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Protein

Histamine H2 receptor

Gene

Hrh2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The H2 subclass of histamine receptors mediates gastric acid secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei98Essential for histamine bindingBy similarity1
Sitei185Essential for tiotidine binding and implicated in histamine bindingBy similarity1
Sitei189Implicated in histamine bindingBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-390650 Histamine receptors
R-MMU-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Histamine H2 receptor
Short name:
H2R
Short name:
HH2R
Alternative name(s):
Gastric receptor I
Gene namesi
Name:Hrh2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:108482 Hrh2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22ExtracellularSequence analysisAdd BLAST22
Transmembranei23 – 44Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini45 – 57CytoplasmicSequence analysisAdd BLAST13
Transmembranei58 – 81Helical; Name=2Sequence analysisAdd BLAST24
Topological domaini82 – 92ExtracellularSequence analysisAdd BLAST11
Transmembranei93 – 114Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini115 – 134CytoplasmicSequence analysisAdd BLAST20
Transmembranei135 – 159Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini160 – 179ExtracellularSequence analysisAdd BLAST20
Transmembranei180 – 203Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini204 – 233CytoplasmicSequence analysisAdd BLAST30
Transmembranei234 – 257Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini258 – 266ExtracellularSequence analysis9
Transmembranei267 – 288Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini289 – 397CytoplasmicSequence analysisAdd BLAST109

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2245

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696851 – 397Histamine H2 receptorAdd BLAST397

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi91 ↔ 173PROSITE-ProRule annotation
Lipidationi304S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP97292
PRIDEiP97292

PTM databases

iPTMnetiP97292
PhosphoSitePlusiP97292

Expressioni

Gene expression databases

BgeeiENSMUSG00000034987 Expressed in 93 organ(s), highest expression level in stomach
CleanExiMM_HRH2
ExpressionAtlasiP97292 baseline and differential
GenevisibleiP97292 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038170

Chemistry databases

BindingDBiP97292

Structurei

3D structure databases

ProteinModelPortaliP97292
SMRiP97292
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00890000139331
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiP97292
KOiK04150
OrthoDBiEOG091G06VI
PhylomeDBiP97292
TreeFamiTF316350

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000503 Histamine_H2_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00531 HISTAMINEH2R
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P97292-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPNGTVHSC CLDSIALKVT ISVVLTTLIF ITVAGNVVVC LAVSLNRRLR
60 70 80 90 100
SLTNCFIVSL AATDLLLGLL VMPFSAIYQL SFKWSFGQVF CNIYTSLDVM
110 120 130 140 150
LCTASILNLF MISLDRYCAV TDPLRYPVLV TPVRVAISLV FIWVISITLS
160 170 180 190 200
FLSIHLGWNS RNGTRGGNDT FKCKVQVNEV YGLVDGMVTF YLPLLIMCVT
210 220 230 240 250
YYRIFKIARE QAKRINHISS WKAATIREHK ATVTLAAVMG AFIVCWFPYF
260 270 280 290 300
TAFVYRGLRG DDAVNEVVEG IVLWLGYANS ALNPILYATL NRDFRMAYQQ
310 320 330 340 350
LFHCKLASHN SHKTSLRLNN SLLSRSQSRE GRWQEEKPLK LQVWSGTELT
360 370 380 390
HPQGSPVRTR LSHSSCLLSL SLLSFIWKLG TWIHHRRPFQ PSLHISA
Length:397
Mass (Da):44,794
Last modified:October 16, 2013 - v2
Checksum:iBB4719084F4BDD59
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GR79A0A1B0GR79_MOUSE
Histamine H2 receptor
Hrh2
371Annotation score:
A0A1B0GSX9A0A1B0GSX9_MOUSE
Histamine H2 receptor
Hrh2
421Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti85S → R in BAA08792 (PubMed:8938453).Curated1
Sequence conflicti263A → P in BAA08792 (PubMed:8938453).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020259 mRNA Translation: BAB32044.1
AK163760 mRNA Translation: BAE37484.1
AC163343 Genomic DNA No translation available.
AC164086 Genomic DNA No translation available.
D50096 Genomic DNA Translation: BAA08792.1
CCDSiCCDS26526.1
RefSeqiNP_001010973.1, NM_001010973.2
NP_032312.2, NM_008286.2
XP_006516915.1, XM_006516852.2
XP_017170886.1, XM_017315397.1
UniGeneiMm.57243

Genome annotation databases

EnsembliENSMUST00000038101; ENSMUSP00000038170; ENSMUSG00000034987
GeneIDi15466
KEGGimmu:15466
UCSCiuc007qob.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK020259 mRNA Translation: BAB32044.1
AK163760 mRNA Translation: BAE37484.1
AC163343 Genomic DNA No translation available.
AC164086 Genomic DNA No translation available.
D50096 Genomic DNA Translation: BAA08792.1
CCDSiCCDS26526.1
RefSeqiNP_001010973.1, NM_001010973.2
NP_032312.2, NM_008286.2
XP_006516915.1, XM_006516852.2
XP_017170886.1, XM_017315397.1
UniGeneiMm.57243

3D structure databases

ProteinModelPortaliP97292
SMRiP97292
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038170

Chemistry databases

BindingDBiP97292
ChEMBLiCHEMBL2245

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP97292
PhosphoSitePlusiP97292

Proteomic databases

PaxDbiP97292
PRIDEiP97292

Protocols and materials databases

DNASUi15466
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038101; ENSMUSP00000038170; ENSMUSG00000034987
GeneIDi15466
KEGGimmu:15466
UCSCiuc007qob.1 mouse

Organism-specific databases

CTDi3274
MGIiMGI:108482 Hrh2

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00890000139331
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiP97292
KOiK04150
OrthoDBiEOG091G06VI
PhylomeDBiP97292
TreeFamiTF316350

Enzyme and pathway databases

ReactomeiR-MMU-390650 Histamine receptors
R-MMU-418555 G alpha (s) signalling events

Miscellaneous databases

PROiPR:P97292
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034987 Expressed in 93 organ(s), highest expression level in stomach
CleanExiMM_HRH2
ExpressionAtlasiP97292 baseline and differential
GenevisibleiP97292 MM

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000503 Histamine_H2_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00531 HISTAMINEH2R
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHRH2_MOUSE
AccessioniPrimary (citable) accession number: P97292
Secondary accession number(s): Q9D282
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 16, 2013
Last modified: November 7, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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