Homeobox protein prophet of Pit-1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• beta-catenin binding Source: MGI <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination."
    Olson L.E., Tollkuhn J., Scafoglio C., Krones A., Zhang J., Ohgi K.A., Wu W., Taketo M.M., Kemler R., Grosschedl R., Rose D., Li X., Rosenfeld M.G.
    Cell 125:593-605(2006) [PubMed] [Europe PMC] [Abstract]
• chromatin binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination."
    Olson L.E., Tollkuhn J., Scafoglio C., Krones A., Zhang J., Ohgi K.A., Wu W., Taketo M.M., Kemler R., Grosschedl R., Rose D., Li X., Rosenfeld M.G.
    Cell 125:593-605(2006) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SBInferred from direct assayⁱ
  • "Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination."
    Olson L.E., Tollkuhn J., Scafoglio C., Krones A., Zhang J., Ohgi K.A., Wu W., Taketo M.M., Kemler R., Grosschedl R., Rose D., Li X., Rosenfeld M.G.
    Cell 125:593-605(2006) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SBInferred from direct assayⁱ
  • "Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination."
    Olson L.E., Tollkuhn J., Scafoglio C., Krones A., Zhang J., Ohgi K.A., Wu W., Taketo M.M., Kemler R., Grosschedl R., Rose D., Li X., Rosenfeld M.G.
    Cell 125:593-605(2006) [PubMed] [Europe PMC] [Abstract]
• protein C-terminus binding Source: MGIInferred from physical interactionⁱ
  • "Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination."
    Olson L.E., Tollkuhn J., Scafoglio C., Krones A., Zhang J., Ohgi K.A., Wu W., Taketo M.M., Kemler R., Grosschedl R., Rose D., Li X., Rosenfeld M.G.
    Cell 125:593-605(2006) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SBInferred from direct assayⁱ
  • "Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination."
    Olson L.E., Tollkuhn J., Scafoglio C., Krones A., Zhang J., Ohgi K.A., Wu W., Taketo M.M., Kemler R., Grosschedl R., Rose D., Li X., Rosenfeld M.G.
    Cell 125:593-605(2006) [PubMed] [Europe PMC] [Abstract]
• sequence-specific double-stranded DNA binding Source: MGI

