Cdk2

Functionⁱ

Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization. Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (PubMed:23853094). Phosphorylates CDK2AP2 (By similarity).By similarity5 Publications

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.1 Publication

Cofactorⁱ

Mg²⁺By similarityNote: Binds 2 Mg²⁺ ions.By similarity

Activity regulationⁱ

Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-160 activates it. Stimulated by MYC. Inactivated by CDKN1A (p21) (By similarity).By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Siteⁱ	9	CDK7 bindingBy similarity	1
Binding siteⁱ	33	ATPPROSITE-ProRule annotation	1
Binding siteⁱ	86	ATPPROSITE-ProRule annotation	1
Siteⁱ	88 – 89	CDK7 bindingBy similarity	2
Active siteⁱ	127	Proton acceptorPROSITE-ProRule annotation	1
Metal bindingⁱ	132	MagnesiumBy similarity	1
Metal bindingⁱ	145	MagnesiumBy similarity	1
Binding siteⁱ	145	ATPPROSITE-ProRule annotation	1
Siteⁱ	166	CDK7 bindingBy similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	10 – 18	ATPPROSITE-ProRule annotation	9
Nucleotide bindingⁱ	81 – 83	ATPPROSITE-ProRule annotation	3
Nucleotide bindingⁱ	129 – 132	ATPPROSITE-ProRule annotation	4

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
cyclin binding Source: MGI
cyclin-dependent protein kinase activity Source: MGI
cyclin-dependent protein serine/threonine kinase activity
Source: MGI
Inferred from direct assayⁱ
- 12970171
- 12970760
histone kinase activity Source: Ensembl
kinase activity
Source: MGI
Inferred from direct assayⁱ
- 12124778
magnesium ion binding
Source: UniProtKB
Inferred from direct assayⁱ
- 23599433
protein-containing complex binding Source: MGI
protein domain specific binding Source: MGI
protein kinase activity
Source: MGI
Inferred from direct assayⁱ
- 21508411
protein serine/threonine kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 23599433

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell division Source: UniProtKB-KW
cellular response to insulin stimulus Source: MGI
centriole replication Source: MGI
DNA repair Source: UniProtKB-KW
G1/S transition of mitotic cell cycle
Source: MGI
Inferred from direct assayⁱ
- 12970171
histone phosphorylation Source: MGI
meiotic cell cycle Source: UniProtKB-KW
negative regulation of transcription by RNA polymerase II
Source: MGI
Inferred from genetic interactionⁱ
- 7797074
peptidyl-serine phosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 23599433
positive regulation of cell proliferation
Source: BHF-UCL
Inferred from direct assayⁱ
- 23904268
positive regulation of DNA-dependent DNA replication initiation
Source: MGI
Inferred from genetic interactionⁱ
- 20215406
positive regulation of transcription, DNA-templated
Source: MGI
Inferred from genetic interactionⁱ
- 16137671
potassium ion transport
Source: MGI
Inferred from genetic interactionⁱ
- 16393152
protein phosphorylation
Source: MGI
Inferred from direct assayⁱ
- 12124778
Ras protein signal transduction Source: Ensembl
regulation of G2/M transition of mitotic cell cycle
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of gene silencing Source: MGI
response to cAMP Source: MGI
response to electrical stimulus Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Biological process	Cell cycle, Cell division, DNA damage, DNA repair, Meiosis, Mitosis
Ligand	ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.11.22 3474
Reactomeⁱ	R-MMU-1538133 G0 and Early G1 R-MMU-176187 Activation of ATR in response to replication stress R-MMU-176408 Regulation of APC/C activators between G1/S and early anaphase R-MMU-187577 SCF(Skp2)-mediated degradation of p27/p21 R-MMU-2559582 Senescence-Associated Secretory Phenotype (SASP) R-MMU-2559586 DNA Damage/Telomere Stress Induced Senescence R-MMU-5693607 Processing of DNA double-strand break ends R-MMU-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-MMU-6804756 Regulation of TP53 Activity through Phosphorylation R-MMU-6804757 Regulation of TP53 Degradation R-MMU-68911 G2 Phase R-MMU-68949 Orc1 removal from chromatin R-MMU-68962 Activation of the pre-replicative complex R-MMU-69017 CDK-mediated phosphorylation and removal of Cdc6 R-MMU-69200 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-MMU-69202 Cyclin E associated events during G1/S transition R-MMU-69273 Cyclin A/B1/B2 associated events during G2/M transition R-MMU-69563 p53-Dependent G1 DNA Damage Response R-MMU-69656 Cyclin A:Cdk2-associated events at S phase entry R-MMU-8849470 PTK6 Regulates Cell Cycle

