UniProtKB - P97443 (SMYD1_MOUSE)

BLAST

>sp|P97443|SMYD1_MOUSE Histone-lysine N-methyltransferase Smyd1 OS=Mus musculus OX=10090 GN=Smyd1 PE=1 SV=3
MTIGSMENVEVFTSEGKGRGLKATKEFWAADVIFAERAYSAVVFDSLINFVCHTCFKRQE
KLHRCGQCKFAHYCDRTCQKDAWLNHKNECAAIKKYGKVPNENIRLAARIMWRVEREGTG
LTEGCLVSVDDLQNHVEHFGEEEQKELRVDVDTFLQYWPPQSQQFSMQYISHIFGVINCN
GFTLSDQRGLQAVGVGIFPNLGLVNHDCWPNCTVIFNNGNHEAVKSMFHTQMRIELRALG
KISEGEELTVSYIDFLHLSEERRRQLKKQYYFDCSCEHCQKGLKDDLFLAAKEDPKPSQE
VVKEMIQFSKDTLEKIDKARSEGLYHEVVKLCRECLEKQEPVFADTNLYVLRLLSIASEV
LSYLQAYEEASHYARRMVDGYMKLYHHNNAQLGMAVMRAGLTNWHAGHIEVGHGMICKAY
AILLVTHGPSHPITKDLEAMRMQTEMELRMFRQNEFMYHKMREAALNNQPMQVMAEPSNE
PAPALFHKKQ

Align

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History
Entry version 132 (12 Sep 2018)
Sequence version 3 (03 May 2011)
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Protein

Histone-lysine N-methyltransferase Smyd1

Gene

Smyd1

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Methylates histone H3 at 'Lys-4' (H3K4me). Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis.2 Publications

Catalytic activityⁱ

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N₆-methyl-L-lysine-[histone].1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	135	S-adenosyl-L-methionine	1
Metal bindingⁱ	208	Zinc	1
Metal bindingⁱ	274	Zinc	1
Metal bindingⁱ	276	Zinc	1
Metal bindingⁱ	279	Zinc	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	52 – 90	MYND-typePROSITE-ProRule annotationAdd BLAST		39

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
histone-lysine N-methyltransferase activity Source: UniProtKB-EC
metal ion binding Source: UniProtKB-KW
transcription corepressor activity
Source: MGI
Inferred from direct assayⁱ
- 11923873

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

chromatin remodeling
Source: MGI
Inferred from physical interactionⁱ
- 11923873
heart development
Source: MGI
Inferred from mutant phenotypeⁱ
- 11923873
negative regulation of transcription, DNA-templated
Source: MGI
Inferred from direct assayⁱ
- 11923873
positive regulation of myoblast differentiation Source: MGI
positive regulation of myotube differentiation Source: MGI
skeletal muscle cell differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 22147266
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Methyltransferase, Repressor, Transferase
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, S-adenosyl-L-methionine, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Histone-lysine N-methyltransferase Smyd1 (EC:2.1.1.43) Alternative name(s): CD8b-opposite SET and MYND domain-containing protein 1 Zinc finger protein BOP Short name: m-BOP
Gene namesⁱ	Name:Smyd1 Synonyms:Bop
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 6

Organism-specific databases

MGIⁱ	MGI:104790 Smyd1

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000218308	1 – 490	Histone-lysine N-methyltransferase Smyd1Add BLAST		490

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P97443
PaxDbⁱ	P97443
PRIDEⁱ	P97443

PTM databases

iPTMnetⁱ	P97443
PhosphoSitePlusⁱ	P97443

Expressionⁱ

Tissue specificityⁱ

Expressed in cardiac and skeletal muscle, lymphocytes and thymus.2 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000055027 Expressed in 198 organ(s), highest expression level in skeletal muscle tissue
CleanExⁱ	MM_SMYD1
ExpressionAtlasⁱ	P97443 baseline and differential
Genevisibleⁱ	P97443 MM

Interactionⁱ

Subunit structureⁱ

Interacts with HDAC1, HDAC2 and HDAC3. Interacts (via MYND-type zinc finger) with NACA isoform skNAC.2 Publications

