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Protein

Plasma protease C1 inhibitor

Gene

Serping1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. May inhibit chymotrypsin and kallikrein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei470 – 471Reactive bondBy similarity2

GO - Molecular functioni

  • serine-type endopeptidase inhibitor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor
Biological processBlood coagulation, Complement pathway, Fibrinolysis, Hemostasis, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation
R-MMU-140837 Intrinsic Pathway of Fibrin Clot Formation
R-MMU-977606 Regulation of Complement cascade

Protein family/group databases

MEROPSiI04.024

Names & Taxonomyi

Protein namesi
Recommended name:
Plasma protease C1 inhibitor
Short name:
C1 Inh
Short name:
C1Inh
Alternative name(s):
C1 esterase inhibitor
C1-inhibiting factor
Serpin G1
Gene namesi
Name:Serping1
Synonyms:C1nh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:894696 Serping1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000003251523 – 504Plasma protease C1 inhibitorAdd BLAST482

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi83N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi107N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi128 ↔ 432By similarity
Disulfide bondi135 ↔ 210By similarity
Glycosylationi243N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi356N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP97290
PaxDbiP97290
PeptideAtlasiP97290
PRIDEiP97290

PTM databases

iPTMnetiP97290
PhosphoSitePlusiP97290

Expressioni

Gene expression databases

BgeeiENSMUSG00000023224 Expressed in 248 organ(s), highest expression level in carotid body
ExpressionAtlasiP97290 baseline and differential
GenevisibleiP97290 MM

Interactioni

Subunit structurei

Interacts with MASP1.By similarity

Protein-protein interaction databases

IntActiP97290, 1 interactor
MINTiP97290
STRINGi10090.ENSMUSP00000023994

Structurei

3D structure databases

ProteinModelPortaliP97290
SMRiP97290
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00930000150820
HOGENOMiHOG000231936
HOVERGENiHBG104060
InParanoidiP97290
KOiK04001
OMAiMSKFQPT
OrthoDBiEOG091G03BW
TreeFamiTF317350

Family and domain databases

InterProiView protein in InterPro
IPR015553 C1-inh
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PTHR11461:SF159 PTHR11461:SF159, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P97290-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASRLTPLTL LLLLLAGDRA FSDPEATSHS TQDPLEAQAK SRESFPERDD
60 70 80 90 100
SWSPPEPTVL PSTWPTTSVA ITITNDTMGK VANESFSQHS QPAAQLPTDS
110 120 130 140 150
PGQPPLNSSS QPSTASDLPT QATTEPFCPE PLAQCSDSDR DSSEAKLSEA
160 170 180 190 200
LTDFSVKLYH AFSATKMAKT NMAFSPFSIA SLLTQVLLGA GDSTKSNLES
210 220 230 240 250
ILSYPKDFAC VHQALKGFSS KGVTSVSQIF HSPDLAIRDT YVNASQSLYG
260 270 280 290 300
SSPRVLGPDS AANLELINTW VAENTNHKIR KLLDSLPSDT CLVLLNAVYL
310 320 330 340 350
SAKWKITFEP KKMMAPFFYK NSMIKVPMMS SVKYPVAQFD DHTLKAKVGQ
360 370 380 390 400
LQLSHNLSFV IVVPVFPKHQ LKDVEKALNP TVFKAIMKKL ELSKFLPTYL
410 420 430 440 450
TMPHIKVKSS QDMLSVMEKL EFFDFTYDLN LCGLTEDPDL QVSAMKHETV
460 470 480 490 500
LELTESGVEA AAASAISFGR SLPIFEVQRP FLFLLWDQQH RFPVFMGRVY

DPRG
Length:504
Mass (Da):55,585
Last modified:July 27, 2011 - v3
Checksum:iB27BBDC05D318E62
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2ATR8A2ATR8_MOUSE
Plasma protease C1 inhibitor
Serping1
347Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti291C → R in AAC40136 (PubMed:9652403).Curated1
Sequence conflicti421E → K in CAA71412 (PubMed:9199246).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10386 mRNA Translation: CAA71412.1
AF010254 mRNA Translation: AAC40136.1
AF052039 Genomic DNA Translation: AAC40149.1
AL928914 Genomic DNA Translation: CAM23311.1
BC002026 mRNA Translation: AAH02026.1
CCDSiCCDS16193.1
RefSeqiNP_033906.2, NM_009776.3
XP_006498686.1, XM_006498623.3
UniGeneiMm.38888

Genome annotation databases

EnsembliENSMUST00000023994; ENSMUSP00000023994; ENSMUSG00000023224
GeneIDi12258
KEGGimmu:12258
UCSCiuc008kjd.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10386 mRNA Translation: CAA71412.1
AF010254 mRNA Translation: AAC40136.1
AF052039 Genomic DNA Translation: AAC40149.1
AL928914 Genomic DNA Translation: CAM23311.1
BC002026 mRNA Translation: AAH02026.1
CCDSiCCDS16193.1
RefSeqiNP_033906.2, NM_009776.3
XP_006498686.1, XM_006498623.3
UniGeneiMm.38888

3D structure databases

ProteinModelPortaliP97290
SMRiP97290
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP97290, 1 interactor
MINTiP97290
STRINGi10090.ENSMUSP00000023994

Protein family/group databases

MEROPSiI04.024

PTM databases

iPTMnetiP97290
PhosphoSitePlusiP97290

Proteomic databases

MaxQBiP97290
PaxDbiP97290
PeptideAtlasiP97290
PRIDEiP97290

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023994; ENSMUSP00000023994; ENSMUSG00000023224
GeneIDi12258
KEGGimmu:12258
UCSCiuc008kjd.2 mouse

Organism-specific databases

CTDi710
MGIiMGI:894696 Serping1

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00930000150820
HOGENOMiHOG000231936
HOVERGENiHBG104060
InParanoidiP97290
KOiK04001
OMAiMSKFQPT
OrthoDBiEOG091G03BW
TreeFamiTF317350

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation
R-MMU-140837 Intrinsic Pathway of Fibrin Clot Formation
R-MMU-977606 Regulation of Complement cascade

Miscellaneous databases

ChiTaRSiSerping1 mouse
PROiPR:P97290
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023224 Expressed in 248 organ(s), highest expression level in carotid body
ExpressionAtlasiP97290 baseline and differential
GenevisibleiP97290 MM

Family and domain databases

InterProiView protein in InterPro
IPR015553 C1-inh
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PTHR11461:SF159 PTHR11461:SF159, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIC1_MOUSE
AccessioniPrimary (citable) accession number: P97290
Secondary accession number(s): A2ATR7
, O88330, Q99M43, Q9QX09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 165 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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