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Entry version 159 (07 Apr 2021)
Sequence version 2 (21 Feb 2006)
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Protein

Myosin phosphatase Rho-interacting protein

Gene

Mprip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin filament binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myosin phosphatase Rho-interacting protein
Alternative name(s):
Rho-interacting protein 3
Short name:
RIP3
p116Rip
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mprip
Synonyms:Kiaa0864, Mrip, Rhoip3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1349438, Mprip

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi857L → P: Loss of interaction with PPP1R12C and PPP1R12A. 1 Publication1
Mutagenesisi905L → P: No effect. 1 Publication1
Mutagenesisi919I → P: Loss of interaction with PPP1R12C and PPP1R12A. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002238701 – 1024Myosin phosphatase Rho-interacting proteinAdd BLAST1024

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei193PhosphoserineBy similarity1
Modified residuei219PhosphoserineCombined sources1
Modified residuei221PhosphoserineCombined sources1
Modified residuei225PhosphoserineCombined sources1
Modified residuei227PhosphoserineCombined sources1
Modified residuei266PhosphoserineBy similarity1
Modified residuei270PhosphoserineBy similarity1
Modified residuei289PhosphoserineCombined sources1
Modified residuei292PhosphoserineBy similarity1
Modified residuei295PhosphothreonineBy similarity1
Modified residuei364PhosphoserineCombined sources1
Modified residuei492PhosphoserineBy similarity1
Modified residuei617PhosphoserineCombined sources1
Modified residuei645PhosphothreonineBy similarity1
Modified residuei799PhosphoserineBy similarity1
Modified residuei976PhosphoserineCombined sources1
Modified residuei992PhosphoserineBy similarity1
Modified residuei1013PhosphoserineCombined sources1
Modified residuei1015PhosphoserineCombined sources1
Isoform 3 (identifier: P97434-3)
Modified residuei979PhosphoserineCombined sources1
Isoform 2 (identifier: P97434-2)
Modified residuei1015PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P97434

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P97434

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P97434

PeptideAtlas

More...
PeptideAtlasi
P97434

PRoteomics IDEntifications database

More...
PRIDEi
P97434

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
291497 [P97434-1]
291498 [P97434-2]
291499 [P97434-3]
291500 [P97434-4]
291501 [P97434-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P97434

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P97434

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in Kidney, Brain, Heart and Lung.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000005417, Expressed in striatum and 316 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P97434, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P97434, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds RHOA, PPP1R12A/MBS and PPP1R12C/MBS85 through adjacent coiled coil domains.

Interacts with MYZAP. Binds F-actin through its N-terminus.

4 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
205073, 12 interactors

Protein interaction database and analysis system

More...
IntActi
P97434, 13 interactors

Molecular INTeraction database

More...
MINTi
P97434

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000112072

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P97434, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P97434

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini43 – 150PH 1PROSITE-ProRule annotationAdd BLAST108
Domaini386 – 482PH 2PROSITE-ProRule annotationAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 382Interaction with F-actinAdd BLAST382
Regioni545 – 823Interaction with RHOA1 PublicationAdd BLAST279
Regioni823 – 878Interaction with PPP1R12ABy similarityAdd BLAST56

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili672 – 976Sequence analysisAdd BLAST305

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi184 – 190Poly-Ser7

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4807, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155286

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011327_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P97434

