Mesp1

Functionⁱ

Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways.2 Publications

GO - Molecular functionⁱ

DNA-binding transcription factor activity
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18297060
enhancer binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 18593560
protein dimerization activity Source: InterPro
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- 18297060
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 18297060
transcription regulatory region DNA binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cardiac atrium formation Source: MGI
cardiac cell fate determination
Source: BHF-UCL
Inferred from direct assayⁱ
- 18593560
cardiac muscle cell differentiation Source: MGI
cardiac vascular smooth muscle cell differentiation Source: MGI
cardiac ventricle formation Source: MGI
cardioblast anterior-lateral migration
Source: BHF-UCL
Inferred from expression patternⁱ
- 18297060
cardioblast migration
Source: MGI
Inferred from mutant phenotypeⁱ
- 10393122
cardioblast migration to the midline involved in heart field formation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 10393122
embryonic heart tube morphogenesis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 10393122
endothelial cell differentiation Source: MGI
gastrulation
Source: BHF-UCL
Inferred from expression patternⁱ
- 8787751
growth involved in heart morphogenesis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 10393122
heart looping
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 10393122
heart morphogenesis
Source: MGI
Inferred from mutant phenotypeⁱ
- 10393122
lateral mesoderm development
Source: BHF-UCL
Inferred from expression patternⁱ
- 10393122
mesodermal cell migration
Source: MGI
Inferred from genetic interactionⁱ
- 10393122
negative regulation of endodermal cell fate specification
Source: BHF-UCL
Inferred from direct assayⁱ
- 18593560
negative regulation of mesodermal cell fate specification
Source: BHF-UCL
Inferred from direct assayⁱ
- 18593560
negative regulation of transcription, DNA-templated
Source: BHF-UCL
Inferred from direct assayⁱ
- 18593560
neurogenesis Source: MGI
Notch signaling pathway Source: UniProtKB-KW
positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 18297060
positive regulation of hepatocyte differentiation
Source: BHF-UCL
Inferred from direct assayⁱ
- 18593560
positive regulation of Notch signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 18593560
positive regulation of Notch signaling pathway involved in heart induction
Source: BHF-UCL
Inferred from direct assayⁱ
- 18593560
positive regulation of striated muscle cell differentiation
Source: BHF-UCL
Inferred from direct assayⁱ
- 18593560
positive regulation of transcription, DNA-templated
Source: BHF-UCL
Inferred from direct assayⁱ
- 18593560
positive regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18297060
secondary heart field specification
Source: BHF-UCL
Inferred from direct assayⁱ
- 18593560
signal transduction involved in regulation of gene expression
Source: MGI
Inferred from direct assayⁱ
- 18462699
sinoatrial node cell differentiation Source: MGI
sinus venosus morphogenesis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 10393122
somitogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Biological process	Notch signaling pathway, Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mesoderm posterior protein 1
Gene namesⁱ	Name:Mesp1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:107785 Mesp1

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Mice embryos exhibit defects in single heart tube formation, due to a delay in mesodermal migration. However, the cells eventually acquired migratory activity and gave rise to an abnormal heart tube. Mice lacking Mesp1 and Mesp2 die around 9.5 dpc. The major defect is the apparent lack of any mesodermal layer between endoderm and ectoderm and a defect in the migratory activity of mesodermal cells. It seems that a compensatory mechanism exists in which Mesp1 expression is up-regulated in the absence of Mesp2. Mesp1 may be involved in the rescue of somitogenesis in the null Mesp2 embryos.3 Publications

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000304405	1 – 243	Mesoderm posterior protein 1Add BLAST		243

Proteomic databases

PaxDbⁱ	P97309
PRIDEⁱ	P97309

PTM databases

PhosphoSitePlusⁱ	P97309

PhosphoSitePlusⁱ

P97309

Expressionⁱ

Tissue specificityⁱ

No expression was detected in adult tissues except the testis. Expression in the testis was regulated developmentally; expressed 2 weeks after birth, and increases, reaching the full expression level in mature testes.1 Publication

Developmental stageⁱ

The earliest expression is detected at the junction of the epiblast and extraembryonic ectoderm, which is the initiation site for gastrulation. Around 6.5-6.75 dpc, expression becomes evident as gastrulation progresses. Expression does not spread over all mesodermal cells; it is seen only in a fraction of cells, particularly those in the early emergence group destined to become the extraembryonic mesoderm and the most posterior part of the tailbud. Expression remains for a while at the base of the allantois, and then spreads out to the lateral margins of the tail bud mesoderm. Expressed in the anterior presomitic mesoderm in a broad or thin stripe pattern. Expressed in the paraxial mesoderm during somitogenesis. Expression disappears before 8.5 dpc.4 Publications

Inductionⁱ

Expression is induced by Notch signaling.

