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UniProtKB - P97333 (NRP1_MOUSE)

Entry version 194 (17 Jun 2020)
Sequence version 2 (27 Jul 2011)
Previous versions | rss
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Protein

Neuropilin-1

Gene

Nrp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system (By similarity). Mediates the chemorepulsant activity of semaphorins (PubMed:26503042). Binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB (By similarity). Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis (By similarity). Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (PubMed:26503042). Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi195CalciumBy similarity1
Metal bindingi209CalciumBy similarity1
Metal bindingi250CalciumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Heparin-binding, Receptor
Biological processAngiogenesis, Differentiation, Neurogenesis
LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-194306 Neurophilin interactions with VEGF and VEGFR
R-MMU-399954 Sema3A PAK dependent Axon repulsion
R-MMU-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-MMU-399956 CRMPs in Sema3A signaling
R-MMU-445144 Signal transduction by L1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neuropilin-1
Alternative name(s):
A5 protein
CD_antigen: CD304
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nrp1Imported
Synonyms:Nrp
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:106206 Nrp1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 856ExtracellularSequence analysisAdd BLAST835
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei857 – 879HelicalSequence analysisAdd BLAST23
Topological domaini880 – 923CytoplasmicSequence analysisAdd BLAST44

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Knockout embryos display higher susceptibility to oxidative stress in endothelium cells located in the intersomitic vessels.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002186022 – 923Neuropilin-1Add BLAST902

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi27 ↔ 54By similarity
Disulfide bondi82 ↔ 104By similarity
Disulfide bondi147 ↔ 173By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi150N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi206 ↔ 228By similarity
Glycosylationi261N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi275 ↔ 424By similarity
Glycosylationi300N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi431 ↔ 583By similarity
Glycosylationi522N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi612O-linked (Xyl...) (chondroitin sulfate) serine; alternateBy similarity1
Glycosylationi612O-linked (Xyl...) (heparan sulfate) serine; alternateBy similarity1
Glycosylationi842N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei894PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Heparan sulfate, Phosphoprotein, Proteoglycan

Proteomic databases

The CPTAC Assay portal

More...CPTACi		non-CPTAC-3597
non-CPTAC-3661

MaxQB - The MaxQuant DataBase

More...MaxQBi		P97333

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P97333

PeptideAtlas

More...PeptideAtlasi		P97333

PRoteomics IDEntifications database

More...PRIDEi		P97333

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P97333

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		2556

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P97333

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P97333

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P97333

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Nervous system.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000025810 Expressed in internal carotid artery and 317 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P97333 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer, and heterodimer with NRP2 (By similarity). Binds PLXNB1 (By similarity).

Interacts with FER (PubMed:20133938).

Interacts with VEGFA (PubMed:26503042).

Interacts with ABCB8/MITOSUR in mitochondria (By similarity).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		201848, 19 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P97333

Database of interacting proteins

More...DIPi		DIP-39360N

Protein interaction database and analysis system

More...IntActi		P97333, 16 interactors

Molecular INTeraction database

More...MINTi		P97333

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000026917

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P97333 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1923
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P97333

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 141CUB 1PROSITE-ProRule annotationAdd BLAST115
Domaini147 – 265CUB 2PROSITE-ProRule annotationAdd BLAST119
Domaini275 – 424F5/8 type C 1PROSITE-ProRule annotationAdd BLAST150
Domaini431 – 583F5/8 type C 2PROSITE-ProRule annotationAdd BLAST153
Domaini645 – 811MAMPROSITE-ProRule annotationAdd BLAST167

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the neuropilin family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IE8T Eukaryota
ENOG410YRBE LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157169

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_015228_6_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P97333

KEGG Orthology (KO)

