Serping1

Functionⁱ

Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. May inhibit chymotrypsin and kallikrein.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	470 – 471	Reactive bondBy similarity		2

GO - Molecular functionⁱ

serine-type endopeptidase inhibitor activity
Source: MGI
Inferred from direct assayⁱ
- 9199246

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

blood coagulation Source: UniProtKB-KW
complement activation, classical pathway Source: UniProtKB-KW
fibrinolysis Source: UniProtKB-KW
innate immune response Source: UniProtKB-KW
negative regulation of complement activation, lectin pathway Source: UniProtKB
negative regulation of endopeptidase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Protease inhibitor, Serine protease inhibitor
Biological process	Blood coagulation, Complement pathway, Fibrinolysis, Hemostasis, Immunity, Innate immunity

Enzyme and pathway databases

Reactomeⁱ	R-MMU-114608 Platelet degranulation R-MMU-140837 Intrinsic Pathway of Fibrin Clot Formation R-MMU-977606 Regulation of Complement cascade

Reactomeⁱ

R-MMU-114608 Platelet degranulation
R-MMU-140837 Intrinsic Pathway of Fibrin Clot Formation
R-MMU-977606 Regulation of Complement cascade

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	I04.024

MEROPSⁱ

I04.024

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Plasma protease C1 inhibitor Short name: C1 Inh Short name: C1Inh Alternative name(s): C1 esterase inhibitor C1-inhibiting factor Serpin G1
Gene namesⁱ	Name:Serping1 Synonyms:C1nh
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:894696 Serping1

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 22	By similarityAdd BLAST		22
ChainⁱPRO_0000032515	23 – 504	Plasma protease C1 inhibitorAdd BLAST		482

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	75	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	83	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	107	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	128 ↔ 432	By similarity
Disulfide bondⁱ	135 ↔ 210	By similarity
Glycosylationⁱ	243	N-linked (GlcNAc...) asparagine2 Publications	1
Glycosylationⁱ	356	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P97290
PaxDbⁱ	P97290
PeptideAtlas More...PeptideAtlasⁱ	P97290
PRIDEⁱ	P97290

PTM databases

iPTMnetⁱ	P97290
PhosphoSitePlusⁱ	P97290

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000023224 Expressed in 248 organ(s), highest expression level in carotid body
ExpressionAtlasⁱ	P97290 baseline and differential
Genevisibleⁱ	P97290 MM

Interactionⁱ

Subunit structureⁱ

Interacts with MASP1.By similarity

Protein-protein interaction databases

IntActⁱ	P97290, 1 interactor
Molecular INTeraction database More...MINTⁱ	P97290
STRINGⁱ	10090.ENSMUSP00000023994

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P97290
SMRⁱ	P97290
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the serpin family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG2392 Eukaryota COG4826 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150820
HOGENOMⁱ	HOG000231936
HOVERGENⁱ	HBG104060
InParanoidⁱ	P97290
KEGG Orthology (KO) More...KOⁱ	K04001
OMAⁱ	MSKFQPT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03BW
TreeFamⁱ	TF317350

Family and domain databases

InterProⁱ	View protein in InterPro IPR015553 C1-inh IPR023795 Serpin_CS IPR023796 Serpin_dom IPR000215 Serpin_fam IPR036186 Serpin_sf
PANTHERⁱ	PTHR11461 PTHR11461, 1 hit PTHR11461:SF159 PTHR11461:SF159, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00079 Serpin, 1 hit
SMARTⁱ	View protein in SMART SM00093 SERPIN, 1 hit
SUPFAMⁱ	SSF56574 SSF56574, 1 hit
PROSITEⁱ	View protein in PROSITE PS00284 SERPIN, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P97290-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASRLTPLTL LLLLLAGDRA FSDPEATSHS TQDPLEAQAK SRESFPERDD 
        60         70         80         90        100
SWSPPEPTVL PSTWPTTSVA ITITNDTMGK VANESFSQHS QPAAQLPTDS 
       110        120        130        140        150
PGQPPLNSSS QPSTASDLPT QATTEPFCPE PLAQCSDSDR DSSEAKLSEA 
       160        170        180        190        200
LTDFSVKLYH AFSATKMAKT NMAFSPFSIA SLLTQVLLGA GDSTKSNLES 
       210        220        230        240        250
ILSYPKDFAC VHQALKGFSS KGVTSVSQIF HSPDLAIRDT YVNASQSLYG 
       260        270        280        290        300
SSPRVLGPDS AANLELINTW VAENTNHKIR KLLDSLPSDT CLVLLNAVYL 
       310        320        330        340        350
SAKWKITFEP KKMMAPFFYK NSMIKVPMMS SVKYPVAQFD DHTLKAKVGQ 
       360        370        380        390        400
LQLSHNLSFV IVVPVFPKHQ LKDVEKALNP TVFKAIMKKL ELSKFLPTYL 
       410        420        430        440        450
TMPHIKVKSS QDMLSVMEKL EFFDFTYDLN LCGLTEDPDL QVSAMKHETV 
       460        470        480        490        500
LELTESGVEA AAASAISFGR SLPIFEVQRP FLFLLWDQQH RFPVFMGRVY 

