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Protein

Zinc transporter 3

Gene

Slc30a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in accumulation of zinc in synaptic vesicles.1 Publication

GO - Molecular functioni

  • zinc ion transmembrane transporter activity Source: GO_Central

GO - Biological processi

  • detoxification of zinc ion Source: BHF-UCL
  • positive regulation of transport Source: MGI
  • regulation of sequestering of zinc ion Source: MGI
  • response to zinc ion Source: GO_Central
  • sequestering of zinc ion Source: BHF-UCL
  • zinc ion import into synaptic vesicle Source: SynGO
  • zinc ion transmembrane transport Source: GO_Central
  • zinc ion transport Source: BHF-UCL

Keywordsi

Biological processIon transport, Transport, Zinc transport
LigandZinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 3
Short name:
ZnT-3
Alternative name(s):
Solute carrier family 30 member 3
Gene namesi
Name:Slc30a3
Synonyms:Znt3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1345280 Slc30a3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 75CytoplasmicSequence analysisAdd BLAST75
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Topological domaini97 – 105VacuolarSequence analysis9
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Topological domaini127 – 145CytoplasmicSequence analysisAdd BLAST19
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Topological domaini167 – 177VacuolarSequence analysisAdd BLAST11
Transmembranei178 – 198HelicalSequence analysisAdd BLAST21
Topological domaini199 – 235CytoplasmicSequence analysisAdd BLAST37
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 263VacuolarSequence analysis7
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Topological domaini285 – 388CytoplasmicSequence analysisAdd BLAST104

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Endosome, Lysosome, Membrane, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002060971 – 388Zinc transporter 3Add BLAST388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei63PhosphoserineBy similarity1
Modified residuei66PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP97441
PeptideAtlasiP97441
PRIDEiP97441

PTM databases

iPTMnetiP97441
PhosphoSitePlusiP97441
SwissPalmiP97441

Expressioni

Tissue specificityi

Brain and testis. In the brain, most abundant in hippocampus and cerebral cortex. In the testis, expression is restricted to germ cells and is highest in pachytene spermatocytes and round spermatids.1 Publication

Gene expression databases

BgeeiENSMUSG00000029151 Expressed in 200 organ(s), highest expression level in prefrontal cortex
ExpressionAtlasiP97441 baseline and differential
GenevisibleiP97441 MM

Interactioni

Protein-protein interaction databases

BioGridi204705, 1 interactor
IntActiP97441, 3 interactors
MINTiP97441
STRINGi10090.ENSMUSP00000031037

Structurei

3D structure databases

ProteinModelPortaliP97441
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1482 Eukaryota
COG1230 LUCA
GeneTreeiENSGT00550000074381
HOGENOMiHOG000079023
HOVERGENiHBG003345
InParanoidiP97441
KOiK14690
OrthoDBiEOG091G07UN
PhylomeDBiP97441
TreeFamiTF313382

