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Protein

Inter-alpha-trypsin inhibitor heavy chain H2

Gene

ITIH2

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Inter-alpha-trypsin inhibitor heavy chain H2
Short name:
ITI heavy chain H2
Short name:
ITI-HC2
Short name:
Inter-alpha-inhibitor heavy chain 2
Gene namesi
Name:ITIH2
OrganismiMesocricetus auratus (Golden hamster)
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaCricetidaeCricetinaeMesocricetus
Proteomesi
  • UP000189706 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000001652319 – 54By similarityAdd BLAST36
ChainiPRO_000001652455 – 702Inter-alpha-trypsin inhibitor heavy chain H2Add BLAST648
PropeptideiPRO_0000016525703 – 946By similarityAdd BLAST244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60PhosphoserineBy similarity1
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi263N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei2824-carboxyglutamateBy similarity1
Modified residuei2834-carboxyglutamateBy similarity1
Glycosylationi445N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei466PhosphoserineBy similarity1
Glycosylationi578N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei702Aspartate 1-(chondroitin 4-sulfate)-esterBy similarity1
Modified residuei886PhosphoserineBy similarity1

Post-translational modificationi

Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage.By similarity
Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Gamma-carboxyglutamic acid, Glycoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

PRIDEiP97279

Interactioni

Subunit structurei

I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (H1, H2 or H3) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2 and bikunin, inter-alpha-like inhibitor (I-alpha-LI) of H2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP97279
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 185VITPROSITE-ProRule annotationAdd BLAST130
Domaini308 – 468VWFAPROSITE-ProRule annotationAdd BLAST161

Sequence similaritiesi

Belongs to the ITIH family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG057734
OrthoDBiEOG091G01HF

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR010600 ITI_HC_C
IPR013694 VIT
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF06668 ITI_HC_C, 1 hit
PF08487 VIT, 1 hit
PF00092 VWA, 1 hit
SMARTiView protein in SMART
SM00609 VIT, 1 hit
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS51468 VIT, 1 hit
PS50234 VWFA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97279-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQRLACVLIW LFLLEEQAFE IPANEYSEFA GYSNLVELAP DKFPFVQENR
60 70 80 90 100
RYQRSLPEES GEMTDNVDQV TLYSYKVQST ITSRMATTII QSKLVNNSPQ
110 120 130 140 150
SQNVVFDVQI PKGAFISNFT MTVNGITFTS TIREKTVGRA LYSQARAKGK
160 170 180 190 200
TAGWVRSRTL DMENFNTEVN IPPGAKVQFE LHYQEMKWRK LGSYEHKIHL
210 220 230 240 250
QPGRLAKHLE VNVWIVELQG MRFLHVPDTF EGHFQGVPVI SKGQKKSHVS
260 270 280 290 300
FKPTVAQQRK CPNCTYTAVD GELVVMYDVN REEKVGELEV FNGYFVHFFA
310 320 330 340 350
PENLDPIPKN ILFVIDVSGS MWGIKMKQTV EAMKTILDDL RTEDQFSVVD
360 370 380 390 400
FNHNVRTWRN DLVSATKTQI TDAKRYIEKI QPSGGTNINE ALLRAIFILN
410 420 430 440 450
EASNLGMLNP DSVSLIVLVS DGDPTVGELK LSKIQKNVKQ NIQDNISLFS
460 470 480 490 500
LGIGFDVDYD FLKRLSNENR GIAQRIYGNR DTSSQLKKFY NQVSTPLLRN
510 520 530 540 550
VQFNYPQASV TDVTQNSFHN YFGGSEIVVA GKYDPSKLAE VQSIITATST
560 570 580 590 600
NTELVLETLS QMDDLEDFLS KDKHADPNFT KKLWAYLTIN QLLAERSLAP
610 620 630 640 650
TAAIKRKITK TILQMSLDHH IVTPLTAMVI ENEAGDERML ADSPPQDHSC
660 670 680 690 700
CSGALYYGTK VASASIPSWA SPSPTPVMAM LAVGANRLES TPPPHVIRVE
710 720 730 740 750
NDPHFIIYLP KSQKNICFNI DSEPGKILSL VSDPESGILV NGQLIGAKKA
760 770 780 790 800
ENGKLRTYFG KLGFYFQKED MKIEISTENI TLINGSSTTS LFWSDTAHLG
810 820 830 840 850
NQRVLISVKK GKSVTLTLNK EMFFSVLLHH VWKKHPVNVD FLGIYLPPTN
860 870 880 890 900
KFSPSAHGLL GQFMNKPNIH IFNERPGKDP EKPEASMEVK GHKLTVTRGL
910 920 930 940
QKDYRTDIAF GTDVPCWFVH NSGKGFIDGH YKDYLVPQLY SFLKRP
Length:946
Mass (Da):106,581
Last modified:May 1, 1997 - v1
Checksum:iCA8BF565458E7B2E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti510V → Y AA sequence (PubMed:8864857).Curated1
Sequence conflicti595E → I AA sequence (PubMed:8864857).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89286 mRNA Translation: BAA13939.1
PIRiJC5575
RefSeqiNP_001268591.1, NM_001281662.1

Genome annotation databases

GeneIDi101837243

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89286 mRNA Translation: BAA13939.1
PIRiJC5575
RefSeqiNP_001268591.1, NM_001281662.1

3D structure databases

ProteinModelPortaliP97279
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP97279

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101837243

Organism-specific databases

CTDi3698

Phylogenomic databases

HOVERGENiHBG057734
OrthoDBiEOG091G01HF

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR010600 ITI_HC_C
IPR013694 VIT
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF06668 ITI_HC_C, 1 hit
PF08487 VIT, 1 hit
PF00092 VWA, 1 hit
SMARTiView protein in SMART
SM00609 VIT, 1 hit
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS51468 VIT, 1 hit
PS50234 VWFA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiITIH2_MESAU
AccessioniPrimary (citable) accession number: P97279
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: October 25, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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