Prop1

Functionⁱ

Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	66 – 125	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

beta-catenin binding
Source: MGI
Inferred from physical interactionⁱ
- 16678101
chromatin binding
Source: MGI
Inferred from direct assayⁱ
- 16678101
distal enhancer DNA-binding transcription activator activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- 16678101
distal enhancer DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- 16678101
protein C-terminus binding
Source: MGI
Inferred from physical interactionⁱ
- 16678101
RNA polymerase II distal enhancer sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 16678101

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenohypophysis development
Source: MGI
Inferred from mutant phenotypeⁱ
- 18996108
animal organ morphogenesis
Source: MGI
Inferred from mutant phenotypeⁱ
- 12183375
- 15459176
blood vessel development
Source: MGI
Inferred from mutant phenotypeⁱ
- 16556738
canonical Wnt signaling pathway
Source: MGI
Inferred from genetic interactionⁱ
- 16678101
cell migration
Source: MGI
Inferred from genetic interactionⁱ
- 18996108
dorsal/ventral pattern formation
Source: MGI
Inferred from mutant phenotypeⁱ
- 12183375
- 15459176
gland development
Source: MGI
Inferred from mutant phenotypeⁱ
- 16556738
hypophysis morphogenesis
Source: MGI
Inferred from mutant phenotypeⁱ
- 16678101
hypothalamus cell differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 9067988
negative regulation of apoptotic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 16556738
negative regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 16678101
positive regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 16678101
somatotropin secreting cell differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 6194978

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding

Molecular function

DNA-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Homeobox protein prophet of Pit-1 Short name: PROP-1 Alternative name(s): Pituitary-specific homeodomain factor
Gene namesⁱ	Name:Prop1 Synonyms:Prop-1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 11

Organism-specific databases

MGIⁱ	MGI:109330 Prop1

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	83	S → P: Shows very weak DNA binding to a Prop1 response element in gel shift assays; transcriptional activation of a luciferase reporter gene is reduced to 43% compared with that of wild-type Prop1 in transiently transfected human embryonic kidney cells. 1 Publication		1
Mutagenesisⁱ	85	F → S: Shows no significant DNA binding to a Prop1 response element in gel shift assays; transcriptional activation of a luciferase reporter gene is reduced to approximately 34% compared with that of wild-type Prop1 in transiently transfected human embryonic kidney cells. 1 Publication		1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000049272	1 – 223	Homeobox protein prophet of Pit-1Add BLAST		223

Proteomic databases

PaxDbⁱ	P97458
PRIDEⁱ	P97458

PTM databases

PhosphoSitePlusⁱ	P97458

PhosphoSitePlusⁱ

P97458

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000044542 Expressed in 23 organ(s), highest expression level in pituitary gland
CleanExⁱ	MM_PROP1
ExpressionAtlasⁱ	P97458 baseline and differential
Genevisibleⁱ	P97458 MM

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Ctnnb1	Q02248	2	EBI-937831,EBI-397872

With

Entry

#Exp.

IntAct

Notes

Ctnnb1

Q02248

2

EBI-937831,EBI-397872

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	202394, 4 interactors
IntActⁱ	P97458, 1 interactor
STRINGⁱ	10090.ENSMUSP00000057231

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P97458
SMRⁱ	P97458
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the paired homeobox family.Curated

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG0490 Eukaryota ENOG410YIJ3 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150828
HOVERGENⁱ	HBG053691
InParanoidⁱ	P97458
KEGG Orthology (KO) More...KOⁱ	K09327
OMAⁱ	TCFPHPY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0R1U
PhylomeDBⁱ	P97458
TreeFamⁱ	TF315976

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P97458-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEAQRRSHQE KQTKGHACGR SLPEPRVASG TLISTVDRSS EAYRRLSGTE 
        60         70         80         90        100
LGRPKLCPQR GRPHSRRRHR TTFNPAQLEQ LESAFGRNQY PDIWAREGLA 
       110        120        130        140        150
QDTGLSEARI QVWFQNRRAK QRKQERSLLQ PIAHLSTATF SGFLPESSAY 
       160        170        180        190        200
PYTYGTPPPP APCFPHPYSH SLPSQPSTAA SLALPPQPED WYPTLHPAPT 
       210        220 
GHLPCPPPPP MFPLSLETPK SWN

Length:223

Mass (Da):25,025

Last modified:May 1, 1997 - v1

Checksum:ⁱCD0AC4DFDC383679

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	E0CZF7	E0CZF7_MOUSE		Homeobox protein prophet of Pit-1 Homeobox protein prophet of Pit-1	Prop1	47	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U77946 mRNA Translation: AAB38884.1 AL627215 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS24643.1
NCBI Reference Sequences More...RefSeqⁱ	NP_032962.1, NM_008936.1
UniGeneⁱ	Mm.1386

Genome annotation databases

Ensemblⁱ	ENSMUST00000051159; ENSMUSP00000057231; ENSMUSG00000044542
GeneIDⁱ	19127
KEGGⁱ	mmu:19127
UCSC genome browser More...UCSCⁱ	uc007itg.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P97458	Pituitary specific homeodomain factor		MOUSE		224	UniRef90_P97458
UPI000A30D295		MUSPA		223
UPI000A31976C		MUSCR		223

Protein	Similar proteins		Species	Score	Length	Source
P97458	Homeobox protein prophet of Pit-1		ALOBE		226	UniRef50_P97458
Homeobox protein prophet of Pit-1		THEGE		226
Homeobox protein prophet of Pit-1		SAPAP		226
Homeobox protein prophet of Pit-1		BOVIN		226
Homeobox protein prophet of Pit-1		HUMAN		226
+115

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U77946 mRNA Translation: AAB38884.1 AL627215 Genomic DNA No translation available.
CCDSⁱ	CCDS24643.1
RefSeqⁱ	NP_032962.1, NM_008936.1
UniGeneⁱ	Mm.1386

3D structure databases

ProteinModelPortalⁱ	P97458
SMRⁱ	P97458
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	202394, 4 interactors
IntActⁱ	P97458, 1 interactor
STRINGⁱ	10090.ENSMUSP00000057231

PTM databases

PhosphoSitePlusⁱ	P97458

PhosphoSitePlusⁱ

P97458

Proteomic databases

PaxDbⁱ	P97458
PRIDEⁱ	P97458

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	19127
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000051159; ENSMUSP00000057231; ENSMUSG00000044542
GeneIDⁱ	19127
KEGGⁱ	mmu:19127
UCSCⁱ	uc007itg.1 mouse

Organism-specific databases

CTDⁱ	5626
MGIⁱ	MGI:109330 Prop1

Phylogenomic databases

eggNOGⁱ	KOG0490 Eukaryota ENOG410YIJ3 LUCA
GeneTreeⁱ	ENSGT00930000150828
HOVERGENⁱ	HBG053691
InParanoidⁱ	P97458
KOⁱ	K09327
OMAⁱ	TCFPHPY
OrthoDBⁱ	EOG091G0R1U
PhylomeDBⁱ	P97458
TreeFamⁱ	TF315976

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P97458
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000044542 Expressed in 23 organ(s), highest expression level in pituitary gland
CleanExⁱ	MM_PROP1
ExpressionAtlasⁱ	P97458 baseline and differential
Genevisibleⁱ	P97458 MM

Family and domain databases

CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom
Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PROP1_MOUSE
Accessionⁱ	P97458Primary (citable) accession number: P97458 Secondary accession number(s): Q5NCG9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	May 1, 1997
	Last modified:	November 7, 2018
	This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P97458 (PROP1_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Homeobox protein prophet of Pit-1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