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Protein

Homeobox protein Nkx-2.3

Gene

Nkx2-3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional regulator essential for normal development and functions of the small intestine and spleen. Activates directly MADCAM1 expression. Required for homing of lymphocytes in spleen and mucosa-associated lymphoid tissue. May have a role during pharyngeal organogenesis.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi145 – 204HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Nkx-2.3
Alternative name(s):
Homeobox protein NK-2 homolog 3
Homeobox protein NK-2 homolog C
Nkx2-C
Gene namesi
Name:Nkx2-3
Synonyms:Nkx-2.3, Nkx2c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:97348 Nkx2-3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000489341 – 362Homeobox protein Nkx-2.3Add BLAST362

Proteomic databases

PaxDbiP97334
PRIDEiP97334

PTM databases

iPTMnetiP97334
PhosphoSitePlusiP97334

Expressioni

Tissue specificityi

Expressed in spleen and intestine. Also expressed in salivary gland and tongue.1 Publication

Developmental stagei

Expressed in gut mesenchyme during pre- and postnatal development. Expressed as well in the pharyngeal floor and pouches, and in the oral and branchial arch ectoderm. Expression persisted in the developing thyroid until birth, in mucous forming cells of salivary glands and in odontogenic epithelium of the mandible.

Gene expression databases

BgeeiENSMUSG00000044220 Expressed in 76 organ(s), highest expression level in associated mesenchyme of midgut
GenevisibleiP97334 MM

Interactioni

Protein-protein interaction databases

BioGridi201777, 2 interactors
STRINGi10090.ENSMUSP00000050933

Structurei

3D structure databases

ProteinModelPortaliP97334
SMRiP97334
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi59 – 67Poly-Glu9
Compositional biasi216 – 220Poly-Pro5
Compositional biasi268 – 283Poly-AlaAdd BLAST16
Compositional biasi295 – 302Poly-Gly8

Sequence similaritiesi

Belongs to the NK-2 homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0842 Eukaryota
ENOG410XR21 LUCA
GeneTreeiENSGT00910000144003
HOGENOMiHOG000231923
HOVERGENiHBG006689
InParanoidiP97334
KOiK09343
OMAiYGCAYPT
OrthoDBiEOG091G0LZ2
TreeFamiTF351204

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P97334-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMLPSPVTST PFSVKDILNL EQQRHFHGAH LQAELEQHFH SAPCMLATAE
60 70 80 90 100
GTQFSDAGEE DEEEEGEKLS YLNSLAAAEG HGDSGLCPQS YVHTVLRDAC
110 120 130 140 150
SGPKEQEEEV VSERSQKSCQ LKKSLEAAGD CKTSEDGERP KPRSRRKPRV
160 170 180 190 200
LFSQAQVFEL ERRFKQQRYL SAPEREHLAS SLKLTSTQVK IWFQNRRYKC
210 220 230 240 250
KRQRQDKSLE LGTHAPPPPP RRVAVPVLVR DGKPCVTPSA QTYGSPYGVG
260 270 280 290 300
AGAYSYNSFP AYGYGNSAAA AAAAAAAAAA AAAYSGSYGC AYPTGGGGGG
310 320 330 340 350
GGTASAATTA MQPACSATGG GSFVNVSNLG GFGSGGGAQP LHQGAAAGSA
360
CTQGTLQGIR AW
Length:362
Mass (Da):38,090
Last modified:August 2, 2002 - v2
Checksum:i48886528EC3E1622
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44C → R in CAA72002 (PubMed:9142493).Curated1
Sequence conflicti61D → E in CAA72002 (PubMed:9142493).Curated1
Sequence conflicti132K → R in CAA72002 (PubMed:9142493).Curated1
Sequence conflicti248 – 250GVG → RC in CAA72002 (PubMed:9142493).Curated3
Sequence conflicti261 – 357AYGYG…QGTLQ → TATGTRPPQPLQPPQPQQQG LQRQLRLAYRPVAAVVVAAR PPRRPPPCNPPAAPPGDLRV TAGIEAFVPLVR in CAA72002 (PubMed:9142493).CuratedAdd BLAST97
Sequence conflicti349S → A in AAD38415 (PubMed:10926756).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11117 mRNA Translation: CAA72002.1
AF202036 mRNA Translation: AAF08008.1
AF155583 Genomic DNA Translation: AAD38415.1
BC072614 mRNA Translation: AAH72614.1
CCDSiCCDS29833.1
RefSeqiNP_032725.1, NM_008699.2
UniGeneiMm.56994

Genome annotation databases

EnsembliENSMUST00000057178; ENSMUSP00000050933; ENSMUSG00000044220
GeneIDi18089
KEGGimmu:18089
UCSCiuc008hok.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11117 mRNA Translation: CAA72002.1
AF202036 mRNA Translation: AAF08008.1
AF155583 Genomic DNA Translation: AAD38415.1
BC072614 mRNA Translation: AAH72614.1
CCDSiCCDS29833.1
RefSeqiNP_032725.1, NM_008699.2
UniGeneiMm.56994

3D structure databases

ProteinModelPortaliP97334
SMRiP97334
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201777, 2 interactors
STRINGi10090.ENSMUSP00000050933

PTM databases

iPTMnetiP97334
PhosphoSitePlusiP97334

Proteomic databases

PaxDbiP97334
PRIDEiP97334

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057178; ENSMUSP00000050933; ENSMUSG00000044220
GeneIDi18089
KEGGimmu:18089
UCSCiuc008hok.1 mouse

Organism-specific databases

CTDi159296
MGIiMGI:97348 Nkx2-3

Phylogenomic databases

eggNOGiKOG0842 Eukaryota
ENOG410XR21 LUCA
GeneTreeiENSGT00910000144003
HOGENOMiHOG000231923
HOVERGENiHBG006689
InParanoidiP97334
KOiK09343
OMAiYGCAYPT
OrthoDBiEOG091G0LZ2
TreeFamiTF351204

Miscellaneous databases

ChiTaRSiNkx2-3 mouse
PROiPR:P97334
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044220 Expressed in 76 organ(s), highest expression level in associated mesenchyme of midgut
GenevisibleiP97334 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNKX23_MOUSE
AccessioniPrimary (citable) accession number: P97334
Secondary accession number(s): Q9QZ60, Q9WV67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: August 2, 2002
Last modified: November 7, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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