UniProtKB - P97371 (PSME1_MOUSE)
Protein
Proteasome activator complex subunit 1
Gene
Psme1
Organism
Mus musculus (Mouse)
Status
Functioni
Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.
GO - Biological processi
- antigen processing and presentation of exogenous antigen Source: MGI
- positive regulation of endopeptidase activity Source: GO_Central
- regulation of G1/S transition of mitotic cell cycle Source: GO_Central
- regulation of proteasomal protein catabolic process Source: GO_Central
Enzyme and pathway databases
Reactomei | R-MMU-1169091, Activation of NF-kappaB in B cells R-MMU-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-MMU-1236978, Cross-presentation of soluble exogenous antigens (endosomes) R-MMU-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-MMU-174154, APC/C:Cdc20 mediated degradation of Securin R-MMU-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-MMU-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-MMU-187577, SCF(Skp2)-mediated degradation of p27/p21 R-MMU-195253, Degradation of beta-catenin by the destruction complex R-MMU-202424, Downstream TCR signaling R-MMU-2467813, Separation of Sister Chromatids R-MMU-2871837, FCERI mediated NF-kB activation R-MMU-349425, Autodegradation of the E3 ubiquitin ligase COP1 R-MMU-350562, Regulation of ornithine decarboxylase (ODC) R-MMU-382556, ABC-family proteins mediated transport R-MMU-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-MMU-4608870, Asymmetric localization of PCP proteins R-MMU-4641257, Degradation of AXIN R-MMU-4641258, Degradation of DVL R-MMU-5358346, Hedgehog ligand biogenesis R-MMU-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-MMU-5607764, CLEC7A (Dectin-1) signaling R-MMU-5610780, Degradation of GLI1 by the proteasome R-MMU-5610785, GLI3 is processed to GLI3R by the proteasome R-MMU-5632684, Hedgehog 'on' state R-MMU-5658442, Regulation of RAS by GAPs R-MMU-5668541, TNFR2 non-canonical NF-kB pathway R-MMU-5676590, NIK-->noncanonical NF-kB signaling R-MMU-5687128, MAPK6/MAPK4 signaling R-MMU-5689603, UCH proteinases R-MMU-5689880, Ub-specific processing proteases R-MMU-68827, CDT1 association with the CDC6:ORC:origin complex R-MMU-68949, Orc1 removal from chromatin R-MMU-69017, CDK-mediated phosphorylation and removal of Cdc6 R-MMU-69481, G2/M Checkpoints R-MMU-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-MMU-75815, Ubiquitin-dependent degradation of Cyclin D R-MMU-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-MMU-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-MMU-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-MMU-8939902, Regulation of RUNX2 expression and activity R-MMU-8941858, Regulation of RUNX3 expression and activity R-MMU-8948751, Regulation of PTEN stability and activity R-MMU-8951664, Neddylation R-MMU-9020702, Interleukin-1 signaling R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Names & Taxonomyi
Protein namesi | Recommended name: Proteasome activator complex subunit 1Alternative name(s): 11S regulator complex subunit alpha Short name: REG-alpha Activator of multicatalytic protease subunit 1 Proteasome activator 28 subunit alpha Short name: PA28a Short name: PA28alpha |
Gene namesi | Name:Psme1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1096367, Psme1 |
Subcellular locationi
Nucleus
- nucleoplasm Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
- proteasome activator complex Source: InterPro
Keywords - Cellular componenti
ProteasomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000161781 | 1 – 249 | Proteasome activator complex subunit 1Add BLAST | 249 |
Proteomic databases
EPDi | P97371 |
jPOSTi | P97371 |
PaxDbi | P97371 |
PRIDEi | P97371 |
PTM databases
iPTMneti | P97371 |
PhosphoSitePlusi | P97371 |
SwissPalmi | P97371 |
Expressioni
Inductioni
By interferon gamma.
