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Protein

Serine/threonine-protein kinase Kist

Gene

Uhmk1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei54ATPPROSITE-ProRule annotation1
Active sitei158Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 37ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • enzyme binding Source: MGI
  • protein kinase activity Source: BHF-UCL
  • protein serine/threonine kinase activity Source: UniProtKB
  • ribonucleoprotein complex binding Source: BHF-UCL
  • RNA binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionKinase, RNA-binding, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1 3474

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase Kist (EC:2.7.11.1)
Alternative name(s):
Kinase interacting with stathmin
PAM COOH-terminal interactor protein 2
Short name:
P-CIP2
U2AF homology motif kinase 1
Gene namesi
Name:Uhmk1
Synonyms:Kis, Kist
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1341908 Uhmk1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000867781 – 419Serine/threonine-protein kinase KistAdd BLAST419

Proteomic databases

PaxDbiP97343
PRIDEiP97343

PTM databases

iPTMnetiP97343
PhosphoSitePlusiP97343

Expressioni

Inductioni

By serum growth factors.

Gene expression databases

BgeeiENSMUSG00000026667 Expressed in 285 organ(s), highest expression level in retina
CleanExiMM_UHMK1
ExpressionAtlasiP97343 baseline and differential
GenevisibleiP97343 MM

Interactioni

Subunit structurei

Interacts with PAM and CDKN1B/p27Kip1 (By similarity). Interacts with stathmin.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200956, 7 interactors
IntActiP97343, 1 interactor
STRINGi10090.ENSMUSP00000027979

Structurei

3D structure databases

ProteinModelPortaliP97343
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 303Protein kinasePROSITE-ProRule annotationAdd BLAST281
Domaini323 – 405RRMPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0032 Eukaryota
ENOG410XRMJ LUCA
GeneTreeiENSGT00790000123065
HOGENOMiHOG000013166
HOVERGENiHBG056149
InParanoidiP97343
KOiK08877
OrthoDBiEOG091G08EY
PhylomeDBiP97343
TreeFamiTF331856

Family and domain databases

CDDicd12465 RRM_UHMK1, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR000719 Prot_kinase_dom
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034372 UHMK1
IPR034371 UHMK1_RRM
PANTHERiPTHR23139:SF14 PTHR23139:SF14, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS50102 RRM, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P97343-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGSGCAWGA EPPRFLEAFG RLWQVQSRLG SGSSASVYRV RCCGTPGSPP
60 70 80 90 100
GALKQFLPPG TTGAAASAAE YGFRKERAAL EQLQGHRNIV TLYGVFTIHF
110 120 130 140 150
SPNVPSRCLL LELLDVSVSE LLLYSSHQGC SMWMIQHCAR DVLEALAFLH
160 170 180 190 200
HEGYVHADLK PRNILWSAEN ECFKLIDFGL SFKEGNQDVK YIQTDGYRAP
210 220 230 240 250
EAELQNCLAQ AGLQSDTECT SAVDLWSLGI ILLEMFSGMK LKHTVRSQEW
260 270 280 290 300
KANSSAIIDH IFASKAVVNA AIPAYHLRDL IKSMLHDDPG RRIPAEMALC
310 320 330 340 350
SPFFSIPFAP HIEDLVMLPT PVLRLLNVLD DDYLENEDEY EDVVEDVKEE
360 370 380 390 400
CQKYGPVVSL LVPKENPGRG QVFVEYANAG DSKAAQKLLT GRMFDGKFVV
410
ATFYPLSAYK RGYLYQTLL
Length:419
Mass (Da):46,489
Last modified:January 4, 2005 - v3
Checksum:i3BD3C06A59E22540
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8C0N6Q8C0N6_MOUSE
Serine/threonine-protein kinase Kis...
Uhmk1 Kist
330Annotation score:
D3YUF5D3YUF5_MOUSE
Serine/threonine-protein kinase Kis...
Uhmk1
344Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti170N → D in CAA57763 (PubMed:7724523).Curated1
Sequence conflicti231I → T (PubMed:16141072).Curated1
Sequence conflicti231I → T (PubMed:9287318).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY180177 Genomic DNA Translation: AAO13515.1
Y10725 mRNA Translation: CAA71714.2
BC058732 mRNA Translation: AAH58732.1
AK013347 mRNA Translation: BAB28802.1
X82320 mRNA Translation: CAA57763.1
CCDSiCCDS15468.1
PIRiI48615
RefSeqiNP_034763.3, NM_010633.3
UniGeneiMm.209150
Mm.389214

Genome annotation databases

EnsembliENSMUST00000027979; ENSMUSP00000027979; ENSMUSG00000026667
GeneIDi16589
KEGGimmu:16589
UCSCiuc007dma.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY180177 Genomic DNA Translation: AAO13515.1
Y10725 mRNA Translation: CAA71714.2
BC058732 mRNA Translation: AAH58732.1
AK013347 mRNA Translation: BAB28802.1
X82320 mRNA Translation: CAA57763.1
CCDSiCCDS15468.1
PIRiI48615
RefSeqiNP_034763.3, NM_010633.3
UniGeneiMm.209150
Mm.389214

3D structure databases

ProteinModelPortaliP97343
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200956, 7 interactors
IntActiP97343, 1 interactor
STRINGi10090.ENSMUSP00000027979

PTM databases

iPTMnetiP97343
PhosphoSitePlusiP97343

Proteomic databases

PaxDbiP97343
PRIDEiP97343

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027979; ENSMUSP00000027979; ENSMUSG00000026667
GeneIDi16589
KEGGimmu:16589
UCSCiuc007dma.1 mouse

Organism-specific databases

CTDi127933
MGIiMGI:1341908 Uhmk1

Phylogenomic databases

eggNOGiKOG0032 Eukaryota
ENOG410XRMJ LUCA
GeneTreeiENSGT00790000123065
HOGENOMiHOG000013166
HOVERGENiHBG056149
InParanoidiP97343
KOiK08877
OrthoDBiEOG091G08EY
PhylomeDBiP97343
TreeFamiTF331856

Enzyme and pathway databases

BRENDAi2.7.11.1 3474

Miscellaneous databases

PROiPR:P97343
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026667 Expressed in 285 organ(s), highest expression level in retina
CleanExiMM_UHMK1
ExpressionAtlasiP97343 baseline and differential
GenevisibleiP97343 MM

Family and domain databases

CDDicd12465 RRM_UHMK1, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR000719 Prot_kinase_dom
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034372 UHMK1
IPR034371 UHMK1_RRM
PANTHERiPTHR23139:SF14 PTHR23139:SF14, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS50102 RRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUHMK1_MOUSE
AccessioniPrimary (citable) accession number: P97343
Secondary accession number(s): Q61775, Q9CYT1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: January 4, 2005
Last modified: November 7, 2018
This is version 156 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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Main funding by: National Institutes of Health

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