Gene expression databases

Bgeeⁱ	ENSMUSG00000030544 Expressed in 61 organ(s), highest expression level in seminiferous tubule of testis
CleanExⁱ	MM_MESP1
Genevisibleⁱ	P97309 MM

Interactionⁱ

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000032760

STRINGⁱ

10090.ENSMUSP00000032760

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P97309
SMRⁱ	P97309
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	76 – 130	bHLHPROSITE-ProRule annotationAdd BLAST		55

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	153 – 157	CPLCP		5

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG4029 Eukaryota ENOG411227D LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063712
HOGENOMⁱ	HOG000113566
HOVERGENⁱ	HBG094949
InParanoidⁱ	P97309
KEGG Orthology (KO) More...KOⁱ	K09076
OMAⁱ	LETWMPL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0LDC
PhylomeDBⁱ	P97309
TreeFamⁱ	TF325707

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P97309-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAQPLCEPRS ESWILSPAGR QPPMPSDGNS VCSPAWSSDP WDGAQASSPA 
        60         70         80         90        100
PPCARPARRA GTPGRRGTHG SRLGSGQRQS ASEREKLRMR TLARALHELR 
       110        120        130        140        150
RFLPPSVAPT GQNLTKIETL RLAIRYIGHL SAVLGLSEDN LRRQRHAVSP 
       160        170        180        190        200
RGCPLCPDSD LAQSQSLGPR LSPAVCSGVS WGSPPAYPRP RVAAESWDPS 
       210        220        230        240 
FLYAETASQE RQEMEPSPSS PLFSSDMLAL LETWTPPQEW PPA

Length:243

Mass (Da):26,386

Last modified:September 11, 2007 - v2

Checksum:ⁱD82F72C0B0FB05EE

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	170	R → G in BAA12041 (PubMed:8787751).Curated		1
Sequence conflictⁱ	202	L → Q in BAA12041 (PubMed:8787751).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D83674 mRNA Translation: BAA12041.1 BC125505 mRNA Translation: AAI25506.1 BC125507 mRNA Translation: AAI25508.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS21387.1
NCBI Reference Sequences More...RefSeqⁱ	NP_032614.2, NM_008588.2
UniGeneⁱ	Mm.1404

Genome annotation databases

Ensemblⁱ	ENSMUST00000032760; ENSMUSP00000032760; ENSMUSG00000030544
GeneIDⁱ	17292
KEGGⁱ	mmu:17292
UCSC genome browser More...UCSCⁱ	uc009hzb.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P97309	Mesoderm posterior 1 protein (Fragment)		PIG		18	UniRef100_P97309

Protein	Similar proteins		Species	Score	Length	Source
P97309	Mesoderm posterior 1 protein (Fragment)		PIG		18	UniRef90_P97309
Mesoderm posterior bHLH transcription factor 1		RAT		242
UPI000A3165DD		MUSCR		244
UPI000A30B248		MUSPA		242

Protein	Similar proteins		Species	Score	Length	Source
P97309	Mesoderm posterior protein 1		HUMAN		268	UniRef50_P97309
Mesoderm posterior 1 protein (Fragment)		PIG		18
Mesoderm posterior bHLH transcription factor 1		RAT		242
Uncharacterized protein		RHIBE		272
Uncharacterized protein		PAPAN		272
+71

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D83674 mRNA Translation: BAA12041.1 BC125505 mRNA Translation: AAI25506.1 BC125507 mRNA Translation: AAI25508.1
CCDSⁱ	CCDS21387.1
RefSeqⁱ	NP_032614.2, NM_008588.2
UniGeneⁱ	Mm.1404

3D structure databases

ProteinModelPortalⁱ	P97309
SMRⁱ	P97309
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000032760

STRINGⁱ

10090.ENSMUSP00000032760

PTM databases

PhosphoSitePlusⁱ	P97309

PhosphoSitePlusⁱ

P97309

Proteomic databases

PaxDbⁱ	P97309
PRIDEⁱ	P97309

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000032760; ENSMUSP00000032760; ENSMUSG00000030544
GeneIDⁱ	17292
KEGGⁱ	mmu:17292
UCSCⁱ	uc009hzb.2 mouse

Organism-specific databases

CTDⁱ	55897
MGIⁱ	MGI:107785 Mesp1

Phylogenomic databases

eggNOGⁱ	KOG4029 Eukaryota ENOG411227D LUCA
GeneTreeⁱ	ENSGT00530000063712
HOGENOMⁱ	HOG000113566
HOVERGENⁱ	HBG094949
InParanoidⁱ	P97309
KOⁱ	K09076
OMAⁱ	LETWMPL
OrthoDBⁱ	EOG091G0LDC
PhylomeDBⁱ	P97309
TreeFamⁱ	TF325707

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P97309
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000030544 Expressed in 61 organ(s), highest expression level in seminiferous tubule of testis
CleanExⁱ	MM_MESP1
Genevisibleⁱ	P97309 MM

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MESP1_MOUSE
Accessionⁱ	P97309Primary (citable) accession number: P97309 Secondary accession number(s): Q059W2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
	Last sequence update:	September 11, 2007
	Last modified:	November 7, 2018
	This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P97309 (MESP1_MOUSE)

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Mesoderm posterior protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