Protein-protein interaction databases

BioGridⁱ	198379, 5 interactors
ELMⁱ	P97443
IntActⁱ	P97443, 2 interactors
Molecular INTeraction database More...MINTⁱ	P97443
STRINGⁱ	10090.ENSMUSP00000073911

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	9 – 13	Combined sources	5
Beta strandⁱ	15 – 17	Combined sources	3
Beta strandⁱ	19 – 25	Combined sources	7
Beta strandⁱ	32 – 36	Combined sources	5
Beta strandⁱ	39 – 43	Combined sources	5
Helixⁱ	45 – 47	Combined sources	3
Turnⁱ	48 – 50	Combined sources	3
Turnⁱ	53 – 55	Combined sources	3
Turnⁱ	66 – 68	Combined sources	3
Beta strandⁱ	72 – 75	Combined sources	4
Helixⁱ	76 – 96	Combined sources	21
Helixⁱ	102 – 116	Combined sources	15
Beta strandⁱ	119 – 121	Combined sources	3
Beta strandⁱ	126 – 128	Combined sources	3
Helixⁱ	129 – 131	Combined sources	3
Helixⁱ	136 – 138	Combined sources	3
Helixⁱ	141 – 157	Combined sources	17
Helixⁱ	167 – 178	Combined sources	12
Beta strandⁱ	181 – 185	Combined sources	5
Beta strandⁱ	191 – 197	Combined sources	7
Helixⁱ	201 – 203	Combined sources	3
Beta strandⁱ	211 – 217	Combined sources	7
Beta strandⁱ	222 – 224	Combined sources	3
Helixⁱ	228 – 230	Combined sources	3
Beta strandⁱ	233 – 240	Combined sources	8
Helixⁱ	259 – 270	Combined sources	12
Helixⁱ	277 – 281	Combined sources	5
Turnⁱ	282 – 284	Combined sources	3
Helixⁱ	285 – 288	Combined sources	4
Beta strandⁱ	293 – 295	Combined sources	3
Helixⁱ	299 – 320	Combined sources	22
Turnⁱ	321 – 323	Combined sources	3
Helixⁱ	325 – 339	Combined sources	15
Turnⁱ	340 – 342	Combined sources	3
Helixⁱ	348 – 363	Combined sources	16
Helixⁱ	367 – 384	Combined sources	18
Helixⁱ	390 – 405	Combined sources	16
Helixⁱ	409 – 426	Combined sources	18
Helixⁱ	432 – 465	Combined sources	34

Show more details

3D structure databases

ProteinModelPortalⁱ	P97443
SMRⁱ	P97443
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P97443

EvolutionaryTraceⁱ

P97443

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	7 – 253	SETPROSITE-ProRule annotationAdd BLAST		247

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	17 – 19	S-adenosyl-L-methionine binding	3
Regionⁱ	205 – 206	S-adenosyl-L-methionine binding	2
Regionⁱ	270 – 272	S-adenosyl-L-methionine bindingBy similarity	3

Domainⁱ

The SET domain is split between the S-sequence (residues 1-49) and the core SET domain (residues 181-258), however the two segments still come together to form a conserved SET domain fold.

Sequence similaritiesⁱ

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	52 – 90	MYND-typePROSITE-ProRule annotationAdd BLAST		39

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG2084 Eukaryota COG2940 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063077
HOGENOMⁱ	HOG000050244
HOVERGENⁱ	HBG054953
InParanoidⁱ	P97443
KEGG Orthology (KO) More...KOⁱ	K11426
OMAⁱ	VTHGPTH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G066T
PhylomeDBⁱ	P97443
TreeFamⁱ	TF106487

Family and domain databases

Gene3Dⁱ	1.25.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR001214 SET_dom IPR011990 TPR-like_helical_dom_sf IPR002893 Znf_MYND
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00856 SET, 1 hit PF01753 zf-MYND, 1 hit
SMARTⁱ	View protein in SMART SM00317 SET, 1 hit
PROSITEⁱ	View protein in PROSITE PS50280 SET, 1 hit PS01360 ZF_MYND_1, 1 hit PS50865 ZF_MYND_2, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P97443-1) [UniParc]FASTA Add to basket

