UniProtKB - P97295 (NPY2R_MOUSE)
Protein
Neuropeptide Y receptor type 2
Gene
Npy2r
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor for neuropeptide Y and peptide YY.
GO - Molecular functioni
- neuropeptide Y receptor activity Source: MGI
- peptide YY receptor activity Source: MGI
GO - Biological processi
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: MGI
- aging Source: Ensembl
- behavioral fear response Source: MGI
- cardiac left ventricle morphogenesis Source: MGI
- G protein-coupled receptor signaling pathway Source: MGI
- negative regulation of cAMP-mediated signaling Source: MGI
- negative regulation of excitatory postsynaptic potential Source: MGI
- negative regulation of feeding behavior Source: MGI
- negative regulation of nervous system process Source: MGI
- negative regulation of secretion Source: MGI
- negative regulation of synaptic transmission Source: MGI
- negative regulation of synaptic transmission, glutamatergic Source: MGI
- nitric oxide mediated signal transduction Source: MGI
- outflow tract morphogenesis Source: MGI
- positive regulation of cell-substrate adhesion Source: MGI
- positive regulation of circadian sleep/wake cycle, non-REM sleep Source: MGI
- positive regulation of cytosolic calcium ion concentration Source: MGI
- positive regulation of dopamine secretion Source: MGI
- positive regulation of peptide secretion Source: MGI
- positive regulation of smooth muscle contraction Source: MGI
- regulation of sensory perception of pain Source: MGI
- secretion Source: MGI
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-MMU-375276, Peptide ligand-binding receptors R-MMU-418594, G alpha (i) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Neuropeptide Y receptor type 2Short name: NPY2-R Alternative name(s): NPY-Y2 receptor Short name: Y2 receptor |
Gene namesi | Name:Npy2r |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:108418, Npy2r |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: MGI
- plasma membrane Source: MGI
Other locations
- cilium Source: MGI
- membrane Source: MGI
- non-motile cilium Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 51 | ExtracellularSequence analysisAdd BLAST | 51 | |
Transmembranei | 52 – 72 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 73 – 86 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 87 – 107 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 108 – 124 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 125 – 145 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 146 – 165 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 166 – 186 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 187 – 216 | ExtracellularSequence analysisAdd BLAST | 30 | |
Transmembranei | 217 – 237 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 238 – 268 | CytoplasmicSequence analysisAdd BLAST | 31 | |
Transmembranei | 269 – 289 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 290 – 304 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 305 – 325 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 326 – 381 | CytoplasmicSequence analysisAdd BLAST | 56 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069930 | 1 – 381 | Neuropeptide Y receptor type 2Add BLAST | 381 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 11 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 123 ↔ 203 | PROSITE-ProRule annotation | ||
Lipidationi | 342 | S-palmitoyl cysteineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, PalmitateProteomic databases
PaxDbi | P97295 |
PRIDEi | P97295 |
PTM databases
GlyGeni | P97295, 1 site |
PhosphoSitePlusi | P97295 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000028004, Expressed in dentate gyrus of hippocampal formation and 117 other tissues |
Genevisiblei | P97295, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000029633 |
Chemistry databases
BindingDBi | P97295 |
Miscellaneous databases
RNActi | P97295, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000155973 |
HOGENOMi | CLU_009579_6_1_1 |
InParanoidi | P97295 |
OMAi | AYTRIWT |
