UniProtKB - P97458 (PROP1_MOUSE)
Protein
Homeobox protein prophet of Pit-1
Gene
Prop1
Organism
Mus musculus (Mouse)
Status
Functioni
Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 66 – 125 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- beta-catenin binding Source: MGI
- chromatin binding Source: MGI
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
- protein C-terminus binding Source: MGI
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- adenohypophysis development Source: MGI
- animal organ morphogenesis Source: MGI
- blood vessel development Source: MGI
- canonical Wnt signaling pathway Source: MGI
- cell migration Source: MGI
- dorsal/ventral pattern formation Source: MGI
- gland development Source: MGI
- hypophysis morphogenesis Source: MGI
- hypothalamus cell differentiation Source: MGI
- negative regulation of apoptotic process Source: MGI
- negative regulation of transcription by RNA polymerase II Source: NTNU_SB
- pituitary gland development Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
- somatotropin secreting cell differentiation Source: MGI
Keywordsi
Molecular function | DNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein prophet of Pit-1Short name: PROP-1 Alternative name(s): Pituitary-specific homeodomain factor |
Gene namesi | Name:Prop1 Synonyms:Prop-1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:109330, Prop1 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- transcription regulator complex Source: MGI
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 83 | S → P: Shows very weak DNA binding to a Prop1 response element in gel shift assays; transcriptional activation of a luciferase reporter gene is reduced to 43% compared with that of wild-type Prop1 in transiently transfected human embryonic kidney cells. 1 Publication | 1 | |
Mutagenesisi | 85 | F → S: Shows no significant DNA binding to a Prop1 response element in gel shift assays; transcriptional activation of a luciferase reporter gene is reduced to approximately 34% compared with that of wild-type Prop1 in transiently transfected human embryonic kidney cells. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000049272 | 1 – 223 | Homeobox protein prophet of Pit-1Add BLAST | 223 |
Proteomic databases
jPOSTi | P97458 |
PaxDbi | P97458 |
PRIDEi | P97458 |
ProteomicsDBi | 291817 |
PTM databases
PhosphoSitePlusi | P97458 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000044542, Expressed in pituitary gland and 49 other tissues |
ExpressionAtlasi | P97458, baseline and differential |
Genevisiblei | P97458, MM |
Interactioni
Binary interactionsi
P97458
With | #Exp. | IntAct |
---|---|---|
Ctnnb1 [Q02248] | 2 | EBI-937831,EBI-397872 |
GO - Molecular functioni
- beta-catenin binding Source: MGI
- protein C-terminus binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 202394, 4 interactors |
IntActi | P97458, 1 interactor |
STRINGi | 10090.ENSMUSP00000057231 |
Miscellaneous databases
RNActi | P97458, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the paired homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0490, Eukaryota |
GeneTreei | ENSGT00940000162292 |
HOGENOMi | CLU_044912_1_0_1 |
InParanoidi | P97458 |
OMAi | CFPHPYN |
OrthoDBi | 1351285at2759 |
PhylomeDBi | P97458 |
TreeFami | TF315976 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR042412, PROP1 |
PANTHERi | PTHR47409, PTHR47409, 1 hit |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P97458-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEAQRRSHQE KQTKGHACGR SLPEPRVASG TLISTVDRSS EAYRRLSGTE
60 70 80 90 100
LGRPKLCPQR GRPHSRRRHR TTFNPAQLEQ LESAFGRNQY PDIWAREGLA
110 120 130 140 150
QDTGLSEARI QVWFQNRRAK QRKQERSLLQ PIAHLSTATF SGFLPESSAY
160 170 180 190 200
PYTYGTPPPP APCFPHPYSH SLPSQPSTAA SLALPPQPED WYPTLHPAPT
210 220
GHLPCPPPPP MFPLSLETPK SWN
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE0CZF7 | E0CZF7_MOUSE | Homeobox protein prophet of Pit-1 | Prop1 | 47 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U77946 mRNA Translation: AAB38884.1 AL627215 Genomic DNA No translation available. |
CCDSi | CCDS24643.1 |
RefSeqi | NP_032962.1, NM_008936.1 |
Genome annotation databases
Ensembli | ENSMUST00000051159; ENSMUSP00000057231; ENSMUSG00000044542 |
GeneIDi | 19127 |
KEGGi | mmu:19127 |
UCSCi | uc007itg.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U77946 mRNA Translation: AAB38884.1 AL627215 Genomic DNA No translation available. |
CCDSi | CCDS24643.1 |
RefSeqi | NP_032962.1, NM_008936.1 |
3D structure databases
SMRi | P97458 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 202394, 4 interactors |
IntActi | P97458, 1 interactor |
STRINGi | 10090.ENSMUSP00000057231 |
PTM databases
PhosphoSitePlusi | P97458 |
Proteomic databases
jPOSTi | P97458 |
PaxDbi | P97458 |
PRIDEi | P97458 |
ProteomicsDBi | 291817 |
Protocols and materials databases
Antibodypediai | 29400, 100 antibodies |
DNASUi | 19127 |
Genome annotation databases
Ensembli | ENSMUST00000051159; ENSMUSP00000057231; ENSMUSG00000044542 |
GeneIDi | 19127 |
KEGGi | mmu:19127 |
UCSCi | uc007itg.1, mouse |
Organism-specific databases
CTDi | 5626 |
MGIi | MGI:109330, Prop1 |
Phylogenomic databases
eggNOGi | KOG0490, Eukaryota |
GeneTreei | ENSGT00940000162292 |
HOGENOMi | CLU_044912_1_0_1 |
InParanoidi | P97458 |
OMAi | CFPHPYN |
OrthoDBi | 1351285at2759 |
PhylomeDBi | P97458 |
TreeFami | TF315976 |
Miscellaneous databases
BioGRID-ORCSi | 19127, 0 hits in 52 CRISPR screens |
PROi | PR:P97458 |
RNActi | P97458, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000044542, Expressed in pituitary gland and 49 other tissues |
ExpressionAtlasi | P97458, baseline and differential |
Genevisiblei | P97458, MM |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR042412, PROP1 |
PANTHERi | PTHR47409, PTHR47409, 1 hit |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PROP1_MOUSE | |
Accessioni | P97458Primary (citable) accession number: P97458 Secondary accession number(s): Q5NCG9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | May 1, 1997 | |
Last modified: | April 7, 2021 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families