UniProtKB - P97297 (ADML_MOUSE)
Protein
Pro-adrenomedullin
Gene
Adm
Organism
Mus musculus (Mouse)
Status
Functioni
AM and PAMP are potent hypotensive and vasodilatator agents.
GO - Molecular functioni
- adrenomedullin receptor binding Source: MGI
- hormone activity Source: UniProtKB-KW
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: MGI
- adrenomedullin receptor signaling pathway Source: MGI
- aging Source: Ensembl
- amylin receptor signaling pathway Source: MGI
- androgen metabolic process Source: MGI
- animal organ regeneration Source: Ensembl
- antibacterial humoral response Source: MGI
- antimicrobial humoral immune response mediated by antimicrobial peptide Source: MGI
- branching involved in labyrinthine layer morphogenesis Source: MGI
- calcium ion homeostasis Source: MGI
- defense response to Gram-negative bacterium Source: MGI
- defense response to Gram-positive bacterium Source: MGI
- developmental growth Source: MGI
- female pregnancy Source: Ensembl
- G protein-coupled receptor internalization Source: MGI
- heart development Source: UniProtKB
- hormone secretion Source: MGI
- negative regulation of cell population proliferation Source: MGI
- negative regulation of vascular permeability Source: UniProtKB
- negative regulation of vasoconstriction Source: MGI
- neural tube closure Source: MGI
- neuron projection regeneration Source: MGI
- odontogenesis of dentin-containing tooth Source: Ensembl
- positive regulation of angiogenesis Source: UniProtKB
- positive regulation of apoptotic process Source: MGI
- positive regulation of blood vessel diameter Source: MGI
- positive regulation of cell population proliferation Source: MGI
- positive regulation of cytosolic calcium ion concentration Source: MGI
- positive regulation of heart rate Source: MGI
- positive regulation of vasculogenesis Source: UniProtKB
- receptor internalization Source: MGI
- regulation of systemic arterial blood pressure Source: MGI
- regulation of the force of heart contraction Source: MGI
- regulation of urine volume Source: MGI
- response to cold Source: Ensembl
- response to glucocorticoid Source: Ensembl
- response to hypoxia Source: Ensembl
- response to insulin Source: Ensembl
- response to lipopolysaccharide Source: MGI
- response to starvation Source: Ensembl
- response to wounding Source: MGI
- spongiotrophoblast layer development Source: MGI
- vascular associated smooth muscle cell development Source: UniProtKB
- vasculogenesis Source: MGI
Keywordsi
Molecular function | Hormone |
Enzyme and pathway databases
Reactomei | R-MMU-418555, G alpha (s) signalling events R-MMU-419812, Calcitonin-like ligand receptors |
Names & Taxonomyi
Protein namesi | Recommended name: Pro-adrenomedullinCleaved into the following 2 chains: Alternative name(s): ProAM N-terminal 20 peptide Short name: PAMP Short name: ProAM-N20 |
Gene namesi | Name:Adm |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:108058, Adm |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: MGI
Other locations
- cytoplasm Source: MGI
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | By similarityAdd BLAST | 21 | |
PeptideiPRO_0000000965 | 22 – 41 | Proadrenomedullin N-20 terminal peptideBy similarityAdd BLAST | 20 | |
PropeptideiPRO_0000000966 | 45 – 92 | By similarityAdd BLAST | 48 | |
PeptideiPRO_0000000967 | 95 – 144 | AdrenomedullinBy similarityAdd BLAST | 50 | |
PropeptideiPRO_0000000968 | 151 – 184 | PreproAM C-terminal fragmentBy similarityAdd BLAST | 34 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 41 | Arginine amideBy similarity | 1 | |
Disulfide bondi | 108 ↔ 113 | By similarity | ||
Modified residuei | 144 | Tyrosine amideBy similarity | 1 |
Keywords - PTMi
Amidation, Cleavage on pair of basic residues, Disulfide bondProteomic databases
MaxQBi | P97297 |
PaxDbi | P97297 |
PeptideAtlasi | P97297 |
PRIDEi | P97297 |
PTM databases
iPTMneti | P97297 |
PhosphoSitePlusi | P97297 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000030790, Expressed in ectoplacental cone and 233 other tissues |
Genevisiblei | P97297, MM |
Interactioni