Database of Orthologous Groups

More...
OrthoDBi
428862at2759

TreeFam database of animal gene trees

More...
TreeFami
TF329258

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13275, PH_M-RIP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039597, M-RIP_PH
IPR011993, PH-like_dom_sf
IPR001849, PH_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00169, PH, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233, PH, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50003, PH_DOMAIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P97434-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAAKENPCR KFQANIFNKS KCQNCFKPRE SHLLNDEDLT QAKPIYGGWL
60 70 80 90 100
LLAPDGTDFD NPVHRSRKWQ RRFFILYEHG LLRYALDEMP TTLPQGTINM
110 120 130 140 150
NQCTDVVDGE ARTGQKFSLC ILTPDKEHFI RAETKEIISG WLEMLMVYPR
160 170 180 190 200
TNKQNQKKKR KVEPPTPQEP GPAKMAVTSS SGGSSGSSSS IPSAEKVPTT
210 220 230 240 250
KSTLWQEEMR AKDQPDGTSL SPAQSPSQSQ PPAACTPREP GLESKEDEST
260 270 280 290 300
ISGDRVDGGR KVRVESGYFS LEKAKQDLRA EEQLPPLLSP PSPSTPHSRR
310 320 330 340 350
SQVIEKFEAL DIEKAEHMET NMLILTTPSS DTRQGRSERR AIPRKRDFAS
360 370 380 390 400
EAPTAPLSDA CPLSPHRRAK SLDRRSTESS MTPDLLNFKK GWLTKQYEDG
410 420 430 440 450
QWKKHWFVLA DQSLRYYRDS VAEEAADLDG EINLSTCYDV TEYPVQRNYG
460 470 480 490 500
FQIHTKEGEF TLSAMTSGIR RNWIQTIMKH VLPASAPDVT SSLPEGKNKS
510 520 530 540 550
TSFETCSRST EKQEAEPGEP DPEQKKSRAR ERRREGRSKT FDWAEFRPIQ
560 570 580 590 600
QALAQERASA VGSSDSGDPG CLEAEPGELE RERARRREER RKRFGMLDTI
610 620 630 640 650
DGPGMEDTAL RMDIDRSPGL LGTPDLKTQN VHVEIEQRWH QVETTPLREE
660 670 680 690 700
KQVPIAPLHL SLEDRSERLS THELTSLLEK ELEQSQKEAS DLLEQNRLLQ
710 720 730 740 750
DQLRVALGRE QSAREGYVLQ ATCERGFAAM EETHQKKIED LQRQHQRELE
760 770 780 790 800
KLREEKDRLL AEETAATISA IEAMKNAHRE EMERELEKSQ RSQISSINSD
810 820 830 840 850
IEALRRQYLE ELQSVQRELE VLSEQYSQKC LENAHLAQAL EAERQALRQC
860 870 880 890 900
QRENQELNAH NQELNNRLAA EITRLRTLLT GDGGGESTGL PLTQGKDAYE
910 920 930 940 950
LEVLLRVKES EIQYLKQEIS SLKDELQTAL RDKKYASDKY KDIYTELSIA
960 970 980 990 1000
KAKADCDISR LKEQLKAATE ALGEKSPEGT TVSGYDIMKS KSNPDFLKKD
1010 1020
RSCVTRQLRN IRSKSVIEQV SWDN
Length:1,024
Mass (Da):116,408
Last modified:February 21, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7BE3BFB89011ECC5
GO
Isoform 2 (identifier: P97434-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1016-1024: VIEQVSWDN → LKEGLTVQERLKLFESRDLKKD

Show »
Length:1,037
Mass (Da):117,965
Checksum:i44AD4103995E08F7
GO
Isoform 3 (identifier: P97434-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     347-382: Missing.
     1016-1024: VIEQVSWDN → LKEGLTVQERLKLFESRDLKKD

Show »
Length:1,001
Mass (Da):114,094
Checksum:iC718480566C25CA9
GO
Isoform 4 (identifier: P97434-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     168-205: Missing.

Show »
Length:986
Mass (Da):112,703
Checksum:iF8F9FF6AA58B6330
GO
Isoform 5 (identifier: P97434-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     402-409: WKKHWFVL → TQVPFLRTKIGTF

Show »
Length:1,029
Mass (Da):116,773
Checksum:iB14325EC3B88E5A5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SWZ5Q5SWZ5_MOUSE
Myosin phosphatase Rho-interacting ...
Mprip
2,269Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6RND9F6RND9_MOUSE
Myosin phosphatase Rho-interacting ...
Mprip
1,010Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6S5I0F6S5I0_MOUSE
Myosin phosphatase Rho-interacting ...
Mprip
848Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6XZM9F6XZM9_MOUSE
Myosin phosphatase Rho-interacting ...
Mprip
498Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAE36957 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti43K → E in BAE32843 (PubMed:16141072).Curated1
Sequence conflicti70Q → R in BAE33355 (PubMed:16141072).Curated1
Sequence conflicti184S → T in AAB18198 (PubMed:9199174).Curated1
Sequence conflicti289S → P in BAE42242 (PubMed:16141072).Curated1
Sequence conflicti301S → P in BAE32843 (PubMed:16141072).Curated1
Sequence conflicti484A → T in BAE42242 (PubMed:16141072).Curated1
Sequence conflicti484A → T in BAE42072 (PubMed:16141072).Curated1
Sequence conflicti590R → P in AAB18198 (PubMed:9199174).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_017290168 – 205Missing in isoform 4. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_017292347 – 382Missing in isoform 3. CuratedAdd BLAST36
Alternative sequenceiVSP_017291402 – 409WKKHWFVL → TQVPFLRTKIGTF in isoform 5. 1 Publication8
Alternative sequenceiVSP_0172931016 – 1024VIEQVSWDN → LKEGLTVQERLKLFESRDLK KD in isoform 2 and isoform 3. 2 Publications9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U73200 mRNA Translation: AAB18198.1
AK154807 mRNA Translation: BAE32843.1
AK155630 mRNA Translation: BAE33355.1
AK158296 mRNA Translation: BAE34450.1
AK162530 mRNA Translation: BAE36957.1 Different initiation.
AK170849 mRNA Translation: BAE42072.1
AK171089 mRNA Translation: BAE42242.1
AL596204 Genomic DNA No translation available.
BC049803 mRNA Translation: AAH49803.1
BC063067 mRNA Translation: AAH63067.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS24774.1 [P97434-2]
CCDS24775.1 [P97434-1]

