UniProtKB - P97290 (IC1_MOUSE)
Protein
Plasma protease C1 inhibitor
Gene
Serping1
Organism
Mus musculus (Mouse)
Status
Functioni
Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. May inhibit chymotrypsin and kallikrein.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 470 – 471 | Reactive bondBy similarity | 2 |
GO - Molecular functioni
- serine-type endopeptidase inhibitor activity Source: MGI
GO - Biological processi
- blood coagulation Source: UniProtKB-KW
- complement activation, classical pathway Source: UniProtKB-KW
- fibrinolysis Source: UniProtKB-KW
- innate immune response Source: UniProtKB-KW
- negative regulation of complement activation, lectin pathway Source: UniProtKB
- negative regulation of endopeptidase activity Source: GO_Central
Keywordsi
Molecular function | Protease inhibitor, Serine protease inhibitor |
Biological process | Blood coagulation, Complement pathway, Fibrinolysis, Hemostasis, Immunity, Innate immunity |
Enzyme and pathway databases
Reactomei | R-MMU-114608, Platelet degranulation R-MMU-140837, Intrinsic Pathway of Fibrin Clot Formation R-MMU-977606, Regulation of Complement cascade |
Protein family/group databases
MEROPSi | I04.024 |
Names & Taxonomyi
Protein namesi | Recommended name: Plasma protease C1 inhibitorShort name: C1 Inh Short name: C1Inh Alternative name(s): C1 esterase inhibitor C1-inhibiting factor Serpin G1 |
Gene namesi | Name:Serping1 Synonyms:C1nh |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:894696, Serping1 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular space Source: MGI
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | By similarityAdd BLAST | 22 | |
ChainiPRO_0000032515 | 23 – 504 | Plasma protease C1 inhibitorAdd BLAST | 482 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 75 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 83 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 107 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 128 ↔ 432 | By similarity | ||
Disulfide bondi | 135 ↔ 210 | By similarity | ||
Glycosylationi | 243 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Glycosylationi | 356 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
CPTACi | non-CPTAC-3370 |
jPOSTi | P97290 |
MaxQBi | P97290 |
PaxDbi | P97290 |
PeptideAtlasi | P97290 |
PRIDEi | P97290 |
PTM databases
GlyGeni | P97290, 5 sites |
iPTMneti | P97290 |
PhosphoSitePlusi | P97290 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000023224, Expressed in carotid body and 267 other tissues |
ExpressionAtlasi | P97290, baseline and differential |
Genevisiblei | P97290, MM |
Interactioni
Subunit structurei
Interacts with MASP1.
By similarityProtein-protein interaction databases
IntActi | P97290, 1 interactor |
MINTi | P97290 |
STRINGi | 10090.ENSMUSP00000023994 |
Miscellaneous databases
RNActi | P97290, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the serpin family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG2392, Eukaryota |
GeneTreei | ENSGT00940000159681 |
HOGENOMi | CLU_023330_3_0_1 |
InParanoidi | P97290 |
OMAi | EFFDFTY |
OrthoDBi | 1124079at2759 |
TreeFami | TF317350 |
Family and domain databases
Gene3Di | 2.30.39.10, 1 hit 3.30.497.10, 1 hit |
InterProi | View protein in InterPro IPR015553, C1-inh IPR023795, Serpin_CS IPR023796, Serpin_dom IPR000215, Serpin_fam IPR036186, Serpin_sf IPR042178, Serpin_sf_1 IPR042185, Serpin_sf_2 |
PANTHERi | PTHR11461, PTHR11461, 1 hit PTHR11461:SF159, PTHR11461:SF159, 1 hit |
Pfami | View protein in Pfam PF00079, Serpin, 1 hit |
SMARTi | View protein in SMART SM00093, SERPIN, 1 hit |
SUPFAMi | SSF56574, SSF56574, 1 hit |
PROSITEi | View protein in PROSITE PS00284, SERPIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P97290-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASRLTPLTL LLLLLAGDRA FSDPEATSHS TQDPLEAQAK SRESFPERDD
60 70 80 90 100
SWSPPEPTVL PSTWPTTSVA ITITNDTMGK VANESFSQHS QPAAQLPTDS
110 120 130 140 150
PGQPPLNSSS QPSTASDLPT QATTEPFCPE PLAQCSDSDR DSSEAKLSEA
160 170 180 190 200