BRENDAⁱ

2.7.11.22 3474

Reactomeⁱ

R-MMU-1538133 G0 and Early G1
R-MMU-176187 Activation of ATR in response to replication stress
R-MMU-176408 Regulation of APC/C activators between G1/S and early anaphase
R-MMU-187577 SCF(Skp2)-mediated degradation of p27/p21
R-MMU-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-MMU-2559586 DNA Damage/Telomere Stress Induced Senescence
R-MMU-5693607 Processing of DNA double-strand break ends
R-MMU-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
R-MMU-6804756 Regulation of TP53 Activity through Phosphorylation
R-MMU-6804757 Regulation of TP53 Degradation
R-MMU-68911 G2 Phase
R-MMU-68949 Orc1 removal from chromatin
R-MMU-68962 Activation of the pre-replicative complex
R-MMU-69017 CDK-mediated phosphorylation and removal of Cdc6
R-MMU-69200 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
R-MMU-69202 Cyclin E associated events during G1/S transition
R-MMU-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-MMU-69563 p53-Dependent G1 DNA Damage Response
R-MMU-69656 Cyclin A:Cdk2-associated events at S phase entry
R-MMU-8849470 PTK6 Regulates Cell Cycle

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cyclin-dependent kinase 2 (EC:2.7.11.221 Publication) Alternative name(s): Cell division protein kinase 2
Gene namesⁱ	Name:Cdk2 Synonyms:Cdkn2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 10

Organism-specific databases

MGIⁱ	MGI:104772 Cdk2

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Endosome, Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Reduced body size and impaired neural progenitor cell proliferation. Sterility due to defective meiosis; no effect on mitotic cells. Premature translocation of CDK1 from the cytoplasm to the nucleus compensating CDK2 loss. Prolonged and impaired DNA repair activity upon DNA damage by gamma-irradiation.3 Publications

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	15	Y → F: Loss of tyrosine phosphorylation by WEE1 and CABLES1. 1 Publication		1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000085771	1 – 346	Cyclin-dependent kinase 2Add BLAST		346

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineBy similarity	1
Modified residueⁱ	6	N6-acetyllysineBy similarity	1
Modified residueⁱ	14	PhosphothreonineBy similarity	1
Modified residueⁱ	15	Phosphotyrosine; by WEE11 Publication	1
Modified residueⁱ	19	PhosphotyrosineBy similarity	1
Modified residueⁱ	160	Phosphothreonine; by CAK and CCRKBy similarity	1
Modified residueⁱ	218	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylated at Thr-160 by CDK7 in a CAK complex. Phosphorylation at Thr-160 promotes kinase activity, whereas phosphorylation at Tyr-15 by WEE1 reduces slightly kinase activity. Phosphorylated on Thr-14 and Tyr-15 during S and G2 phases before being dephosphorylated by CDC25A.By similarity

Nitrosylated after treatment with nitric oxide (DETA-NO).By similarity

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

PaxDbⁱ	P97377
PeptideAtlas More...PeptideAtlasⁱ	P97377
PRIDEⁱ	P97377

PTM databases

iPTMnetⁱ	P97377
PhosphoSitePlusⁱ	P97377
SwissPalmⁱ	P97377

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000025358 Expressed in 248 organ(s), highest expression level in bone marrow
CleanExⁱ	MM_CDK2
ExpressionAtlasⁱ	P97377 baseline and differential
Genevisibleⁱ	P97377 MM