DPRG

Length:504

Mass (Da):55,585

Last modified:July 27, 2011 - v3

Checksum:ⁱB27BBDC05D318E62

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A2ATR8	A2ATR8_MOUSE		Plasma protease C1 inhibitor Plasma protease C1 inhibitor	Serping1	347	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	291	C → R in AAC40136 (PubMed:9652403).Curated		1
Sequence conflictⁱ	421	E → K in CAA71412 (PubMed:9199246).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y10386 mRNA Translation: CAA71412.1 AF010254 mRNA Translation: AAC40136.1 AF052039 Genomic DNA Translation: AAC40149.1 AL928914 Genomic DNA Translation: CAM23311.1 BC002026 mRNA Translation: AAH02026.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS16193.1
NCBI Reference Sequences More...RefSeqⁱ	NP_033906.2, NM_009776.3 XP_006498686.1, XM_006498623.3
UniGeneⁱ	Mm.38888

Genome annotation databases

Ensemblⁱ	ENSMUST00000023994; ENSMUSP00000023994; ENSMUSG00000023224
GeneIDⁱ	12258
KEGGⁱ	mmu:12258
UCSC genome browser More...UCSCⁱ	uc008kjd.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P97290	Plasma protease C1 inhibitor		MOUSE		347	UniRef100_P97290

Protein	Similar proteins		Species	Score	Length	Source
P97290	Plasma protease C1 inhibitor		MOUSE		347	UniRef90_P97290
UPI000A31221B		MUSPA		505
UPI000A31AB42		MUSCR		504

Protein	Similar proteins		Species	Score	Length	Source
P97290	Plasma protease C1 inhibitor		RAT		504	UniRef50_P97290
Factor XIIa inhibitor		BOVIN		468
Plasma protease C1 inhibitor		MOUSE		347
Serpin family G member 1		LOXAF		515
plasma protease C1 inhibitor		Florida manatee		508
+53

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y10386 mRNA Translation: CAA71412.1 AF010254 mRNA Translation: AAC40136.1 AF052039 Genomic DNA Translation: AAC40149.1 AL928914 Genomic DNA Translation: CAM23311.1 BC002026 mRNA Translation: AAH02026.1
CCDSⁱ	CCDS16193.1
RefSeqⁱ	NP_033906.2, NM_009776.3 XP_006498686.1, XM_006498623.3
UniGeneⁱ	Mm.38888

3D structure databases

ProteinModelPortalⁱ	P97290
SMRⁱ	P97290
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	P97290, 1 interactor
MINTⁱ	P97290
STRINGⁱ	10090.ENSMUSP00000023994

Protein family/group databases

MEROPSⁱ	I04.024

MEROPSⁱ

I04.024

PTM databases

iPTMnetⁱ	P97290
PhosphoSitePlusⁱ	P97290

Proteomic databases

MaxQBⁱ	P97290
PaxDbⁱ	P97290
PeptideAtlasⁱ	P97290
PRIDEⁱ	P97290

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000023994; ENSMUSP00000023994; ENSMUSG00000023224
GeneIDⁱ	12258
KEGGⁱ	mmu:12258
UCSCⁱ	uc008kjd.2 mouse

Organism-specific databases

CTDⁱ	710
MGIⁱ	MGI:894696 Serping1

Phylogenomic databases

eggNOGⁱ	KOG2392 Eukaryota COG4826 LUCA
GeneTreeⁱ	ENSGT00930000150820
HOGENOMⁱ	HOG000231936
HOVERGENⁱ	HBG104060
InParanoidⁱ	P97290
KOⁱ	K04001
OMAⁱ	MSKFQPT
OrthoDBⁱ	EOG091G03BW
TreeFamⁱ	TF317350

Enzyme and pathway databases

Reactomeⁱ	R-MMU-114608 Platelet degranulation R-MMU-140837 Intrinsic Pathway of Fibrin Clot Formation R-MMU-977606 Regulation of Complement cascade

Reactomeⁱ

R-MMU-114608 Platelet degranulation
R-MMU-140837 Intrinsic Pathway of Fibrin Clot Formation
R-MMU-977606 Regulation of Complement cascade

Miscellaneous databases

ChiTaRSⁱ	Serping1 mouse
Protein Ontology More...PROⁱ	PR:P97290
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000023224 Expressed in 248 organ(s), highest expression level in carotid body
ExpressionAtlasⁱ	P97290 baseline and differential
Genevisibleⁱ	P97290 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR015553 C1-inh IPR023795 Serpin_CS IPR023796 Serpin_dom IPR000215 Serpin_fam IPR036186 Serpin_sf
PANTHERⁱ	PTHR11461 PTHR11461, 1 hit PTHR11461:SF159 PTHR11461:SF159, 1 hit
Pfamⁱ	View protein in Pfam PF00079 Serpin, 1 hit
SMARTⁱ	View protein in SMART SM00093 SERPIN, 1 hit
SUPFAMⁱ	SSF56574 SSF56574, 1 hit
PROSITEⁱ	View protein in PROSITE PS00284 SERPIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IC1_MOUSE
Accessionⁱ	P97290Primary (citable) accession number: P97290 Secondary accession number(s): A2ATR7 , O88330, Q99M43, Q9QX09
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
	Last sequence update:	July 27, 2011
	Last modified:	November 7, 2018
	This is version 165 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P97290 (IC1_MOUSE)

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Plasma protease C1 inhibitor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