UniProtKB - P97452 (BOP1_MOUSE)
Protein
Ribosome biogenesis protein BOP1
Gene
Bop1
Organism
Mus musculus (Mouse)
Status
Functioni
Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.UniRule annotation3 Publications
GO - Molecular functioni
- ribonucleoprotein complex binding Source: MGI
GO - Biological processi
- cell population proliferation Source: UniProtKB
- cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: UniProtKB
- maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: UniProtKB
- regulation of cell cycle Source: UniProtKB
- regulation of signal transduction by p53 class mediator Source: MGI
- ribosomal large subunit assembly Source: MGI
- ribosomal large subunit biogenesis Source: MGI
- rRNA processing Source: MGI
Keywordsi
Biological process | Ribosome biogenesis, rRNA processing |
Enzyme and pathway databases
Reactomei | R-MMU-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
Names & Taxonomyi
Protein namesi | Recommended name: Ribosome biogenesis protein BOP1UniRule annotationAlternative name(s): Block of proliferation 1 proteinUniRule annotation |
Gene namesi | Name:Bop1 Synonyms:Kiaa0124 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1334460, Bop1 |
Subcellular locationi
Nucleus
Nucleus
- nucleolus Source: UniProtKB
- nucleoplasm Source: MGI
- PeBoW complex Source: UniProtKB
Other locations
- preribosome, large subunit precursor Source: GO_Central
- ribonucleoprotein complex Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050886 | 1 – 732 | Ribosome biogenesis protein BOP1Add BLAST | 732 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 108 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 112 | PhosphoserineCombined sources | 1 | |
Modified residuei | 113 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P97452 |
jPOSTi | P97452 |
MaxQBi | P97452 |
PaxDbi | P97452 |
PeptideAtlasi | P97452 |
PRIDEi | P97452 |
PTM databases
iPTMneti | P97452 |
PhosphoSitePlusi | P97452 |
SwissPalmi | P97452 |
Expressioni
Tissue specificityi
Expressed in brain, gut, heart, kidney, liver, lung, muscle, ovary, skin, spleen and testis.
Inductioni
Expression in quiescent fibroblasts is induced by serum stimulation.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000022557, Expressed in ear vesicle and 316 other tissues |
Genevisiblei | P97452, MM |
Interactioni
Subunit structurei
Component of the PeBoW complex, composed of BOP1, PES1 and WDR12 (PubMed:15225545, ECO:0000269|PubMed:17353269). The complex is held together by BOP1, which interacts with PES1 via its N-terminal domain and with WDR12 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome. The PeBoW complex associates with DDX27, BOP1 interacts directly with DDX27 (By similarity).
UniRule annotation2 PublicationsProtein-protein interaction databases
BioGRIDi | 198380, 4 interactors |
CORUMi | P97452 |
IntActi | P97452, 1 interactor |
MINTi | P97452 |
STRINGi | 10090.ENSMUSP00000023217 |
Miscellaneous databases
RNActi | P97452, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 397 – 436 | WD 1Add BLAST | 40 | |
Repeati | 438 – 478 | WD 2Add BLAST | 41 | |
Repeati | 518 – 560 | WD 3Add BLAST | 43 | |
Repeati | 563 – 601 | WD 4Add BLAST | 39 | |
Repeati | 604 – 643 | WD 5Add BLAST | 40 | |
Repeati | 647 – 686 | WD 6Add BLAST | 40 | |
Repeati | 702 – 732 | WD 7Add BLAST | 31 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 251 – 413 | Sufficient for nucleolar localizationAdd BLAST | 163 |
Sequence similaritiesi
Belongs to the WD repeat BOP1/ERB1 family.UniRule annotation
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0650, Eukaryota |
GeneTreei | ENSGT00390000018422 |
HOGENOMi | CLU_011390_1_0_1 |
InParanoidi | P97452 |
OMAi | SHGMVYN |
OrthoDBi | 759498at2759 |
PhylomeDBi | P97452 |
TreeFami | TF300437 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
HAMAPi | MF_03027, BOP1, 1 hit |
InterProi | View protein in InterPro IPR028598, BOP1/Erb1 IPR012953, BOP1_N_dom IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR17605, PTHR17605, 1 hit |
Pfami | View protein in Pfam PF08145, BOP1NT, 1 hit PF00400, WD40, 4 hits |
SMARTi | View protein in SMART SM01035, BOP1NT, 1 hit SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 1 hit PS50082, WD_REPEATS_2, 3 hits PS50294, WD_REPEATS_REGION, 1 hit |
i Sequence
Sequence statusi: Complete.
