UniProtKB - P97343 (UHMK1_MOUSE)

BLAST

>sp|P97343|UHMK1_MOUSE Serine/threonine-protein kinase Kist OS=Mus musculus OX=10090 GN=Uhmk1 PE=1 SV=3
MAGSGCAWGAEPPRFLEAFGRLWQVQSRLGSGSSASVYRVRCCGTPGSPPGALKQFLPPG
TTGAAASAAEYGFRKERAALEQLQGHRNIVTLYGVFTIHFSPNVPSRCLLLELLDVSVSE
LLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGL
SFKEGNQDVKYIQTDGYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMK
LKHTVRSQEWKANSSAIIDHIFASKAVVNAAIPAYHLRDLIKSMLHDDPGRRIPAEMALC
SPFFSIPFAPHIEDLVMLPTPVLRLLNVLDDDYLENEDEYEDVVEDVKEECQKYGPVVSL
LVPKENPGRGQVFVEYANAGDSKAAQKLLTGRMFDGKFVVATFYPLSAYKRGYLYQTLL

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History
Entry version 156 (07 Nov 2018)
Sequence version 3 (04 Jan 2005)
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Protein

Serine/threonine-protein kinase Kist

Gene

Uhmk1

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity).By similarity

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.Curated

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	54	ATPPROSITE-ProRule annotation		1
Active siteⁱ	158	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	29 – 37	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
enzyme binding Source: MGI
protein kinase activity
Source: BHF-UCL
Traceable author statementⁱ
- 19015237
protein serine/threonine kinase activity Source: UniProtKB
ribonucleoprotein complex binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 19015237
RNA binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell cycle arrest Source: HGNC
neuron projection development
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19015237
peptidyl-serine phosphorylation Source: UniProtKB
positive regulation of translational initiation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19015237
protein autophosphorylation Source: HGNC
regulation of protein export from nucleus Source: HGNC

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, RNA-binding, Serine/threonine-protein kinase, Transferase
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.11.1 3474

BRENDAⁱ

2.7.11.1 3474

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Serine/threonine-protein kinase Kist (EC:2.7.11.1) Alternative name(s): Kinase interacting with stathmin PAM COOH-terminal interactor protein 2 Short name: P-CIP2 U2AF homology motif kinase 1
Gene namesⁱ	Name:Uhmk1 Synonyms:Kis, Kist
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 1

Organism-specific databases

MGIⁱ	MGI:1341908 Uhmk1

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000086778	1 – 419	Serine/threonine-protein kinase KistAdd BLAST		419

Proteomic databases

PaxDbⁱ	P97343
PRIDEⁱ	P97343

PTM databases

iPTMnetⁱ	P97343
PhosphoSitePlusⁱ	P97343

Expressionⁱ

Inductionⁱ

By serum growth factors.

Gene expression databases

Bgeeⁱ	ENSMUSG00000026667 Expressed in 285 organ(s), highest expression level in retina
CleanExⁱ	MM_UHMK1
ExpressionAtlasⁱ	P97343 baseline and differential
Genevisibleⁱ	P97343 MM

Interactionⁱ

Subunit structureⁱ

Interacts with PAM and CDKN1B/p27Kip1 (By similarity). Interacts with stathmin.By similarity2 Publications

GO - Molecular functionⁱ

enzyme binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	200956, 7 interactors
IntActⁱ	P97343, 1 interactor
STRINGⁱ	10090.ENSMUSP00000027979

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P97343
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	23 – 303	Protein kinasePROSITE-ProRule annotationAdd BLAST		281
Domainⁱ	323 – 405	RRMPROSITE-ProRule annotationAdd BLAST		83

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG0032 Eukaryota ENOG410XRMJ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00790000123065
HOGENOMⁱ	HOG000013166
HOVERGENⁱ	HBG056149
InParanoidⁱ	P97343
KEGG Orthology (KO) More...KOⁱ	K08877
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08EY
PhylomeDBⁱ	P97343
TreeFamⁱ	TF331856

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd12465 RRM_UHMK1, 1 hit
Gene3Dⁱ	3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR012677 Nucleotide-bd_a/b_plait_sf IPR000719 Prot_kinase_dom IPR035979 RBD_domain_sf IPR000504 RRM_dom IPR034372 UHMK1 IPR034371 UHMK1_RRM
PANTHERⁱ	PTHR23139:SF14 PTHR23139:SF14, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit PF00076 RRM_1, 1 hit
SMARTⁱ	View protein in SMART SM00360 RRM, 1 hit SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF54928 SSF54928, 1 hit SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50011 PROTEIN_KINASE_DOM, 1 hit PS50102 RRM, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

P97343-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAGSGCAWGA EPPRFLEAFG RLWQVQSRLG SGSSASVYRV RCCGTPGSPP 
        60         70         80         90        100
GALKQFLPPG TTGAAASAAE YGFRKERAAL EQLQGHRNIV TLYGVFTIHF 
       110        120        130        140        150
SPNVPSRCLL LELLDVSVSE LLLYSSHQGC SMWMIQHCAR DVLEALAFLH 
       160        170        180        190        200
HEGYVHADLK PRNILWSAEN ECFKLIDFGL SFKEGNQDVK YIQTDGYRAP 
       210        220        230        240        250
EAELQNCLAQ AGLQSDTECT SAVDLWSLGI ILLEMFSGMK LKHTVRSQEW 
       260        270        280        290        300
KANSSAIIDH IFASKAVVNA AIPAYHLRDL IKSMLHDDPG RRIPAEMALC 
       310        320        330        340        350
SPFFSIPFAP HIEDLVMLPT PVLRLLNVLD DDYLENEDEY EDVVEDVKEE 
       360        370        380        390        400
CQKYGPVVSL LVPKENPGRG QVFVEYANAG DSKAAQKLLT GRMFDGKFVV 
       410 
ATFYPLSAYK RGYLYQTLL

