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Protein

Islet cell autoantigen 1

Gene

Ica1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in neurotransmitter secretion.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processNeurotransmitter transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Islet cell autoantigen 1
Alternative name(s):
69 kDa islet cell autoantigen
Short name:
ICA69
Islet cell autoantigen p69
Short name:
ICAp69
Short name:
p69
Gene namesi
Name:Ica1Imported
Synonyms:Icap69
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:96391 Ica1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane, Synapse

Pathology & Biotechi

Disruption phenotypei

129/SvJ mice lacking Ica1 do not display an obvious phenotype and age normally, while NOD mice without Ica1 develop diabetes and display sudden mid-life lethality but are resistant to cyclophosphamide-induced disease acceleration.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000841311 – 478Islet cell autoantigen 1Add BLAST478

Proteomic databases

MaxQBiP97411
PaxDbiP97411
PRIDEiP97411

PTM databases

iPTMnetiP97411
PhosphoSitePlusiP97411

Expressioni

Tissue specificityi

Predominantly expressed in brain, pancreas and stomach mucosa. High expression also found in stomach muscle and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000062995 Expressed in 249 organ(s), highest expression level in testis
CleanExiMM_ICA1
ExpressionAtlasiP97411 baseline and differential
GenevisibleiP97411 MM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Pick1Q620832EBI-16056188,EBI-77550

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-60170N
IntActiP97411, 1 interactor
STRINGi10090.ENSMUSP00000040062

Structurei

3D structure databases

ProteinModelPortaliP97411
SMRiP97411
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 253AHPROSITE-ProRule annotationAdd BLAST204

Phylogenomic databases

eggNOGiKOG3891 Eukaryota
ENOG410YJKW LUCA
GeneTreeiENSGT00390000005530
HOGENOMiHOG000006612
HOVERGENiHBG061005
InParanoidiP97411
KOiK19863
OMAiHESFRGY
OrthoDBiEOG091G0BDC
TreeFamiTF317186

Family and domain databases

Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR010504 AH_dom
IPR030796 ICA1
IPR024114 Islet_autoAg_Ica1/Ica1-like
IPR006723 Islet_autoAg_Ica1_C
PANTHERiPTHR10164 PTHR10164, 1 hit
PTHR10164:SF3 PTHR10164:SF3, 1 hit
PfamiView protein in Pfam
PF06456 Arfaptin, 1 hit
PF04629 ICA69, 2 hits
SMARTiView protein in SMART
SM01015 Arfaptin, 1 hit
SM01237 ICA69, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
PROSITEiView protein in PROSITE
PS50870 AH, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: P97411-1) [UniParc]FASTAAdd to basket
Also known as: Alpha1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGHKCYSWE LQDRFAQDKS VVNKMQQKYW ETKQAFIKAT GKKEDEHVVA
60 70 80 90 100
SDADLDAKLE LFHSIQRTCL DLSKAIVLYQ KRICFLSQEE NELGKFLRSQ
110 120 130 140 150
GFQDKTRAGK MMQATGKALC FSSQQRLALR NPLCRFHQEV ETFRHRAISD
160 170 180 190 200
TWLTVNRMEQ YRTEYRGALL WMKDVSQELD PDLYKQMEKF RKVQTQVRLA
210 220 230 240 250
KKNFDKLKMD VCQKVDLLGA SRCNLLSHML ATYQTTLLHF WEKTSHTMAA
260 270 280 290 300
IHESFKGYQP YEFTTLKSLQ DPMKKLVEKE GKKTSWRENR EAVAPEPRQL
310 320 330 340 350
ISLEDEHKDS SAYKTEEGTS VLSSVDKGSV HDTCSGPIDE LLDGKPEEAC
360 370 380 390 400
LGPTAGTPEP ESGDKDDLLL LNEIFSTSCL DEGEFSREWA AVFGDDQLKE
410 420 430 440 450
PAPMGAQGEP DPKPQIGSGF LPSQLLDQNM KDLQASLQEP AKAASDLTAW
460 470
FSLFADLDPL SNPDAVGKTD KEHELLNA
Length:478
Mass (Da):54,324
Last modified:July 27, 2011 - v3
Checksum:iB7B1EE18AC39E2F9
GO
Isoform 21 Publication (identifier: P97411-2) [UniParc]FASTAAdd to basket
Also known as: Beta1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     315-315: T → R
     316-336: Missing.

