Mcl1

Functionⁱ

Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 2 has antiapoptotic activity.2 Publications

GO - Molecular functionⁱ

BH3 domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 15901672
BH domain binding Source: MGI
protein dimerization activity Source: MGI
protein heterodimerization activity Source: MGI
protein homodimerization activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic mitochondrial changes
Source: MGI
Inferred from direct assayⁱ
- 19919825
cell differentiation Source: UniProtKB-KW
extrinsic apoptotic signaling pathway in absence of ligand
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16543145
intrinsic apoptotic signaling pathway in response to DNA damage
Source: MGI
Inferred from direct assayⁱ
- 15901672
multicellular organism development Source: UniProtKB-KW
negative regulation of anoikis Source: MGI
negative regulation of apoptotic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17289999
negative regulation of autophagy Source: MGI
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
negative regulation of intrinsic apoptotic signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
Source: ParkinsonsUK-UCL
Inferred from mutant phenotypeⁱ
- 23858059
regulation of response to DNA damage stimulus Source: MGI
response to cytokine
Source: MGI
Inferred from sequence orthologyⁱ
- 9184696

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein
Biological process	Apoptosis, Differentiation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Induced myeloid leukemia cell differentiation protein Mcl-1 homolog Alternative name(s): Bcl-2-related protein EAT/mcl1
Gene namesⁱ	Name:Mcl1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 3

Organism-specific databases

MGIⁱ	MGI:101769 Mcl1

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	308 – 330	HelicalSequence analysisAdd BLAST		23

Keywords - Cellular componentⁱ

Cytoplasm, Membrane, Mitochondrion, Nucleus

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL5768

ChEMBLⁱ

CHEMBL5768

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000143081	1 – 331	Induced myeloid leukemia cell differentiation protein Mcl-1 homologAdd BLAST		331

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	102	PhosphoserineBy similarity	1
Cross-linkⁱ	117	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residueⁱ	140	Phosphoserine; by GSK3-alpha and GSK3-beta1 Publication	1
Modified residueⁱ	143	PhosphoserineBy similarity	1
Modified residueⁱ	144	Phosphothreonine; by MAPKBy similarity	1
Cross-linkⁱ	175	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linkⁱ	178	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationⁱ

Cleaved by CASP3 during apoptosis, yielding a pro-apoptotic C-terminal fragment.By similarity

Rapidly degraded in the absence of phosphorylation in the PEST region.By similarity

Phosphorylated on Ser-140, by GSK3, in response to IL3/interleukin-3 withdrawal. Phosphorylation at Ser-140 induces ubiquitination and proteasomal degradation, abrogating the anti-apoptotic activity. Treatment with taxol or okadaic acid induces phosphorylation on additional sites.1 Publication

Ubiquitinated. Ubiquitination is induced by phosphorylation at Ser-140 (By similarity).By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	108 – 109	Cleavage; by caspase-3By similarity		2
Siteⁱ	138 – 139	Cleavage; by caspase-3By similarity		2

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P97287
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P97287
PaxDbⁱ	P97287
PeptideAtlas More...PeptideAtlasⁱ	P97287
PRIDEⁱ	P97287

PTM databases

iPTMnetⁱ	P97287
PhosphoSitePlusⁱ	P97287

Expressionⁱ

Inductionⁱ

Up-regulated by IL3 and CSF2. Up-regulated in murine embryonal carcinoma cells in response to retinoic acid treatment. Levels reach a maximum after 4 hours, are decreased after 8 hours and are back to maximum after 12 hours. Levels are decreased after 24 hours and back to basal levels after 48 hours. Expression remains constant in retinoic acid-treated embryonic stem cells.2 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000038612 Expressed in 302 organ(s), highest expression level in ear vesicle
CleanExⁱ	MM_MCL1
Genevisibleⁱ	P97287 MM

Interactionⁱ

Subunit structureⁱ

Interacts with HIF3A isoform 2 (via C-terminus domain) (PubMed:21546903). Interacts with BAD, BOK, BIK, BAX, BAK1, and TPT1. Interacts with BBC3, BMF and PMAIP1 (PubMed:15550399, PubMed:18589438). Interacts with BOP. Interacts with BCL2L11; this interaction may sequester BCL2L11 and prevent its pro-apoptotic activity (PubMed:16543145, PubMed:27013495, PubMed:15550399).5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
BAK1	Q16611	3	EBI-707292,EBI-519866	From Homo sapiens.
BAX	Q07812	2	EBI-707292,EBI-516580	From Homo sapiens.
BBC3	Q9BXH1	5	EBI-707292,EBI-519884	From Homo sapiens.
BCL2L11	O43521	7	EBI-707292,EBI-526406	From Homo sapiens.
Bcl2l11	O54918	4	EBI-707292,EBI-526067
Pmaip1	Q9JM54	6	EBI-707292,EBI-709183