GO - Biological processⁱ

• adenohypophysis development Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Premature differentiation and aberrant movement of pituitary cells lacking both Hes1 and Prop1."
    Himes A.D., Raetzman L.T.
    Dev Biol 325:151-161(2009) [PubMed] [Europe PMC] [Abstract]
• animal organ morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Lhx4 and Prop1 are required for cell survival and expansion of the pituitary primordia."
    Raetzman L.T., Ward R., Camper S.A.
    Development 129:4229-4239(2002) [PubMed] [Europe PMC] [Abstract]
  • "Pituitary hypoplasia and respiratory distress syndrome in Prop1 knockout mice."
    Nasonkin I.O., Ward R.D., Raetzman L.T., Seasholtz A.F., Saunders T.L., Gillespie P.J., Camper S.A.
    Hum Mol Genet 13:2727-2735(2004) [PubMed] [Europe PMC] [Abstract]
• blood vessel development Source: MGIInferred from mutant phenotypeⁱ
  • "Cell proliferation and vascularization in mouse models of pituitary hormone deficiency."
    Ward R.D., Stone B.M., Raetzman L.T., Camper S.A.
    Mol Endocrinol 20:1378-1390(2006) [PubMed] [Europe PMC] [Abstract]
• canonical Wnt signaling pathway Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination."
    Olson L.E., Tollkuhn J., Scafoglio C., Krones A., Zhang J., Ohgi K.A., Wu W., Taketo M.M., Kemler R., Grosschedl R., Rose D., Li X., Rosenfeld M.G.
    Cell 125:593-605(2006) [PubMed] [Europe PMC] [Abstract]
• cell migration Source: MGIInferred from genetic interactionⁱ
  • "Premature differentiation and aberrant movement of pituitary cells lacking both Hes1 and Prop1."
    Himes A.D., Raetzman L.T.
    Dev Biol 325:151-161(2009) [PubMed] [Europe PMC] [Abstract]
• dorsal/ventral pattern formation Source: MGIInferred from mutant phenotypeⁱ
  • "Lhx4 and Prop1 are required for cell survival and expansion of the pituitary primordia."
    Raetzman L.T., Ward R., Camper S.A.
    Development 129:4229-4239(2002) [PubMed] [Europe PMC] [Abstract]
  • "Pituitary hypoplasia and respiratory distress syndrome in Prop1 knockout mice."
    Nasonkin I.O., Ward R.D., Raetzman L.T., Seasholtz A.F., Saunders T.L., Gillespie P.J., Camper S.A.
    Hum Mol Genet 13:2727-2735(2004) [PubMed] [Europe PMC] [Abstract]
• gland development Source: MGIInferred from mutant phenotypeⁱ
  • "Cell proliferation and vascularization in mouse models of pituitary hormone deficiency."
    Ward R.D., Stone B.M., Raetzman L.T., Camper S.A.
    Mol Endocrinol 20:1378-1390(2006) [PubMed] [Europe PMC] [Abstract]
• hypophysis morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination."
    Olson L.E., Tollkuhn J., Scafoglio C., Krones A., Zhang J., Ohgi K.A., Wu W., Taketo M.M., Kemler R., Grosschedl R., Rose D., Li X., Rosenfeld M.G.
    Cell 125:593-605(2006) [PubMed] [Europe PMC] [Abstract]
• hypothalamus cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Identification of growth hormone-releasing hormone and somatostatin neurons projecting to the median eminence in normal and growth hormone-deficient Ames dwarf mice."
    Romero M.I., Phelps C.J.
    Neuroendocrinology 65:107-116(1997) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic process Source: MGIInferred from mutant phenotypeⁱ
  • "Cell proliferation and vascularization in mouse models of pituitary hormone deficiency."
    Ward R.D., Stone B.M., Raetzman L.T., Camper S.A.
    Mol Endocrinol 20:1378-1390(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: NTNU_SBInferred from direct assayⁱ
  • "Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination."
    Olson L.E., Tollkuhn J., Scafoglio C., Krones A., Zhang J., Ohgi K.A., Wu W., Taketo M.M., Kemler R., Grosschedl R., Rose D., Li X., Rosenfeld M.G.
    Cell 125:593-605(2006) [PubMed] [Europe PMC] [Abstract]
• pituitary gland development Source: MGIInferred from mutant phenotypeⁱ
  • "Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis."
    Dasen J.S., Martinez-Barbera J.-P., Herman T.S., O'Connell S., Olson L., Ju B., Tollkuhn J., Baek S.H., Rose D.W., Rosenfeld M.G.
    Genes Dev. 15:3193-3207(2001) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • "Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination."
    Olson L.E., Tollkuhn J., Scafoglio C., Krones A., Zhang J., Ohgi K.A., Wu W., Taketo M.M., Kemler R., Grosschedl R., Rose D., Li X., Rosenfeld M.G.
    Cell 125:593-605(2006) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• somatotropin secreting cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Etiology of growth hormone deficiency in little, Ames, and Snell dwarf mice."
    Cheng T.C., Beamer W.G., Phillips J.A., Bartke A., Mallonee R.L., Dowling C.
    Endocrinology 113:1669-1678(1983) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• beta-catenin binding Source: MGIInferred from physical interactionⁱ
  • "Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination."
    Olson L.E., Tollkuhn J., Scafoglio C., Krones A., Zhang J., Ohgi K.A., Wu W., Taketo M.M., Kemler R., Grosschedl R., Rose D., Li X., Rosenfeld M.G.
    Cell 125:593-605(2006) [PubMed] [Europe PMC] [Abstract]
• protein C-terminus binding Source: MGIInferred from physical interactionⁱ
  • "Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination."
    Olson L.E., Tollkuhn J., Scafoglio C., Krones A., Zhang J., Ohgi K.A., Wu W., Taketo M.M., Kemler R., Grosschedl R., Rose D., Li X., Rosenfeld M.G.
    Cell 125:593-605(2006) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MEAQRRSHQE KQTKGHACGR SLPEPRVASG TLISTVDRSS EAYRRLSGTE 
        60         70         80         90        100
LGRPKLCPQR GRPHSRRRHR TTFNPAQLEQ LESAFGRNQY PDIWAREGLA 
       110        120        130        140        150
QDTGLSEARI QVWFQNRRAK QRKQERSLLQ PIAHLSTATF SGFLPESSAY 
       160        170        180        190        200
PYTYGTPPPP APCFPHPYSH SLPSQPSTAA SLALPPQPED WYPTLHPAPT 
       210        220 
GHLPCPPPPP MFPLSLETPK SWN                              

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. SIMILARITY comments
   Index of protein domains and families