Protein sequence database of the Protein Information Resource

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PIRi
T30868

NCBI Reference Sequences

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RefSeqi
NP_036157.2, NM_012027.2 [P97434-1]
NP_957697.1, NM_201245.3 [P97434-2]
XP_006533503.1, XM_006533440.1 [P97434-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000072031; ENSMUSP00000071914; ENSMUSG00000005417 [P97434-2]
ENSMUST00000108751; ENSMUSP00000104382; ENSMUSG00000005417 [P97434-4]
ENSMUST00000116371; ENSMUSP00000112072; ENSMUSG00000005417 [P97434-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
26936

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:26936

UCSC genome browser

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UCSCi
uc007jen.2, mouse [P97434-1]
uc007jeo.2, mouse [P97434-2]
uc007jep.2, mouse [P97434-4]
uc011xvo.1, mouse [P97434-5]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73200 mRNA Translation: AAB18198.1
AK154807 mRNA Translation: BAE32843.1
AK155630 mRNA Translation: BAE33355.1
AK158296 mRNA Translation: BAE34450.1
AK162530 mRNA Translation: BAE36957.1 Different initiation.
AK170849 mRNA Translation: BAE42072.1
AK171089 mRNA Translation: BAE42242.1
AL596204 Genomic DNA No translation available.
BC049803 mRNA Translation: AAH49803.1
BC063067 mRNA Translation: AAH63067.1
CCDSiCCDS24774.1 [P97434-2]
CCDS24775.1 [P97434-1]
PIRiT30868
RefSeqiNP_036157.2, NM_012027.2 [P97434-1]
NP_957697.1, NM_201245.3 [P97434-2]
XP_006533503.1, XM_006533440.1 [P97434-3]

3D structure databases

SMRiP97434
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi205073, 12 interactors
IntActiP97434, 13 interactors
MINTiP97434
STRINGi10090.ENSMUSP00000112072

PTM databases

iPTMnetiP97434
PhosphoSitePlusiP97434

Proteomic databases

jPOSTiP97434
MaxQBiP97434
PaxDbiP97434
PeptideAtlasiP97434
PRIDEiP97434
ProteomicsDBi291497 [P97434-1]
291498 [P97434-2]
291499 [P97434-3]
291500 [P97434-4]
291501 [P97434-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
13293, 214 antibodies

Genome annotation databases

EnsembliENSMUST00000072031; ENSMUSP00000071914; ENSMUSG00000005417 [P97434-2]
ENSMUST00000108751; ENSMUSP00000104382; ENSMUSG00000005417 [P97434-4]
ENSMUST00000116371; ENSMUSP00000112072; ENSMUSG00000005417 [P97434-1]
GeneIDi26936
KEGGimmu:26936
UCSCiuc007jen.2, mouse [P97434-1]
uc007jeo.2, mouse [P97434-2]
uc007jep.2, mouse [P97434-4]
uc011xvo.1, mouse [P97434-5]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23164
MGIiMGI:1349438, Mprip

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG4807, Eukaryota
GeneTreeiENSGT00940000155286
HOGENOMiCLU_011327_0_0_1
InParanoidiP97434
OrthoDBi428862at2759
TreeFamiTF329258

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
26936, 3 hits in 53 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Mprip, mouse

Protein Ontology

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PROi
PR:P97434
RNActiP97434, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000005417, Expressed in striatum and 316 other tissues
ExpressionAtlasiP97434, baseline and differential
GenevisibleiP97434, MM

Family and domain databases

CDDicd13275, PH_M-RIP, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR039597, M-RIP_PH
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
PfamiView protein in Pfam
PF00169, PH, 2 hits
SMARTiView protein in SMART
SM00233, PH, 2 hits
PROSITEiView protein in PROSITE
PS50003, PH_DOMAIN, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMPRIP_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P97434
Secondary accession number(s): Q3TBR5
, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 21, 2006
Last modified: April 7, 2021
This is version 159 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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