GO - Molecular functionⁱ

BH3 domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 15901672
BH domain binding Source: MGI
protein dimerization activity Source: MGI
protein heterodimerization activity Source: MGI
protein homodimerization activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	201344, 16 interactors
ComplexPortalⁱ	CPX-305 MCL1:PMAIP1 complex CPX-629 MCL-1-BIM complex
CORUMⁱ	P97287
Database of interacting proteins More...DIPⁱ	DIP-33343N
ELMⁱ	P97287
IntActⁱ	P97287, 14 interactors
Molecular INTeraction database More...MINTⁱ	P97287
STRINGⁱ	10090.ENSMUSP00000044048

Chemistry databases

BindingDBⁱ

P97287

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	154 – 172	Combined sources	19
Beta strandⁱ	181 – 183	Combined sources	3
Helixⁱ	185 – 202	Combined sources	18
Helixⁱ	206 – 216	Combined sources	11
Helixⁱ	221 – 225	Combined sources	5
Helixⁱ	227 – 234	Combined sources	8
Turnⁱ	235 – 237	Combined sources	3
Helixⁱ	242 – 261	Combined sources	20
Helixⁱ	265 – 267	Combined sources	3
Helixⁱ	268 – 289	Combined sources	22
Helixⁱ	292 – 300	Combined sources	9
Turnⁱ	301 – 303	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P97287
SMRⁱ	P97287
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P97287

EvolutionaryTraceⁱ

P97287

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	85 – 156	PEST-likeBy similarityAdd BLAST		72

Motif

Feature key	Position(s)	DescriptionActions	Length
Motifⁱ	190 – 204	BH3Add BLAST	15
Motifⁱ	234 – 253	BH1Add BLAST	20
Motifⁱ	285 – 300	BH2Add BLAST	16

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	149 – 152	Poly-Glu		4

Sequence similaritiesⁱ

Belongs to the Bcl-2 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4728 Eukaryota ENOG41123S0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000048923
HOGENOMⁱ	HOG000232116
HOVERGENⁱ	HBG003527
InParanoidⁱ	P97287
KEGG Orthology (KO) More...KOⁱ	K02539
OMAⁱ	KDAKPMG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0E6Q
PhylomeDBⁱ	P97287
TreeFamⁱ	TF315834

Family and domain databases

Gene3Dⁱ	1.10.437.10, 1 hit
InterProⁱ	View protein in InterPro IPR013281 Apop_reg_Mc1 IPR002475 Bcl2-like IPR020717 Bcl2_BH1_motif_CS IPR020726 Bcl2_BH2_motif_CS IPR020728 Bcl2_BH3_motif_CS IPR036834 Blc2-like_sf IPR026298 Blc2_fam
PANTHERⁱ	PTHR11256 PTHR11256, 1 hit PTHR11256:SF46 PTHR11256:SF46, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00452 Bcl-2, 1 hit
PRINTSⁱ	PR01866 APOPREGMCL1 PR01862 BCL2FAMILY
SUPFAMⁱ	SSF56854 SSF56854, 1 hit
PROSITEⁱ	View protein in PROSITE PS50062 BCL2_FAMILY, 1 hit PS01080 BH1, 1 hit PS01258 BH2, 1 hit PS01259 BH3, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: P97287-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFGLRRNAVI GLNLYCGGAS LGAGGGSPAG ARLVAEEAKA RREGGGEAAL 
        60         70         80         90        100
LPGARVVARP PPVGAEDPDV TASAERRLHK SPGLLAVPPE EMAASAAAAI 
       110        120        130        140        150
VSPEEELDGC EPEAIGKRPA VLPLLERVSE AAKSSGADGS LPSTPPPPEE 
       160        170        180        190        200
EEDDLYRQSL EIISRYLREQ ATGSKDSKPL GEAGAAGRRA LETLRRVGDG 
       210        220        230        240        250
VQRNHETAFQ GMLRKLDIKN EGDVKSFSRV MVHVFKDGVT NWGRIVTLIS 
       260        270        280        290        300
FGAFVAKHLK SVNQESFIEP LAETITDVLV RTKRDWLVKQ RGWDGFVEFF 
       310        320        330 
HVQDLEGGIR NVLLAFAGVA GVGAGLAYLI R

Length:331

Mass (Da):35,217

Last modified:November 1, 1998 - v3

Checksum:ⁱE4FD369DB0EC6723

GO

Isoform 2 (identifier: P97287-2) [UniParc]FASTA Add to basket

Also known as: Mck-1V

The sequence of this isoform differs from the canonical sequence as follows:
18-63: Missing.