Also known as: ISKM-BOP11 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTIGSMENVE VFTSEGKGRG LKATKEFWAA DVIFAERAYS AVVFDSLINF 
        60         70         80         90        100
VCHTCFKRQE KLHRCGQCKF AHYCDRTCQK DAWLNHKNEC AAIKKYGKVP 
       110        120        130        140        150
NENIRLAARI MWRVEREGTG LTEGCLVSVD DLQNHVEHFG EEEQKELRVD 
       160        170        180        190        200
VDTFLQYWPP QSQQFSMQYI SHIFGVINCN GFTLSDQRGL QAVGVGIFPN 
       210        220        230        240        250
LGLVNHDCWP NCTVIFNNGN HEAVKSMFHT QMRIELRALG KISEGEELTV 
       260        270        280        290        300
SYIDFLHLSE ERRRQLKKQY YFDCSCEHCQ KGLKDDLFLA AKEDPKPSQE 
       310        320        330        340        350
VVKEMIQFSK DTLEKIDKAR SEGLYHEVVK LCRECLEKQE PVFADTNLYV 
       360        370        380        390        400
LRLLSIASEV LSYLQAYEEA SHYARRMVDG YMKLYHHNNA QLGMAVMRAG 
       410        420        430        440        450
LTNWHAGHIE VGHGMICKAY AILLVTHGPS HPITKDLEAM RMQTEMELRM 
       460        470        480        490
FRQNEFMYHK MREAALNNQP MQVMAEPSNE PAPALFHKKQ

Length:490

Mass (Da):56,496

Last modified:May 3, 2011 - v3

Checksum:ⁱ5D18208678771CBE

Isoform 2 (identifier: P97443-2) [UniParc]FASTA Add to basket

Also known as: SKM-BOP21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
220-220: N → K
221-233: Missing.

« Hide

        10         20         30         40         50
MTIGSMENVE VFTSEGKGRG LKATKEFWAA DVIFAERAYS AVVFDSLINF 
        60         70         80         90        100
VCHTCFKRQE KLHRCGQCKF AHYCDRTCQK DAWLNHKNEC AAIKKYGKVP 
       110        120        130        140        150
NENIRLAARI MWRVEREGTG LTEGCLVSVD DLQNHVEHFG EEEQKELRVD 
       160        170        180        190        200
VDTFLQYWPP QSQQFSMQYI SHIFGVINCN GFTLSDQRGL QAVGVGIFPN 
       210        220        230        240        250
LGLVNHDCWP NCTVIFNNGK IELRALGKIS EGEELTVSYI DFLHLSEERR 
       260        270        280        290        300
RQLKKQYYFD CSCEHCQKGL KDDLFLAAKE DPKPSQEVVK EMIQFSKDTL 
       310        320        330        340        350
EKIDKARSEG LYHEVVKLCR ECLEKQEPVF ADTNLYVLRL LSIASEVLSY 
       360        370        380        390        400
LQAYEEASHY ARRMVDGYMK LYHHNNAQLG MAVMRAGLTN WHAGHIEVGH 
       410        420        430        440        450
GMICKAYAIL LVTHGPSHPI TKDLEAMRMQ TEMELRMFRQ NEFMYHKMRE 
       460        470 
AALNNQPMQV MAEPSNEPAP ALFHKKQ

Show »

Length:477

Mass (Da):54,926

Checksum:ⁱA927C87FA4B6CAC7

Isoform 3 (identifier: P97443-3) [UniParc]FASTA Add to basket

Also known as: T-BOP1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
6-45: MENVEVFTSEGKGRGLKATKEFWAADVIFAERAYSAVVFD → MKNGEACGGWQ