Gene expression databases
Bgeei | ENSMUSG00000022216, Expressed in adult mammalian kidney and 311 other tissues |
ExpressionAtlasi | P97371, baseline and differential |
Genevisiblei | P97371, MM |
Interactioni
Subunit structurei
Heterodimer of PSME1 and PSME2, which forms a hexameric ring. PSME1 can form homoheptamers (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 202432, 52 interactors |
IntActi | P97371, 3 interactors |
MINTi | P97371 |
STRINGi | 10090.ENSMUSP00000134735 |
Miscellaneous databases
RNActi | P97371, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P97371 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the PA28 family.Curated
Phylogenomic databases
eggNOGi | KOG4470, Eukaryota |
GeneTreei | ENSGT00950000183098 |
InParanoidi | P97371 |
OMAi | KTSFSCD |
OrthoDBi | 1251022at2759 |
PhylomeDBi | P97371 |
TreeFami | TF106236 |
Family and domain databases
Gene3Di | 1.20.120.180, 1 hit 1.20.5.120, 1 hit |
InterProi | View protein in InterPro IPR003186, PA28_C IPR036997, PA28_C_sf IPR036996, PA28_N_sf IPR009077, Proteasome_activ_PA28 IPR003185, Proteasome_activ_PA28_N IPR036252, Proteasome_activ_sf |
PANTHERi | PTHR10660, PTHR10660, 1 hit |
Pfami | View protein in Pfam PF02251, PA28_alpha, 1 hit PF02252, PA28_beta, 1 hit |
SUPFAMi | SSF47216, SSF47216, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
P97371-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATLRVHPEA QAKVDVFRED LCSKTENLLG SYFPKKISEL DAFLKEPALN
60 70 80 90 100
EANLSNLKAP LDIPVPDPVK EKEKEERKKQ QEKEEKEEKK KGDEDDKGPP
110 120 130 140 150
CGPVNCNEKI VVLLQRLKPE IKDVTEQLNL VTTWLQLQIP RIEDGNNFGV
160 170 180 190 200
AVQEKVFELM TNLHTKLEGF HTQISKYFSE RGDAVAKAAK QPHVGDYRQL
210 220 230 240
VHELDEAEYQ EIRLMVMEIR NAYAVLYDII LKNFEKLKKP RGETKGMIY
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3UXZ5 | G3UXZ5_MOUSE | Proteasome activator complex subuni... | Psme1 | 238 | Annotation score: | ||
G3UWN9 | G3UWN9_MOUSE | Proteasome activator complex subuni... | Psme1 | 173 | Annotation score: | ||
G3X9K9 | G3X9K9_MOUSE | Proteasome activator complex subuni... | Psme1 | 236 | Annotation score: | ||
G3UXY0 | G3UXY0_MOUSE | Proteasome activator complex subuni... | Psme1 | 226 | Annotation score: | ||
G3UXR1 | G3UXR1_MOUSE | Proteasome activator complex subuni... | Psme1 | 42 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 17 | F → L in BAB25712 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 97 | K → E in BAB25712 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 151 | A → S in AAC53295 (PubMed:9162094).Curated | 1 | |
Sequence conflicti | 156 | V → L in AAC53295 (PubMed:9162094).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D87909 mRNA Translation: BAA22039.1 U60328 mRNA Translation: AAC53295.1 AB007136 Genomic DNA Translation: BAA28835.1 AB053120 Genomic DNA Translation: BAB47403.1 AK019390 mRNA Translation: BAB31696.1 AK008514 mRNA Translation: BAB25712.1 |
CCDSi | CCDS36931.1 |
RefSeqi | NP_035319.1, NM_011189.1 |
Genome annotation databases
Ensembli | ENSMUST00000174259; ENSMUSP00000134735; ENSMUSG00000022216 |
GeneIDi | 19186 |
KEGGi | mmu:19186 |
UCSCi | uc007tzd.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D87909 mRNA Translation: BAA22039.1 U60328 mRNA Translation: AAC53295.1 AB007136 Genomic DNA Translation: BAA28835.1 AB053120 Genomic DNA Translation: BAB47403.1 AK019390 mRNA Translation: BAB31696.1 AK008514 mRNA Translation: BAB25712.1 |
CCDSi | CCDS36931.1 |
RefSeqi | NP_035319.1, NM_011189.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5MSJ | X-ray | 3.50 | A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X/Y/Z/a/b | 1-249 | [»] | |
5MX5 | X-ray | 2.90 | A/C/E/G/H/J/L/N | 1-249 | [»] | |
SMRi | P97371 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 202432, 52 interactors |
IntActi | P97371, 3 interactors |
MINTi | P97371 |
STRINGi | 10090.ENSMUSP00000134735 |
PTM databases
iPTMneti | P97371 |
PhosphoSitePlusi | P97371 |
SwissPalmi | P97371 |
Proteomic databases
EPDi | P97371 |
jPOSTi | P97371 |
PaxDbi | P97371 |
PRIDEi | P97371 |
Protocols and materials databases
