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Protein

Secreted frizzled-related protein 2

Gene

Sfrp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.

GO - Molecular functioni

  • endopeptidase activator activity Source: MGI
  • enzyme activator activity Source: MGI
  • receptor ligand activity Source: BHF-UCL
  • Wnt-protein binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Wnt signaling pathway

Protein family/group databases

MEROPSiI93.002

Names & Taxonomyi

Protein namesi
Recommended name:
Secreted frizzled-related protein 2
Short name:
sFRP-2
Alternative name(s):
Protein SDF5
Secreted apoptosis-related protein 1
Short name:
SARP-1
Gene namesi
Name:Sfrp2
Synonyms:Sarp1, Sdf5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:108078 Sfrp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000003254325 – 295Secreted frizzled-related protein 2Add BLAST271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi40 ↔ 103By similarity
Disulfide bondi50 ↔ 96By similarity
Disulfide bondi87 ↔ 125By similarity
Disulfide bondi114 ↔ 152By similarity
Disulfide bondi118 ↔ 142By similarity
Disulfide bondi172 ↔ 245By similarity
Disulfide bondi175 ↔ 247By similarity
Disulfide bondi190 ↔ 295By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP97299
PRIDEiP97299

PTM databases

iPTMnetiP97299
PhosphoSitePlusiP97299

Expressioni

Tissue specificityi

Highly expressed in the eye. Weaker expression in heart and lung.1 Publication

Developmental stagei

During kidney development, expressed at E10.5 in the mesonephric tubules, and at E12.5 strongly expressed in the comma shaped bodies and surrounding ureter stalk. In E14.5 kidney, expressed in the S-shaped bodies. In the developing nervous system, expressed in the presumptive hindbrain and the ventral part of the neural tube from E8.0 onwards. At E9.5, expression is additionally detected in the mesonephros and the optic vesicle. E10 expression is found in the second and third branchial cleft, in the eye, the ventral neural tube and specific rhombomeres and prosomers. E10.5 brain shows specific expression in the basal and alar plate. In developing eye, expressed at E9.0 in the optic placode, and at E9.5 in the optic vesicle. By E10.5, expression found in the lens vesicle and the inner layer of the invaginating optic vesicle. Strong expression at E14.5 in the anterior lens epithelium, decreasing thereafter. Expression also found in the prospective neural retina. In developing limbs, expression found at E11.5 in the shoulder and at the distal end of the cartilaginous condensation. At E12.5, expressed in the foot and hand paddle extending along the digital rays. Expressed, at E13.5 and E14.5, in the forelimb and hindlimb where the interphalangeal joints will develop. Also expressed at E14.5 between the sternal bands and where the ribs contact the sternum. In other developing structures, expression found at E11.5, in the maxillary and mandibular component of the first branchial arch, and later, in the loose mesenchyme surrounding cartilage and epithelia of the skull as well as in the whisker follicles. Also expressed in developing teeth, with the highest levels at E15.5 and E16.5 in the mesenchyme and the dental epithelium of the developing molars. Expressed in development smooth muscle surrounding the esophagus at E11.5, the dorsal aorta and the ductus arteriosus at E14.5, and the ureter stalk at E15.5.2 Publications

Gene expression databases

BgeeiENSMUSG00000027996 Expressed in 307 organ(s), highest expression level in ureter smooth muscle
CleanExiMM_SFRP2
ExpressionAtlasiP97299 baseline and differential
GenevisibleiP97299 MM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BMP1P13497-22EBI-15892646,EBI-12509497From a different organism.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203142, 9 interactors
DIPiDIP-59486N
IntActiP97299, 1 interactor
STRINGi10090.ENSMUSP00000029625

Structurei

3D structure databases

ProteinModelPortaliP97299
SMRiP97299
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 155FZPROSITE-ProRule annotationAdd BLAST121
Domaini172 – 295NTRPROSITE-ProRule annotationAdd BLAST124

Domaini

The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3577 Eukaryota
ENOG410XRC8 LUCA
GeneTreeiENSGT00930000150923
HOGENOMiHOG000231058
HOVERGENiHBG052928
InParanoidiP97299
KOiK02176
OMAiTSLKRWQ
OrthoDBiEOG091G0F7I
PhylomeDBiP97299
TreeFamiTF350133