OrthoDBi | 746515at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001358, NPY2_rcpt IPR000611, NPY_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01014, NRPEPTIDEY2R PR01012, NRPEPTIDEYR |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P97295-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGPVGAEADE NQTVEVKVEP YGPGHTTPRG ELPPDPEPEL IDSTKLVEVQ
60 70 80 90 100
VILILAYCSI ILLGVVGNSL VIHVVIKFKS MRTVTNFFIA NLAVADLLVN
110 120 130 140 150
TLCLPFTLTY TLMGEWKMGP VLCHLVPYAQ GLAVQVSTIT LTVIALDRHR
160 170 180 190 200
CIVYHLESKI SKRISFLIIG LAWGISALLA SPLAIFREYS LIEIIPDFEI
210 220 230 240 250
VACTEKWPGE EKSVYGTVYS LSTLLILYVL PLGIISFSYT RIWSKLRNHV
260 270 280 290 300
SPGAASDHYH QRRHKMTKML VCVVVVFAVS WLPLHAFQLA VDIDSHVLDL
310 320 330 340 350
KEYKLIFTVF HIIAMCSTFA NPLLYGWMNS NYRKAFLSAF RCEQRLDAIH
360 370 380
SEVSMTFKAK KNLEVKKNNG PTDSFSEATN V
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ3SWR9 | Q3SWR9_MOUSE | NPY-Y2 receptor | Npy2r | 268 | Annotation score: |
Sequence cautioni
The sequence BAA13050 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D86238 mRNA Translation: BAA13050.1 Different initiation. AK049892 mRNA Translation: BAC33975.1 AC091478 Genomic DNA No translation available. CH466547 Genomic DNA Translation: EDL15430.1 CH466547 Genomic DNA Translation: EDL15431.1 BC104490 mRNA Translation: AAI04491.1 BC104734 mRNA Translation: AAI04735.1 |
CCDSi | CCDS59646.1 |
RefSeqi | NP_032757.2, NM_008731.3 XP_006501178.1, XM_006501115.1 XP_006501179.1, XM_006501116.1 |
Genome annotation databases
Ensembli | ENSMUST00000029633; ENSMUSP00000029633; ENSMUSG00000028004 ENSMUST00000098997; ENSMUSP00000096595; ENSMUSG00000028004 ENSMUST00000182831; ENSMUSP00000138282; ENSMUSG00000028004 |
GeneIDi | 18167 |
KEGGi | mmu:18167 |
UCSCi | uc008ppa.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D86238 mRNA Translation: BAA13050.1 Different initiation. AK049892 mRNA Translation: BAC33975.1 AC091478 Genomic DNA No translation available. CH466547 Genomic DNA Translation: EDL15430.1 CH466547 Genomic DNA Translation: EDL15431.1 BC104490 mRNA Translation: AAI04491.1 BC104734 mRNA Translation: AAI04735.1 |
CCDSi | CCDS59646.1 |
RefSeqi | NP_032757.2, NM_008731.3 XP_006501178.1, XM_006501115.1 XP_006501179.1, XM_006501116.1 |
3D structure databases
SMRi | P97295 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000029633 |
Chemistry databases
BindingDBi | P97295 |
ChEMBLi | CHEMBL4106178 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P97295, 1 site |
PhosphoSitePlusi | P97295 |
Proteomic databases
PaxDbi | P97295 |
PRIDEi | P97295 |
Protocols and materials databases
Antibodypediai | 2964, 308 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000029633; ENSMUSP00000029633; ENSMUSG00000028004 ENSMUST00000098997; ENSMUSP00000096595; ENSMUSG00000028004 ENSMUST00000182831; ENSMUSP00000138282; ENSMUSG00000028004 |
GeneIDi | 18167 |
KEGGi | mmu:18167 |
UCSCi | uc008ppa.1, mouse |
Organism-specific databases
CTDi | 4887 |
MGIi | MGI:108418, Npy2r |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000155973 |
HOGENOMi | CLU_009579_6_1_1 |
InParanoidi | P97295 |
OMAi | AYTRIWT |
OrthoDBi | 746515at2759 |
Enzyme and pathway databases
Reactomei | R-MMU-375276, Peptide ligand-binding receptors R-MMU-418594, G alpha (i) signalling events |
Miscellaneous databases
BioGRID-ORCSi | 18167, 0 hits in 17 CRISPR screens |
PROi | PR:P97295 |
RNActi | P97295, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000028004, Expressed in dentate gyrus of hippocampal formation and 117 other tissues |
Genevisiblei | P97295, MM |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001358, NPY2_rcpt IPR000611, NPY_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01014, NRPEPTIDEY2R PR01012, NRPEPTIDEYR |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NPY2R_MOUSE | |
Accessioni | P97295Primary (citable) accession number: P97295 Secondary accession number(s): F7C6W7, Q8BWV1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | November 28, 2012 | |
Last modified: | December 2, 2020 | |
This is version 156 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families