UniProtKB - P97343 (UHMK1_MOUSE)
Protein
Serine/threonine-protein kinase Kist
Gene
Uhmk1
Organism
Mus musculus (Mouse)
Status
Functioni
Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity).By similarity
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 54 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 158 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 29 – 37 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- enzyme binding Source: MGI
- protein kinase activity Source: BHF-UCL
- protein serine/threonine kinase activity Source: UniProtKB
- protein serine kinase activity Source: UniProtKB-EC
- protein threonine kinase activity Source: UniProtKB-EC
- ribonucleoprotein complex binding Source: BHF-UCL
- RNA binding Source: UniProtKB-KW
GO - Biological processi
- cell cycle arrest Source: HGNC-UCL
- neuron projection development Source: BHF-UCL
- peptidyl-serine phosphorylation Source: UniProtKB
- positive regulation of translational initiation Source: BHF-UCL
- protein autophosphorylation Source: HGNC-UCL
- regulation of protein export from nucleus Source: HGNC-UCL
Keywordsi
Molecular function | Kinase, RNA-binding, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 3474 |
Reactomei | R-MMU-9634638, Estrogen-dependent nuclear events downstream of ESR-membrane signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein kinase Kist (EC:2.7.11.1)Alternative name(s): Kinase interacting with stathmin PAM COOH-terminal interactor protein 2 Short name: P-CIP2 U2AF homology motif kinase 1 |
Gene namesi | Name:Uhmk1 Synonyms:Kis, Kist |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1341908, Uhmk1 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Note: Mostly nuclear.
Golgi apparatus
- Golgi apparatus Source: MGI
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: UniProtKB
Other locations
- axon Source: BHF-UCL
- cytoplasm Source: UniProtKB
- dendrite cytoplasm Source: BHF-UCL
- midbody Source: MGI
- neuronal ribonucleoprotein granule Source: BHF-UCL
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086778 | 1 – 419 | Serine/threonine-protein kinase KistAdd BLAST | 419 |
Proteomic databases
EPDi | P97343 |
PaxDbi | P97343 |
PRIDEi | P97343 |
PTM databases
iPTMneti | P97343 |
PhosphoSitePlusi | P97343 |
Expressioni
Inductioni
By serum growth factors.
Gene expression databases
Bgeei | ENSMUSG00000026667, Expressed in retina and 300 other tissues |
Genevisiblei | P97343, MM |
Interactioni
Subunit structurei
Interacts with PAM and CDKN1B/p27Kip1 (By similarity).
Interacts with stathmin.
By similarity2 PublicationsGO - Molecular functioni
- enzyme binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 200956, 7 interactors |
IntActi | P97343, 1 interactor |
STRINGi | 10090.ENSMUSP00000027979 |
Miscellaneous databases
RNActi | P97343, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 303 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 281 | |
Domaini | 323 – 405 | RRMPROSITE-ProRule annotationAdd BLAST | 83 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0032, Eukaryota |
GeneTreei | ENSGT00940000157769 |
InParanoidi | P97343 |
OrthoDBi | 1490376at2759 |
PhylomeDBi | P97343 |
TreeFami | TF331856 |
Family and domain databases
CDDi | cd12465, RRM_UHMK1, 1 hit |
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR012677, Nucleotide-bd_a/b_plait_sf IPR000719, Prot_kinase_dom IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR034372, UHMK1 IPR034371, UHMK1_RRM |
PANTHERi | PTHR46962, PTHR46962, 1 hit |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS50102, RRM, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P97343-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGSGCAWGA EPPRFLEAFG RLWQVQSRLG SGSSASVYRV RCCGTPGSPP
60 70 80 90 100
