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Protein

Protein S100-A13

Gene

S100a13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi24 – 371By similarityAdd BLAST14
Calcium bindingi64 – 752By similarityAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandCalcium, Copper, Lipid-binding, Metal-binding

Protein family/group databases

TCDBi9.A.48.1.1 the unconventional protein secretion (ups) system

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A13
Alternative name(s):
S100 calcium-binding protein A13
Gene namesi
Name:S100a13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:109581 S100a13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001440201 – 98Protein S100-A13Add BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei32PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP97352
MaxQBiP97352
PaxDbiP97352
PeptideAtlasiP97352
PRIDEiP97352
TopDownProteomicsiP97352

PTM databases

iPTMnetiP97352
PhosphoSitePlusiP97352

Expressioni

Gene expression databases

CleanExiMM_S100A13

Interactioni

Subunit structurei

Homodimer. Part of a copper-dependent multiprotein complex containing S100A13, FGF1 and SYT1. Interacts with FGF1 and SYT1.3 Publications

GO - Molecular functioni

Protein-protein interaction databases

IntActiP97352, 1 interactor
MINTiP97352
STRINGi10090.ENSMUSP00000047737

Structurei

Secondary structure

198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP97352
SMRiP97352
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP97352

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 53EF-handAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IZIJ Eukaryota
ENOG410ZHGQ LUCA
HOGENOMiHOG000246968
HOVERGENiHBG001479
InParanoidiP97352
PhylomeDBiP97352
TreeFamiTF332727

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR013787 S100_Ca-bd_sub
IPR028487 S100A13
PANTHERiPTHR11639:SF57 PTHR11639:SF57, 1 hit
PfamiView protein in Pfam
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P97352-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAETLTELE AAIETVVSTF FTFAGREGRK GSLNINEFKE LATQQLPHLL
60 70 80 90
KDVGSLDEKM KTLDVNQDSE LRFSEYWRLI GELAKEVRKE KALGIRKK
Length:98
Mass (Da):11,158
Last modified:May 1, 1997 - v1
Checksum:i0A8CE8DA822BD530
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MQ90A0A0A0MQ90_MOUSE
Protein S100-A13
S100a13
160Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99921 mRNA Translation: CAA68189.1
BC005687 mRNA Translation: AAH05687.1
PIRiJC5065
UniGeneiMm.6523

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99921 mRNA Translation: CAA68189.1
BC005687 mRNA Translation: AAH05687.1
PIRiJC5065
UniGeneiMm.6523

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CXJNMR-A/B1-98[»]
ProteinModelPortaliP97352
SMRiP97352
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP97352, 1 interactor
MINTiP97352
STRINGi10090.ENSMUSP00000047737

Protein family/group databases

TCDBi9.A.48.1.1 the unconventional protein secretion (ups) system

PTM databases

iPTMnetiP97352
PhosphoSitePlusiP97352

Proteomic databases

EPDiP97352
MaxQBiP97352
PaxDbiP97352
PeptideAtlasiP97352
PRIDEiP97352
TopDownProteomicsiP97352

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:109581 S100a13

Phylogenomic databases

eggNOGiENOG410IZIJ Eukaryota
ENOG410ZHGQ LUCA
HOGENOMiHOG000246968
HOVERGENiHBG001479
InParanoidiP97352
PhylomeDBiP97352
TreeFamiTF332727

Miscellaneous databases

EvolutionaryTraceiP97352
PROiPR:P97352
SOURCEiSearch...

Gene expression databases

CleanExiMM_S100A13

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR013787 S100_Ca-bd_sub
IPR028487 S100A13
PANTHERiPTHR11639:SF57 PTHR11639:SF57, 1 hit
PfamiView protein in Pfam
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS10AD_MOUSE
AccessioniPrimary (citable) accession number: P97352
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: November 7, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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