Bop1

Functionⁱ

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.UniRule annotation3 Publications

GO - Molecular functionⁱ

ribonucleoprotein complex binding
Source: MGI
Inferred from direct assayⁱ
- 10891491

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell proliferation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17353269
cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17353269
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: UniProtKB
regulation of cell cycle Source: UniProtKB
regulation of signal transduction by p53 class mediator Source: MGI
ribosomal large subunit assembly Source: MGI
ribosomal large subunit biogenesis
Source: MGI
Inferred from mutant phenotypeⁱ
- 10891491
rRNA processing
Source: MGI
Inferred from mutant phenotypeⁱ
- 10891491

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Ribosome biogenesis, rRNA processing

Biological process

Ribosome biogenesis, rRNA processing

Enzyme and pathway databases

Reactomeⁱ	R-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Reactomeⁱ

R-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ribosome biogenesis protein BOP1UniRule annotation Alternative name(s): Block of proliferation 1 proteinUniRule annotation
Gene namesⁱ	Name:Bop1 Synonyms:Kiaa0124
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 15

Organism-specific databases

MGIⁱ	MGI:1334460 Bop1

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000050886	1 – 732	Ribosome biogenesis protein BOP1Add BLAST		732

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	108	PhosphotyrosineBy similarity	1
Modified residueⁱ	112	PhosphoserineCombined sources	1
Modified residueⁱ	113	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	P97452
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P97452
PaxDbⁱ	P97452
PeptideAtlas More...PeptideAtlasⁱ	P97452
PRIDEⁱ	P97452

PTM databases

iPTMnetⁱ	P97452
PhosphoSitePlusⁱ	P97452
SwissPalmⁱ	P97452

Expressionⁱ

Tissue specificityⁱ

Expressed in brain, gut, heart, kidney, liver, lung, muscle, ovary, skin, spleen and testis.

Inductionⁱ

Expression in quiescent fibroblasts is induced by serum stimulation.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000022557 Expressed in 297 organ(s), highest expression level in ear vesicle
CleanExⁱ	MM_BOP1
Genevisibleⁱ	P97452 MM

Interactionⁱ

Subunit structureⁱ

Component of the PeBoW complex, composed of BOP1, PES1 and WDR12 (PubMed:15225545, ECO:0000269|PubMed:17353269). The complex is held together by BOP1, which interacts with PES1 via its N-terminal domain and with WDR12 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome. The PeBoW complex associates with DDX27, BOP1 interacts directly with DDX27 (By similarity).UniRule annotation2 Publications

Protein-protein interaction databases

BioGridⁱ	198380, 3 interactors
CORUMⁱ	P97452
IntActⁱ	P97452, 1 interactor
Molecular INTeraction database More...MINTⁱ	P97452
STRINGⁱ	10090.ENSMUSP00000023217

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P97452
SMRⁱ	P97452
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	397 – 436	WD 1Add BLAST	40
Repeatⁱ	438 – 478	WD 2Add BLAST	41
Repeatⁱ	518 – 560	WD 3Add BLAST	43
Repeatⁱ	563 – 601	WD 4Add BLAST	39
Repeatⁱ	604 – 643	WD 5Add BLAST	40
Repeatⁱ	647 – 686	WD 6Add BLAST	40
Repeatⁱ	702 – 732	WD 7Add BLAST	31

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	251 – 413	Sufficient for nucleolar localizationAdd BLAST		163

Sequence similaritiesⁱ

Belongs to the WD repeat BOP1/ERB1 family.UniRule annotation

Keywords - Domainⁱ

Repeat, WD repeat

Phylogenomic databases

eggNOGⁱ	KOG0650 Eukaryota ENOG410XRBX LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000018422
HOGENOMⁱ	HOG000029368
HOVERGENⁱ	HBG008113
InParanoidⁱ	P97452
KEGG Orthology (KO) More...KOⁱ	K14824
OMAⁱ	SHGMVYN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0389
PhylomeDBⁱ	P97452
TreeFamⁱ	TF300437