Interactionⁱ

Subunit structureⁱ

Found in a complex with CABLES1, CCNA1 and CCNE1. Interacts with CABLES1 (PubMed:11585773). Interacts with UHRF2. Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts with the Speedy/Ringo proteins SPDYA and SPDYC. Interaction with SPDYA promotes kinase activation via a conformation change that alleviates obstruction of the substrate-binding cleft by the T-loop. Found in a complex with both SPDYA and CDKN1B/KIP1. Binds to RB1 and CDK7. Binding to CDKN1A (p21) leads to CDK2/cyclin E inactivation at the G1-S phase DNA damage checkpoint, thereby arresting cells at the G1-S transition during DNA repair. Associated with PTPN6 and beta-catenin/CTNNB1. Interacts with CACUL1. May interact with CEP63. Interacts with ANKRD17 (By similarity). Interacts with CEBPA (when phosphorylated) (PubMed:15107404). Forms a ternary complex with CCNA2 and CDKN1B; CDKN1B inhibits the kinase activity of CDK2 through conformational rearrangements. Interacts with cyclins A, B1, B3, D, or E. Interacts with CDK2AP2 (By similarity).By similarity2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Ccna2	P51943	3	EBI-847048,EBI-846980
Ccne1	Q61457	3	EBI-847048,EBI-643090

GO - Molecular functionⁱ

cyclin binding Source: MGI
protein domain specific binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	198644, 30 interactors
ComplexPortalⁱ	CPX-2065 Cyclin A1-CDK2 complex CPX-2066 Cyclin A2-CDK2 complex CPX-2071 Cyclin B3-CDK2 complex CPX-2081 Cyclin E1-CDK2 complex CPX-2082 Cyclin E2-CDK2 complex
CORUMⁱ	P97377
Database of interacting proteins More...DIPⁱ	DIP-24176N
ELMⁱ	P97377
IntActⁱ	P97377, 7 interactors
Molecular INTeraction database More...MINTⁱ	P97377
STRINGⁱ	10090.ENSMUSP00000026416

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P97377
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	4 – 334	Protein kinasePROSITE-ProRule annotationAdd BLAST		331

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0594 Eukaryota ENOG410XPP3 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144030
HOGENOMⁱ	HOG000233024
HOVERGENⁱ	HBG014652
InParanoidⁱ	P97377
KEGG Orthology (KO) More...KOⁱ	K02206
OMAⁱ	RHTNETI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CH0
PhylomeDBⁱ	P97377
TreeFamⁱ	TF101021

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 2 hits
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 2 hits
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform CDK2-beta (identifier: P97377-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MENFQKVEKI GEGTYGVVYK AKNKLTGEVV ALKKIRLDTE TEGVPSTAIR 
        60         70         80         90        100
EISLLKELNH PNIVKLLDVI HTENKLYLVF EFLHQDLKKF MDASALTGIP 
       110        120        130        140        150
LPLIKSYLFQ LLQGLAFCHS HRVLHRDLKP QNLLINAEGS IKLADFGLAR 
       160        170        180        190        200
AFGVPVRTYT HEVVTLWYRA PEILLGCKYY STAVDIWSLG CIFAEMHLVC 
       210        220        230        240        250
TQHHAKCCGE HRRNGRHSLC PLCSYLEVAA SQGGGMTAVS APHPVTRRAL 
       260        270        280        290        300
FPGDSEIDQL FRIFRTLGTP DEVVWPGVTS MPDYKPSFPK WARQDFSKVV 
       310        320        330        340 
PPLDEDGRSL LSQMLHYDPN KRISAKAALA HPFFQDVTKP VPHLRL

Length:346

Mass (Da):38,978

Last modified:May 30, 2000 - v2

Checksum:ⁱD806BC2F150AEDFC

GO

Isoform CDK2-alpha (identifier: P97377-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
197-244: Missing.

« Hide

        10         20         30         40         50
MENFQKVEKI GEGTYGVVYK AKNKLTGEVV ALKKIRLDTE TEGVPSTAIR 
        60         70         80         90        100
EISLLKELNH PNIVKLLDVI HTENKLYLVF EFLHQDLKKF MDASALTGIP 
       110        120        130        140        150
LPLIKSYLFQ LLQGLAFCHS HRVLHRDLKP QNLLINAEGS IKLADFGLAR 
       160        170        180        190        200
AFGVPVRTYT HEVVTLWYRA PEILLGCKYY STAVDIWSLG CIFAEMVTRR 
       210        220        230        240        250
ALFPGDSEID QLFRIFRTLG TPDEVVWPGV TSMPDYKPSF PKWARQDFSK 
       260        270        280        290 
VVPPLDEDGR SLLSQMLHYD PNKRISAKAA LAHPFFQDVT KPVPHLRL

Show »

