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Protein

Vacuolar protein sorting-associated protein 45

Gene

Vps45

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network.

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6811438 Intra-Golgi traffic
R-MMU-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 45
Short name:
mVps45
Gene namesi
Name:Vps45
Synonyms:Vps45a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:891965 Vps45

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002063131 – 570Vacuolar protein sorting-associated protein 45Add BLAST570

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei307PhosphoserineBy similarity1
Modified residuei441PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP97390
MaxQBiP97390
PaxDbiP97390
PeptideAtlasiP97390
PRIDEiP97390

PTM databases

iPTMnetiP97390
PhosphoSitePlusiP97390

Expressioni

Gene expression databases

BgeeiENSMUSG00000015747 Expressed in 264 organ(s), highest expression level in brain
CleanExiMM_VPS45
GenevisibleiP97390 MM

Interactioni

Subunit structurei

Interacts with ZFYVE20 (By similarity). Interacts with STX6.By similarity1 Publication

Protein-protein interaction databases

BioGridi204535, 3 interactors
IntActiP97390, 4 interactors
MINTiP97390
STRINGi10090.ENSMUSP00000015891

Structurei

3D structure databases

ProteinModelPortaliP97390
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the STXBP/unc-18/SEC1 family.Curated

Phylogenomic databases

eggNOGiKOG1299 Eukaryota
COG5158 LUCA
GeneTreeiENSGT00550000075028
HOGENOMiHOG000200803
HOVERGENiHBG059810
InParanoidiP97390
KOiK12479
OMAiIADMKNF
OrthoDBiEOG091G05OR
PhylomeDBiP97390
TreeFamiTF300407

Family and domain databases

Gene3Di3.40.50.1910, 1 hit
InterProiView protein in InterPro
IPR027482 Sec-1-like_dom2
IPR001619 Sec1-like
IPR036045 Sec1-like_sf
PANTHERiPTHR11679 PTHR11679, 1 hit
PfamiView protein in Pfam
PF00995 Sec1, 1 hit
PIRSFiPIRSF005715 VPS45_Sec1, 1 hit
SUPFAMiSSF56815 SSF56815, 1 hit

Sequencei

Sequence statusi: Complete.

P97390-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNVVFAVKQY ISKMIEDSGP GMKVLLMDKE TTGIVSMVYT QSEILQKEVY
60 70 80 90 100
LFERIDSQNR EIMKHLKAIC FLRPTKENVE YLIQELRRPK YSIYFIYFSN
110 120 130 140 150
VISKSDVKSL AEADEQEVVA EVQEFYGDYI AVNPHLFSLN ILGCCQGRNW
160 170 180 190 200
DPAQLSRTTQ GLTALLLSLK KCPMIRYQLS SEAAKRLGEC VKQVISKEYE
210 220 230 240 250
LFEFRRTEVP PLLLILDRCD DAITPLLNQW TYQAMVHELL GINNNRIDLS
260 270 280 290 300
RVPGISKDLR EVVLSAENDE FYANNMYLNF AEIGSNIKNL MEDFQKKRPK
310 320 330 340 350
EQQKLESIAD MKAFVENYPQ FKKMSGTVSK HVTVVGELSR LVSERNLLEV
360 370 380 390 400
SEVEQELACQ NDHSSALQNV KRLLQNPKVT EFDAVRLVML YALHYERHSS
410 420 430 440 450
NSLPGLIVDL RSKGVAEKYR KLVSAVVEYG GKRVRGSDLF SPKDAVAITK
460 470 480 490 500
QFLKGLKGVE NVYTQHQPFL HETLDHLIKG RLKENLYPYL GPSTLRDRPQ
510 520 530 540 550
DIIVFIIGGA TYEEALTVYN LNRTTPGVRI VLGGTTIHNT KSFLEEVLAS
560 570
GLHSRSRESS QATSRSANRR
Length:570
Mass (Da):65,053
Last modified:May 1, 1997 - v1
Checksum:iDA704FDE8469F488
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55I → M in AAH12691 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66865 mRNA Translation: AAB37577.1
BC012691 mRNA Translation: AAH12691.1
BC058528 mRNA Translation: AAH58528.1
CCDSiCCDS17628.1
RefSeqiNP_038869.1, NM_013841.3
UniGeneiMm.263185

Genome annotation databases

EnsembliENSMUST00000015891; ENSMUSP00000015891; ENSMUSG00000015747
GeneIDi22365
KEGGimmu:22365
UCSCiuc008qly.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66865 mRNA Translation: AAB37577.1
BC012691 mRNA Translation: AAH12691.1
BC058528 mRNA Translation: AAH58528.1
CCDSiCCDS17628.1
RefSeqiNP_038869.1, NM_013841.3
UniGeneiMm.263185

3D structure databases

ProteinModelPortaliP97390
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204535, 3 interactors
IntActiP97390, 4 interactors
MINTiP97390
STRINGi10090.ENSMUSP00000015891

PTM databases

iPTMnetiP97390
PhosphoSitePlusiP97390

Proteomic databases

EPDiP97390
MaxQBiP97390
PaxDbiP97390
PeptideAtlasiP97390
PRIDEiP97390

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015891; ENSMUSP00000015891; ENSMUSG00000015747
GeneIDi22365
KEGGimmu:22365
UCSCiuc008qly.2 mouse

Organism-specific databases

CTDi11311
MGIiMGI:891965 Vps45

Phylogenomic databases

eggNOGiKOG1299 Eukaryota
COG5158 LUCA
GeneTreeiENSGT00550000075028
HOGENOMiHOG000200803
HOVERGENiHBG059810
InParanoidiP97390
KOiK12479
OMAiIADMKNF
OrthoDBiEOG091G05OR
PhylomeDBiP97390
TreeFamiTF300407

Enzyme and pathway databases

ReactomeiR-MMU-6811438 Intra-Golgi traffic
R-MMU-983231 Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

PROiPR:P97390
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015747 Expressed in 264 organ(s), highest expression level in brain
CleanExiMM_VPS45
GenevisibleiP97390 MM

Family and domain databases

Gene3Di3.40.50.1910, 1 hit
InterProiView protein in InterPro
IPR027482 Sec-1-like_dom2
IPR001619 Sec1-like
IPR036045 Sec1-like_sf
PANTHERiPTHR11679 PTHR11679, 1 hit
PfamiView protein in Pfam
PF00995 Sec1, 1 hit
PIRSFiPIRSF005715 VPS45_Sec1, 1 hit
SUPFAMiSSF56815 SSF56815, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVPS45_MOUSE
AccessioniPrimary (citable) accession number: P97390
Secondary accession number(s): Q91VK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: May 1, 1997
Last modified: November 7, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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