P97452-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGACGKPHM SPASLPGKRR LEPDQELQIQ EPPLLSDPDS SLSDSEESVF
60 70 80 90 100
SGLEDLGSDS SEEDTEGVAG SSGDEDNHRA EETSEELAQA APLCSRTEEA
110 120 130 140 150
GALAQDEYEE DSSDEEDIRN TVGNVPLAWY DEFPHVGYDL DGKRIYKPLR
160 170 180 190 200
TRDELDQFLD KMDDPDFWRT VQDKMTGRDL RLTDEQVALV HRLQRGQFGD
210 220 230 240 250
SGFNPYEPAV DFFSGDIMIH PVTNRPADKR SFIPSLVEKE KVSRMVHAIK
260 270 280 290 300
MGWIKPRRPH DPTPSFYDLW AQEDPNAVLG RHKMHVPAPK LALPGHAESY
310 320 330 340 350
NPPPEYLPTE EERSAWMQQE PVERKLNFLP QKFPSLRTVP AYSRFIQERF
360 370 380 390 400
ERCLDLYLCP RQRKMRVNVD PEDLIPKLPR PRDLQPFPVC QALVYRGHSD
410 420 430 440 450
LVRCLSVSPG GQWLASGSDD GTLKLWEVAT ARCMKTVHVG GVVRSIAWNP
460 470 480 490 500
NPTICLVAAA MDDAVLLLNP ALGDRLLVGS TDQLLEAFTP PEEPALQPAR
510 520 530 540 550
WLEVSEEEHQ RGLRLRICHS KPVTQVTWHG RGDYLAVVLS SQEHTQVLLH
560 570 580 590 600
QVSRRRSQSP FRRSHGQVQC VAFHPSRPFL LVASQRSIRI YHLLRQELTK
610 620 630 640 650
KLMPNCKWVS SMAVHPAGDN IICGSYDSKL VWFDLDLSTK PYKVLRHHKK
660 670 680 690 700
ALRAVAFHPR YPLFASGSDD GSVIVCHGMV YNDLLQNPLL VPVKVLKGHT
710 720 730
LTRDLGVLDV AFHPTQPWVF SSGADGTIRL FS
Sequence cautioni
The sequence BAC97868 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 56 | L → S in BAC97868 (PubMed:14621295).Curated | 1 | |
Sequence conflicti | 56 | L → S in AAH12693 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 234 | P → L in BAC97868 (PubMed:14621295).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U77415 mRNA Translation: AAB19223.1 AK129058 mRNA Translation: BAC97868.1 Different initiation. AK079627 mRNA Translation: BAC37708.1 AK167110 mRNA Translation: BAE39258.1 BC012693 mRNA Translation: AAH12693.1 AF061503 Genomic DNA Translation: AAC80429.1 |
CCDSi | CCDS27570.1 |
RefSeqi | NP_038509.1, NM_013481.1 |
Genome annotation databases
Ensembli | ENSMUST00000023217; ENSMUSP00000023217; ENSMUSG00000022557 |
GeneIDi | 12181 |
KEGGi | mmu:12181 |
UCSCi | uc007wkf.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U77415 mRNA Translation: AAB19223.1 AK129058 mRNA Translation: BAC97868.1 Different initiation. AK079627 mRNA Translation: BAC37708.1 AK167110 mRNA Translation: BAE39258.1 BC012693 mRNA Translation: AAH12693.1 AF061503 Genomic DNA Translation: AAC80429.1 |
CCDSi | CCDS27570.1 |
RefSeqi | NP_038509.1, NM_013481.1 |
3D structure databases
SMRi | P97452 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198380, 4 interactors |
CORUMi | P97452 |
IntActi | P97452, 1 interactor |
MINTi | P97452 |
STRINGi | 10090.ENSMUSP00000023217 |
PTM databases
iPTMneti | P97452 |
PhosphoSitePlusi | P97452 |
SwissPalmi | P97452 |
Proteomic databases
EPDi | P97452 |
jPOSTi | P97452 |
MaxQBi | P97452 |
PaxDbi | P97452 |
PeptideAtlasi | P97452 |
PRIDEi | P97452 |
Protocols and materials databases
Antibodypediai | 59721, 140 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000023217; ENSMUSP00000023217; ENSMUSG00000022557 |
GeneIDi | 12181 |
KEGGi | mmu:12181 |
UCSCi | uc007wkf.1, mouse |
Organism-specific databases
CTDi | 23246 |
MGIi | MGI:1334460, Bop1 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG0650, Eukaryota |
GeneTreei | ENSGT00390000018422 |
HOGENOMi | CLU_011390_1_0_1 |
InParanoidi | P97452 |
OMAi | SHGMVYN |
OrthoDBi | 759498at2759 |
PhylomeDBi | P97452 |
TreeFami | TF300437 |
Enzyme and pathway databases
Reactomei | R-MMU-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
Miscellaneous databases
BioGRID-ORCSi | 12181, 8 hits in 17 CRISPR screens |
ChiTaRSi | Bop1, mouse |
PROi | PR:P97452 |
RNActi | P97452, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022557, Expressed in ear vesicle and 316 other tissues |
Genevisiblei | P97452, MM |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
HAMAPi | MF_03027, BOP1, 1 hit |
InterProi | View protein in InterPro IPR028598, BOP1/Erb1 IPR012953, BOP1_N_dom IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR17605, PTHR17605, 1 hit |
Pfami | View protein in Pfam PF08145, BOP1NT, 1 hit PF00400, WD40, 4 hits |
SMARTi | View protein in SMART SM01035, BOP1NT, 1 hit SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 1 hit PS50082, WD_REPEATS_2, 3 hits PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BOP1_MOUSE | |
Accessioni | P97452Primary (citable) accession number: P97452 Secondary accession number(s): Q3TK87, Q6ZQI9, Q91X31 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 13, 2004 |
Last sequence update: | May 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 164 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families