        570        580        590 
AELSLMYPHL HRLGAGPSLP EAFYPTLGLP YPGPTGTRVQ RKGD

Length:594

Mass (Da):63,737

Last modified:May 1, 1997 - v1

Checksum:ⁱD6477696DF69A4B3

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U77967 mRNA Translation: AAB47247.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS20850.1
NCBI Reference Sequences More...RefSeqⁱ	NP_032744.1, NM_008718.2 XP_017177510.1, XM_017322021.1
UniGeneⁱ	Mm.145821

Genome annotation databases

Ensemblⁱ	ENSMUST00000002053; ENSMUSP00000002053; ENSMUSG00000001988 ENSMUST00000210748; ENSMUSP00000147412; ENSMUSG00000001988
GeneIDⁱ	18142
KEGGⁱ	mmu:18142
UCSC genome browser More...UCSCⁱ	uc009fhv.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P97459	Neuronal PAS domain protein 1		MOUSE		594	UniRef100_P97459

Protein	Similar proteins		Species	Score	Length	Source
P97459	Neuronal PAS domain protein 1		MOUSE		594	UniRef90_P97459
neuronal PAS domain-containing protein 1		MESAU		595
Neuronal PAS domain protein 1		RAT		595
UPI00038C030E		MICOH		595
UPI00042AB37A		PERMB		595
+7

Protein	Similar proteins		Species	Score	Length	Source
P97459	Neuronal PAS domain protein 1		MOUSE		594	UniRef50_P97459
Neuronal PAS domain protein 1		RAT		595
neuronal PAS domain-containing protein 1		MESAU		595
NPAS1 isoform 2		PONAB		415
neuronal PAS domain-containing protein 1		Florida manatee		592
+43

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U77967 mRNA Translation: AAB47247.1
CCDSⁱ	CCDS20850.1
RefSeqⁱ	NP_032744.1, NM_008718.2 XP_017177510.1, XM_017322021.1
UniGeneⁱ	Mm.145821

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5SY5	X-ray	3.20	B/D/F	43-423	[»]
ProteinModelPortalⁱ	P97459
SMRⁱ	P97459
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000002053

STRINGⁱ

10090.ENSMUSP00000002053

PTM databases

PhosphoSitePlusⁱ	P97459

PhosphoSitePlusⁱ

P97459

Proteomic databases

PaxDbⁱ	P97459
PRIDEⁱ	P97459

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000002053; ENSMUSP00000002053; ENSMUSG00000001988 ENSMUST00000210748; ENSMUSP00000147412; ENSMUSG00000001988
GeneIDⁱ	18142
KEGGⁱ	mmu:18142
UCSCⁱ	uc009fhv.2 mouse

Organism-specific databases

CTDⁱ	4861
MGIⁱ	MGI:109205 Npas1

Phylogenomic databases

eggNOGⁱ	KOG3558 Eukaryota ENOG410YK57 LUCA
GeneTreeⁱ	ENSGT00760000118788
HOGENOMⁱ	HOG000236298
HOVERGENⁱ	HBG052655
InParanoidⁱ	P97459
KOⁱ	K09098
OMAⁱ	VPWDFLP
OrthoDBⁱ	EOG091G02J4
PhylomeDBⁱ	P97459
TreeFamⁱ	TF317772

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P97459
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000001988 Expressed in 58 organ(s), highest expression level in head
CleanExⁱ	MM_NPAS1
ExpressionAtlasⁱ	P97459 baseline and differential
Genevisibleⁱ	P97459 MM

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit cd00130 PAS, 2 hits
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR000014 PAS IPR035965 PAS-like_dom_sf IPR013767 PAS_fold IPR013655 PAS_fold_3
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit PF00989 PAS, 1 hit PF08447 PAS_3, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit SM00091 PAS, 2 hits
SUPFAMⁱ	SSF47459 SSF47459, 1 hit SSF55785 SSF55785, 2 hits
TIGRFAMsⁱ	TIGR00229 sensory_box, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit PS50112 PAS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NPAS1_MOUSE
Accessionⁱ	P97459Primary (citable) accession number: P97459
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	May 1, 1997
	Last modified:	November 7, 2018
	This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P97459 (NPAS1_MOUSE)

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Neuronal PAS domain-containing protein 1

Npas1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