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit
HAMAPⁱ	MF_03027 BOP1, 1 hit
InterProⁱ	View protein in InterPro IPR028598 BOP1/Erb1 IPR012953 BOP1_N_dom IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
PANTHERⁱ	PTHR17605 PTHR17605, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08145 BOP1NT, 1 hit PF00400 WD40, 4 hits
SMARTⁱ	View protein in SMART SM01035 BOP1NT, 1 hit SM00320 WD40, 7 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS00678 WD_REPEATS_1, 1 hit PS50082 WD_REPEATS_2, 3 hits PS50294 WD_REPEATS_REGION, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P97452-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAGACGKPHM SPASLPGKRR LEPDQELQIQ EPPLLSDPDS SLSDSEESVF 
        60         70         80         90        100
SGLEDLGSDS SEEDTEGVAG SSGDEDNHRA EETSEELAQA APLCSRTEEA 
       110        120        130        140        150
GALAQDEYEE DSSDEEDIRN TVGNVPLAWY DEFPHVGYDL DGKRIYKPLR 
       160        170        180        190        200
TRDELDQFLD KMDDPDFWRT VQDKMTGRDL RLTDEQVALV HRLQRGQFGD 
       210        220        230        240        250
SGFNPYEPAV DFFSGDIMIH PVTNRPADKR SFIPSLVEKE KVSRMVHAIK 
       260        270        280        290        300
MGWIKPRRPH DPTPSFYDLW AQEDPNAVLG RHKMHVPAPK LALPGHAESY 
       310        320        330        340        350
NPPPEYLPTE EERSAWMQQE PVERKLNFLP QKFPSLRTVP AYSRFIQERF 
       360        370        380        390        400
ERCLDLYLCP RQRKMRVNVD PEDLIPKLPR PRDLQPFPVC QALVYRGHSD 
       410        420        430        440        450
LVRCLSVSPG GQWLASGSDD GTLKLWEVAT ARCMKTVHVG GVVRSIAWNP 
       460        470        480        490        500
NPTICLVAAA MDDAVLLLNP ALGDRLLVGS TDQLLEAFTP PEEPALQPAR 
       510        520        530        540        550
WLEVSEEEHQ RGLRLRICHS KPVTQVTWHG RGDYLAVVLS SQEHTQVLLH 
       560        570        580        590        600
QVSRRRSQSP FRRSHGQVQC VAFHPSRPFL LVASQRSIRI YHLLRQELTK 
       610        620        630        640        650
KLMPNCKWVS SMAVHPAGDN IICGSYDSKL VWFDLDLSTK PYKVLRHHKK 
       660        670        680        690        700
ALRAVAFHPR YPLFASGSDD GSVIVCHGMV YNDLLQNPLL VPVKVLKGHT 
       710        720        730 
LTRDLGVLDV AFHPTQPWVF SSGADGTIRL FS

Length:732

Mass (Da):82,546

Last modified:May 1, 1997 - v1

Checksum:ⁱ48939C86071A84A9

GO

Sequence cautionⁱ

The sequence BAC97868 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	56	L → S in BAC97868 (PubMed:14621295).Curated	1
Sequence conflictⁱ	56	L → S in AAH12693 (PubMed:15489334).Curated	1
Sequence conflictⁱ	234	P → L in BAC97868 (PubMed:14621295).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U77415 mRNA Translation: AAB19223.1 AK129058 mRNA Translation: BAC97868.1 Different initiation. AK079627 mRNA Translation: BAC37708.1 AK167110 mRNA Translation: BAE39258.1 BC012693 mRNA Translation: AAH12693.1 AF061503 Genomic DNA Translation: AAC80429.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS27570.1
NCBI Reference Sequences More...RefSeqⁱ	NP_038509.1, NM_013481.1
UniGeneⁱ	Mm.4283

