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Protein

Homeobox protein prophet of Pit-1

Gene

Prop1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi66 – 125HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein prophet of Pit-1
Short name:
PROP-1
Alternative name(s):
Pituitary-specific homeodomain factor
Gene namesi
Name:Prop1
Synonyms:Prop-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:109330 Prop1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi83S → P: Shows very weak DNA binding to a Prop1 response element in gel shift assays; transcriptional activation of a luciferase reporter gene is reduced to 43% compared with that of wild-type Prop1 in transiently transfected human embryonic kidney cells. 1 Publication1
Mutagenesisi85F → S: Shows no significant DNA binding to a Prop1 response element in gel shift assays; transcriptional activation of a luciferase reporter gene is reduced to approximately 34% compared with that of wild-type Prop1 in transiently transfected human embryonic kidney cells. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492721 – 223Homeobox protein prophet of Pit-1Add BLAST223

Proteomic databases

PaxDbiP97458
PRIDEiP97458

PTM databases

PhosphoSitePlusiP97458

Expressioni

Gene expression databases

BgeeiENSMUSG00000044542 Expressed in 23 organ(s), highest expression level in pituitary gland
CleanExiMM_PROP1
ExpressionAtlasiP97458 baseline and differential
GenevisibleiP97458 MM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Ctnnb1Q022482EBI-937831,EBI-397872

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202394, 4 interactors
IntActiP97458, 1 interactor
STRINGi10090.ENSMUSP00000057231

Structurei

3D structure databases

ProteinModelPortaliP97458
SMRiP97458
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the paired homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00930000150828
HOVERGENiHBG053691
InParanoidiP97458
KOiK09327
OMAiTCFPHPY
OrthoDBiEOG091G0R1U
PhylomeDBiP97458
TreeFamiTF315976

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P97458-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAQRRSHQE KQTKGHACGR SLPEPRVASG TLISTVDRSS EAYRRLSGTE
60 70 80 90 100
LGRPKLCPQR GRPHSRRRHR TTFNPAQLEQ LESAFGRNQY PDIWAREGLA
110 120 130 140 150
QDTGLSEARI QVWFQNRRAK QRKQERSLLQ PIAHLSTATF SGFLPESSAY
160 170 180 190 200
PYTYGTPPPP APCFPHPYSH SLPSQPSTAA SLALPPQPED WYPTLHPAPT
210 220
GHLPCPPPPP MFPLSLETPK SWN
Length:223
Mass (Da):25,025
Last modified:May 1, 1997 - v1
Checksum:iCD0AC4DFDC383679
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CZF7E0CZF7_MOUSE
Homeobox protein prophet of Pit-1
Prop1
47Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77946 mRNA Translation: AAB38884.1
AL627215 Genomic DNA No translation available.
CCDSiCCDS24643.1
RefSeqiNP_032962.1, NM_008936.1
UniGeneiMm.1386

Genome annotation databases

EnsembliENSMUST00000051159; ENSMUSP00000057231; ENSMUSG00000044542
GeneIDi19127
KEGGimmu:19127
UCSCiuc007itg.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77946 mRNA Translation: AAB38884.1
AL627215 Genomic DNA No translation available.
CCDSiCCDS24643.1
RefSeqiNP_032962.1, NM_008936.1
UniGeneiMm.1386

3D structure databases

ProteinModelPortaliP97458
SMRiP97458
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202394, 4 interactors
IntActiP97458, 1 interactor
STRINGi10090.ENSMUSP00000057231

PTM databases

PhosphoSitePlusiP97458

Proteomic databases

PaxDbiP97458
PRIDEiP97458

Protocols and materials databases

DNASUi19127
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051159; ENSMUSP00000057231; ENSMUSG00000044542
GeneIDi19127
KEGGimmu:19127
UCSCiuc007itg.1 mouse

Organism-specific databases

CTDi5626
MGIiMGI:109330 Prop1

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00930000150828
HOVERGENiHBG053691
InParanoidiP97458
KOiK09327
OMAiTCFPHPY
OrthoDBiEOG091G0R1U
PhylomeDBiP97458
TreeFamiTF315976

Miscellaneous databases

PROiPR:P97458
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044542 Expressed in 23 organ(s), highest expression level in pituitary gland
CleanExiMM_PROP1
ExpressionAtlasiP97458 baseline and differential
GenevisibleiP97458 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPROP1_MOUSE
AccessioniPrimary (citable) accession number: P97458
Secondary accession number(s): Q5NCG9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: November 7, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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