Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

40S ribosomal protein S3a

Gene

Rps3a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role during erythropoiesis through regulation of transcription factor DDIT3.UniRule annotation1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein
Biological processDifferentiation

Enzyme and pathway databases

ReactomeiR-MMU-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-MMU-72649 Translation initiation complex formation
R-MMU-72689 Formation of a pool of free 40S subunits
R-MMU-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-MMU-72702 Ribosomal scanning and start codon recognition
R-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S3aUniRule annotation
Alternative name(s):
Protein TU-11
Gene namesi
Name:Rps3a
Synonyms:Rps3a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1202063 Rps3a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001535251 – 26440S ribosomal protein S3aAdd BLAST264

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34N6-acetyllysine; alternateBy similarity1
Cross-linki34Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei56N6-acetyllysineCombined sources1
Modified residuei237PhosphoserineCombined sources1
Modified residuei249N6-acetyllysine; alternateBy similarity1
Cross-linki249Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei256PhosphotyrosineCombined sources1
Modified residuei263PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP97351
PaxDbiP97351
PeptideAtlasiP97351
PRIDEiP97351
TopDownProteomicsiP97351

PTM databases

iPTMnetiP97351
PhosphoSitePlusiP97351
SwissPalmiP97351

Expressioni

Gene expression databases

BgeeiENSMUSG00000028081
CleanExiMM_RPS3A
ExpressionAtlasiP97351 baseline and differential
GenevisibleiP97351 MM

Interactioni

Subunit structurei

Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.UniRule annotation2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203010, 7 interactors
CORUMiP97351
IntActiP97351, 6 interactors
STRINGi10090.ENSMUSP00000029722

Structurei

3D structure databases

ProteinModelPortaliP97351
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic ribosomal protein eS1 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1628 Eukaryota
COG1890 LUCA
GeneTreeiENSGT00390000018433
HOGENOMiHOG000105220
HOVERGENiHBG000783
InParanoidiP97351
KOiK02984
OMAiMFEIMTR
OrthoDBiEOG091G0HTU
PhylomeDBiP97351
TreeFamiTF300037

Family and domain databases

HAMAPiMF_03122 Ribosomal_S3Ae_euk, 1 hit
InterProiView protein in InterPro
IPR027500 Ribosomal_S1/3_euk
IPR001593 Ribosomal_S3Ae
IPR018281 Ribosomal_S3Ae_CS
PfamiView protein in Pfam
PF01015 Ribosomal_S3Ae, 1 hit
SMARTiView protein in SMART
SM01397 Ribosomal_S3Ae, 1 hit
PROSITEiView protein in PROSITE
PS01191 RIBOSOMAL_S3AE, 1 hit

Sequencei

Sequence statusi: Complete.

P97351-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVGKNKRLT KGGKKGAKKK VVDPFSKKDW YDVKAPAMFN IRNIGKTLVT
60 70 80 90 100
RTQGTKIASD GLKGRVFEVS LADLQNDEVA FRKFKLITED VQGKNCLTNF
110 120 130 140 150
HGMDLTRDKM CSMVKKWQTM IEAHVDVKTT DGYLLRLFCV GFTKKRNNQI
160 170 180 190 200
RKTSYAQHQQ VRQIRKKMME IMTREVQTND LKEVVNKLIP DSIGKDIEKA
210 220 230 240 250
CQSIYPLHDV FVRKVKMLKK PKFELGKLME LHGEGGSSGK AAGDETGAKV
260
ERADGYEPPV QESV
Length:264
Mass (Da):29,885
Last modified:January 23, 2007 - v3
Checksum:iF50037AE0C1E359C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83368 Genomic DNA Translation: CAB05955.1
AK088113 mRNA Translation: BAC40152.1
BC039659 mRNA Translation: AAH39659.1
BC081451 mRNA Translation: AAH81451.1
BC083338 mRNA Translation: AAH83338.1
BC084675 mRNA Translation: AAH84675.1
CCDSiCCDS17446.1
RefSeqiNP_058655.3, NM_016959.4
UniGeneiMm.391785
Mm.399829

Genome annotation databases

EnsembliENSMUST00000029722; ENSMUSP00000029722; ENSMUSG00000028081
GeneIDi20091
KEGGimmu:20091
UCSCiuc008prc.2 mouse

Similar proteinsi

Entry informationi

Entry nameiRS3A_MOUSE
AccessioniPrimary (citable) accession number: P97351
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 149 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health