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Protein

Cadherin-6

Gene

Cdh6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

  • cadherin binding Source: GO_Central
  • calcium ion binding Source: GO_Central
  • cytoskeletal protein binding Source: GO_Central
  • protein homodimerization activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-418990 Adherens junctions interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-6
Alternative name(s):
Kidney cadherin
Short name:
K-cadherin
Gene namesi
Name:Cdh6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:107435 Cdh6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini54 – 615ExtracellularSequence analysisAdd BLAST562
Transmembranei616 – 636HelicalSequence analysisAdd BLAST21
Topological domaini637 – 790CytoplasmicSequence analysisAdd BLAST154

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000000376319 – 53Sequence analysisAdd BLAST35
ChainiPRO_000000376454 – 790Cadherin-6Add BLAST737

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi255N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi399N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi437N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi455N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi536N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei786PhosphoserineCombined sources1
Modified residuei790PhosphoserineCombined sources1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP97326
PaxDbiP97326
PeptideAtlasiP97326
PRIDEiP97326

PTM databases

iPTMnetiP97326
PhosphoSitePlusiP97326

Expressioni

Developmental stagei

Expressed in fetal, newborn and 7-day-old testis but not in 21-day-old or adult testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000039385 Expressed in 283 organ(s), highest expression level in metanephros
CleanExiMM_CDH6
GenevisibleiP97326 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037113

Structurei

Secondary structure

1790
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP97326
SMRiP97326
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP97326

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 159Cadherin 1PROSITE-ProRule annotationAdd BLAST106
Domaini160 – 268Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini269 – 383Cadherin 3PROSITE-ProRule annotationAdd BLAST115
Domaini384 – 486Cadherin 4PROSITE-ProRule annotationAdd BLAST103
Domaini487 – 608Cadherin 5PROSITE-ProRule annotationAdd BLAST122

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00760000118954
HOGENOMiHOG000231252
HOVERGENiHBG005217
InParanoidiP97326
KOiK06798
OMAiQPYPTFS
OrthoDBiEOG091G0298
TreeFamiTF329887