« Hide

        10         20         30         40         50
MTIGSMKNGE ACGGWQSLIN FVCHTCFKRQ EKLHRCGQCK FAHYCDRTCQ 
        60         70         80         90        100
KDAWLNHKNE CAAIKKYGKV PNENIRLAAR IMWRVEREGT GLTEGCLVSV 
       110        120        130        140        150
DDLQNHVEHF GEEEQKELRV DVDTFLQYWP PQSQQFSMQY ISHIFGVINC 
       160        170        180        190        200
NGFTLSDQRG LQAVGVGIFP NLGLVNHDCW PNCTVIFNNG NHEAVKSMFH 
       210        220        230        240        250
TQMRIELRAL GKISEGEELT VSYIDFLHLS EERRRQLKKQ YYFDCSCEHC 
       260        270        280        290        300
QKGLKDDLFL AAKEDPKPSQ EVVKEMIQFS KDTLEKIDKA RSEGLYHEVV 
       310        320        330        340        350
KLCRECLEKQ EPVFADTNLY VLRLLSIASE VLSYLQAYEE ASHYARRMVD 
       360        370        380        390        400
GYMKLYHHNN AQLGMAVMRA GLTNWHAGHI EVGHGMICKA YAILLVTHGP 
       410        420        430        440        450
SHPITKDLEA MRMQTEMELR MFRQNEFMYH KMREAALNNQ PMQVMAEPSN 
       460 
EPAPALFHKK Q

Show »

Length:461

Mass (Da):53,206

Checksum:ⁱ782D59F2992BBA22

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

G5E8R7	G5E8R7_MOUSE	Histone-lysine N-methyltransferase ... Histone-lysine N-methyltransferase Smyd1	Smyd1	456	Annotation score:
G3UZ94	G3UZ94_MOUSE	Histone-lysine N-methyltransferase ... Histone-lysine N-methyltransferase Smyd1	Smyd1	58	Annotation score:
Q8BMV4	Q8BMV4_MOUSE	Histone-lysine N-methyltransferase ... Histone-lysine N-methyltransferase Smyd1	Smyd1	69	Annotation score:
G3UXZ0	G3UXZ0_MOUSE	Histone-lysine N-methyltransferase ... Histone-lysine N-methyltransferase Smyd1	Smyd1	21	Annotation score:

Sequence cautionⁱ

The sequence AAC53021 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence AAC53022 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱ	95	K → R in strain: C57BL/6. 1 Publication	1
Natural variantⁱ	160	P → L in strain: C57BL/6. 1 Publication	1
Natural variantⁱ	344	A → T in strain: C57BL/6. 1 Publication	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_050402	6 – 45	MENVE…AVVFD → MKNGEACGGWQ in isoform 3. 1 PublicationAdd BLAST	40
Alternative sequenceⁱVSP_050403	220	N → K in isoform 2. 1 Publication	1
Alternative sequenceⁱVSP_050404	221 – 233	Missing in isoform 2. 1 PublicationAdd BLAST	13

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U76371 mRNA Translation: AAC53020.1 U76373 mRNA Translation: AAC53021.2 Different initiation. U76374 mRNA Translation: AAC53022.2 Different initiation. AK142252 mRNA Translation: BAE24995.1 CH466523 Genomic DNA Translation: EDK98934.1 BC076601 mRNA Translation: AAH76601.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS20227.2 [P97443-2] CCDS51805.1 [P97443-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001153599.1, NM_001160127.1 [P97443-1] NP_033892.2, NM_009762.2 [P97443-2]
UniGeneⁱ	Mm.234274 Mm.440892

Genome annotation databases

Ensemblⁱ	ENSMUST00000074301; ENSMUSP00000073911; ENSMUSG00000055027 [P97443-1] ENSMUST00000114186; ENSMUSP00000109824; ENSMUSG00000055027 [P97443-2]
GeneIDⁱ	12180
KEGGⁱ	mmu:12180
UCSC genome browser More...UCSCⁱ	uc009cgj.2 mouse [P97443-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P97443	Histone-lysine N-methyltransferase SMYD1		HUMAN		490	UniRef90_P97443
SET and MYND domain containing 1		MUSPF		581
Uncharacterized protein		COLAP		497
Uncharacterized protein		PANPA		497
SET and MYND domain containing 1		HORSE		492
+162
P97443-3	Uncharacterized protein		NOMLE		473	UniRef90_G1QRL5
Uncharacterized protein		MYOLU		490
Histone-lysine N-methyltransferase Smyd1		MOUSE		456
UPI0003C82796		CAMFR		564
UPI000579BD35		CAMBA		490
+8

