Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ribosome biogenesis protein BOP1

Gene

Bop1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.UniRule annotation3 Publications

GO - Molecular functioni

  • ribonucleoprotein complex binding Source: MGI

GO - Biological processi

Keywordsi

Biological processRibosome biogenesis, rRNA processing

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome biogenesis protein BOP1UniRule annotation
Alternative name(s):
Block of proliferation 1 proteinUniRule annotation
Gene namesi
Name:Bop1
Synonyms:Kiaa0124
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1334460 Bop1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000508861 – 732Ribosome biogenesis protein BOP1Add BLAST732

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei108PhosphotyrosineBy similarity1
Modified residuei112PhosphoserineCombined sources1
Modified residuei113PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP97452
MaxQBiP97452
PaxDbiP97452
PeptideAtlasiP97452
PRIDEiP97452

PTM databases

iPTMnetiP97452
PhosphoSitePlusiP97452
SwissPalmiP97452

Expressioni

Tissue specificityi

Expressed in brain, gut, heart, kidney, liver, lung, muscle, ovary, skin, spleen and testis.

Inductioni

Expression in quiescent fibroblasts is induced by serum stimulation.1 Publication

Gene expression databases

BgeeiENSMUSG00000022557 Expressed in 297 organ(s), highest expression level in ear vesicle
CleanExiMM_BOP1
GenevisibleiP97452 MM

Interactioni

Subunit structurei

Component of the PeBoW complex, composed of BOP1, PES1 and WDR12 (PubMed:15225545, ECO:0000269|PubMed:17353269). The complex is held together by BOP1, which interacts with PES1 via its N-terminal domain and with WDR12 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome. The PeBoW complex associates with DDX27, BOP1 interacts directly with DDX27 (By similarity).UniRule annotation2 Publications

Protein-protein interaction databases

BioGridi198380, 3 interactors
CORUMiP97452
IntActiP97452, 1 interactor
MINTiP97452
STRINGi10090.ENSMUSP00000023217

Structurei

3D structure databases

ProteinModelPortaliP97452
SMRiP97452
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati397 – 436WD 1Add BLAST40
Repeati438 – 478WD 2Add BLAST41
Repeati518 – 560WD 3Add BLAST43
Repeati563 – 601WD 4Add BLAST39
Repeati604 – 643WD 5Add BLAST40
Repeati647 – 686WD 6Add BLAST40
Repeati702 – 732WD 7Add BLAST31

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni251 – 413Sufficient for nucleolar localizationAdd BLAST163

Sequence similaritiesi

Belongs to the WD repeat BOP1/ERB1 family.UniRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0650 Eukaryota
ENOG410XRBX LUCA
GeneTreeiENSGT00390000018422
HOGENOMiHOG000029368
HOVERGENiHBG008113
InParanoidiP97452
KOiK14824
OMAiSHGMVYN
OrthoDBiEOG091G0389
PhylomeDBiP97452
TreeFamiTF300437

Family and domain databases

Gene3Di2.130.10.10, 1 hit
HAMAPiMF_03027 BOP1, 1 hit
InterProiView protein in InterPro
IPR028598 BOP1/Erb1
IPR012953 BOP1_N_dom
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR17605 PTHR17605, 1 hit
PfamiView protein in Pfam
PF08145 BOP1NT, 1 hit
PF00400 WD40, 4 hits
SMARTiView protein in SMART
SM01035 BOP1NT, 1 hit
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

