UniProtKB - P97306 (STAC_MOUSE)
Protein
SH3 and cysteine-rich domain-containing protein
Gene
Stac
Organism
Mus musculus (Mouse)
Status
Functioni
Promotes expression of the ion channel CACNA1H at the cell membrane, and thereby contributes to the regulation of channel activity (PubMed:27149520). Plays a minor and redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity (PubMed:29467163). Slows the rate of calcium-mediated inactivation of CACNA1C calcium channel activity (PubMed:29363593).3 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 108 – 160 | Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST | 53 |
GO - Molecular functioni
- ion channel binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- cellular response to heat Source: MGI
- intracellular signal transduction Source: InterPro
- muscle contraction Source: MGI
- positive regulation of cation channel activity Source: UniProtKB
- positive regulation of protein localization to plasma membrane Source: UniProtKB
- positive regulation of voltage-gated calcium channel activity Source: UniProtKB
- regulation of voltage-gated calcium channel activity Source: MGI
- skeletal muscle contraction Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: SH3 and cysteine-rich domain-containing proteinAlternative name(s): Src homology 3 and cysteine-rich domain-containing protein |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1201400, Stac |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
- sarcolemma 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
Cytosol
- cytosol 2 Publications
Cytosol
- cytosol Source: UniProtKB-SubCell
Plasma Membrane
- extrinsic component of cytoplasmic side of plasma membrane Source: UniProtKB
- T-tubule Source: MGI
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000072236 | 1 – 403 | SH3 and cysteine-rich domain-containing proteinAdd BLAST | 403 |
Proteomic databases
PaxDbi | P97306 |
PRIDEi | P97306 |
PTM databases
iPTMneti | P97306 |
PhosphoSitePlusi | P97306 |
Expressioni
Tissue specificityi
Expressed predominantly in brain (PubMed:8954993, PubMed:23818578) Detected in brain neurons, more specifically in hippocampus, cerebellum and inferior olive (PubMed:8954993). Highly expressed in urinary bladder, and detected at lower levels in adrenal gland (PubMed:23818578). Detected at very low levels in heart, liver, lung and kidney (PubMed:8954993).2 Publications
Developmental stagei
Expression in brain started at late 13.5 dpc and continued to adult (8W) with a peak around P10.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000032502, Expressed in urinary bladder and 126 other tissues |
ExpressionAtlasi | P97306, baseline and differential |
Genevisiblei | P97306, MM |
Interactioni
Subunit structurei
GO - Molecular functioni
- ion channel binding Source: UniProtKB
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000035083 |
Miscellaneous databases
RNActi | P97306, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 286 – 345 | SH3 1PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 348 – 403 | SH3 2PROSITE-ProRule annotationAdd BLAST | 56 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 108 – 160 | Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST | 53 |
Keywords - Domaini
Repeat, SH3 domain, Zinc-fingerPhylogenomic databases
eggNOGi | ENOG502QW0M, Eukaryota |
GeneTreei | ENSGT00950000183092 |
HOGENOMi | CLU_048120_2_0_1 |
InParanoidi | P97306 |
OMAi | SIHHKCA |
OrthoDBi | 584382at2759 |
PhylomeDBi | P97306 |
TreeFami | TF332878 |
Family and domain databases
CDDi | cd00029, C1, 1 hit |