Protein	Similar proteins		Species	Score	Length	Source
P97443	Histone-lysine N-methyltransferase SMYD1		HUMAN		490	UniRef50_P97443
SET and MYND domain containing 1		MUSPF		581
Uncharacterized protein		PANPA		497
Uncharacterized protein		COLAP		497
SET and MYND domain containing 1		HORSE		492
+592

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U76371 mRNA Translation: AAC53020.1 U76373 mRNA Translation: AAC53021.2 Different initiation. U76374 mRNA Translation: AAC53022.2 Different initiation. AK142252 mRNA Translation: BAE24995.1 CH466523 Genomic DNA Translation: EDK98934.1 BC076601 mRNA Translation: AAH76601.1
CCDSⁱ	CCDS20227.2 [P97443-2] CCDS51805.1 [P97443-1]
RefSeqⁱ	NP_001153599.1, NM_001160127.1 [P97443-1] NP_033892.2, NM_009762.2 [P97443-2]
UniGeneⁱ	Mm.234274 Mm.440892

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3N71	X-ray	2.30	A	1-490	[»]
ProteinModelPortalⁱ	P97443
SMRⁱ	P97443
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	198379, 5 interactors
ELMⁱ	P97443
IntActⁱ	P97443, 2 interactors
MINTⁱ	P97443
STRINGⁱ	10090.ENSMUSP00000073911

PTM databases

iPTMnetⁱ	P97443
PhosphoSitePlusⁱ	P97443

Proteomic databases

MaxQBⁱ	P97443
PaxDbⁱ	P97443
PRIDEⁱ	P97443

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000074301; ENSMUSP00000073911; ENSMUSG00000055027 [P97443-1] ENSMUST00000114186; ENSMUSP00000109824; ENSMUSG00000055027 [P97443-2]
GeneIDⁱ	12180
KEGGⁱ	mmu:12180
UCSCⁱ	uc009cgj.2 mouse [P97443-1]

Organism-specific databases

CTDⁱ	150572
MGIⁱ	MGI:104790 Smyd1

Phylogenomic databases

eggNOGⁱ	KOG2084 Eukaryota COG2940 LUCA
GeneTreeⁱ	ENSGT00530000063077
HOGENOMⁱ	HOG000050244
HOVERGENⁱ	HBG054953
InParanoidⁱ	P97443
KOⁱ	K11426
OMAⁱ	VTHGPTH
OrthoDBⁱ	EOG091G066T
PhylomeDBⁱ	P97443
TreeFamⁱ	TF106487

Miscellaneous databases

ChiTaRSⁱ	Smyd1 mouse
EvolutionaryTraceⁱ	P97443
Protein Ontology More...PROⁱ	PR:P97443
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000055027 Expressed in 198 organ(s), highest expression level in skeletal muscle tissue
CleanExⁱ	MM_SMYD1
ExpressionAtlasⁱ	P97443 baseline and differential
Genevisibleⁱ	P97443 MM

Family and domain databases

Gene3Dⁱ	1.25.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR001214 SET_dom IPR011990 TPR-like_helical_dom_sf IPR002893 Znf_MYND
Pfamⁱ	View protein in Pfam PF00856 SET, 1 hit PF01753 zf-MYND, 1 hit
SMARTⁱ	View protein in SMART SM00317 SET, 1 hit
PROSITEⁱ	View protein in PROSITE PS50280 SET, 1 hit PS01360 ZF_MYND_1, 1 hit PS50865 ZF_MYND_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SMYD1_MOUSE
Accessionⁱ	P97443Primary (citable) accession number: P97443 Secondary accession number(s): P97442, P97444, Q6DFW7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 19, 2003
	Last sequence update:	May 3, 2011
	Last modified:	September 12, 2018
	This is version 132 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniRef

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Supporting data

UniProtKB - P97443 (SMYD1_MOUSE)

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Histone-lysine N-methyltransferase Smyd1

Smyd1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