UniProtKB - P97384 (ANX11_MOUSE)
Protein
Annexin A11
Gene
Anxa11
Organism
Mus musculus (Mouse)
Status
Functioni
Required for midbody formation and completion of the terminal phase of cytokinesis (By similarity). Binds specifically to calcyclin in a calcium-dependent manner.By similarity
GO - Molecular functioni
- calcium-dependent phospholipid binding Source: MGI
- calcium-dependent protein binding Source: MGI
- calcium ion binding Source: MGI
- phosphatidylethanolamine binding Source: MGI
- S100 protein binding Source: UniProtKB
GO - Biological processi
- cytokinetic process Source: UniProtKB
- phagocytosis Source: GO_Central
- response to calcium ion Source: MGI
Keywordsi
Biological process | Cell cycle, Cell division |
Ligand | Calcium, Calcium/phospholipid-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Annexin A11Alternative name(s): Annexin XI Annexin-11 Calcyclin-associated annexin 50 Short name: CAP-50 |
Gene namesi | Name:Anxa11 Synonyms:Anx11 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:108481, Anxa11 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Nucleus
- Nucleus envelope By similarity
- nucleoplasm By similarity
Cytoskeleton
- spindle By similarity
Other locations
- Melanosome By similarity
Note: Found throughout the nucleoplasm at interphase and during mitosis concentrates around the mitotic apparatus. Elevation of intracellular calcium causes relocalization from the nucleoplasm to the nuclear envelope, with little effect on the cytoplasmic pool. Localization to the nuclear envelope is cell-cycle dependent.By similarity
Cytoskeleton
- spindle Source: UniProtKB
Cytosol
- cytosol Source: MGI
Lysosome
- azurophil granule Source: MGI
Nucleus
- nuclear envelope Source: MGI
- nucleoplasm Source: MGI
Other locations
- collagen-containing extracellular matrix Source: BHF-UCL
- cytoplasm Source: MGI
- melanosome Source: UniProtKB-SubCell
- midbody Source: UniProtKB
- phagocytic vesicle Source: MGI
- specific granule Source: MGI
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000067511 | 1 – 503 | Annexin A11Add BLAST | 503 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 246 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 253 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 477 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | P97384 |
jPOSTi | P97384 |
MaxQBi | P97384 |
PaxDbi | P97384 |
PeptideAtlasi | P97384 |
PRIDEi | P97384 |
ProteomicsDBi | 282126 |
2D gel databases
SWISS-2DPAGEi | P97384 |
PTM databases
iPTMneti | P97384 |
PhosphoSitePlusi | P97384 |
SwissPalmi | P97384 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000021866, Expressed in granulocyte and 88 other tissues |
ExpressionAtlasi | P97384, baseline and differential |
Genevisiblei | P97384, MM |
Interactioni
Subunit structurei
Interacts with S100A6.
Interacts with PDCD6 in a calcium-dependent manner.
Interacts with KIF23 during cytokinesis.
By similarityGO - Molecular functioni
- calcium-dependent protein binding Source: MGI
- S100 protein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 198108, 4 interactors |
IntActi | P97384, 1 interactor |
MINTi | P97384 |
STRINGi | 10090.ENSMUSP00000022416 |
Miscellaneous databases
RNActi | P97384, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 198 – 269 | Annexin 1PROSITE-ProRule annotationAdd BLAST | 72 | |
Repeati | 270 – 341 | Annexin 2PROSITE-ProRule annotationAdd BLAST | 72 | |
Repeati | 353 – 425 | Annexin 3PROSITE-ProRule annotationAdd BLAST | 73 | |
Repeati | 429 – 500 | Annexin 4PROSITE-ProRule annotationAdd BLAST | 72 |
Domaini
A pair of annexin repeats may form one binding site for calcium and phospholipid.
Sequence similaritiesi
Keywords - Domaini
Annexin, RepeatPhylogenomic databases
eggNOGi | KOG0819, Eukaryota |
GeneTreei | ENSGT00940000156914 |
HOGENOMi | CLU_025300_6_0_1 |
InParanoidi | P97384 |
OMAi | MTYPGQQ |
OrthoDBi | 856254at2759 |
TreeFami | TF105452 |
Family and domain databases
Gene3Di | 1.10.220.10, 4 hits |
InterProi | View protein in InterPro IPR001464, Annexin IPR018502, Annexin_repeat IPR018252, Annexin_repeat_CS IPR037104, Annexin_sf IPR008157, ANX11 |
PANTHERi | PTHR10502:SF29, PTHR10502:SF29, 1 hit |
Pfami | View protein in Pfam PF00191, Annexin, 4 hits |
PRINTSi | PR00196, ANNEXIN PR01810, ANNEXINXI |
SMARTi | View protein in SMART SM00335, ANX, 4 hits |
SUPFAMi | SSF47874, SSF47874, 1 hit |