GO - Molecular functioni
- adrenomedullin receptor binding Source: MGI
- hormone activity Source: UniProtKB-KW
Protein-protein interaction databases
BioGRIDi | 197989, 1 interactor |
STRINGi | 10090.ENSMUSP00000140890 |
Miscellaneous databases
RNActi | P97297, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the adrenomedullin family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S4SF, Eukaryota |
GeneTreei | ENSGT00940000154380 |
HOGENOMi | CLU_099291_1_0_1 |
InParanoidi | P97297 |
OMAi | HCVELEV |
OrthoDBi | 1555764at2759 |
TreeFami | TF333447 |
Family and domain databases
InterProi | View protein in InterPro IPR021116, Calcitonin/adrenomedullin IPR001710, Pro-ADM |
Pfami | View protein in Pfam PF00214, Calc_CGRP_IAPP, 1 hit |
PRINTSi | PR00801, ADRENOMEDULN |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P97297-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKLVSITLML LGSLAFLGAD TAGPDTPSQF RKKWNKWALS RGKRELQASS
60 70 80 90 100
SYPTGLADET TVPTQTLDPF LDEQNTTGPL QASNQSEAHI RVKRYRQSMN
110 120 130 140 150
QGSRSNGCRF GTCTFQKLAH QIYQLTDKDK DGMAPRNKIS PQGYGRRRRR
160 170 180
SLLEVLRSRT VESSQEQTHT APGPWAHISR LFRI
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 173 | G → A in BAA11367 (PubMed:8938454).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D78349 Genomic DNA Translation: BAA11367.1 U77630 mRNA Translation: AAB36535.1 AK144181 mRNA Translation: BAE25751.1 AK144600 mRNA Translation: BAE25959.1 AK144649 mRNA Translation: BAE25989.1 AK171066 mRNA Translation: BAE42225.1 CH466531 Genomic DNA Translation: EDL16987.1 BC052665 mRNA Translation: AAH52665.1 |
CCDSi | CCDS21745.1 |
RefSeqi | NP_033757.1, NM_009627.1 |
Genome annotation databases
Ensembli | ENSMUST00000033054; ENSMUSP00000033054; ENSMUSG00000030790 |
GeneIDi | 11535 |
KEGGi | mmu:11535 |
UCSCi | uc009jfj.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D78349 Genomic DNA Translation: BAA11367.1 U77630 mRNA Translation: AAB36535.1 AK144181 mRNA Translation: BAE25751.1 AK144600 mRNA Translation: BAE25959.1 AK144649 mRNA Translation: BAE25989.1 AK171066 mRNA Translation: BAE42225.1 CH466531 Genomic DNA Translation: EDL16987.1 BC052665 mRNA Translation: AAH52665.1 |
CCDSi | CCDS21745.1 |
RefSeqi | NP_033757.1, NM_009627.1 |
3D structure databases
SMRi | P97297 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 197989, 1 interactor |
STRINGi | 10090.ENSMUSP00000140890 |
PTM databases
iPTMneti | P97297 |
PhosphoSitePlusi | P97297 |
Proteomic databases
MaxQBi | P97297 |
PaxDbi | P97297 |
PeptideAtlasi | P97297 |
PRIDEi | P97297 |
Protocols and materials databases
Antibodypediai | 4233, 597 antibodies |
DNASUi | 11535 |
Genome annotation databases
Ensembli | ENSMUST00000033054; ENSMUSP00000033054; ENSMUSG00000030790 |
GeneIDi | 11535 |
KEGGi | mmu:11535 |
UCSCi | uc009jfj.1, mouse |
Organism-specific databases
CTDi | 133 |
MGIi | MGI:108058, Adm |
Phylogenomic databases
eggNOGi | ENOG502S4SF, Eukaryota |
GeneTreei | ENSGT00940000154380 |
HOGENOMi | CLU_099291_1_0_1 |
InParanoidi | P97297 |
OMAi | HCVELEV |
OrthoDBi | 1555764at2759 |
TreeFami | TF333447 |
Enzyme and pathway databases
Reactomei | R-MMU-418555, G alpha (s) signalling events R-MMU-419812, Calcitonin-like ligand receptors |
Miscellaneous databases
BioGRID-ORCSi | 11535, 0 hits in 17 CRISPR screens |
PROi | PR:P97297 |
RNActi | P97297, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030790, Expressed in ectoplacental cone and 233 other tissues |
Genevisiblei | P97297, MM |
Family and domain databases
InterProi | View protein in InterPro IPR021116, Calcitonin/adrenomedullin IPR001710, Pro-ADM |
Pfami | View protein in Pfam PF00214, Calc_CGRP_IAPP, 1 hit |
PRINTSi | PR00801, ADRENOMEDULN |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ADML_MOUSE | |
Accessioni | P97297Primary (citable) accession number: P97297 Secondary accession number(s): P97453, Q6GTK2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | June 28, 2011 | |
Last modified: | December 2, 2020 | |
This is version 144 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families