More...KOi		K06724

Identification of Orthologs from Complete Genome Data

More...OMAi		HPYTNEW

Database of Orthologous Groups

More...OrthoDBi		124611at2759

TreeFam database of animal gene trees

More...TreeFami		TF316506

Family and domain databases

Conserved Domains Database

More...CDDi		cd00041 CUB, 2 hits
cd00057 FA58C, 2 hits
cd06263 MAM, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.260, 2 hits
2.60.120.290, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000859 CUB_dom
IPR000421 FA58C
IPR008979 Galactose-bd-like_sf
IPR000998 MAM_dom
IPR014648 Neuropilin
IPR022579 Neuropilin_C
IPR027146 NRP1
IPR035914 Sperma_CUB_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR46806:SF4 PTHR46806:SF4, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00431 CUB, 2 hits
PF11980 DUF3481, 1 hit
PF00754 F5_F8_type_C, 2 hits
PF00629 MAM, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF036960 Neuropilin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00020 MAMDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00042 CUB, 2 hits
SM00231 FA58C, 2 hits
SM00137 MAM, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49785 SSF49785, 2 hits
SSF49854 SSF49854, 2 hits
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01180 CUB, 2 hits
PS01285 FA58C_1, 2 hits
PS01286 FA58C_2, 2 hits
PS50022 FA58C_3, 2 hits
PS00740 MAM_1, 1 hit
PS50060 MAM_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P97333-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERGLPLLCA TLALALALAG AFRSDKCGGT IKIENPGYLT SPGYPHSYHP 
        60         70         80         90        100
SEKCEWLIQA PEPYQRIMIN FNPHFDLEDR DCKYDYVEVI DGENEGGRLW 
       110        120        130        140        150
GKFCGKIAPS PVVSSGPFLF IKFVSDYETH GAGFSIRYEI FKRGPECSQN 
       160        170        180        190        200
YTAPTGVIKS PGFPEKYPNS LECTYIIFAP KMSEIILEFE SFDLEQDSNP 
       210        220        230        240        250
PGGMFCRYDR LEIWDGFPEV GPHIGRYCGQ KTPGRIRSSS GVLSMVFYTD 
       260        270        280        290        300
SAIAKEGFSA NYSVLQSSIS EDFKCMEALG MESGEIHSDQ ITASSQYGTN 
       310        320        330        340        350
WSVERSRLNY PENGWTPGED SYKEWIQVDL GLLRFVTAVG TQGAISKETK 
       360        370        380        390        400
KKYYVKTYRV DISSNGEDWI SLKEGNKAII FQGNTNPTDV VLGVFSKPLI 
       410        420        430        440        450
TRFVRIKPVS WETGISMRFE VYGCKITDYP CSGMLGMVSG LISDSQITAS 
       460        470        480        490        500
NQADRNWMPE NIRLVTSRTG WALPPSPHPY TNEWLQVDLG DEKIVRGVII 
       510        520        530        540        550
QGGKHRENKV FMRKFKIAYS NNGSDWKTIM DDSKRKAKSF EGNNNYDTPE 
       560        570        580        590        600
LRTFSPLSTR FIRIYPERAT HSGLGLRMEL LGCEVEAPTA GPTTPNGNPV 
       610        620        630        640        650
DECDDDQANC HSGTGDDFQL TGGTTVLATE KPTIIDSTIQ SEFPTYGFNC 
       660        670        680        690        700
EFGWGSHKTF CHWEHDSHAQ LRWSVLTSKT GPIQDHTGDG NFIYSQADEN 
       710        720        730        740        750
QKGKVARLVS PVVYSQSSAH CMTFWYHMSG SHVGTLRVKL RYQKPEEYDQ 
       760        770        780        790        800
LVWMVVGHQG DHWKEGRVLL HKSLKLYQVI FEGEIGKGNL GGIAVDDISI 
       810        820        830        840        850
NNHISQEDCA KPTDLDKKNT EIKIDETGST PGYEGEGEGD KNISRKPGNV 
       860        870        880        890        900
LKTLDPILIT IIAMSALGVL LGAVCGVVLY CACWHNGMSE RNLSALENYN 
       910        920 
FELVDGVKLK KDKLNPQSNY SEA
Length:923
Mass (Da):103,000
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i23209818C5C42137
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti68M → I in BAA08789 (PubMed:8748368).Curated1
Sequence conflicti170S → C in BAA08789 (PubMed:8748368).Curated1
Sequence conflicti601D → H in BAA08789 (PubMed:8748368).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D50086 mRNA Translation: BAA08789.1
CH466525 Genomic DNA Translation: EDL11828.1
BC060129 mRNA Translation: AAH60129.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS22790.1