Genome annotation databases

Ensemblⁱ	ENSMUST00000023217; ENSMUSP00000023217; ENSMUSG00000022557
GeneIDⁱ	12181
KEGGⁱ	mmu:12181
UCSC genome browser More...UCSCⁱ	uc007wkf.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P97452	Ribosome biogenesis protein BOP1		RAT		731	UniRef90_P97452
Ribosome biogenesis protein BOP1		CRIGR		732
Ribosome biogenesis protein BOP1		MOUSE		732
UPI000A327CE6		MESAU		741
UPI00038C3457		MICOH		734
+7

Protein	Similar proteins		Species	Score	Length	Source
P97452	Ribosome biogenesis protein BOP1		HUMAN		746	UniRef50_Q14137
Ribosome biogenesis protein bop1		DANRE		777
Ribosome biogenesis protein BOP1		RAT		731
Ribosome biogenesis protein BOP1		PAPAN		746
Ribosome biogenesis protein BOP1		MACMU		746
+156

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U77415 mRNA Translation: AAB19223.1 AK129058 mRNA Translation: BAC97868.1 Different initiation. AK079627 mRNA Translation: BAC37708.1 AK167110 mRNA Translation: BAE39258.1 BC012693 mRNA Translation: AAH12693.1 AF061503 Genomic DNA Translation: AAC80429.1
CCDSⁱ	CCDS27570.1
RefSeqⁱ	NP_038509.1, NM_013481.1
UniGeneⁱ	Mm.4283

3D structure databases

ProteinModelPortalⁱ	P97452
SMRⁱ	P97452
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	198380, 3 interactors
CORUMⁱ	P97452
IntActⁱ	P97452, 1 interactor
MINTⁱ	P97452
STRINGⁱ	10090.ENSMUSP00000023217

PTM databases

iPTMnetⁱ	P97452
PhosphoSitePlusⁱ	P97452
SwissPalmⁱ	P97452

Proteomic databases

EPDⁱ	P97452
MaxQBⁱ	P97452
PaxDbⁱ	P97452
PeptideAtlasⁱ	P97452
PRIDEⁱ	P97452

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000023217; ENSMUSP00000023217; ENSMUSG00000022557
GeneIDⁱ	12181
KEGGⁱ	mmu:12181
UCSCⁱ	uc007wkf.1 mouse

Organism-specific databases

CTDⁱ	23246
MGIⁱ	MGI:1334460 Bop1
Rougeⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0650 Eukaryota ENOG410XRBX LUCA
GeneTreeⁱ	ENSGT00390000018422
HOGENOMⁱ	HOG000029368
HOVERGENⁱ	HBG008113
InParanoidⁱ	P97452
KOⁱ	K14824
OMAⁱ	SHGMVYN
OrthoDBⁱ	EOG091G0389
PhylomeDBⁱ	P97452
TreeFamⁱ	TF300437

Enzyme and pathway databases

Reactomeⁱ	R-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Reactomeⁱ

R-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRSⁱ	Bop1 mouse
Protein Ontology More...PROⁱ	PR:P97452
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000022557 Expressed in 297 organ(s), highest expression level in ear vesicle
CleanExⁱ	MM_BOP1
Genevisibleⁱ	P97452 MM

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit
HAMAPⁱ	MF_03027 BOP1, 1 hit
InterProⁱ	View protein in InterPro IPR028598 BOP1/Erb1 IPR012953 BOP1_N_dom IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
PANTHERⁱ	PTHR17605 PTHR17605, 1 hit
Pfamⁱ	View protein in Pfam PF08145 BOP1NT, 1 hit PF00400 WD40, 4 hits
SMARTⁱ	View protein in SMART SM01035 BOP1NT, 1 hit SM00320 WD40, 7 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS00678 WD_REPEATS_1, 1 hit PS50082 WD_REPEATS_2, 3 hits PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BOP1_MOUSE
Accessionⁱ	P97452Primary (citable) accession number: P97452 Secondary accession number(s): Q3TK87, Q6ZQI9, Q91X31
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
	Last sequence update:	May 1, 1997
	Last modified:	November 7, 2018
	This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P97452 (BOP1_MOUSE)

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Ribosome biogenesis protein BOP1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