Show »
Length:457
Mass (Da):52,303
Checksum:i06645C68B867D942
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R217S4R217_MOUSE
Islet cell autoantigen 1
Ica1
302Annotation score:
D3Z118D3Z118_MOUSE
Islet cell autoantigen 1
Ica1
465Annotation score:
D3Z376D3Z376_MOUSE
Islet cell autoantigen 1
Ica1
277Annotation score:
D3Z119D3Z119_MOUSE
Islet cell autoantigen 1
Ica1 mCG_2771
310Annotation score:
D3Z020D3Z020_MOUSE
Islet cell autoantigen 1
Ica1
73Annotation score:
F6UY19F6UY19_MOUSE
Islet cell autoantigen 1
Ica1
66Annotation score:
D3Z699D3Z699_MOUSE
Islet cell autoantigen 1
Ica1
45Annotation score:
F7BG11F7BG11_MOUSE
Islet cell autoantigen 1
Ica1
141Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti170L → F in AAB19182 (PubMed:8975715).Curated1
Sequence conflicti312A → T in AAB19182 (PubMed:8975715).Curated1
Sequence conflicti312A → T in AAC52992 (PubMed:8975715).Curated1
Sequence conflicti312A → T in AAC52993 (PubMed:8975715).Curated1
Sequence conflicti312A → T in AAB40939 (PubMed:8975715).Curated1
Sequence conflicti312A → T in AAH02030 (PubMed:15489334).Curated1
Sequence conflicti312A → T in AAC99989 (Ref. 5) Curated1
Sequence conflicti397Q → R in AAB19182 (PubMed:8975715).Curated1
Sequence conflicti397Q → R in AAC52992 (PubMed:8975715).Curated1
Sequence conflicti397Q → R in AAC52993 (PubMed:8975715).Curated1
Sequence conflicti397Q → R in AAB40939 (PubMed:8975715).Curated1
Sequence conflicti397Q → R in AAH02030 (PubMed:15489334).Curated1
Sequence conflicti397Q → R in AAC99989 (Ref. 5) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_050425315T → R in isoform 2. 1 Publication1
Alternative sequenceiVSP_050426316 – 336Missing in isoform 2. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26459 mRNA Translation: AAC52992.1
U26460 mRNA Translation: AAB40939.1
U26461 mRNA Translation: AAC52993.1
U37186
, U37013, U37014, U37015, U37082, U37083, U37084, U37085, U37086, U37184, U37185 Genomic DNA Translation: AAB19182.1
AC158670 Genomic DNA No translation available.
BC002030 mRNA Translation: AAH02030.1
U34595 mRNA Translation: AAC99989.1
CCDSiCCDS19911.1 [P97411-1]
RefSeqiNP_001239195.1, NM_001252266.1 [P97411-2]
NP_034622.3, NM_010492.3 [P97411-1]
XP_006505056.1, XM_006504993.3 [P97411-1]
XP_006505057.1, XM_006504994.3 [P97411-1]
XP_006505058.1, XM_006504995.3 [P97411-2]
UniGeneiMm.275683

Genome annotation databases

EnsembliENSMUST00000038403; ENSMUSP00000040062; ENSMUSG00000062995 [P97411-1]
ENSMUST00000115520; ENSMUSP00000111182; ENSMUSG00000062995 [P97411-1]
GeneIDi15893
KEGGimmu:15893
UCSCiuc009axx.1 mouse [P97411-2]
uc009axy.1 mouse [P97411-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26459 mRNA Translation: AAC52992.1
U26460 mRNA Translation: AAB40939.1
U26461 mRNA Translation: AAC52993.1
U37186
, U37013, U37014, U37015, U37082, U37083, U37084, U37085, U37086, U37184, U37185 Genomic DNA Translation: AAB19182.1
AC158670 Genomic DNA No translation available.
BC002030 mRNA Translation: AAH02030.1
U34595 mRNA Translation: AAC99989.1
CCDSiCCDS19911.1 [P97411-1]
RefSeqiNP_001239195.1, NM_001252266.1 [P97411-2]
NP_034622.3, NM_010492.3 [P97411-1]
XP_006505056.1, XM_006504993.3 [P97411-1]
XP_006505057.1, XM_006504994.3 [P97411-1]
XP_006505058.1, XM_006504995.3 [P97411-2]
UniGeneiMm.275683

3D structure databases

ProteinModelPortaliP97411
SMRiP97411
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60170N
IntActiP97411, 1 interactor
STRINGi10090.ENSMUSP00000040062

PTM databases

iPTMnetiP97411
PhosphoSitePlusiP97411

Proteomic databases

MaxQBiP97411
PaxDbiP97411
PRIDEiP97411

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038403; ENSMUSP00000040062; ENSMUSG00000062995 [P97411-1]
ENSMUST00000115520; ENSMUSP00000111182; ENSMUSG00000062995 [P97411-1]
GeneIDi15893
KEGGimmu:15893
UCSCiuc009axx.1 mouse [P97411-2]
uc009axy.1 mouse [P97411-1]

Organism-specific databases

CTDi3382
MGIiMGI:96391 Ica1

Phylogenomic databases

eggNOGiKOG3891 Eukaryota
ENOG410YJKW LUCA
GeneTreeiENSGT00390000005530
HOGENOMiHOG000006612
HOVERGENiHBG061005
InParanoidiP97411
KOiK19863
OMAiHESFRGY
OrthoDBiEOG091G0BDC
TreeFamiTF317186

Miscellaneous databases

ChiTaRSiIca1 mouse
PROiPR:P97411
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000062995 Expressed in 249 organ(s), highest expression level in testis
CleanExiMM_ICA1
ExpressionAtlasiP97411 baseline and differential
GenevisibleiP97411 MM

Family and domain databases

Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR010504 AH_dom
IPR030796 ICA1
IPR024114 Islet_autoAg_Ica1/Ica1-like
IPR006723 Islet_autoAg_Ica1_C
PANTHERiPTHR10164 PTHR10164, 1 hit
PTHR10164:SF3 PTHR10164:SF3, 1 hit
PfamiView protein in Pfam
PF06456 Arfaptin, 1 hit
PF04629 ICA69, 2 hits
SMARTiView protein in SMART
SM01015 Arfaptin, 1 hit
SM01237 ICA69, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
PROSITEiView protein in PROSITE
PS50870 AH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiICA69_MOUSE
AccessioniPrimary (citable) accession number: P97411
Secondary accession number(s): E9QLS3
, P97362, P97954, Q99M40, Q9R2C4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 125 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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