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Protein

Cadherin-8

Gene

Cdh8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

  • cadherin binding Source: GO_Central
  • calcium ion binding Source: GO_Central
  • cytoskeletal protein binding Source: GO_Central
  • identical protein binding Source: IntAct
  • protein homodimerization activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-418990 Adherens junctions interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-8
Gene namesi
Name:Cdh8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:107434 Cdh8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini62 – 621ExtracellularSequence analysisAdd BLAST560
Transmembranei622 – 642HelicalSequence analysisAdd BLAST21
Topological domaini643 – 799CytoplasmicSequence analysisAdd BLAST157

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
PropeptideiPRO_000000377530 – 61Sequence analysisAdd BLAST32
ChainiPRO_000000377662 – 799Cadherin-8Add BLAST738

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi463N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi473N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi544N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei795PhosphoserineCombined sources1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP97291
PaxDbiP97291
PRIDEiP97291

PTM databases

iPTMnetiP97291
PhosphoSitePlusiP97291

Expressioni

Gene expression databases

BgeeiENSMUSG00000036510 Expressed in 179 organ(s), highest expression level in habenula
CleanExiMM_CDH8
ExpressionAtlasiP97291 baseline and differential
GenevisibleiP97291 MM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-15719457,EBI-15719457

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-46028N
STRINGi10090.ENSMUSP00000117326

Structurei

Secondary structure

1799
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP97291
SMRiP97291
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP97291

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 167Cadherin 1PROSITE-ProRule annotationAdd BLAST106
Domaini168 – 276Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini277 – 391Cadherin 3PROSITE-ProRule annotationAdd BLAST115
Domaini392 – 494Cadherin 4PROSITE-ProRule annotationAdd BLAST103
Domaini495 – 616Cadherin 5PROSITE-ProRule annotationAdd BLAST122

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00760000118954
HOGENOMiHOG000231252
HOVERGENiHBG005217
InParanoidiP97291
KOiK06800
OrthoDBiEOG091G0241
TreeFamiTF329887

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR039808 Cadherin
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
PANTHERiPTHR24027 PTHR24027, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 5 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P97291-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPERLAETLM DLWTPLIILW ITLPSCVYTA PMNQAHVLTT GSPLELSRQS
60 70 80 90 100
EDMRILSRSK RGWVWNQMFV LEEFSGPEPI LVGRLHTDLD PGSKKIKYIL
110 120 130 140 150
SGDGAGTIFQ INDITGDIHA IKRLDREEKA EYTLTAQAVD FETNKPLEPP
160 170 180 190 200
SEFIIKVQDI NDNAPEFLNG PYHATVPEMS ILGTSVTNVT ATDADDPVYG
210 220 230 240 250
NSAKLVYSIL EGQPYFSIEP ETAIIKTALP NMDREAKEEY LVVIQAKDMG
260 270 280 290 300
GHSGGLSGTT TLTVTLTDVN DNPPKFAQSL YHFSVPEDVV LGTAIGRVKA
310 320 330 340 350
NDQDIGENAQ SSYDIIDGDG TALFEITSDA QAQDGVIRLR KPLDFETKKS
360 370 380 390 400
YTLKVEAANI HIDPRFSSRG PFKDTATVKI VVEDADEPPV FSSPTYLLEV
410 420 430 440 450
HENAALNSVI GQVTARDPDI TSSPIRFSID RHTDLERQFN INADDGKITL
460 470 480 490 500
ATPLDRELSV WHNITIIATE IRNHSQISRV PVAIKVLDVN DNAPEFASEY
510 520 530 540 550
EAFLCENGKP GQVIQTVSAM DKDDPKNGHF FLYSLLPEMV NNPNFTIKKN
560 570 580 590 600
EDNSLSILAK HNGFNRQKQE VYLLPIVISD SGNPPLSSTS TLTIRVCGCS
610 620 630 640 650
NDGVVQSCNV EAYVLPIGLS MGALIAILAC IILLLVIVVL FVTLRRHKNE
660 670 680 690 700
PLIIKDDEDV RENIIRYDDE GGGEEDTEAF DIATLQNPDG INGFLPRKDI
710 720 730 740 750
KPDLQFMPRQ GLAPVPNGVD VDEFINVRLH EADNDPTAPP YDSIQIYGYE
760 770 780 790
GRGSVAGSLS SLESTTSDSD QNFDYLSDWG PRFKRLGELY SVGESDKET
Length:799
Mass (Da):88,215
Last modified:October 3, 2012 - v2
Checksum:i0EF1285E5DD67F76
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PYB2E9PYB2_MOUSE
Cadherin-8
Cdh8
711Annotation score:
E9Q451E9Q451_MOUSE
Cadherin-8
Cdh8
754Annotation score:
Q8C449Q8C449_MOUSE
Cadherin-8
Cdh8
716Annotation score:
D6RG94D6RG94_MOUSE
Cadherin-8
Cdh8
509Annotation score:
E9PZC1E9PZC1_MOUSE
Cadherin-8
Cdh8
247Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti247K → I in CAA64857 (PubMed:9022055).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95600 mRNA Translation: CAA64857.1
AC102643 Genomic DNA No translation available.
AC103397 Genomic DNA No translation available.
AC162519 Genomic DNA No translation available.
AC162867 Genomic DNA No translation available.
CH466525 Genomic DNA Translation: EDL11191.1
CCDSiCCDS40448.1
RefSeqiNP_031693.2, NM_007667.3
XP_006530694.1, XM_006530631.2
UniGeneiMm.441131

Genome annotation databases

EnsembliENSMUST00000128860; ENSMUSP00000117326; ENSMUSG00000036510
GeneIDi12564
KEGGimmu:12564
UCSCiuc009mzo.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95600 mRNA Translation: CAA64857.1
AC102643 Genomic DNA No translation available.
AC103397 Genomic DNA No translation available.
AC162519 Genomic DNA No translation available.
AC162867 Genomic DNA No translation available.
CH466525 Genomic DNA Translation: EDL11191.1
CCDSiCCDS40448.1
RefSeqiNP_031693.2, NM_007667.3
XP_006530694.1, XM_006530631.2
UniGeneiMm.441131

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZXKX-ray2.00A/B62-159[»]
2A62X-ray4.50A63-383[»]
ProteinModelPortaliP97291
SMRiP97291
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-46028N
STRINGi10090.ENSMUSP00000117326

PTM databases

iPTMnetiP97291
PhosphoSitePlusiP97291

Proteomic databases

MaxQBiP97291
PaxDbiP97291
PRIDEiP97291

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000128860; ENSMUSP00000117326; ENSMUSG00000036510
GeneIDi12564
KEGGimmu:12564
UCSCiuc009mzo.2 mouse

Organism-specific databases

CTDi1006
MGIiMGI:107434 Cdh8

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00760000118954
HOGENOMiHOG000231252
HOVERGENiHBG005217
InParanoidiP97291
KOiK06800
OrthoDBiEOG091G0241
TreeFamiTF329887

Enzyme and pathway databases

ReactomeiR-MMU-418990 Adherens junctions interactions

Miscellaneous databases

EvolutionaryTraceiP97291
PROiPR:P97291
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036510 Expressed in 179 organ(s), highest expression level in habenula
CleanExiMM_CDH8
ExpressionAtlasiP97291 baseline and differential
GenevisibleiP97291 MM

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR039808 Cadherin
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
PANTHERiPTHR24027 PTHR24027, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCADH8_MOUSE
AccessioniPrimary (citable) accession number: P97291
Secondary accession number(s): G3UVU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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