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Protein

Inter-alpha-trypsin inhibitor heavy chain H3

Gene

ITIH3

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Inter-alpha-trypsin inhibitor heavy chain H3
Short name:
ITI heavy chain H3
Short name:
ITI-HC3
Short name:
Inter-alpha-inhibitor heavy chain 3
Gene namesi
Name:ITIH3
OrganismiMesocricetus auratus (Golden hamster)
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaCricetidaeCricetinaeMesocricetus
Proteomesi
  • UP000189706 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000001653219 – 30By similarityAdd BLAST12
ChainiPRO_000001653331 – 646Inter-alpha-trypsin inhibitor heavy chain H3Add BLAST616
PropeptideiPRO_0000016534647 – 886By similarityAdd BLAST240

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi88N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi577N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei646Aspartate 1-(chondroitin 4-sulfate)-esterBy similarity1

Post-translational modificationi

Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Proteoglycan

Proteomic databases

PRIDEiP97280

Interactioni

Subunit structurei

I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (H1, H2 or H3) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2 and bikunin, inter-alpha-like inhibitor (I-alpha-LI) of H2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP97280
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 155VITPROSITE-ProRule annotationAdd BLAST130
Domaini279 – 439VWFAPROSITE-ProRule annotationAdd BLAST161

Sequence similaritiesi

Belongs to the ITIH family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG057734
OrthoDBiEOG091G01HF

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR010600 ITI_HC_C
IPR013694 VIT
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF06668 ITI_HC_C, 1 hit
PF08487 VIT, 1 hit
PF00092 VWA, 1 hit
SMARTiView protein in SMART
SM00609 VIT, 1 hit
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS51468 VIT, 1 hit
PS50234 VWFA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97280-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWWPYLVLAL LSGLEASGFP RSPLRLLGKR SLPEGVVDGV EVYSTKISCK
60 70 80 90 100
VTSRFAHNVV TTRAVNRADQ AKEVSFDVEL PKTAFITNFT LTIDGVTYPG
110 120 130 140 150
NIKEKEVAQK QYDKAVSQGK TAGLVKASGR KLEKFTVSVN VAAGSKVTFE
160 170 180 190 200
LTYEELLKRH KGKYEMYLKV QPKQLVRHFE IDAHIFEPQG ISMLDAEASF
210 220 230 240 250
ITNDLLGSAL TKSFSGKKGH VSFKPSLDQQ RSCPTCTDSL LNGDFTIVYD
260 270 280 290 300
VNRESPGNVQ VVNGYFVHFF APQGLPVVPK NIVFVIDISG SMAGRKIQQT
310 320 330 340 350
RVALLKILDD MKQDDYLNFI LFSTGVTTWK DSLVQATPAN LEEARTFVRS
360 370 380 390 400
ISDQGMTNIN DGLLRGIRML TDAREQHTVP ERSTSIIIML TDGDANTGES
410 420 430 440 450
RPEKIQENVR KAIEGRFPLY NLGFGNNLNY NFLETMALEN HGVARRIYED
460 470 480 490 500
SDANLQLQGF YEEVANPLLT NVEVEYPENA ILDLTKNSYP HFYDGSETAV
510 520 530 540 550
AGRLADSDMN NFKADVKGHG ALNDLTFTEE VDMKEMDAAL KEQGYIFGNY
560 570 580 590 600
IERLWAYLTI EQLLEKRKNA HGEEKENLTA QALELSLKYH FVTPLTPMVV
610 620 630 640 650
TKPEDNEDQT SIADKPGEDA PYAATSTAYL TSHQSPPTPY YYVDGDPHFI
660 670 680 690 700
IQVPGKNDTI CFNIDEKPGT VLRLIQDPVT GITVTGQIIG DKGSSPYSRT
710 720 730 740 750
GKTYFGKLGI THAWMDFRIE VTTEKIILGT EDELSTFSWL DTVTITQTGL
760 770 780 790 800
FVAINRKKNM VVSFGDGVNF VIVLHQVWKK HPLHQDFLGF YVVDSHRMSA
810 820 830 840 850
RTHGLLGQFF RPFDFEVSDV RPGSDPAKPD ATMVVKNHQL TVTRGSQRDY
860 870 880
RKDASVGTKV TCWFVHNNGE GLIDGVHTDY IVPSLF
Length:886
Mass (Da):99,018
Last modified:May 1, 1997 - v1
Checksum:iAC0594C6852576B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89287 mRNA Translation: BAA13940.1
RefSeqiNP_001268279.1, NM_001281350.1

Genome annotation databases

GeneIDi101826575

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89287 mRNA Translation: BAA13940.1
RefSeqiNP_001268279.1, NM_001281350.1

3D structure databases

ProteinModelPortaliP97280
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP97280

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101826575

Organism-specific databases

CTDi3699

Phylogenomic databases

HOVERGENiHBG057734
OrthoDBiEOG091G01HF

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR010600 ITI_HC_C
IPR013694 VIT
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF06668 ITI_HC_C, 1 hit
PF08487 VIT, 1 hit
PF00092 VWA, 1 hit
SMARTiView protein in SMART
SM00609 VIT, 1 hit
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS51468 VIT, 1 hit
PS50234 VWFA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiITIH3_MESAU
AccessioniPrimary (citable) accession number: P97280
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: October 25, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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