P97452-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGACGKPHM SPASLPGKRR LEPDQELQIQ EPPLLSDPDS SLSDSEESVF
60 70 80 90 100
SGLEDLGSDS SEEDTEGVAG SSGDEDNHRA EETSEELAQA APLCSRTEEA
110 120 130 140 150
GALAQDEYEE DSSDEEDIRN TVGNVPLAWY DEFPHVGYDL DGKRIYKPLR
160 170 180 190 200
TRDELDQFLD KMDDPDFWRT VQDKMTGRDL RLTDEQVALV HRLQRGQFGD
210 220 230 240 250
SGFNPYEPAV DFFSGDIMIH PVTNRPADKR SFIPSLVEKE KVSRMVHAIK
260 270 280 290 300
MGWIKPRRPH DPTPSFYDLW AQEDPNAVLG RHKMHVPAPK LALPGHAESY
310 320 330 340 350
NPPPEYLPTE EERSAWMQQE PVERKLNFLP QKFPSLRTVP AYSRFIQERF
360 370 380 390 400
ERCLDLYLCP RQRKMRVNVD PEDLIPKLPR PRDLQPFPVC QALVYRGHSD
410 420 430 440 450
LVRCLSVSPG GQWLASGSDD GTLKLWEVAT ARCMKTVHVG GVVRSIAWNP
460 470 480 490 500
NPTICLVAAA MDDAVLLLNP ALGDRLLVGS TDQLLEAFTP PEEPALQPAR
510 520 530 540 550
WLEVSEEEHQ RGLRLRICHS KPVTQVTWHG RGDYLAVVLS SQEHTQVLLH
560 570 580 590 600
QVSRRRSQSP FRRSHGQVQC VAFHPSRPFL LVASQRSIRI YHLLRQELTK
610 620 630 640 650
KLMPNCKWVS SMAVHPAGDN IICGSYDSKL VWFDLDLSTK PYKVLRHHKK
660 670 680 690 700
ALRAVAFHPR YPLFASGSDD GSVIVCHGMV YNDLLQNPLL VPVKVLKGHT
710 720 730
LTRDLGVLDV AFHPTQPWVF SSGADGTIRL FS
Length:732
Mass (Da):82,546
Last modified:May 1, 1997 - v1
Checksum:i48939C86071A84A9
GO

Sequence cautioni

The sequence BAC97868 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56L → S in BAC97868 (PubMed:14621295).Curated1
Sequence conflicti56L → S in AAH12693 (PubMed:15489334).Curated1
Sequence conflicti234P → L in BAC97868 (PubMed:14621295).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77415 mRNA Translation: AAB19223.1
AK129058 mRNA Translation: BAC97868.1 Different initiation.
AK079627 mRNA Translation: BAC37708.1
AK167110 mRNA Translation: BAE39258.1
BC012693 mRNA Translation: AAH12693.1
AF061503 Genomic DNA Translation: AAC80429.1
CCDSiCCDS27570.1
RefSeqiNP_038509.1, NM_013481.1
UniGeneiMm.4283

Genome annotation databases

EnsembliENSMUST00000023217; ENSMUSP00000023217; ENSMUSG00000022557
GeneIDi12181
KEGGimmu:12181
UCSCiuc007wkf.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77415 mRNA Translation: AAB19223.1
AK129058 mRNA Translation: BAC97868.1 Different initiation.
AK079627 mRNA Translation: BAC37708.1
AK167110 mRNA Translation: BAE39258.1
BC012693 mRNA Translation: AAH12693.1
AF061503 Genomic DNA Translation: AAC80429.1
CCDSiCCDS27570.1
RefSeqiNP_038509.1, NM_013481.1
UniGeneiMm.4283

3D structure databases

ProteinModelPortaliP97452
SMRiP97452
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198380, 3 interactors
CORUMiP97452
IntActiP97452, 1 interactor
MINTiP97452
STRINGi10090.ENSMUSP00000023217

PTM databases

iPTMnetiP97452
PhosphoSitePlusiP97452
SwissPalmiP97452

Proteomic databases

EPDiP97452
MaxQBiP97452
PaxDbiP97452
PeptideAtlasiP97452
PRIDEiP97452

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023217; ENSMUSP00000023217; ENSMUSG00000022557
GeneIDi12181
KEGGimmu:12181
UCSCiuc007wkf.1 mouse

Organism-specific databases

CTDi23246
MGIiMGI:1334460 Bop1
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0650 Eukaryota
ENOG410XRBX LUCA
GeneTreeiENSGT00390000018422
HOGENOMiHOG000029368
HOVERGENiHBG008113
InParanoidiP97452
KOiK14824
OMAiSHGMVYN
OrthoDBiEOG091G0389
PhylomeDBiP97452
TreeFamiTF300437

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRSiBop1 mouse
PROiPR:P97452
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022557 Expressed in 297 organ(s), highest expression level in ear vesicle
CleanExiMM_BOP1
GenevisibleiP97452 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
HAMAPiMF_03027 BOP1, 1 hit
InterProiView protein in InterPro
IPR028598 BOP1/Erb1
IPR012953 BOP1_N_dom
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR17605 PTHR17605, 1 hit
PfamiView protein in Pfam
PF08145 BOP1NT, 1 hit
PF00400 WD40, 4 hits
SMARTiView protein in SMART
SM01035 BOP1NT, 1 hit
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBOP1_MOUSE
AccessioniPrimary (citable) accession number: P97452
Secondary accession number(s): Q3TK87, Q6ZQI9, Q91X31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: May 1, 1997
Last modified: November 7, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again