« Hide

        10         20         30         40         50
MFGLRRNAVI GLNLYCGGAE DPDVTASAER RLHKSPGLLA VPPEEMAASA 
        60         70         80         90        100
AAAIVSPEEE LDGCEPEAIG KRPAVLPLLE RVSEAAKSSG ADGSLPSTPP 
       110        120        130        140        150
PPEEEEDDLY RQSLEIISRY LREQATGSKD SKPLGEAGAA GRRALETLRR 
       160        170        180        190        200
VGDGVQRNHE TAFQGMLRKL DIKNEGDVKS FSRVMVHVFK DGVTNWGRIV 
       210        220        230        240        250
TLISFGAFVA KHLKSVNQES FIEPLAETIT DVLVRTKRDW LVKQRGWDGF 
       260        270        280 
VEFFHVQDLE GGIRNVLLAF AGVAGVGAGL AYLIR

Note: This isoform is more stable than isoform 1 in cells undergoing apoptosis.

Show »

Length:285

Mass (Da):30,930

Checksum:ⁱ73643EE7EE849B27

GO

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_046443	18 – 63	Missing in isoform 2. 1 PublicationAdd BLAST		46

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U35623 mRNA Translation: AAC31790.1 GU182318 mRNA Translation: ACZ54910.1 AK010424 mRNA Translation: BAB26927.1 AK159504 mRNA Translation: BAE35137.1 AK160594 mRNA Translation: BAE35901.1 AC092479 Genomic DNA No translation available. FO082281 Genomic DNA No translation available. BC003839 mRNA Translation: AAH03839.1 BC005427 mRNA Translation: AAH05427.1 BC021638 mRNA Translation: AAH21638.1 AF063886 Genomic DNA Translation: AAC27929.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS57236.1 [P97287-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_032588.1, NM_008562.3 [P97287-1]
UniGeneⁱ	Mm.1639

Genome annotation databases

Ensemblⁱ	ENSMUST00000037947; ENSMUSP00000044048; ENSMUSG00000038612 [P97287-1] ENSMUST00000178686; ENSMUSP00000135915; ENSMUSG00000038612 [P97287-2]
GeneIDⁱ	17210
KEGGⁱ	mmu:17210
UCSC genome browser More...UCSCⁱ	uc029unp.1 mouse [P97287-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P97287	Induced myeloid leukemia cell differentiation protein Mcl-1 homolog		RAT		330	UniRef90_P97287
Isoform 2 of Induced myeloid leukemia cell differentiation protein Mcl-1 homolog		MOUSE		285
UPI000A3107F6		MUSPA		332
UPI000A318436		MUSCR		332
UPI000A31F9BF		MESAU		330
+1

Protein	Similar proteins		Species	Score	Length	Source
P97287	Induced myeloid leukemia cell differentiation protein Mcl-1	)	HUMAN		350	UniRef50_Q07820
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog		CANLF		350
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog		FELCA		350
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog		RAT		330
MCL1 isoform 2		PONAB		350
+135

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U35623 mRNA Translation: AAC31790.1 GU182318 mRNA Translation: ACZ54910.1 AK010424 mRNA Translation: BAB26927.1 AK159504 mRNA Translation: BAE35137.1 AK160594 mRNA Translation: BAE35901.1 AC092479 Genomic DNA No translation available. FO082281 Genomic DNA No translation available. BC003839 mRNA Translation: AAH03839.1 BC005427 mRNA Translation: AAH05427.1 BC021638 mRNA Translation: AAH21638.1 AF063886 Genomic DNA Translation: AAC27929.1
CCDSⁱ	CCDS57236.1 [P97287-1]
RefSeqⁱ	NP_032588.1, NM_008562.3 [P97287-1]
UniGeneⁱ	Mm.1639

