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Protein

Regulator of G-protein signaling 16

Gene

Rgs16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates G protein-coupled receptor signaling cascades (PubMed:9079700). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:10373502). Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha (PubMed:8917514). May regulate extra and intracellular mitogenic signals.Curated2 Publications

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: UniProtKB
  • negative regulation of signal transduction Source: UniProtKB-KW
  • positive regulation of GTPase activity Source: UniProtKB

Keywordsi

Molecular functionGTPase activation, Signal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 16
Short name:
RGS16
Alternative name(s):
A28-RGS14P
Retinal-specific RGS
Short name:
RGS-r1 Publication
Retinally abundant regulator of G-protein signaling
Gene namesi
Name:Rgs16
Synonyms:Rgsr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:108407 Rgs16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002042221 – 201Regulator of G-protein signaling 16Add BLAST201

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2S-palmitoyl cysteine1 Publication1
Lipidationi12S-palmitoyl cysteine1 Publication1
Modified residuei167Phosphotyrosine; by EGFRBy similarity1
Modified residuei176PhosphotyrosineBy similarity1

Post-translational modificationi

Palmitoylated on Cys-2 and/or Cys-12.1 Publication
Phosphorylated. Phosphorylation at Tyr-167 by EGFR enhances GTPase accelerating (GAP) activity toward GNAI1.By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP97428
PRIDEiP97428

PTM databases

iPTMnetiP97428
PhosphoSitePlusiP97428
SwissPalmiP97428

Expressioni

Tissue specificityi

Retinal; also predominantly expressed in the liver and pituitary.

Gene expression databases

BgeeiENSMUSG00000026475
CleanExiMM_RGS16
ExpressionAtlasiP97428 baseline and differential
GenevisibleiP97428 MM

Interactioni

Subunit structurei

Interacts with GNAI1 and GNAQ (By similarity). Interacts with GNAI3, GNAI3 and GNAO1 (PubMed:9079700, PubMed:18434540).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Gnao1P18872-12EBI-643424,EBI-1018790

Protein-protein interaction databases

DIPiDIP-29922N
ELMiP97428
IntActiP97428, 2 interactors
STRINGi10090.ENSMUSP00000027748

Structurei

Secondary structure

1201
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi58 – 63Combined sources6
Helixi65 – 68Combined sources4
Helixi72 – 83Combined sources12
Turni84 – 86Combined sources3
Helixi88 – 100Combined sources13
Helixi106 – 120Combined sources15
Helixi133 – 144Combined sources12
Turni148 – 151Combined sources4
Helixi152 – 163Combined sources12
Helixi166 – 171Combined sources6
Helixi174 – 177Combined sources4

3D structure databases

ProteinModelPortaliP97428
SMRiP97428
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP97428

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 180RGSPROSITE-ProRule annotationAdd BLAST117

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000118903
HOGENOMiHOG000233512
HOVERGENiHBG013233
InParanoidiP97428
KOiK16449
OMAiHTFLKTE
OrthoDBiEOG091G0BDG
PhylomeDBiP97428
TreeFamiTF315837

Family and domain databases

Gene3Di1.10.196.10, 2 hits
InterProiView protein in InterPro
IPR016137 RGS
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit

Sequencei

Sequence statusi: Complete.

P97428-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCRTLATFPN TCLERAKEFK TRLGIFLHKS ELSSDTGGIS KFEWASKHNK
60 70 80 90 100
ERSFSEDVLG WRESFDLLLN SKNGVAAFHA FLKTEFSEEN LEFWLACEEF
110 120 130 140 150
KKIRSATKLA SRAHHIFDEY IRSEAPKEVN IDHETRELTK TNLQAATTSC
160 170 180 190 200
FDVAQGKTRT LMEKDSYPRF LKSPAYRDLA AQASATSTSA PSGSPAEPSH

T
Length:201
Mass (Da):22,691
Last modified:May 1, 1997 - v1
Checksum:iAE3D798F15787392
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51E → EN in AAC16913 (PubMed:9223279).Curated1
Sequence conflicti115H → Q in AAC16913 (PubMed:9223279).Curated1
Sequence conflicti118D → E in AAC16913 (PubMed:9223279).Curated1
Sequence conflicti190A → V in AAC16913 (PubMed:9223279).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72881 mRNA Translation: AAC52927.1
U67189 mRNA Translation: AAB50619.1
U70427 Genomic DNA Translation: AAC16913.1
U94828 mRNA Translation: AAC53549.1
BC010980 mRNA Translation: AAH10980.1
BC049968 mRNA Translation: AAH49968.2
CCDSiCCDS15376.1
RefSeqiNP_035397.2, NM_011267.3
UniGeneiMm.181709

Genome annotation databases

EnsembliENSMUST00000027748; ENSMUSP00000027748; ENSMUSG00000026475
GeneIDi19734
KEGGimmu:19734
UCSCiuc007dae.2 mouse

Similar proteinsi

Entry informationi

Entry nameiRGS16_MOUSE
AccessioniPrimary (citable) accession number: P97428
Secondary accession number(s): O09091, P97420, Q80V16
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: June 20, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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