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Protein

Dihydropyrimidinase-related protein 1

Gene

Crmp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May participate in cytokinesis.1 Publication

Caution

Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure.Curated

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-399956 CRMPs in Sema3A signaling

Protein family/group databases

MEROPSiM38.974

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropyrimidinase-related protein 1
Short name:
DRP-1
Alternative name(s):
Collapsin response mediator protein 1
Short name:
CRMP-1
Unc-33-like phosphoprotein 3
Short name:
ULIP-3
Gene namesi
Name:Crmp1
Synonyms:Dpysl1, Ulip3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:107793 Crmp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001659101 – 572Dihydropyrimidinase-related protein 1Add BLAST572

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphoserineBy similarity1
Modified residuei101Phosphothreonine; by AURKABy similarity1
Modified residuei102Phosphothreonine; by AURKABy similarity1
Modified residuei316Nitrated tyrosineCombined sources1
Modified residuei504PhosphotyrosineCombined sources1
Modified residuei509PhosphothreonineCombined sources1
Modified residuei521PhosphoserineBy similarity1
Modified residuei522PhosphoserineBy similarity1
Modified residuei537PhosphoserineCombined sources1
Modified residuei540PhosphoserineCombined sources1
Modified residuei542PhosphoserineCombined sources1

Keywords - PTMi

Nitration, Phosphoprotein

Proteomic databases

EPDiP97427
MaxQBiP97427
PaxDbiP97427
PeptideAtlasiP97427
PRIDEiP97427

PTM databases

iPTMnetiP97427
PhosphoSitePlusiP97427
SwissPalmiP97427

Expressioni

Gene expression databases

BgeeiENSMUSG00000029121 Expressed in 218 organ(s), highest expression level in cerebral cortex
CleanExiMM_CRMP1
ExpressionAtlasiP97427 baseline and differential
GenevisibleiP97427 MM

Interactioni

Subunit structurei

Homotetramer, and heterotetramer with DPYSL2, DPYSL3, DPYSL4 or DPYSL5. Interacts with PLXNA1.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198890, 8 interactors
IntActiP97427, 6 interactors
MINTiP97427
STRINGi10090.ENSMUSP00000109795

Structurei

Secondary structure

1572
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP97427
SMRiP97427
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP97427

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2584 Eukaryota
COG0044 LUCA
GeneTreeiENSGT00760000119241
HOGENOMiHOG000219145
HOVERGENiHBG000806
InParanoidiP97427
PhylomeDBiP97427

Family and domain databases

CDDicd01314 D-HYD, 1 hit
Gene3Di2.30.40.10, 2 hits
InterProiView protein in InterPro
IPR006680 Amidohydro-rel
IPR030624 CRMP1
IPR011778 Hydantoinase/dihydroPyrase
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
PANTHERiPTHR11647:SF54 PTHR11647:SF54, 1 hit
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
SUPFAMiSSF51338 SSF51338, 2 hits
SSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR02033 D-hydantoinase, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P97427-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSHQGKKSIP HITSDRLLIR GGRIINDDQS FYADVYLEDG LIKQIGENLI
60 70 80 90 100
VPGGVKTIEA NGRMVIPGGI DVNTYLQKPS QGMTSADDFF QGTKAALAGG
110 120 130 140 150
TTMIIDHVVP EPGSSLLTSF EKWHEAADTK SCCDYSLHVD ITSWYDGVRE
160 170 180 190 200
ELEVLVQDKG VNSFQVYMAY KDLYQMSDSQ LYEAFTFLKG LGAVILVHAE
210 220 230 240 250
NGDLIAQEQK RILEMGITGP EGHALSRPEE LEAEAVFRAI AIAGRINCPV
260 270 280 290 300
YITKVMSKSA ADIIALARKK GPLVFGEPIA ASLGTDGTHY WSKNWAKAAA
310 320 330 340 350
FVTSPPLSPD PTTPDYLTSL LACGDLQVTG SGHCPYSTAQ KAVGKDNFTL
360 370 380 390 400
IPEGVNGIEE RMTVVWDKAV ATGKMDENQF VAVTSTNAAK IFNLYPRKGR
410 420 430 440 450
IAVGSDADVV IWDPDKMKTI TAKSHKSTVE YNIFEGMECH GSPLVVISQG
460 470 480 490 500
KIVFEDGNIS VSKGMGRFIP RKPFPEHLYQ RVRIRSKVFG LHSVSRGMYD
510 520 530 540 550
GPVYEVPATP KHAAPAPSAK SSPSKHQPPP IRNLHQSNFS LSGAQIDDNN
560 570
PRRTGHRIVA PPGGRSNITS LG
Length:572
Mass (Da):62,168
Last modified:May 1, 1997 - v1
Checksum:iFE17DDCD735CAF8F
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6P1J1Q6P1J1_MOUSE
Crmp1 protein
Crmp1
686Annotation score:
Q71H75Q71H75_MOUSE
Collapsin response mediator protein...
Crmp1
191Annotation score:
A0A0J9YUZ1A0A0J9YUZ1_MOUSE
Dihydropyrimidinase-related protein...
Crmp1
143Annotation score:
A0A0J9YTX5A0A0J9YTX5_MOUSE
Dihydropyrimidinase-related protein...
Crmp1
157Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti338T → I in CAA70300 (PubMed:9652388).Curated1
Sequence conflicti476E → K in BAA21887 (Ref. 3) Curated1
Sequence conflicti489F → S in BAA21887 (Ref. 3) Curated1
Sequence conflicti520K → E in CAA70300 (PubMed:9652388).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72875 mRNA Translation: AAB39703.1
Y09080 mRNA Translation: CAA70300.1
AB006714 mRNA Translation: BAA21887.1
BC031738 mRNA Translation: AAH31738.1
CCDSiCCDS39075.1
RefSeqiNP_031791.3, NM_007765.4
UniGeneiMm.290995