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1WSX	NMR	-	A	152-308	[»]
	2JM6	NMR	-	B	152-308	[»]
	2NL9	X-ray	1.55	A	152-189	[»]
	2NLA	X-ray	2.80	A	152-189	[»]
	2ROC	NMR	-	A	152-308	[»]
	2ROD	NMR	-	A	152-308	[»]
	3D7V	X-ray	2.03	A	152-189	[»]
	3IO9	X-ray	2.40	A	152-189	[»]
	4BPI	X-ray	1.98	A	152-189	[»]
	4BPJ	X-ray	1.60	A	152-189	[»]
	4G35	X-ray	2.00	A	152-308	[»]
	5KU9	X-ray	2.20	A/B	152-308	[»]
	5MES	X-ray	2.24	A	153-221	[»]
	5MEV	X-ray	2.94	A	153-221	[»]
	5VX2	X-ray	1.85	A/C	152-221	[»]
	6DM8	X-ray	2.70	A/B/C/D/E/F/G/H	154-302	[»]
ProteinModelPortalⁱ	P97287
SMRⁱ	P97287
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	201344, 16 interactors
ComplexPortalⁱ	CPX-305 MCL1:PMAIP1 complex CPX-629 MCL-1-BIM complex
CORUMⁱ	P97287
DIPⁱ	DIP-33343N
ELMⁱ	P97287
IntActⁱ	P97287, 14 interactors
MINTⁱ	P97287
STRINGⁱ	10090.ENSMUSP00000044048

Chemistry databases

BindingDBⁱ	P97287
ChEMBLⁱ	CHEMBL5768

PTM databases

iPTMnetⁱ	P97287
PhosphoSitePlusⁱ	P97287

Proteomic databases

EPDⁱ	P97287
MaxQBⁱ	P97287
PaxDbⁱ	P97287
PeptideAtlasⁱ	P97287
PRIDEⁱ	P97287

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000037947; ENSMUSP00000044048; ENSMUSG00000038612 [P97287-1] ENSMUST00000178686; ENSMUSP00000135915; ENSMUSG00000038612 [P97287-2]
GeneIDⁱ	17210
KEGGⁱ	mmu:17210
UCSCⁱ	uc029unp.1 mouse [P97287-1]

Organism-specific databases

CTDⁱ	4170
MGIⁱ	MGI:101769 Mcl1

Phylogenomic databases

eggNOGⁱ	KOG4728 Eukaryota ENOG41123S0 LUCA
GeneTreeⁱ	ENSGT00510000048923
HOGENOMⁱ	HOG000232116
HOVERGENⁱ	HBG003527
InParanoidⁱ	P97287
KOⁱ	K02539
OMAⁱ	KDAKPMG
OrthoDBⁱ	EOG091G0E6Q
PhylomeDBⁱ	P97287
TreeFamⁱ	TF315834

Miscellaneous databases

ChiTaRSⁱ	Mcl1 mouse
EvolutionaryTraceⁱ	P97287
Protein Ontology More...PROⁱ	PR:P97287
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000038612 Expressed in 302 organ(s), highest expression level in ear vesicle
CleanExⁱ	MM_MCL1
Genevisibleⁱ	P97287 MM

Family and domain databases

Gene3Dⁱ	1.10.437.10, 1 hit
InterProⁱ	View protein in InterPro IPR013281 Apop_reg_Mc1 IPR002475 Bcl2-like IPR020717 Bcl2_BH1_motif_CS IPR020726 Bcl2_BH2_motif_CS IPR020728 Bcl2_BH3_motif_CS IPR036834 Blc2-like_sf IPR026298 Blc2_fam
PANTHERⁱ	PTHR11256 PTHR11256, 1 hit PTHR11256:SF46 PTHR11256:SF46, 1 hit
Pfamⁱ	View protein in Pfam PF00452 Bcl-2, 1 hit
PRINTSⁱ	PR01866 APOPREGMCL1 PR01862 BCL2FAMILY
SUPFAMⁱ	SSF56854 SSF56854, 1 hit
PROSITEⁱ	View protein in PROSITE PS50062 BCL2_FAMILY, 1 hit PS01080 BH1, 1 hit PS01258 BH2, 1 hit PS01259 BH3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MCL1_MOUSE
Accessionⁱ	P97287Primary (citable) accession number: P97287 Secondary accession number(s): D2K6L9 , Q3TUS0, Q792P0, Q9CRI4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
	Last sequence update:	November 1, 1998
	Last modified:	November 7, 2018
	This is version 163 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - P97287 (MCL1_MOUSE)

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Induced myeloid leukemia cell differentiation protein Mcl-1 homolog

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Nucleus

Other locations

Cytosol

Mitochondrion

Nucleus

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Sites

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