PROSITEi | View protein in PROSITE PS00223, ANNEXIN_1, 4 hits PS51897, ANNEXIN_2, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P97384-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSYPGYPPPA GGYPPAAPGG GPWGGAGYPP PSMPPIGLDN VANYAGQFNQ
60 70 80 90 100
DYLSGMAANM SGTFGGANVP NLYPGAPGGG YPPVPPGGFG QPPPAQQPVP
110 120 130 140 150
PYGMYPPPGG NPPPGMPSYP AYPGAPVPGQ PMPPTGQQPP GAYPGQPPMT
160 170 180 190 200
YPGQSPMPPP GQQPVPSYPG YSGSSTITPA VPPAQFGNRG TITAASGFDP
210 220 230 240 250
LRDAEVLRKA MKGFGTDEQA IIDCLGSRSN KQRQQILLSF KTAYGKDLIK
260 270 280 290 300
DLKSELSGNF EKTILALMKT PVLFDVYEIK EAIKGAGTDE ACLIEIFASR
310 320 330 340 350
SNEHIRELSR AYKTEFQKTL EEAIRSDTSG HFQRLLISLS QGNRDESTNV
360 370 380 390 400
DMSLVQRDVQ ELYAAGENRL GTDESKFNAI LCSRSRAHLV AVFNEYQRMT
410 420 430 440 450
GRDIEKSICR EMSGDLEQGM LAVVKCLKNT PAFFAERLNK AMRGAGTKDR
460 470 480 490 500
TLIRIMVSRS ELDLLDIRAE YKRMYGKSLY HDITGDTSGD YRKILLKICG
GND
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD3Z7U0 | D3Z7U0_MOUSE | Annexin | Anxa11 | 447 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 69 | V → M in AAB42012 (PubMed:8938449).Curated | 1 | |
Sequence conflicti | 69 | V → M in CAB94770 (PubMed:11013079).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U65986 mRNA Translation: AAB42012.1 AJ289760 , AJ289761, AJ289762, AJ289763, AJ289764, AJ289765, AJ289766, AJ289767, AJ289768, AJ289769 Genomic DNA Translation: CAB94770.1 AK140375 mRNA Translation: BAE24363.1 CT010331 mRNA Translation: CAJ18539.1 CH466613 Genomic DNA Translation: EDL01415.1 BC012875 mRNA Translation: AAH12875.1 |
CCDSi | CCDS26875.1 |
RefSeqi | NP_038497.2, NM_013469.2 XP_006518514.1, XM_006518451.3 |
Genome annotation databases
Ensembli | ENSMUST00000022416; ENSMUSP00000022416; ENSMUSG00000021866 |
GeneIDi | 11744 |
KEGGi | mmu:11744 |
UCSCi | uc007srv.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U65986 mRNA Translation: AAB42012.1 AJ289760 , AJ289761, AJ289762, AJ289763, AJ289764, AJ289765, AJ289766, AJ289767, AJ289768, AJ289769 Genomic DNA Translation: CAB94770.1 AK140375 mRNA Translation: BAE24363.1 CT010331 mRNA Translation: CAJ18539.1 CH466613 Genomic DNA Translation: EDL01415.1 BC012875 mRNA Translation: AAH12875.1 |
CCDSi | CCDS26875.1 |
RefSeqi | NP_038497.2, NM_013469.2 XP_006518514.1, XM_006518451.3 |
3D structure databases
SMRi | P97384 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198108, 4 interactors |
IntActi | P97384, 1 interactor |
MINTi | P97384 |
STRINGi | 10090.ENSMUSP00000022416 |
PTM databases
iPTMneti | P97384 |
PhosphoSitePlusi | P97384 |
SwissPalmi | P97384 |
2D gel databases
SWISS-2DPAGEi | P97384 |
Proteomic databases
EPDi | P97384 |
jPOSTi | P97384 |
MaxQBi | P97384 |
PaxDbi | P97384 |
PeptideAtlasi | P97384 |
PRIDEi | P97384 |
ProteomicsDBi | 282126 |
Protocols and materials databases
Antibodypediai | 3904, 312 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000022416; ENSMUSP00000022416; ENSMUSG00000021866 |
GeneIDi | 11744 |
KEGGi | mmu:11744 |
UCSCi | uc007srv.2, mouse |
Organism-specific databases
CTDi | 311 |
MGIi | MGI:108481, Anxa11 |
Phylogenomic databases
eggNOGi | KOG0819, Eukaryota |
GeneTreei | ENSGT00940000156914 |
HOGENOMi | CLU_025300_6_0_1 |
InParanoidi | P97384 |
OMAi | MTYPGQQ |
OrthoDBi | 856254at2759 |
TreeFami | TF105452 |
Miscellaneous databases
BioGRID-ORCSi | 11744, 0 hits in 52 CRISPR screens |
ChiTaRSi | Anxa11, mouse |
PROi | PR:P97384 |
RNActi | P97384, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000021866, Expressed in granulocyte and 88 other tissues |
ExpressionAtlasi | P97384, baseline and differential |
Genevisiblei | P97384, MM |
Family and domain databases
Gene3Di | 1.10.220.10, 4 hits |
InterProi | View protein in InterPro IPR001464, Annexin IPR018502, Annexin_repeat IPR018252, Annexin_repeat_CS IPR037104, Annexin_sf IPR008157, ANX11 |
PANTHERi | PTHR10502:SF29, PTHR10502:SF29, 1 hit |
Pfami | View protein in Pfam PF00191, Annexin, 4 hits |
PRINTSi | PR00196, ANNEXIN PR01810, ANNEXINXI |
SMARTi | View protein in SMART SM00335, ANX, 4 hits |
SUPFAMi | SSF47874, SSF47874, 1 hit |
PROSITEi | View protein in PROSITE PS00223, ANNEXIN_1, 4 hits PS51897, ANNEXIN_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ANX11_MOUSE | |
Accessioni | P97384Primary (citable) accession number: P97384 Secondary accession number(s): Q921F1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | July 27, 2011 | |
Last modified: | April 7, 2021 | |
This is version 156 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families