Genome annotation databases

EnsembliENSMUST00000031004; ENSMUSP00000031004; ENSMUSG00000029121
GeneIDi12933
KEGGimmu:12933
UCSCiuc008xfm.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72875 mRNA Translation: AAB39703.1
Y09080 mRNA Translation: CAA70300.1
AB006714 mRNA Translation: BAA21887.1
BC031738 mRNA Translation: AAH31738.1
CCDSiCCDS39075.1
RefSeqiNP_031791.3, NM_007765.4
UniGeneiMm.290995

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KCXX-ray2.12A/B8-525[»]
ProteinModelPortaliP97427
SMRiP97427
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198890, 8 interactors
IntActiP97427, 6 interactors
MINTiP97427
STRINGi10090.ENSMUSP00000109795

Protein family/group databases

MEROPSiM38.974

PTM databases

iPTMnetiP97427
PhosphoSitePlusiP97427
SwissPalmiP97427

Proteomic databases

EPDiP97427
MaxQBiP97427
PaxDbiP97427
PeptideAtlasiP97427
PRIDEiP97427

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031004; ENSMUSP00000031004; ENSMUSG00000029121
GeneIDi12933
KEGGimmu:12933
UCSCiuc008xfm.2 mouse

Organism-specific databases

CTDi1400
MGIiMGI:107793 Crmp1

Phylogenomic databases

eggNOGiKOG2584 Eukaryota
COG0044 LUCA
GeneTreeiENSGT00760000119241
HOGENOMiHOG000219145
HOVERGENiHBG000806
InParanoidiP97427
PhylomeDBiP97427

Enzyme and pathway databases

ReactomeiR-MMU-399956 CRMPs in Sema3A signaling

Miscellaneous databases

ChiTaRSiCrmp1 mouse
EvolutionaryTraceiP97427
PROiPR:P97427
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029121 Expressed in 218 organ(s), highest expression level in cerebral cortex
CleanExiMM_CRMP1
ExpressionAtlasiP97427 baseline and differential
GenevisibleiP97427 MM

Family and domain databases

CDDicd01314 D-HYD, 1 hit
Gene3Di2.30.40.10, 2 hits
InterProiView protein in InterPro
IPR006680 Amidohydro-rel
IPR030624 CRMP1
IPR011778 Hydantoinase/dihydroPyrase
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
PANTHERiPTHR11647:SF54 PTHR11647:SF54, 1 hit
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
SUPFAMiSSF51338 SSF51338, 2 hits
SSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR02033 D-hydantoinase, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDPYL1_MOUSE
AccessioniPrimary (citable) accession number: P97427
Secondary accession number(s): O08554, O35097
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: September 12, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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