Family and domain databases

Gene3Di1.10.2000.10, 1 hit
InterProiView protein in InterPro
IPR015526 Frizzled/SFRP
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR001134 Netrin_domain
IPR018933 Netrin_module_non-TIMP
IPR026558 SFRP2
IPR008993 TIMP-like_OB-fold
PANTHERiPTHR11309 PTHR11309, 1 hit
PTHR11309:SF45 PTHR11309:SF45, 1 hit
PfamiView protein in Pfam
PF01392 Fz, 1 hit
PF01759 NTR, 1 hit
SMARTiView protein in SMART
SM00643 C345C, 1 hit
SM00063 FRI, 1 hit
SUPFAMiSSF50242 SSF50242, 1 hit
SSF63501 SSF63501, 1 hit
PROSITEiView protein in PROSITE
PS50038 FZ, 1 hit
PS50189 NTR, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97299-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRGPASLLL LVLASHCCLG SARGLFLFGQ PDFSYKRSNC KPIPANLQLC
60 70 80 90 100
HGIEYQNMRL PNLLGHETMK EVLEQAGAWI PLVMKQCHPD TKKFLCSLFA
110 120 130 140 150
PVCLDDLDET IQPCHSLCVQ VKDRCAPVMS AFGFPWPDML ECDRFPQDND
160 170 180 190 200
LCIPLASSDH LLPATEEAPK VCEACKTKNE DDNDIMETLC KNDFALKIKV
210 220 230 240 250
KEITYINRDT KIILETKSKT IYKLNGVSER DLKKSVLWLK DSLQCTCEEM
260 270 280 290
NDINAPYLVM GQKQGGELVI TSVKRWQKGQ REFKRISRSI RKLQC
Length:295
Mass (Da):33,469
Last modified:March 15, 2005 - v2
Checksum:i2D287C177C974C62
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38S → T in AAB70795 (PubMed:9391078).Curated1
Sequence conflicti119V → M in BAA09053 (PubMed:8938438).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50462 mRNA Translation: BAA09053.1
U88567 mRNA Translation: AAC53146.1
AF017989 mRNA Translation: AAB70795.1
BC014722 mRNA Translation: AAH14722.1
CCDSiCCDS17434.1
RefSeqiNP_033170.1, NM_009144.2
UniGeneiMm.19155

Genome annotation databases

EnsembliENSMUST00000029625; ENSMUSP00000029625; ENSMUSG00000027996
GeneIDi20319
KEGGimmu:20319
UCSCiuc008ppl.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50462 mRNA Translation: BAA09053.1
U88567 mRNA Translation: AAC53146.1
AF017989 mRNA Translation: AAB70795.1
BC014722 mRNA Translation: AAH14722.1
CCDSiCCDS17434.1
RefSeqiNP_033170.1, NM_009144.2
UniGeneiMm.19155

3D structure databases

ProteinModelPortaliP97299
SMRiP97299
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203142, 9 interactors
DIPiDIP-59486N
IntActiP97299, 1 interactor
STRINGi10090.ENSMUSP00000029625

Protein family/group databases

MEROPSiI93.002

PTM databases

iPTMnetiP97299
PhosphoSitePlusiP97299

Proteomic databases

PaxDbiP97299
PRIDEiP97299

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029625; ENSMUSP00000029625; ENSMUSG00000027996
GeneIDi20319
KEGGimmu:20319
UCSCiuc008ppl.2 mouse

Organism-specific databases

CTDi6423
MGIiMGI:108078 Sfrp2

Phylogenomic databases

eggNOGiKOG3577 Eukaryota
ENOG410XRC8 LUCA
GeneTreeiENSGT00930000150923
HOGENOMiHOG000231058
HOVERGENiHBG052928
InParanoidiP97299
KOiK02176
OMAiTSLKRWQ
OrthoDBiEOG091G0F7I
PhylomeDBiP97299
TreeFamiTF350133

Miscellaneous databases

ChiTaRSiSfrp2 mouse
PROiPR:P97299
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027996 Expressed in 307 organ(s), highest expression level in ureter smooth muscle
CleanExiMM_SFRP2
ExpressionAtlasiP97299 baseline and differential
GenevisibleiP97299 MM

Family and domain databases

Gene3Di1.10.2000.10, 1 hit
InterProiView protein in InterPro
IPR015526 Frizzled/SFRP
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR001134 Netrin_domain
IPR018933 Netrin_module_non-TIMP
IPR026558 SFRP2
IPR008993 TIMP-like_OB-fold
PANTHERiPTHR11309 PTHR11309, 1 hit
PTHR11309:SF45 PTHR11309:SF45, 1 hit
PfamiView protein in Pfam
PF01392 Fz, 1 hit
PF01759 NTR, 1 hit
SMARTiView protein in SMART
SM00643 C345C, 1 hit
SM00063 FRI, 1 hit
SUPFAMiSSF50242 SSF50242, 1 hit
SSF63501 SSF63501, 1 hit
PROSITEiView protein in PROSITE
PS50038 FZ, 1 hit
PS50189 NTR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSFRP2_MOUSE
AccessioniPrimary (citable) accession number: P97299
Secondary accession number(s): O08862, O35297
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: November 7, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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