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Protein

Myosin regulatory light chain 2, skeletal muscle isoform

Gene

Mylpf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

This chain binds calcium.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi38 – 49Add BLAST12

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • structural constituent of muscle Source: BHF-UCL

GO - Biological processi

  • immune response Source: Ensembl
  • skeletal muscle tissue development Source: BHF-UCL

Keywordsi

Molecular functionMotor protein, Muscle protein, Myosin
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-445355 Smooth Muscle Contraction

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin regulatory light chain 2, skeletal muscle isoform
Alternative name(s):
Fast skeletal myosin light chain 2
MLC2F
Gene namesi
Name:Mylpf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:97273 Mylpf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000193102 – 169Myosin regulatory light chain 2, skeletal muscle isoformAdd BLAST168

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N,N,N-trimethylalanineBy similarity1
Modified residuei15PhosphoserineCombined sources1
Modified residuei16PhosphoserineCombined sources1
Modified residuei25PhosphothreonineBy similarity1
Modified residuei35PhosphothreonineBy similarity1
Modified residuei75PhosphoserineBy similarity1
Modified residuei101PhosphothreonineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiP97457
PeptideAtlasiP97457
PRIDEiP97457

2D gel databases

SWISS-2DPAGEiP97457
UCD-2DPAGEiP97457

PTM databases

iPTMnetiP97457
PhosphoSitePlusiP97457

Expressioni

Gene expression databases

BgeeiENSMUSG00000030672
ExpressionAtlasiP97457 baseline and differential
GenevisibleiP97457 MM

Interactioni

Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains.

Protein-protein interaction databases

BioGridi201660, 4 interactors
IntActiP97457, 2 interactors
MINTiP97457
STRINGi10090.ENSMUSP00000032910

Structurei

3D structure databases

ProteinModelPortaliP97457
SMRiP97457
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 60EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini95 – 130EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini131 – 166EF-hand 3PROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0031 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000119196
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiP97457
KOiK12758
OMAiQCDRFSP
OrthoDBiEOG091G0QF6
PhylomeDBiP97457
TreeFamiTF314218

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13405 EF-hand_6, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97457-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKKAKRRA GAEGSSNVFS MFDQTQIQEF KEAFTVIDQN RDGIIDKEDL
60 70 80 90 100
RDTFAAMGRL NVKNEELDAM MKEASGPINF TVFLTMFGEK LKGADPEDVI
110 120 130 140 150
TGAFKVLDPE GKGTIKKQFL EELLTTQCDR FSQEEIKNMW AAFPPDVGGN
160
VDYKNICYVI THGDAKDQE
Length:169
Mass (Da):18,955
Last modified:July 5, 2004 - v3
Checksum:i06E4E1126D3A6DB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77943 mRNA Translation: AAB19118.1
BC055869 mRNA Translation: AAH55869.1
CCDSiCCDS40140.1
RefSeqiNP_058034.1, NM_016754.5
UniGeneiMm.14526

Genome annotation databases

EnsembliENSMUST00000032910; ENSMUSP00000032910; ENSMUSG00000030672
GeneIDi17907
KEGGimmu:17907
UCSCiuc009jup.1 mouse

Similar proteinsi

Entry informationi

Entry nameiMLRS_MOUSE
AccessioniPrimary (citable) accession number: P97457
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 5, 2004
Last modified: February 28, 2018
This is version 138 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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