NCBI Reference Sequences

More...RefSeqi		NP_032763.2, NM_008737.2
XP_006530829.1, XM_006530766.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000026917; ENSMUSP00000026917; ENSMUSG00000025810

Database of genes from NCBI RefSeq genomes

More...GeneIDi		18186

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:18186

UCSC genome browser

More...UCSCi		uc009nzr.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50086 mRNA Translation: BAA08789.1
CH466525 Genomic DNA Translation: EDL11828.1
BC060129 mRNA Translation: AAH60129.1
CCDSiCCDS22790.1
RefSeqiNP_032763.2, NM_008737.2
XP_006530829.1, XM_006530766.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GZ9X-ray2.70A22-586[»]
4GZAX-ray7.00H22-586[»]
SMRiP97333
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi201848, 19 interactors
CORUMiP97333
DIPiDIP-39360N
IntActiP97333, 16 interactors
MINTiP97333
STRINGi10090.ENSMUSP00000026917

PTM databases

GlyConnecti2556
iPTMnetiP97333
PhosphoSitePlusiP97333
SwissPalmiP97333

Proteomic databases

CPTACinon-CPTAC-3597
non-CPTAC-3661
MaxQBiP97333
PaxDbiP97333
PeptideAtlasiP97333
PRIDEiP97333
TopDownProteomicsiP97333

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3859 855 antibodies

Genome annotation databases

EnsembliENSMUST00000026917; ENSMUSP00000026917; ENSMUSG00000025810
GeneIDi18186
KEGGimmu:18186
UCSCiuc009nzr.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8829
MGIiMGI:106206 Nrp1

Phylogenomic databases

eggNOGiENOG410IE8T Eukaryota
ENOG410YRBE LUCA
GeneTreeiENSGT00940000157169
HOGENOMiCLU_015228_6_1_1
InParanoidiP97333
KOiK06724
OMAiHPYTNEW
OrthoDBi124611at2759
TreeFamiTF316506

Enzyme and pathway databases

ReactomeiR-MMU-194306 Neurophilin interactions with VEGF and VEGFR
R-MMU-399954 Sema3A PAK dependent Axon repulsion
R-MMU-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-MMU-399956 CRMPs in Sema3A signaling
R-MMU-445144 Signal transduction by L1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		18186 2 hits in 12 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Nrp1 mouse

Protein Ontology

More...PROi		PR:P97333
RNActiP97333 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000025810 Expressed in internal carotid artery and 317 other tissues
GenevisibleiP97333 MM

Family and domain databases

CDDicd00041 CUB, 2 hits
cd00057 FA58C, 2 hits
cd06263 MAM, 1 hit
Gene3Di2.60.120.260, 2 hits
2.60.120.290, 2 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000859 CUB_dom
IPR000421 FA58C
IPR008979 Galactose-bd-like_sf
IPR000998 MAM_dom
IPR014648 Neuropilin
IPR022579 Neuropilin_C
IPR027146 NRP1
IPR035914 Sperma_CUB_dom_sf
PANTHERiPTHR46806:SF4 PTHR46806:SF4, 1 hit
PfamiView protein in Pfam
PF00431 CUB, 2 hits
PF11980 DUF3481, 1 hit
PF00754 F5_F8_type_C, 2 hits
PF00629 MAM, 1 hit
PIRSFiPIRSF036960 Neuropilin, 1 hit
PRINTSiPR00020 MAMDOMAIN
SMARTiView protein in SMART
SM00042 CUB, 2 hits
SM00231 FA58C, 2 hits
SM00137 MAM, 1 hit
SUPFAMiSSF49785 SSF49785, 2 hits
SSF49854 SSF49854, 2 hits
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS01180 CUB, 2 hits
PS01285 FA58C_1, 2 hits
PS01286 FA58C_2, 2 hits
PS50022 FA58C_3, 2 hits
PS00740 MAM_1, 1 hit
PS50060 MAM_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNRP1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P97333
Secondary accession number(s): Q6PAR3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: June 17, 2020
This is version 194 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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