Antibodypediai | 1712, 303 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000174259; ENSMUSP00000134735; ENSMUSG00000022216 |
GeneIDi | 19186 |
KEGGi | mmu:19186 |
UCSCi | uc007tzd.1, mouse |
Organism-specific databases
CTDi | 5720 |
MGIi | MGI:1096367, Psme1 |
Phylogenomic databases
eggNOGi | KOG4470, Eukaryota |
GeneTreei | ENSGT00950000183098 |
InParanoidi | P97371 |
OMAi | KTSFSCD |
OrthoDBi | 1251022at2759 |
PhylomeDBi | P97371 |
TreeFami | TF106236 |
Enzyme and pathway databases
Reactomei | R-MMU-1169091, Activation of NF-kappaB in B cells R-MMU-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-MMU-1236978, Cross-presentation of soluble exogenous antigens (endosomes) R-MMU-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-MMU-174154, APC/C:Cdc20 mediated degradation of Securin R-MMU-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-MMU-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-MMU-187577, SCF(Skp2)-mediated degradation of p27/p21 R-MMU-195253, Degradation of beta-catenin by the destruction complex R-MMU-202424, Downstream TCR signaling R-MMU-2467813, Separation of Sister Chromatids R-MMU-2871837, FCERI mediated NF-kB activation R-MMU-349425, Autodegradation of the E3 ubiquitin ligase COP1 R-MMU-350562, Regulation of ornithine decarboxylase (ODC) R-MMU-382556, ABC-family proteins mediated transport R-MMU-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-MMU-4608870, Asymmetric localization of PCP proteins R-MMU-4641257, Degradation of AXIN R-MMU-4641258, Degradation of DVL R-MMU-5358346, Hedgehog ligand biogenesis R-MMU-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-MMU-5607764, CLEC7A (Dectin-1) signaling R-MMU-5610780, Degradation of GLI1 by the proteasome R-MMU-5610785, GLI3 is processed to GLI3R by the proteasome R-MMU-5632684, Hedgehog 'on' state R-MMU-5658442, Regulation of RAS by GAPs R-MMU-5668541, TNFR2 non-canonical NF-kB pathway R-MMU-5676590, NIK-->noncanonical NF-kB signaling R-MMU-5687128, MAPK6/MAPK4 signaling R-MMU-5689603, UCH proteinases R-MMU-5689880, Ub-specific processing proteases R-MMU-68827, CDT1 association with the CDC6:ORC:origin complex R-MMU-68949, Orc1 removal from chromatin R-MMU-69017, CDK-mediated phosphorylation and removal of Cdc6 R-MMU-69481, G2/M Checkpoints R-MMU-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-MMU-75815, Ubiquitin-dependent degradation of Cyclin D R-MMU-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-MMU-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-MMU-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-MMU-8939902, Regulation of RUNX2 expression and activity R-MMU-8941858, Regulation of RUNX3 expression and activity R-MMU-8948751, Regulation of PTEN stability and activity R-MMU-8951664, Neddylation R-MMU-9020702, Interleukin-1 signaling R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Miscellaneous databases
BioGRID-ORCSi | 19186, 2 hits in 20 CRISPR screens |
ChiTaRSi | Psme1, mouse |
PROi | PR:P97371 |
RNActi | P97371, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022216, Expressed in adult mammalian kidney and 311 other tissues |
ExpressionAtlasi | P97371, baseline and differential |
Genevisiblei | P97371, MM |
Family and domain databases
Gene3Di | 1.20.120.180, 1 hit 1.20.5.120, 1 hit |
InterProi | View protein in InterPro IPR003186, PA28_C IPR036997, PA28_C_sf IPR036996, PA28_N_sf IPR009077, Proteasome_activ_PA28 IPR003185, Proteasome_activ_PA28_N IPR036252, Proteasome_activ_sf |
PANTHERi | PTHR10660, PTHR10660, 1 hit |
Pfami | View protein in Pfam PF02251, PA28_alpha, 1 hit PF02252, PA28_beta, 1 hit |
SUPFAMi | SSF47216, SSF47216, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PSME1_MOUSE | |
Accessioni | P97371Primary (citable) accession number: P97371 Secondary accession number(s): O35561, Q9D841 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 29, 2001 |
Last sequence update: | August 29, 2001 | |
Last modified: | February 10, 2021 | |
This is version 155 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families