GALKQFLPPG TTGAAASAAE YGFRKERAAL EQLQGHRNIV TLYGVFTIHF
110 120 130 140 150
SPNVPSRCLL LELLDVSVSE LLLYSSHQGC SMWMIQHCAR DVLEALAFLH
160 170 180 190 200
HEGYVHADLK PRNILWSAEN ECFKLIDFGL SFKEGNQDVK YIQTDGYRAP
210 220 230 240 250
EAELQNCLAQ AGLQSDTECT SAVDLWSLGI ILLEMFSGMK LKHTVRSQEW
260 270 280 290 300
KANSSAIIDH IFASKAVVNA AIPAYHLRDL IKSMLHDDPG RRIPAEMALC
310 320 330 340 350
SPFFSIPFAP HIEDLVMLPT PVLRLLNVLD DDYLENEDEY EDVVEDVKEE
360 370 380 390 400
CQKYGPVVSL LVPKENPGRG QVFVEYANAG DSKAAQKLLT GRMFDGKFVV
410
ATFYPLSAYK RGYLYQTLL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8C0N6 | Q8C0N6_MOUSE | Serine/threonine-protein kinase Kis... | Uhmk1 Kist | 330 | Annotation score: | ||
D3YUF5 | D3YUF5_MOUSE | Serine/threonine-protein kinase Kis... | Uhmk1 | 344 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 170 | N → D in CAA57763 (PubMed:7724523).Curated | 1 | |
Sequence conflicti | 231 | I → T (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 231 | I → T (PubMed:9287318).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY180177 Genomic DNA Translation: AAO13515.1 Y10725 mRNA Translation: CAA71714.2 BC058732 mRNA Translation: AAH58732.1 AK013347 mRNA Translation: BAB28802.1 X82320 mRNA Translation: CAA57763.1 |
CCDSi | CCDS15468.1 |
PIRi | I48615 |
RefSeqi | NP_034763.3, NM_010633.3 |
Genome annotation databases
Ensembli | ENSMUST00000027979; ENSMUSP00000027979; ENSMUSG00000026667 |
GeneIDi | 16589 |
KEGGi | mmu:16589 |
UCSCi | uc007dma.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY180177 Genomic DNA Translation: AAO13515.1 Y10725 mRNA Translation: CAA71714.2 BC058732 mRNA Translation: AAH58732.1 AK013347 mRNA Translation: BAB28802.1 X82320 mRNA Translation: CAA57763.1 |
CCDSi | CCDS15468.1 |
PIRi | I48615 |
RefSeqi | NP_034763.3, NM_010633.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 200956, 7 interactors |
IntActi | P97343, 1 interactor |
STRINGi | 10090.ENSMUSP00000027979 |
PTM databases
iPTMneti | P97343 |
PhosphoSitePlusi | P97343 |
Proteomic databases
EPDi | P97343 |
PaxDbi | P97343 |
PRIDEi | P97343 |
Protocols and materials databases
Antibodypediai | 34322, 318 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000027979; ENSMUSP00000027979; ENSMUSG00000026667 |
GeneIDi | 16589 |
KEGGi | mmu:16589 |
UCSCi | uc007dma.1, mouse |
Organism-specific databases
CTDi | 127933 |
MGIi | MGI:1341908, Uhmk1 |
Phylogenomic databases
eggNOGi | KOG0032, Eukaryota |
GeneTreei | ENSGT00940000157769 |
InParanoidi | P97343 |
OrthoDBi | 1490376at2759 |
PhylomeDBi | P97343 |
TreeFami | TF331856 |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 3474 |
Reactomei | R-MMU-9634638, Estrogen-dependent nuclear events downstream of ESR-membrane signaling |
Miscellaneous databases
BioGRID-ORCSi | 16589, 0 hits in 19 CRISPR screens |
PROi | PR:P97343 |
RNActi | P97343, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000026667, Expressed in retina and 300 other tissues |
Genevisiblei | P97343, MM |
Family and domain databases
CDDi | cd12465, RRM_UHMK1, 1 hit |
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR012677, Nucleotide-bd_a/b_plait_sf IPR000719, Prot_kinase_dom IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR034372, UHMK1 IPR034371, UHMK1_RRM |
PANTHERi | PTHR46962, PTHR46962, 1 hit |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS50102, RRM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UHMK1_MOUSE | |
Accessioni | P97343Primary (citable) accession number: P97343 Secondary accession number(s): Q61775, Q9CYT1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 19, 2002 |
Last sequence update: | January 4, 2005 | |
Last modified: | February 10, 2021 | |
This is version 170 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families