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Protein

Ketohexokinase

Gene

Khk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate.By similarity

Catalytic activityi

ATP + D-fructose = ADP + D-fructose 1-phosphate.By similarity

Enzyme regulationi

Requires potassium. Inhibition by ADP (By similarity).By similarity

Pathwayi: fructose metabolism

This protein is involved in the pathway fructose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway fructose metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei15D-fructoseBy similarity1
Binding sitei41D-fructose; via amide nitrogenBy similarity1
Binding sitei42D-fructoseBy similarity1
Binding sitei45D-fructoseBy similarity1
Binding sitei108ATPBy similarity1
Binding sitei258D-fructoseBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi255 – 258ATPBy similarity4

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ketohexokinase activity Source: MGI

GO - Biological processi

  • fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate Source: MGI
  • fructose metabolic process Source: MGI
  • glycolytic process through fructose-1-phosphate Source: MGI
  • regulation of glycogen metabolic process Source: MGI
  • response to glucose Source: MGI
  • response to insulin Source: MGI
  • response to sucrose Source: MGI
  • response to zinc ion Source: MGI

Keywordsi

Molecular functionKinase, Transferase
Biological processCarbohydrate metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00202

Names & Taxonomyi

Protein namesi
Recommended name:
KetohexokinaseImported (EC:2.7.1.3By similarity)
Alternative name(s):
Hepatic fructokinase
Gene namesi
Name:KhkImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1096353 Khk

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000800891 – 298KetohexokinaseAdd BLAST298

Proteomic databases

MaxQBiP97328
PaxDbiP97328
PeptideAtlasiP97328
PRIDEiP97328

2D gel databases

SWISS-2DPAGEiP97328

PTM databases

iPTMnetiP97328
PhosphoSitePlusiP97328
SwissPalmiP97328

Expressioni

Gene expression databases

CleanExiMM_KHK

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiP97328, 6 interactors
MINTiP97328
STRINGi10090.ENSMUSP00000031053

Structurei

3D structure databases

ProteinModelPortaliP97328
SMRiP97328
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the carbohydrate kinase PfkB family.Curated

Phylogenomic databases

eggNOGiKOG2947 Eukaryota
ENOG4111F4Q LUCA
HOGENOMiHOG000212926
HOVERGENiHBG003335
InParanoidiP97328
KOiK00846
PhylomeDBiP97328
TreeFamiTF323942

Family and domain databases

CDDicd01939 Ketohexokinase, 1 hit
Gene3Di3.40.1190.20, 1 hit
InterProiView protein in InterPro
IPR034093 KHK
IPR011611 PfkB_dom
IPR029056 Ribokinase-like
PfamiView protein in Pfam
PF00294 PfkB, 1 hit
SUPFAMiSSF53613 SSF53613, 1 hit

Sequencei

Sequence statusi: Complete.

P97328-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEKQILCVG LVVLDIINVV DKYPEEDTDR RCLSQRWQRG GNASNSCTVL
60 70 80 90 100
SLLGARCAFM GSLAPGHVAD FLVADFRQRG VDVSQVTWQS QGDTPCSCCI
110 120 130 140 150
VNNSNGSRTI ILYDTNLPDV SAKDFEKVDL TRFKWIHIEG RNASEQVKML
160 170 180 190 200
QRIEEHNAKQ PLPQKVRVSV EIEKPREELF QLFSYGEVVF VSKDVAKHLG
210 220 230 240 250
FQPAVEALRG LYSRVKKGAT LVCAWAEEGA DALGPDGQLL HSDAFPPPRV
260 270 280 290
VDTLGAGDTF NASVIFSLSK GNSMQEALRF GCQVAGKKCG LQGFDGIV
Length:298
Mass (Da):32,750
Last modified:May 1, 1997 - v1
Checksum:iA8181D781A6136D4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti203P → S in AAH13464 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09335 mRNA Translation: CAA70515.1
BC013464 mRNA Translation: AAH13464.1
CCDSiCCDS39050.1
RefSeqiNP_032465.2, NM_008439.4
UniGeneiMm.22451

Genome annotation databases

GeneIDi16548
KEGGimmu:16548
UCSCiuc008wwn.1 mouse

Similar proteinsi

Entry informationi

Entry nameiKHK_MOUSE
AccessioniPrimary (citable) accession number: P97328
Secondary accession number(s): Q91WU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1997
Last modified: June 20, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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