InterProi | View protein in InterPro IPR002219, PE/DAG-bd IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR035508, STAC1 IPR039688, STAC1/2/3 |
PANTHERi | PTHR15135, PTHR15135, 1 hit PTHR15135:SF3, PTHR15135:SF3, 1 hit |
Pfami | View protein in Pfam PF00130, C1_1, 1 hit PF07653, SH3_2, 1 hit PF14604, SH3_9, 1 hit |
PRINTSi | PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00109, C1, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS50002, SH3, 2 hits PS00479, ZF_DAG_PE_1, 1 hit PS50081, ZF_DAG_PE_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P97306-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIPPSGARED SGDGLTGEAT GTEQPPSPAS TSSLESKLQK LKRSLSFKTK
60 70 80 90 100
SLRSKSADNF FPRTNSDVKP QADLLAKASP GPSPIAIPGS PASMPTKAGL
110 120 130 140 150
HPGSNSKLHA FQEHVFKKPT FCDVCNHMIV GTHAKHGLRC GACKMSIHHK
160 170 180 190 200
CADGLAPQRC MGKLPKGFRR YYSSPLLIHE QFGCIKEVMP IACGNKVDPV
210 220 230 240 250
YEALRFGTSL AQRTKKGGSG SGSDSPPRTS TSELVDVPEE ADGPGDGSDM
260 270 280 290 300
RTRSNSVFTY PENGMDDFRD QMKTTNHQGP LSKDPLQMNT YVALYRFIPQ
310 320 330 340 350
ENEDLEMRPG DMITLLEDSN EDWWKGKIQD RVGFFPANFV QRVEEHEKIY
360 370 380 390 400
RCVRTFIGCK DQGQITLKEN QICVTSEEEQ DGFIRVLSGK KRGLVPLDVL
VDV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF2Z462 | F2Z462_MOUSE | SH3 and cysteine-rich domain-contai... | Stac | 51 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D86639 mRNA Translation: BAA13151.1 |
CCDSi | CCDS23586.1 |
PIRi | JC5269 |
RefSeqi | NP_058549.1, NM_016853.3 |
Genome annotation databases
Ensembli | ENSMUST00000035083; ENSMUSP00000035083; ENSMUSG00000032502 |
GeneIDi | 20840 |
KEGGi | mmu:20840 |
UCSCi | uc009rvw.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D86639 mRNA Translation: BAA13151.1 |
CCDSi | CCDS23586.1 |
PIRi | JC5269 |
RefSeqi | NP_058549.1, NM_016853.3 |
3D structure databases
SMRi | P97306 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000035083 |
PTM databases
iPTMneti | P97306 |
PhosphoSitePlusi | P97306 |
Proteomic databases
PaxDbi | P97306 |
PRIDEi | P97306 |
Protocols and materials databases
Antibodypediai | 28130, 159 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000035083; ENSMUSP00000035083; ENSMUSG00000032502 |
GeneIDi | 20840 |
KEGGi | mmu:20840 |
UCSCi | uc009rvw.1, mouse |
Organism-specific databases
CTDi | 6769 |
MGIi | MGI:1201400, Stac |
Phylogenomic databases
eggNOGi | ENOG502QW0M, Eukaryota |
GeneTreei | ENSGT00950000183092 |
HOGENOMi | CLU_048120_2_0_1 |
InParanoidi | P97306 |
OMAi | SIHHKCA |
OrthoDBi | 584382at2759 |
PhylomeDBi | P97306 |
TreeFami | TF332878 |
Miscellaneous databases
BioGRID-ORCSi | 20840, 1 hit in 17 CRISPR screens |
ChiTaRSi | Stac, mouse |
PROi | PR:P97306 |
RNActi | P97306, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000032502, Expressed in urinary bladder and 126 other tissues |
ExpressionAtlasi | P97306, baseline and differential |
Genevisiblei | P97306, MM |
Family and domain databases
CDDi | cd00029, C1, 1 hit |
InterProi | View protein in InterPro IPR002219, PE/DAG-bd IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR035508, STAC1 IPR039688, STAC1/2/3 |
PANTHERi | PTHR15135, PTHR15135, 1 hit PTHR15135:SF3, PTHR15135:SF3, 1 hit |
Pfami | View protein in Pfam PF00130, C1_1, 1 hit PF07653, SH3_2, 1 hit PF14604, SH3_9, 1 hit |
PRINTSi | PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00109, C1, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS50002, SH3, 2 hits PS00479, ZF_DAG_PE_1, 1 hit PS50081, ZF_DAG_PE_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | STAC_MOUSE | |
Accessioni | P97306Primary (citable) accession number: P97306 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot