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Entry version 165 (12 Aug 2020)
Sequence version 2 (15 Mar 2005)
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Protein

Secreted frizzled-related protein 2

Gene

Sfrp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Wnt signaling pathway

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I93.002

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Secreted frizzled-related protein 2
Short name:
sFRP-2
Alternative name(s):
Protein SDF5
Secreted apoptosis-related protein 1
Short name:
SARP-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sfrp2
Synonyms:Sarp1, Sdf5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:108078, Sfrp2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003254325 – 295Secreted frizzled-related protein 2Add BLAST271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi40 ↔ 103By similarity
Disulfide bondi50 ↔ 96By similarity
Disulfide bondi87 ↔ 125By similarity
Disulfide bondi114 ↔ 152By similarity
Disulfide bondi118 ↔ 142By similarity
Disulfide bondi172 ↔ 245By similarity
Disulfide bondi175 ↔ 247By similarity
Disulfide bondi190 ↔ 295By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P97299

PRoteomics IDEntifications database

More...
PRIDEi
P97299

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P97299

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P97299

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the eye. Weaker expression in heart and lung.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

During kidney development, expressed at 10.5 dpc in the mesonephric tubules, and at 12.5 dpc strongly expressed in the comma shaped bodies and surrounding ureter stalk. In 14.5 dpc kidney, expressed in the S-shaped bodies. In the developing nervous system, expressed in the presumptive hindbrain and the ventral part of the neural tube from 8.0 dpc onwards. At 9.5 dpc, expression is additionally detected in the mesonephros and the optic vesicle. 10 dpc expression is found in the second and third branchial cleft, in the eye, the ventral neural tube and specific rhombomeres and prosomers. 10.5 dpc brain shows specific expression in the basal and alar plate. In developing eye, expressed at 9.0 dpc in the optic placode, and at 9.5 dpc in the optic vesicle. By 10.5 dpc, expression found in the lens vesicle and the inner layer of the invaginating optic vesicle. Strong expression at 14.5 dpc in the anterior lens epithelium, decreasing thereafter. Expression also found in the prospective neural retina. In developing limbs, expression found at 11.5 dpc in the shoulder and at the distal end of the cartilaginous condensation. At 12.5 dpc, expressed in the foot and hand paddle extending along the digital rays. Expressed, at 13.5 dpc and 14.5 dpc, in the forelimb and hindlimb where the interphalangeal joints will develop. Also expressed at 14.5 dpc between the sternal bands and where the ribs contact the sternum. In other developing structures, expression found at 11.5 dpc, in the maxillary and mandibular component of the first branchial arch, and later, in the loose mesenchyme surrounding cartilage and epithelia of the skull as well as in the whisker follicles. Also expressed in developing teeth, with the highest levels at 15.5 dpc and 16.5 dpc in the mesenchyme and the dental epithelium of the developing molars. Expressed in development smooth muscle surrounding the esophagus at 11.5 dpc, the dorsal aorta and the ductus arteriosus at 14.5 dpc, and the ureter stalk at 15.5 dpc.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000027996, Expressed in ureter smooth muscle and 328 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P97299, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
203142, 9 interactors

Database of interacting proteins

More...
DIPi
DIP-59486N

Protein interaction database and analysis system

More...
IntActi
P97299, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000029625

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P97299, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P97299

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 155FZPROSITE-ProRule annotationAdd BLAST121
Domaini172 – 295NTRPROSITE-ProRule annotationAdd BLAST124

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The FZ domain is involved in binding with Wnt ligands.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3577, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156432

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_054647_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P97299

KEGG Orthology (KO)

More...
KOi
K02176

Identification of Orthologs from Complete Genome Data

More...
OMAi
AYLVMGQ

Database of Orthologous Groups

More...
OrthoDBi
1306779at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P97299

TreeFam database of animal gene trees

More...
TreeFami
TF350133

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07446, CRD_SFRP2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.2000.10, 1 hit
2.40.50.120, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015526, Frizzled/SFRP
IPR020067, Frizzled_dom
IPR036790, Frizzled_dom_sf
IPR001134, Netrin_domain
IPR018933, Netrin_module_non-TIMP
IPR026558, SFRP2
IPR041764, SFRP2_CRD
IPR008993, TIMP-like_OB-fold

The PANTHER Classification System

More...
PANTHERi
PTHR11309, PTHR11309, 1 hit
PTHR11309:SF45, PTHR11309:SF45, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01392, Fz, 1 hit
PF01759, NTR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00643, C345C, 1 hit
SM00063, FRI, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50242, SSF50242, 1 hit
SSF63501, SSF63501, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50038, FZ, 1 hit
PS50189, NTR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P97299-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRGPASLLL LVLASHCCLG SARGLFLFGQ PDFSYKRSNC KPIPANLQLC
60 70 80 90 100
HGIEYQNMRL PNLLGHETMK EVLEQAGAWI PLVMKQCHPD TKKFLCSLFA
110 120 130 140 150
PVCLDDLDET IQPCHSLCVQ VKDRCAPVMS AFGFPWPDML ECDRFPQDND
160 170 180 190 200
LCIPLASSDH LLPATEEAPK VCEACKTKNE DDNDIMETLC KNDFALKIKV
210 220 230 240 250
KEITYINRDT KIILETKSKT IYKLNGVSER DLKKSVLWLK DSLQCTCEEM
260 270 280 290
NDINAPYLVM GQKQGGELVI TSVKRWQKGQ REFKRISRSI RKLQC
Length:295
Mass (Da):33,469
Last modified:March 15, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2D287C177C974C62
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti38S → T in AAB70795 (PubMed:9391078).Curated1
Sequence conflicti119V → M in BAA09053 (PubMed:8938438).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D50462 mRNA Translation: BAA09053.1
U88567 mRNA Translation: AAC53146.1
AF017989 mRNA Translation: AAB70795.1
BC014722 mRNA Translation: AAH14722.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS17434.1

NCBI Reference Sequences

More...
RefSeqi
NP_033170.1, NM_009144.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000029625; ENSMUSP00000029625; ENSMUSG00000027996

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
20319

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:20319

UCSC genome browser

More...
UCSCi
uc008ppl.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50462 mRNA Translation: BAA09053.1
U88567 mRNA Translation: AAC53146.1
AF017989 mRNA Translation: AAB70795.1
BC014722 mRNA Translation: AAH14722.1
CCDSiCCDS17434.1
RefSeqiNP_033170.1, NM_009144.2

3D structure databases

SMRiP97299
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi203142, 9 interactors
DIPiDIP-59486N
IntActiP97299, 1 interactor
STRINGi10090.ENSMUSP00000029625

Protein family/group databases

MEROPSiI93.002

PTM databases

iPTMnetiP97299
PhosphoSitePlusiP97299

Proteomic databases

PaxDbiP97299
PRIDEiP97299

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
983, 334 antibodies

Genome annotation databases

EnsembliENSMUST00000029625; ENSMUSP00000029625; ENSMUSG00000027996
GeneIDi20319
KEGGimmu:20319
UCSCiuc008ppl.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6423
MGIiMGI:108078, Sfrp2

Phylogenomic databases

eggNOGiKOG3577, Eukaryota
GeneTreeiENSGT00940000156432
HOGENOMiCLU_054647_0_0_1
InParanoidiP97299
KOiK02176
OMAiAYLVMGQ
OrthoDBi1306779at2759
PhylomeDBiP97299
TreeFamiTF350133

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
20319, 1 hit in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Sfrp2, mouse

Protein Ontology

More...
PROi
PR:P97299
RNActiP97299, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000027996, Expressed in ureter smooth muscle and 328 other tissues
GenevisibleiP97299, MM

Family and domain databases

CDDicd07446, CRD_SFRP2, 1 hit
Gene3Di1.10.2000.10, 1 hit
2.40.50.120, 1 hit
InterProiView protein in InterPro
IPR015526, Frizzled/SFRP
IPR020067, Frizzled_dom
IPR036790, Frizzled_dom_sf
IPR001134, Netrin_domain
IPR018933, Netrin_module_non-TIMP
IPR026558, SFRP2
IPR041764, SFRP2_CRD
IPR008993, TIMP-like_OB-fold
PANTHERiPTHR11309, PTHR11309, 1 hit
PTHR11309:SF45, PTHR11309:SF45, 1 hit
PfamiView protein in Pfam
PF01392, Fz, 1 hit
PF01759, NTR, 1 hit
SMARTiView protein in SMART
SM00643, C345C, 1 hit
SM00063, FRI, 1 hit
SUPFAMiSSF50242, SSF50242, 1 hit
SSF63501, SSF63501, 1 hit
PROSITEiView protein in PROSITE
PS50038, FZ, 1 hit
PS50189, NTR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSFRP2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P97299
Secondary accession number(s): O08862, O35297
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: August 12, 2020
This is version 165 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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