Family and domain databases

Gene3Di1.20.1510.10, 1 hit
InterProiView protein in InterPro
IPR002524 Cation_efflux
IPR036837 Cation_efflux_CTD_sf
IPR027469 Cation_efflux_TMD_sf
PfamiView protein in Pfam
PF01545 Cation_efflux, 1 hit
SUPFAMiSSF160240 SSF160240, 1 hit
SSF161111 SSF161111, 1 hit
TIGRFAMsiTIGR01297 CDF, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P97441-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPSLATGGS ETTRLVSARD RSSAGGGLRL KSLFTEPSEP LPEEPKLEGM
60 70 80 90 100
AFHHCHKDPV PQSGLSPERV QARRQLYAAC AVCFIFMAGE VVGGYLAHSL
110 120 130 140 150
AIMTDAAHLL ADIGSMLASL FSLWLSTRPA TRTMTFGWHR SETLGALASV
160 170 180 190 200
VSLWIVTGIL LYLAFLRLLH SDYHIEAGAM LLTASIAVCA NLLMAFVLHQ
210 220 230 240 250
TGAPHSHGST GAEYAPLEEG HGYPMSLGNT SVRAAFVHVL GDLLQSFGVL
260 270 280 290 300
AASILIYFKP QYKVADPIST FLFSICALGS TAPTLRDVLL VLMEGAPRSV
310 320 330 340 350
EFEPVRDTLL SVPGVRATHD LHLWALTLTY HVASAHLAID STADPEAVLA
360 370 380
EASSRLYSRF GFSSCTLQVE QYQPEMAQCL RCQEPSQA
Length:388
Mass (Da):41,824
Last modified:May 1, 1997 - v1
Checksum:i3CCDD0A37074EF41
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R169S4R169_MOUSE
Zinc transporter 3
Slc30a3
339Annotation score:
S4R166S4R166_MOUSE
Zinc transporter 3
Slc30a3
124Annotation score:
S4R2M0S4R2M0_MOUSE
Zinc transporter 3
Slc30a3
173Annotation score:
S4R2S4S4R2S4_MOUSE
Zinc transporter 3
Slc30a3
87Annotation score:
S4R1P0S4R1P0_MOUSE
Zinc transporter 3
Slc30a3
60Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76007 mRNA Translation: AAB39731.1
U76009, U76008 Genomic DNA Translation: AAB39733.1 Sequence problems.
CCDSiCCDS51455.1
RefSeqiNP_035903.2, NM_011773.3
UniGeneiMm.1396

Genome annotation databases

EnsembliENSMUST00000031037; ENSMUSP00000031037; ENSMUSG00000029151
GeneIDi22784
KEGGimmu:22784
UCSCiuc008wxa.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76007 mRNA Translation: AAB39731.1
U76009, U76008 Genomic DNA Translation: AAB39733.1 Sequence problems.
CCDSiCCDS51455.1
RefSeqiNP_035903.2, NM_011773.3
UniGeneiMm.1396

3D structure databases

ProteinModelPortaliP97441
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204705, 1 interactor
IntActiP97441, 3 interactors
MINTiP97441
STRINGi10090.ENSMUSP00000031037

PTM databases

iPTMnetiP97441
PhosphoSitePlusiP97441
SwissPalmiP97441

Proteomic databases

PaxDbiP97441
PeptideAtlasiP97441
PRIDEiP97441

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031037; ENSMUSP00000031037; ENSMUSG00000029151
GeneIDi22784
KEGGimmu:22784
UCSCiuc008wxa.2 mouse

Organism-specific databases

CTDi7781
MGIiMGI:1345280 Slc30a3

Phylogenomic databases

eggNOGiKOG1482 Eukaryota
COG1230 LUCA
GeneTreeiENSGT00550000074381
HOGENOMiHOG000079023
HOVERGENiHBG003345
InParanoidiP97441
KOiK14690
OrthoDBiEOG091G07UN
PhylomeDBiP97441
TreeFamiTF313382

Miscellaneous databases

ChiTaRSiSlc30a3 mouse
PROiPR:P97441
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029151 Expressed in 200 organ(s), highest expression level in prefrontal cortex
ExpressionAtlasiP97441 baseline and differential
GenevisibleiP97441 MM

Family and domain databases

Gene3Di1.20.1510.10, 1 hit
InterProiView protein in InterPro
IPR002524 Cation_efflux
IPR036837 Cation_efflux_CTD_sf
IPR027469 Cation_efflux_TMD_sf
PfamiView protein in Pfam
PF01545 Cation_efflux, 1 hit
SUPFAMiSSF160240 SSF160240, 1 hit
SSF161111 SSF161111, 1 hit
TIGRFAMsiTIGR01297 CDF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZNT3_MOUSE
AccessioniPrimary (citable) accession number: P97441
Secondary accession number(s): P97511
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1997
Last modified: November 7, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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