LTDFSVKLYH AFSATKMAKT NMAFSPFSIA SLLTQVLLGA GDSTKSNLES
210 220 230 240 250
ILSYPKDFAC VHQALKGFSS KGVTSVSQIF HSPDLAIRDT YVNASQSLYG
260 270 280 290 300
SSPRVLGPDS AANLELINTW VAENTNHKIR KLLDSLPSDT CLVLLNAVYL
310 320 330 340 350
SAKWKITFEP KKMMAPFFYK NSMIKVPMMS SVKYPVAQFD DHTLKAKVGQ
360 370 380 390 400
LQLSHNLSFV IVVPVFPKHQ LKDVEKALNP TVFKAIMKKL ELSKFLPTYL
410 420 430 440 450
TMPHIKVKSS QDMLSVMEKL EFFDFTYDLN LCGLTEDPDL QVSAMKHETV
460 470 480 490 500
LELTESGVEA AAASAISFGR SLPIFEVQRP FLFLLWDQQH RFPVFMGRVY
DPRG
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA2ATR8 | A2ATR8_MOUSE | Plasma protease C1 inhibitor | Serping1 | 347 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 291 | C → R in AAC40136 (PubMed:9652403).Curated | 1 | |
Sequence conflicti | 421 | E → K in CAA71412 (PubMed:9199246).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y10386 mRNA Translation: CAA71412.1 AF010254 mRNA Translation: AAC40136.1 AF052039 Genomic DNA Translation: AAC40149.1 AL928914 Genomic DNA No translation available. BC002026 mRNA Translation: AAH02026.1 |
CCDSi | CCDS16193.1 |
RefSeqi | NP_033906.2, NM_009776.3 XP_006498686.1, XM_006498623.3 |
Genome annotation databases
Ensembli | ENSMUST00000023994; ENSMUSP00000023994; ENSMUSG00000023224 |
GeneIDi | 12258 |
KEGGi | mmu:12258 |
UCSCi | uc008kjd.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y10386 mRNA Translation: CAA71412.1 AF010254 mRNA Translation: AAC40136.1 AF052039 Genomic DNA Translation: AAC40149.1 AL928914 Genomic DNA No translation available. BC002026 mRNA Translation: AAH02026.1 |
CCDSi | CCDS16193.1 |
RefSeqi | NP_033906.2, NM_009776.3 XP_006498686.1, XM_006498623.3 |
3D structure databases
SMRi | P97290 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | P97290, 1 interactor |
MINTi | P97290 |
STRINGi | 10090.ENSMUSP00000023994 |
Protein family/group databases
MEROPSi | I04.024 |
PTM databases
GlyGeni | P97290, 5 sites |
iPTMneti | P97290 |
PhosphoSitePlusi | P97290 |
Proteomic databases
CPTACi | non-CPTAC-3370 |
jPOSTi | P97290 |
MaxQBi | P97290 |
PaxDbi | P97290 |
PeptideAtlasi | P97290 |
PRIDEi | P97290 |
Protocols and materials databases
Antibodypediai | 14214, 543 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000023994; ENSMUSP00000023994; ENSMUSG00000023224 |
GeneIDi | 12258 |
KEGGi | mmu:12258 |
UCSCi | uc008kjd.2, mouse |
Organism-specific databases
CTDi | 710 |
MGIi | MGI:894696, Serping1 |
Phylogenomic databases
eggNOGi | KOG2392, Eukaryota |
GeneTreei | ENSGT00940000159681 |
HOGENOMi | CLU_023330_3_0_1 |
InParanoidi | P97290 |
OMAi | EFFDFTY |
OrthoDBi | 1124079at2759 |
TreeFami | TF317350 |
Enzyme and pathway databases
Reactomei | R-MMU-114608, Platelet degranulation R-MMU-140837, Intrinsic Pathway of Fibrin Clot Formation R-MMU-977606, Regulation of Complement cascade |
Miscellaneous databases
BioGRID-ORCSi | 12258, 0 hits in 17 CRISPR screens |
ChiTaRSi | Serping1, mouse |
PROi | PR:P97290 |
RNActi | P97290, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000023224, Expressed in carotid body and 267 other tissues |
ExpressionAtlasi | P97290, baseline and differential |
Genevisiblei | P97290, MM |
Family and domain databases
Gene3Di | 2.30.39.10, 1 hit 3.30.497.10, 1 hit |
InterProi | View protein in InterPro IPR015553, C1-inh IPR023795, Serpin_CS IPR023796, Serpin_dom IPR000215, Serpin_fam IPR036186, Serpin_sf IPR042178, Serpin_sf_1 IPR042185, Serpin_sf_2 |
PANTHERi | PTHR11461, PTHR11461, 1 hit PTHR11461:SF159, PTHR11461:SF159, 1 hit |
Pfami | View protein in Pfam PF00079, Serpin, 1 hit |
SMARTi | View protein in SMART SM00093, SERPIN, 1 hit |
SUPFAMi | SSF56574, SSF56574, 1 hit |
PROSITEi | View protein in PROSITE PS00284, SERPIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IC1_MOUSE | |
Accessioni | P97290Primary (citable) accession number: P97290 Secondary accession number(s): A2ATR7 Q9QX09 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 10, 2021 | |
This is version 181 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families