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Protein

Neuroplastin

Gene

Nptn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroplastin
Alternative name(s):
Stromal cell-derived receptor 1
Short name:
SDR-1
Gene namesi
Name:Nptn
Synonyms:Sdfr1, Sdr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:108077 Nptn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 338ExtracellularSequence analysisAdd BLAST310
Transmembranei339 – 359HelicalSequence analysisAdd BLAST21
Topological domaini360 – 397CytoplasmicSequence analysisAdd BLAST38

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28By similarityAdd BLAST28
ChainiPRO_000039447129 – 397NeuroplastinAdd BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi52 ↔ 116PROSITE-ProRule annotation
Disulfide bondi169 ↔ 217PROSITE-ProRule annotation
Glycosylationi170N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi186N-linked (GlcNAc...) asparagine; atypical1 Publication1
Glycosylationi196N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi199N-linked (GlcNAc...) asparagine; atypical1 Publication1
Glycosylationi228N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi258 ↔ 315PROSITE-ProRule annotation
Glycosylationi275N-linked (GlcNAc...) asparagine; atypical2 Publications1
Glycosylationi283N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi295N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi316N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP97300
PeptideAtlasiP97300
PRIDEiP97300

PTM databases

iPTMnetiP97300
PhosphoSitePlusiP97300

Expressioni

Tissue specificityi

Isoform 1 and isoform 2 are widely expressed with variable levels in brain. Isoform 1 is expressed in cerebellum and midbrain. Isoform 1 and isoform 2 are expressed in cerebral cortex, hipoccampus and striatum. Isoform 2 is more abundant in the cerebral cortex than isoform 1.2 Publications

Gene expression databases

BgeeiENSMUSG00000032336
CleanExiMM_NPTN
ExpressionAtlasiP97300 baseline and differential
GenevisibleiP97300 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203143, 3 interactors
IntActiP97300, 6 interactors
MINTiP97300
STRINGi10090.ENSMUSP00000082793

Structurei

3D structure databases

ProteinModelPortaliP97300
SMRiP97300
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 134Ig-like 1Add BLAST106
Domaini148 – 234Ig-like 2Add BLAST87
Domaini237 – 327Ig-like 3Add BLAST91

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni149 – 161Narpin; mediates binding with FGFR1 and has antidepressant-like activityBy similarityAdd BLAST13

Domaini

Some isoforms lack the first Ig-like domain which may confer homophilic adhesion activity. However, they can bind and activate FGFR1 (By similarity).By similarity

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJET Eukaryota
ENOG4111V1Q LUCA
GeneTreeiENSGT00390000010516
HOGENOMiHOG000263411
HOVERGENiHBG008120
InParanoidiP97300
OMAiQKPRINA
OrthoDBiEOG091G07LY
PhylomeDBiP97300
TreeFamiTF326759

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR027112 Neuroplastin
PANTHERiPTHR10075:SF5 PTHR10075:SF5, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: P97300-2) [UniParc]FASTAAdd to basket
Also known as: SDR-1beta

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGSSLPGAL ALSLLLVSGS LLPGPGAAQN AGFVKSPMSE TKLTGDAFEL
60 70 80 90 100
YCDVVGSPTP EIQWWYAEVN RAESFRQLWD GARKRRVTVN TAYGSNGVSV
110 120 130 140 150
LRITRLTLED SGTYECRASN DPKRNDLRQN PSITWIRAQA TISVLQKPRI
160 170 180 190 200
VTSEEVIIRE SLLPVTLQCN LTSSSHTLMY SYWTRNGVEL TATRKNASNM
210 220 230 240 250
EYRINKPRAE DSGEYHCVYH FVSAPKANAT IEVKAAPDIT GHKRSENKNE
260 270 280 290 300
GQDAMMYCKS VGYPHPEWIW RKKENGVFEE ISNSSGRFFI TNKENYTELS
310 320 330 340 350
IVNLQITEDP GEYECNATNS IGSASVSTVL RVRSHLAPLW PFLGILAEII
360 370 380 390
ILVVIIVVYE KRKRPDEVPD DDEPAGPMKT NSTNNHKDKN LRQRNTN
Length:397
Mass (Da):44,373
Last modified:June 15, 2010 - v3
Checksum:iE9C19EE0BD3A324A
GO
Isoform 1 (identifier: P97300-1) [UniParc]FASTAAdd to basket
Also known as: SDR-1alpha

The sequence of this isoform differs from the canonical sequence as follows:
     31-147: AGFVKSPMSE...AQATISVLQK → E

Show »
Length:281
Mass (Da):31,277
Checksum:iEA6ABF19E5A916EF
GO
Isoform 3 (identifier: P97300-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-147: AGFVKSPMSE...AQATISVLQK → E
     371-374: Missing.

Show »
Length:277
Mass (Da):30,821
Checksum:i386D78C9AADDF437
GO
Isoform 4 (identifier: P97300-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-226: Missing.
     227-235: ANATIEVKA → MSVVDLPNS

Note: No experimental confirmation available.
Show »
Length:171
Mass (Da):19,359
Checksum:iDDE5FE3CA8C948A5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti245S → C in BAE32261 (PubMed:16141072).Curated1
Sequence conflicti246E → R in BAC35855 (PubMed:16141072).Curated1
Sequence conflicti386H → P in BAA09054 (PubMed:8938438).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0392541 – 226Missing in isoform 4. 1 PublicationAdd BLAST226
Alternative sequenceiVSP_03925531 – 147AGFVK…SVLQK → E in isoform 1 and isoform 3. 2 PublicationsAdd BLAST117
Alternative sequenceiVSP_039256227 – 235ANATIEVKA → MSVVDLPNS in isoform 4. 1 Publication9
Alternative sequenceiVSP_039257371 – 374Missing in isoform 3. 1 Publication4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50463 mRNA Translation: BAA09054.1
AK075610 mRNA Translation: BAC35855.1
AK076624 mRNA Translation: BAC36420.1
AK153930 mRNA Translation: BAE32261.1
CT030640 Genomic DNA No translation available.
CCDSiCCDS23245.1 [P97300-1]
CCDS81009.1 [P97300-3]
RefSeqiNP_001280602.1, NM_001293673.1 [P97300-3]
NP_033171.2, NM_009145.2 [P97300-1]
XP_006510945.1, XM_006510882.1 [P97300-2]
XP_006510946.1, XM_006510883.1 [P97300-2]
UniGeneiMm.15125

Genome annotation databases

EnsembliENSMUST00000085651; ENSMUSP00000082793; ENSMUSG00000032336 [P97300-1]
ENSMUST00000176250; ENSMUSP00000135250; ENSMUSG00000032336 [P97300-4]
ENSMUST00000176557; ENSMUSP00000135541; ENSMUSG00000032336 [P97300-3]
ENSMUST00000176916; ENSMUSP00000134977; ENSMUSG00000032336 [P97300-4]
ENSMUST00000177292; ENSMUSP00000135199; ENSMUSG00000032336 [P97300-2]
GeneIDi20320
KEGGimmu:20320
UCSCiuc009pxd.1 mouse [P97300-1]
uc009pxe.1 mouse [P97300-3]
uc009pxf.1 mouse [P97300-4]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNPTN_MOUSE
AccessioniPrimary (citable) accession number: P97300
Secondary accession number(s): Q3U519, Q8C637, Q8C6H8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: June 15, 2010
Last modified: May 23, 2018
This is version 149 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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