Length:298

Mass (Da):33,887

Checksum:ⁱFB28DBD8BA587BDA

GO

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_004800	197 – 244	Missing in isoform CDK2-alpha. 1 PublicationAdd BLAST		48

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U63337 mRNA Translation: AAB37128.1 AJ223732 mRNA Translation: CAA11533.1 AJ223733 Genomic DNA Translation: CAA11534.1 AJ223733 Genomic DNA Translation: CAA11535.1 BC005654 mRNA Translation: AAH05654.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS24288.1 [P97377-2] CCDS24289.1 [P97377-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_058036.1, NM_016756.4 [P97377-2] NP_904326.1, NM_183417.3 [P97377-1]
UniGeneⁱ	Mm.111326

Genome annotation databases

Ensemblⁱ	ENSMUST00000026415; ENSMUSP00000026415; ENSMUSG00000025358 [P97377-2] ENSMUST00000026416; ENSMUSP00000026416; ENSMUSG00000025358 [P97377-1]
GeneIDⁱ	12566
KEGGⁱ	mmu:12566
UCSC genome browser More...UCSCⁱ	uc007hny.2 mouse [P97377-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P97377	Uncharacterized protein		MOUSE		346	UniRef100_P97377
UPI0003D750E4		MOUSE		256
P97377-2	Cyclin-dependent kinase 2, isoform CRA_b		MOUSE		298	UniRef100_Q3U6X7
Cyclin-dependent kinase 2		RAT		298
Cyclin-dependent kinase 2 (Fragment)		RABIT		237

Protein	Similar proteins		Species	Score	Length	Source
P97377	Uncharacterized protein		MOUSE		346	UniRef90_P97377
cyclin-dependent kinase 2 isoform X1		Enhydra lutris kenyoni		346
CDK2 isoform 3		PONAB		346
cyclin-dependent kinase 2 isoform X1		Florida manatee		346
Cyclin dependent kinase 2-beta		RATRT		346
+68
P97377-2	Uncharacterized protein		MYOLU		298	UniRef90_G1P317
Uncharacterized protein		PROCO		298
Cyclin dependent kinase 2		CALJA		298
Uncharacterized protein		Cebus capucinus imitator		298
Uncharacterized protein		AOTNA		298
+28

Protein	Similar proteins		Species	Score	Length	Source
P97377	Cell division control protein 2 homolog 2		MEDSA		294	UniRef50_P97377
Cell division control protein 2 homolog		VIGUN		294
Uncharacterized protein		MOUSE		346
Uncharacterized protein		Cebus capucinus imitator		346
CDK2 isoform 3		PONAB		346
+194
P97377-2	Uncharacterized protein		MYOLU		298	UniRef50_G1P317
Uncharacterized protein		ICTTR		298
Uncharacterized protein		FELCA		298
cyclin-dependent kinase 2 isoform X2		BALAS		298
Uncharacterized protein (Fragment)		AILME		298
+33

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U63337 mRNA Translation: AAB37128.1 AJ223732 mRNA Translation: CAA11533.1 AJ223733 Genomic DNA Translation: CAA11534.1 AJ223733 Genomic DNA Translation: CAA11535.1 BC005654 mRNA Translation: AAH05654.1
CCDSⁱ	CCDS24288.1 [P97377-2] CCDS24289.1 [P97377-1]
RefSeqⁱ	NP_058036.1, NM_016756.4 [P97377-2] NP_904326.1, NM_183417.3 [P97377-1]
UniGeneⁱ	Mm.111326

3D structure databases

ProteinModelPortalⁱ	P97377
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	198644, 30 interactors
ComplexPortalⁱ	CPX-2065 Cyclin A1-CDK2 complex CPX-2066 Cyclin A2-CDK2 complex CPX-2071 Cyclin B3-CDK2 complex CPX-2081 Cyclin E1-CDK2 complex CPX-2082 Cyclin E2-CDK2 complex
CORUMⁱ	P97377
DIPⁱ	DIP-24176N
ELMⁱ	P97377
IntActⁱ	P97377, 7 interactors
MINTⁱ	P97377
STRINGⁱ	10090.ENSMUSP00000026416

PTM databases

iPTMnetⁱ	P97377
PhosphoSitePlusⁱ	P97377
SwissPalmⁱ	P97377

Proteomic databases

PaxDbⁱ	P97377
PeptideAtlasⁱ	P97377
PRIDEⁱ	P97377

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000026415; ENSMUSP00000026415; ENSMUSG00000025358 [P97377-2] ENSMUST00000026416; ENSMUSP00000026416; ENSMUSG00000025358 [P97377-1]
GeneIDⁱ	12566
KEGGⁱ	mmu:12566
UCSCⁱ	uc007hny.2 mouse [P97377-1]

Organism-specific databases

CTDⁱ	1017
MGIⁱ	MGI:104772 Cdk2

Phylogenomic databases

eggNOGⁱ	KOG0594 Eukaryota ENOG410XPP3 LUCA
GeneTreeⁱ	ENSGT00910000144030
HOGENOMⁱ	HOG000233024
HOVERGENⁱ	HBG014652
InParanoidⁱ	P97377
KOⁱ	K02206
OMAⁱ	RHTNETI
OrthoDBⁱ	EOG091G0CH0
PhylomeDBⁱ	P97377
TreeFamⁱ	TF101021

Enzyme and pathway databases

BRENDAⁱ	2.7.11.22 3474
Reactomeⁱ	R-MMU-1538133 G0 and Early G1 R-MMU-176187 Activation of ATR in response to replication stress R-MMU-176408 Regulation of APC/C activators between G1/S and early anaphase R-MMU-187577 SCF(Skp2)-mediated degradation of p27/p21 R-MMU-2559582 Senescence-Associated Secretory Phenotype (SASP) R-MMU-2559586 DNA Damage/Telomere Stress Induced Senescence R-MMU-5693607 Processing of DNA double-strand break ends R-MMU-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-MMU-6804756 Regulation of TP53 Activity through Phosphorylation R-MMU-6804757 Regulation of TP53 Degradation R-MMU-68911 G2 Phase R-MMU-68949 Orc1 removal from chromatin R-MMU-68962 Activation of the pre-replicative complex R-MMU-69017 CDK-mediated phosphorylation and removal of Cdc6 R-MMU-69200 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-MMU-69202 Cyclin E associated events during G1/S transition R-MMU-69273 Cyclin A/B1/B2 associated events during G2/M transition R-MMU-69563 p53-Dependent G1 DNA Damage Response R-MMU-69656 Cyclin A:Cdk2-associated events at S phase entry R-MMU-8849470 PTK6 Regulates Cell Cycle

BRENDAⁱ

2.7.11.22 3474

Reactomeⁱ

R-MMU-1538133 G0 and Early G1
R-MMU-176187 Activation of ATR in response to replication stress
R-MMU-176408 Regulation of APC/C activators between G1/S and early anaphase
R-MMU-187577 SCF(Skp2)-mediated degradation of p27/p21
R-MMU-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-MMU-2559586 DNA Damage/Telomere Stress Induced Senescence
R-MMU-5693607 Processing of DNA double-strand break ends
R-MMU-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
R-MMU-6804756 Regulation of TP53 Activity through Phosphorylation
R-MMU-6804757 Regulation of TP53 Degradation
R-MMU-68911 G2 Phase
R-MMU-68949 Orc1 removal from chromatin
R-MMU-68962 Activation of the pre-replicative complex
R-MMU-69017 CDK-mediated phosphorylation and removal of Cdc6
R-MMU-69200 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
R-MMU-69202 Cyclin E associated events during G1/S transition
R-MMU-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-MMU-69563 p53-Dependent G1 DNA Damage Response
R-MMU-69656 Cyclin A:Cdk2-associated events at S phase entry
R-MMU-8849470 PTK6 Regulates Cell Cycle

Miscellaneous databases

ChiTaRSⁱ	Cdk2 mouse
Protein Ontology More...PROⁱ	PR:P97377
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000025358 Expressed in 248 organ(s), highest expression level in bone marrow
CleanExⁱ	MM_CDK2
ExpressionAtlasⁱ	P97377 baseline and differential
Genevisibleⁱ	P97377 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 2 hits
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 2 hits
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CDK2_MOUSE
Accessionⁱ	P97377Primary (citable) accession number: P97377 Secondary accession number(s): O55105
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
	Last sequence update:	May 30, 2000
	Last modified:	November 7, 2018
	This is version 179 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

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UniProtKB - P97377 (CDK2_MOUSE)

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Cyclin-dependent kinase 2

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

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Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

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Miscellaneousⁱ

Keywords - Technical termⁱ