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Protein

Ecotropic viral integration site 5 protein

Gene

Evi5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis (By similarity).By similarity

Miscellaneous

This gene is a common site of retroviral integration in T-cell lymphomas of AKXD mice.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Ecotropic viral integration site 5 protein
Short name:
EVI-5
Gene namesi
Name:Evi5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:104736 Evi5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002562421 – 809Ecotropic viral integration site 5 proteinAdd BLAST809

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei102PhosphoserineBy similarity1
Modified residuei113PhosphoserineCombined sources1
Modified residuei497PhosphoserineBy similarity1
Modified residuei689PhosphoserineBy similarity1
Modified residuei776PhosphoserineCombined sources1
Modified residuei778PhosphoserineCombined sources1

Post-translational modificationi

Probably phosphorylated by PLK1; may be required for degradation during mitosis.By similarity
Ubiquitinated. Degradation during prophase is ubiquitin-dependent (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP97366
PaxDbiP97366
PRIDEiP97366

PTM databases

iPTMnetiP97366
PhosphoSitePlusiP97366

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Developmental stagei

Detected in the embryo from E7 to E17.1 Publication

Gene expression databases

CleanExiMM_EVI5

Interactioni

Subunit structurei

Dimeric and monomeric. Interacts with alpha- and gamma-tubulin. Interacts with FBXO5. Interacts with the chromosome passenger complex (CPC) which is at least composed of AURKB/aurora-B, BIRC5/survivin, CDCA8/borealin and INCENP (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP97366, 1 interactor
STRINGi10090.ENSMUSP00000108261

Structurei

3D structure databases

ProteinModelPortaliP97366
SMRiP97366
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini163 – 348Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST186

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 483Interaction with alpha-tubulin, gamma-tubulin, BIRC5 and FBXO5By similarityAdd BLAST483
Regioni128 – 693DimerizationBy similarityAdd BLAST566
Regioni377 – 809Targeting to the centrosomesBy similarityAdd BLAST433
Regioni487 – 809Interaction with AURKB and INCENPBy similarityAdd BLAST323

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili406 – 717Sequence analysisAdd BLAST312

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi28 – 128Ser-richAdd BLAST101

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4436 Eukaryota
ENOG410YWJY LUCA
HOGENOMiHOG000044859
HOVERGENiHBG081486
InParanoidiP97366
PhylomeDBiP97366

Family and domain databases

InterProiView protein in InterPro
IPR031214 Evi5
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
PANTHERiPTHR22957:SF254 PTHR22957:SF254, 1 hit
PfamiView protein in Pfam
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00164 TBC, 1 hit
SUPFAMiSSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50086 TBC_RABGAP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P97366-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVTTKMTAAF RNPNRRQVAT DKVAEKLSST LSWVKNTVSH TVSQMASQVA
60 70 80 90 100
SPSASLHTTS SSTTLSTPTQ SPSSPSKLSP DDLELLAKLE EQNRLIETDS
110 120 130 140 150
KSLRSVNGSR RNSGSSLVSS SSASSNLSHL EEDSWILWGR IVNEWDDVRK
160 170 180 190 200
KKEKQVKELV RKGIPHHFRA IVWQLLCNAQ SMTIKDQYSE LLKMTSPCEK
210 220 230 240 250
LIRRDIARTY PEHNFFKEKD SLGQEVLFNV MKAYSLVDRE LVTVRAVLSS
260 270 280 290 300
LDCCCMQMPE EEAFCVFVKL MQDYRLRELF KPSMAELGLC MYQFECMIQE
310 320 330 340 350
YLPELFVHFQ SQSFHTSMYA SSWFLTIFLT TFPLPIATRI FDIFMSEGLE
360 370 380 390 400
IVFRVGLALL QMNQAELMQL DMEGMLQHFQ KVIPHQFDGG PEKLIQSAYQ
410 420 430 440 450
VKYNSKKMKK LEKEYTTIKT KEMEEQGEIK RLRTENRLLK QRIETLEKHK
460 470 480 490 500
CSSTYNEDFV LQLEKELVQA RLSEAESQCA LKEMQDKVLD IEKKNNSFPD
510 520 530 540 550
ENNIARLQEE LIAVKLREAE AIMGLKELRQ QVRTLEEHWQ RHLARTSGRW
560 570 580 590 600
KDPPKKNAVN ELQDELMSIR LREAETQAEI REMKQRMMEM ETQNQINSNQ
610 620 630 640 650
LRRAEQEVNS LQEKVCSLSV KNKGLLAQLS EAKRRQAEIE CKNKEEVMAV
660 670 680 690 700
RLREADSIAA VAELQQHIAE LEIQKEEGKL QGQLNRSDSN QYIRELKDQI
710 720 730 740 750
AELTHELRCL KGQRDFSSRP PFDGIHIVSH LIGDDELFHS SDEDFIDSSL
760 770 780 790 800
QESAIGFPLH RKSGPMSLNP ALADGSESEA EDGMLGPQES DPEAPQKQPP

QRESYSTTV
Length:809
Mass (Da):92,943
Last modified:October 31, 2006 - v2
Checksum:i7AB17F9A403B1189
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VPT6F8VPT6_MOUSE
Ecotropic viral integration site 5 ...
Evi5
809Annotation score:
E9Q9B1E9Q9B1_MOUSE
Ecotropic viral integration site 5 ...
Evi5
365Annotation score:
E9PWR7E9PWR7_MOUSE
Ecotropic viral integration site 5 ...
Evi5
660Annotation score:
E9Q7X9E9Q7X9_MOUSE
Ecotropic viral integration site 5 ...
Evi5
222Annotation score:
Q3TMK4Q3TMK4_MOUSE
Ecotropic viral integration site 5 ...
Evi5
376Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti672E → K in AAB40607 (PubMed:9070650).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53586 mRNA Translation: AAB40607.1
AK164208 mRNA Translation: BAE37684.1
CCDSiCCDS39198.1
UniGeneiMm.35796

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53586 mRNA Translation: AAB40607.1
AK164208 mRNA Translation: BAE37684.1
CCDSiCCDS39198.1
UniGeneiMm.35796

3D structure databases

ProteinModelPortaliP97366
SMRiP97366
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP97366, 1 interactor
STRINGi10090.ENSMUSP00000108261

PTM databases

iPTMnetiP97366
PhosphoSitePlusiP97366

Proteomic databases

MaxQBiP97366
PaxDbiP97366
PRIDEiP97366

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:104736 Evi5

Phylogenomic databases

eggNOGiKOG4436 Eukaryota
ENOG410YWJY LUCA
HOGENOMiHOG000044859
HOVERGENiHBG081486
InParanoidiP97366
PhylomeDBiP97366

Miscellaneous databases

PROiPR:P97366
SOURCEiSearch...

Gene expression databases

CleanExiMM_EVI5

Family and domain databases

InterProiView protein in InterPro
IPR031214 Evi5
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
PANTHERiPTHR22957:SF254 PTHR22957:SF254, 1 hit
PfamiView protein in Pfam
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00164 TBC, 1 hit
SUPFAMiSSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50086 TBC_RABGAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEVI5_MOUSE
AccessioniPrimary (citable) accession number: P97366
Secondary accession number(s): Q3TPQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: November 7, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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