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Protein

Cysteine and glycine-rich protein 2

Gene

Csrp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine and glycine-rich protein 2
Alternative name(s):
Cysteine-rich protein 2
Short name:
CRP2
Double LIM protein 1
Short name:
DLP-1
Gene namesi
Name:Csrp2
Synonyms:Dlp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1202907 Csrp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000757221 – 193Cysteine and glycine-rich protein 2Add BLAST193

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki91Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei112N6-acetyllysineCombined sources1
Modified residuei131N6-acetyllysineBy similarity1
Modified residuei137N6-acetyllysine; alternateBy similarity1
Modified residuei137N6-succinyllysine; alternateCombined sources1
Modified residuei161N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP97314
MaxQBiP97314
PaxDbiP97314
PeptideAtlasiP97314
PRIDEiP97314

PTM databases

iPTMnetiP97314
PhosphoSitePlusiP97314

Expressioni

Gene expression databases

BgeeiENSMUSG00000020186 Expressed in 238 organ(s), highest expression level in aorta
CleanExiMM_CSRP2
ExpressionAtlasiP97314 baseline and differential
GenevisibleiP97314 MM

Interactioni

Subunit structurei

Interacts with KAT14. The LIM domain 1 is necessary and sufficient for this interaction (By similarity). Interacts with GLRX3.By similarity1 Publication

Protein-protein interaction databases

BioGridi198953, 1 interactor
IntActiP97314, 2 interactors
MINTiP97314

Structurei

3D structure databases

ProteinModelPortaliP97314
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 61LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST52
Domaini119 – 170LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST52

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi64 – 69Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi63 – 78Gly-richAdd BLAST16
Compositional biasi176 – 187Gly-richAdd BLAST12

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiENOG410ITI2 Eukaryota
ENOG4111F44 LUCA
GeneTreeiENSGT00550000074548
HOGENOMiHOG000111233
HOVERGENiHBG051143
InParanoidiP97314
KOiK09377
OMAiFHKCCFL
OrthoDBiEOG091G11RX
PhylomeDBiP97314
TreeFamiTF313758

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 2 hits
SMARTiView protein in SMART
SM00132 LIM, 2 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P97314-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPVWGGGNKC GACGRTVYHA EEVQCDGRSF HRCCFLCMVC RKNLDSTTVA
60 70 80 90 100
IHDEEIYCKS CYGKKYGPKG YGYGQGAGTL NMDRGERLGI KPESAQPHRP
110 120 130 140 150
TTNPNTSKFA QKYGGAEKCS RCGDSVYAAE KIIGAGKPWH KNCFRCAKCG
160 170 180 190
KSLESTTLTE KEGEIYCKGC YAKNFGPKGF GYGQGAGALV HAQ
Length:193
Mass (Da):20,926
Last modified:January 23, 2007 - v3
Checksum:iBF792F284C9597E9
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P758A0A1W2P758_MOUSE
Cysteine and glycine-rich protein 2
Csrp2
136Annotation score:
A0A1W2P7N8A0A1W2P7N8_MOUSE
Cysteine and glycine-rich protein 2
Csrp2
84Annotation score:
A0A1W2P6I3A0A1W2P6I3_MOUSE
Cysteine and glycine-rich protein 2
Csrp2 mCG_6486
114Annotation score:
A0A1W2P845A0A1W2P845_MOUSE
Cysteine and glycine-rich protein 2
Csrp2 mCG_6486
197Annotation score:
A0A1W2P780A0A1W2P780_MOUSE
Cysteine and glycine-rich protein 2
Csrp2
59Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30F → Y in BAB28379 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88792 mRNA Translation: BAA13722.1
AK010626 mRNA Translation: BAB27072.1
AK012647 mRNA Translation: BAB28379.1
BC012663 mRNA Translation: AAH12663.1
CCDSiCCDS24165.1
RefSeqiNP_031818.3, NM_007792.4
UniGeneiMm.2020

Genome annotation databases

EnsembliENSMUST00000020403; ENSMUSP00000020403; ENSMUSG00000020186
GeneIDi13008
KEGGimmu:13008
UCSCiuc007gzs.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88792 mRNA Translation: BAA13722.1
AK010626 mRNA Translation: BAB27072.1
AK012647 mRNA Translation: BAB28379.1
BC012663 mRNA Translation: AAH12663.1
CCDSiCCDS24165.1
RefSeqiNP_031818.3, NM_007792.4
UniGeneiMm.2020

3D structure databases

ProteinModelPortaliP97314
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198953, 1 interactor
IntActiP97314, 2 interactors
MINTiP97314

PTM databases

iPTMnetiP97314
PhosphoSitePlusiP97314

Proteomic databases

EPDiP97314
MaxQBiP97314
PaxDbiP97314
PeptideAtlasiP97314
PRIDEiP97314

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020403; ENSMUSP00000020403; ENSMUSG00000020186
GeneIDi13008
KEGGimmu:13008
UCSCiuc007gzs.2 mouse

Organism-specific databases

CTDi1466
MGIiMGI:1202907 Csrp2

Phylogenomic databases

eggNOGiENOG410ITI2 Eukaryota
ENOG4111F44 LUCA
GeneTreeiENSGT00550000074548
HOGENOMiHOG000111233
HOVERGENiHBG051143
InParanoidiP97314
KOiK09377
OMAiFHKCCFL
OrthoDBiEOG091G11RX
PhylomeDBiP97314
TreeFamiTF313758

Miscellaneous databases

PROiPR:P97314
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020186 Expressed in 238 organ(s), highest expression level in aorta
CleanExiMM_CSRP2
ExpressionAtlasiP97314 baseline and differential
GenevisibleiP97314 MM

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 2 hits
SMARTiView protein in SMART
SM00132 LIM, 2 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCSRP2_MOUSE
AccessioniPrimary (citable) accession number: P97314
Secondary accession number(s): Q9CZG5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 137 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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