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR039808 Cadherin
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
PANTHERiPTHR24027 PTHR24027, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 5 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97326-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRTYRYFLLL FWVGQPYPTF SNPLSKRTSG FPAKRKALEL SANSRNELSR
60 70 80 90 100
SKRSWMWNQF FLLEEYTGSD YQYVGKLHSD QDRGDGSLKY ILSGDGAGDL
110 120 130 140 150
FIINENTGDI QATKRLDREE KPVYILRAQA VNRRTGRPVE PESEFIIKIH
160 170 180 190 200
DINDNEPIFT KDVYTATVPE MADVGTFVVQ VTATDADDPT YGNSAKVVYS
210 220 230 240 250
ILQGQPYFSV ESETGIIKTA LLNMDRENRE QYQVVIQAKD MGGQMGGLSG
260 270 280 290 300
TTTVNITLTD VNDNPPRFPQ STYQFKTPES SPPGTPIGRI KASDADVGEN
310 320 330 340 350
AEIEYSITDG EGHEMFDVIT DQETQEGIIT VKKLLDFEKK KVYTLKVEAS
360 370 380 390 400
NPHVEPRFLY LGPFKDSATV RIVVDDVDEP PVFSKLAYIL QIREDARINT
410 420 430 440 450
TIGSVAAQDP DAARNPVKYS VDRHTDMDRI FNIDSGNGSI FTSKLLDRET
460 470 480 490 500
LLWHNITVIA TEINNPKQSS RVPLYIKVLD VNDNAPEFAE FYETFVCEKA
510 520 530 540 550
KADQLIQTLR AVDKDDPYSG HQFSFSLAPE AASSSNFTIQ DNKDNTAGIL
560 570 580 590 600
TRKNGYNRHE MSTYLLPVVI SDNDYPVQSS TGTVTVRVCA CDHHGNMQSC
610 620 630 640 650
HAEALIHPTG LSTGALVAIL LCIVILLVTV VLFAALRRQR KKEPLIISKE
660 670 680 690 700
DIRDNIVSYN DEGGGEEDTQ AFDIGTLRNP EAMEDSKSRR DIVPEALFLP
710 720 730 740 750
RRTPTARDNT DVRDFINQRL KENDTDPTAP PYDSLATYAY EGTGSVADSL
760 770 780 790
SSLESVTTDG DQDYDYLSDW GPRFKKLADM YGGMDSDKDS
Length:790
Mass (Da):88,355
Last modified:July 27, 2011 - v2
Checksum:i14389434D23B2A8F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43N → D in BAA11516 (PubMed:9126293).Curated1
Sequence conflicti54S → G in BAA11516 (PubMed:9126293).Curated1
Sequence conflicti65E → G in BAA11516 (PubMed:9126293).Curated1
Sequence conflicti106N → H in BAA11516 (PubMed:9126293).Curated1
Sequence conflicti346 – 348KVE → RWK in BAA11516 (PubMed:9126293).Curated3
Sequence conflicti403G → V in BAA11516 (PubMed:9126293).Curated1
Sequence conflicti464N → K in BAA11516 (PubMed:9126293).Curated1
Sequence conflicti534S → G in AAB07550 (Ref. 3) Curated1
Sequence conflicti536N → T in AAB07550 (Ref. 3) Curated1
Sequence conflicti597 – 598MQ → IE in BAA11516 (PubMed:9126293).Curated2
Sequence conflicti613T → S in BAA11516 (PubMed:9126293).Curated1
Sequence conflicti640R → E in BAA11516 (PubMed:9126293).Curated1
Sequence conflicti777L → V in BAA11516 (PubMed:9126293).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D82029 mRNA Translation: BAA11516.1
BC107013 mRNA Translation: AAI07014.1
U67399 mRNA Translation: AAB07550.1
CCDSiCCDS27393.1
RefSeqiNP_031692.2, NM_007666.4
XP_006520080.1, XM_006520017.1
UniGeneiMm.458225
Mm.57048

Genome annotation databases

EnsembliENSMUST00000036439; ENSMUSP00000037113; ENSMUSG00000039385
GeneIDi12563
KEGGimmu:12563
UCSCiuc007vif.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D82029 mRNA Translation: BAA11516.1
BC107013 mRNA Translation: AAI07014.1
U67399 mRNA Translation: AAB07550.1
CCDSiCCDS27393.1
RefSeqiNP_031692.2, NM_007666.4
XP_006520080.1, XM_006520017.1
UniGeneiMm.458225
Mm.57048

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LNDX-ray2.82A/B/C/D58-260[»]
6CGBX-ray2.99A156-260[»]
6CGUX-ray1.90A/B/C/D54-260[»]
ProteinModelPortaliP97326
SMRiP97326
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037113

PTM databases

iPTMnetiP97326
PhosphoSitePlusiP97326

Proteomic databases

MaxQBiP97326
PaxDbiP97326
PeptideAtlasiP97326
PRIDEiP97326

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036439; ENSMUSP00000037113; ENSMUSG00000039385
GeneIDi12563
KEGGimmu:12563
UCSCiuc007vif.1 mouse

Organism-specific databases

CTDi1004
MGIiMGI:107435 Cdh6

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00760000118954
HOGENOMiHOG000231252
HOVERGENiHBG005217
InParanoidiP97326
KOiK06798
OMAiQPYPTFS
OrthoDBiEOG091G0298
TreeFamiTF329887

Enzyme and pathway databases

ReactomeiR-MMU-418990 Adherens junctions interactions

Miscellaneous databases

EvolutionaryTraceiP97326
PROiPR:P97326
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039385 Expressed in 283 organ(s), highest expression level in metanephros
CleanExiMM_CDH6
GenevisibleiP97326 MM

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR039808 Cadherin
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
PANTHERiPTHR24027 PTHR24027, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCADH6_MOUSE
AccessioniPrimary (citable) accession number: P97326
Secondary accession number(s): P70393, Q3KNY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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