Length:419

Mass (Da):46,489

Last modified:January 4, 2005 - v3

Checksum:ⁱ3BD3C06A59E22540

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q8C0N6	Q8C0N6_MOUSE	Serine/threonine-protein kinase Kis... Serine/threonine-protein kinase Kist	Uhmk1 Kist	330	Annotation score:
D3YUF5	D3YUF5_MOUSE	Serine/threonine-protein kinase Kis... Serine/threonine-protein kinase Kist	Uhmk1	344	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	170	N → D in CAA57763 (PubMed:7724523).Curated	1
Sequence conflictⁱ	231	I → T (PubMed:16141072).Curated	1
Sequence conflictⁱ	231	I → T (PubMed:9287318).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY180177 Genomic DNA Translation: AAO13515.1 Y10725 mRNA Translation: CAA71714.2 BC058732 mRNA Translation: AAH58732.1 AK013347 mRNA Translation: BAB28802.1 X82320 mRNA Translation: CAA57763.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS15468.1
PIRⁱ	I48615
NCBI Reference Sequences More...RefSeqⁱ	NP_034763.3, NM_010633.3
UniGeneⁱ	Mm.209150 Mm.389214

Genome annotation databases

Ensemblⁱ	ENSMUST00000027979; ENSMUSP00000027979; ENSMUSG00000026667
GeneIDⁱ	16589
KEGGⁱ	mmu:16589
UCSC genome browser More...UCSCⁱ	uc007dma.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P97343	Serine/threonine-protein kinase Kist		HUMAN		419	UniRef90_Q8TAS1
Serine/threonine-protein kinase Kist		PONAB		419
Serine/threonine-protein kinase Kist		RAT		419
U2AF homology motif kinase 1		SAIBB		419
Uncharacterized protein		PROCO		419
+101

Protein	Similar proteins		Species	Score	Length	Source
P97343	Serine/threonine-protein kinase Kist		HUMAN		419	UniRef50_Q8TAS1
Serine/threonine-protein kinase Kist		PONAB		419
Serine/threonine-protein kinase Kist		RAT		419
U2AF homology motif kinase 1		SAIBB		419
Uncharacterized protein		PROCO		419
+217

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY180177 Genomic DNA Translation: AAO13515.1 Y10725 mRNA Translation: CAA71714.2 BC058732 mRNA Translation: AAH58732.1 AK013347 mRNA Translation: BAB28802.1 X82320 mRNA Translation: CAA57763.1
CCDSⁱ	CCDS15468.1
PIRⁱ	I48615
RefSeqⁱ	NP_034763.3, NM_010633.3
UniGeneⁱ	Mm.209150 Mm.389214

3D structure databases

ProteinModelPortalⁱ	P97343
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	200956, 7 interactors
IntActⁱ	P97343, 1 interactor
STRINGⁱ	10090.ENSMUSP00000027979

PTM databases

iPTMnetⁱ	P97343
PhosphoSitePlusⁱ	P97343

Proteomic databases

PaxDbⁱ	P97343
PRIDEⁱ	P97343

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000027979; ENSMUSP00000027979; ENSMUSG00000026667
GeneIDⁱ	16589
KEGGⁱ	mmu:16589
UCSCⁱ	uc007dma.1 mouse

Organism-specific databases

CTDⁱ	127933
MGIⁱ	MGI:1341908 Uhmk1

Phylogenomic databases

eggNOGⁱ	KOG0032 Eukaryota ENOG410XRMJ LUCA
GeneTreeⁱ	ENSGT00790000123065
HOGENOMⁱ	HOG000013166
HOVERGENⁱ	HBG056149
InParanoidⁱ	P97343
KOⁱ	K08877
OrthoDBⁱ	EOG091G08EY
PhylomeDBⁱ	P97343
TreeFamⁱ	TF331856

Enzyme and pathway databases

BRENDAⁱ	2.7.11.1 3474

BRENDAⁱ

2.7.11.1 3474

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P97343
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000026667 Expressed in 285 organ(s), highest expression level in retina
CleanExⁱ	MM_UHMK1
ExpressionAtlasⁱ	P97343 baseline and differential
Genevisibleⁱ	P97343 MM

Family and domain databases

CDDⁱ	cd12465 RRM_UHMK1, 1 hit
Gene3Dⁱ	3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR012677 Nucleotide-bd_a/b_plait_sf IPR000719 Prot_kinase_dom IPR035979 RBD_domain_sf IPR000504 RRM_dom IPR034372 UHMK1 IPR034371 UHMK1_RRM
PANTHERⁱ	PTHR23139:SF14 PTHR23139:SF14, 1 hit
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit PF00076 RRM_1, 1 hit
SMARTⁱ	View protein in SMART SM00360 RRM, 1 hit SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF54928 SSF54928, 1 hit SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50011 PROTEIN_KINASE_DOM, 1 hit PS50102 RRM, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	UHMK1_MOUSE
Accessionⁱ	P97343Primary (citable) accession number: P97343 Secondary accession number(s): Q61775, Q9CYT1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
	Last sequence update:	January 4, 2005
	Last modified:	November 7, 2018
	This is version 156 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

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UniProtKB - P97343 (UHMK1_MOUSE)

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Serine/threonine-protein kinase Kist

Uhmk1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Golgi apparatus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