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Entry version 152 (13 Nov 2019)
Sequence version 2 (01 Aug 1998)
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Protein
Submitted name:

Crotonase/enoyl-CoA hydratase family protein

Gene

echA3

Organism
Mycobacterium tuberculosis
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyaseImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Crotonase/enoyl-CoA hydratase family proteinImported
Submitted name:
Enoyl-CoA hydrataseImported (EC:4.2.1.17Imported)
Submitted name:
Enoyl-coA hydratase homologImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:echA3Imported
ORF Names:DSI35_29360Imported, ERS007657_00900Imported, ERS007661_02140Imported, ERS007663_02226Imported, ERS007665_02614Imported, ERS007670_03220Imported, ERS007672_00578Imported, ERS007679_02442Imported, ERS007681_02414Imported, ERS007688_01951Imported, ERS007703_00864Imported, ERS007720_00743Imported, ERS007722_03326Imported, ERS007741_01193Imported, ERS023446_03043Imported, ERS024213_00694Imported, ERS024276_02425Imported, ERS027644_03488Imported, ERS027646_01620Imported, ERS027651_00445Imported, ERS027652_01958Imported, ERS027656_00425Imported, ERS027659_00137Imported, ERS027661_00216Imported, ERS031537_00908Imported, ERS124361_00834Imported, EZX46_18065Imported, FDK60_01930Imported, SAMEA2682835_04267Imported, SAMEA2682864_00814Imported, SAMEA2683035_02063Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1773 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000048948 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000256252 Componenti: Unassembled WGS sequence
  • UP000049498 Componenti: Unassembled WGS sequence
  • UP000298273 Componenti: Unassembled WGS sequence
  • UP000047075 Componenti: Unassembled WGS sequence
  • UP000298647 Componenti: Unassembled WGS sequence
  • UP000043293 Componenti: Unassembled WGS sequence
  • UP000049023 Componenti: Unassembled WGS sequence
  • UP000048600 Componenti: Unassembled WGS sequence
  • UP000183655 Componenti: Unassembled WGS sequence
  • UP000039953 Componenti: Unassembled WGS sequence
  • UP000305204 Componenti: Unassembled WGS sequence
  • UP000182946 Componenti: Unassembled WGS sequence
  • UP000049139 Componenti: Unassembled WGS sequence
  • UP000050143 Componenti: Unassembled WGS sequence
  • UP000050038 Componenti: Unassembled WGS sequence
  • UP000049058 Componenti: Unassembled WGS sequence
  • UP000050164 Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG1024 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000043437

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029045 ClpP/crotonase-like_dom_sf
IPR001753 Enoyl-CoA_hydra/iso

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00378 ECH_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52096 SSF52096, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P96907-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDPVSYTRK DSIAVISMDD GKVNALGPAM QQALNAAIDN ADRDDVGALV
60 70 80 90 100
ITGNGRVFSG GFDLKILTSG EVQPAIDMLR GGFELAYRLL SYPKPVVMAC
110 120 130 140 150
TGHAIAMGAF LLSCGDHRVA AHAYNIQANE VAIGMTIPYA ALEIMKLRLT
160 170 180 190 200
RSAYQQATGL AKTFFGETAL AAGFIDEIAL PEVVVSRAEE AAREFAGLNQ
210 220 230
HAHAATKLRS RADALTAIRA GIDGIAAEFG L
Length:231
Mass (Da):24,355
Last modified:August 1, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1AE1D51006CD0922
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U88877 Genomic DNA Translation: AAC15848.1
CFOE01000317 Genomic DNA Translation: CFE40188.1
CFOH01000287 Genomic DNA Translation: CFE51655.1
CGCX01000237 Genomic DNA Translation: CFR70556.1
CNDE01000112 Genomic DNA Translation: CKO59071.1
CNCN01000641 Genomic DNA Translation: CKP10639.1
CNFT01000015 Genomic DNA Translation: CKQ78858.1
CNFU01000021 Genomic DNA Translation: CKQ87600.1
CNFV01000036 Genomic DNA Translation: CKR01504.1
CIEA01000003 Genomic DNA Translation: CKR48822.1
CNFQ01000391 Genomic DNA Translation: CKR65024.1
CNGE01000247 Genomic DNA Translation: CKS30465.1
CNFW01000776 Genomic DNA Translation: CKS78101.1
CNIS01000097 Genomic DNA Translation: CKU61699.1
CHDS01000008 Genomic DNA Translation: CNG38495.1
CQGE01000081 Genomic DNA Translation: CNN34369.1
CQPV01000326 Genomic DNA Translation: CNV01275.1
CQPW01000576 Genomic DNA Translation: CNV31784.1
CQQC01000704 Genomic DNA Translation: CNV35207.1
CQPL01000840 Genomic DNA Translation: CNV41656.1
CHEE01000065 Genomic DNA Translation: COU88458.1
CSAE01000060 Genomic DNA Translation: COV22312.1
CSAJ01000059 Genomic DNA Translation: COV69504.1
CSAD01000337 Genomic DNA Translation: COV77753.1
CHKL01000094 Genomic DNA Translation: COW00783.1
CSAM01000322 Genomic DNA Translation: COW73073.1
QSXG01002186 Genomic DNA Translation: REM95595.1
FPPU01000019 Genomic DNA Translation: SGD58374.1
FPTZ01000012 Genomic DNA Translation: SGH80404.1
FPXX01000004 Genomic DNA Translation: SGL55972.1
SMOE01000098 Genomic DNA Translation: TFB18717.1
SZTS01000004 Genomic DNA Translation: TKR42044.1

Protein sequence database of the Protein Information Resource

More...
PIRi
E70612

NCBI Reference Sequences

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RefSeqi
WP_003403259.1, NZ_VOVY01000009.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AMC44950; AMC44950; RN05_0674
CFE40188; CFE40188; ERS007681_02414
CFE51655; CFE51655; ERS007688_01951
CFR70556; CFR70556; ERS007657_00900
CKO59071; CKO59071; ERS024213_00694
CKP10639; CKP10639; ERS024276_02425
CKQ78858; CKQ78858; ERS027659_00137
CKQ87600; CKQ87600; ERS027661_00216
CKR01504; CKR01504; ERS027656_00425
CKR65024; CKR65024; ERS027652_01958
CKS30465; CKS30465; ERS027646_01620
CKS78101; CKS78101; ERS027644_03488
CKU61699; CKU61699; ERS031537_00908
CNG38495; CNG38495; ERS124361_00834
CNN34369; CNN34369; ERS023446_03043
CNV01275; CNV01275; ERS007663_02226
CNV31784; CNV31784; ERS007665_02614
CNV35207; CNV35207; ERS007661_02140
CNV41656; CNV41656; ERS007670_03220
CNZ12841; CNZ12841; ERS013471_03607
COU88458; COU88458; ERS007672_00578
COV22312; COV22312; ERS007703_00864
COV69504; COV69504; ERS007720_00743
COV77753; COV77753; ERS007679_02442
COW00783; COW00783; ERS007741_01193
COW73073; COW73073; ERS007722_03326
CRH15305; CRH15305; BN1303_03080
CRH16313; CRH16313; BN1213_03749

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1773.206.peg.2858

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88877 Genomic DNA Translation: AAC15848.1
CFOE01000317 Genomic DNA Translation: CFE40188.1
CFOH01000287 Genomic DNA Translation: CFE51655.1
CGCX01000237 Genomic DNA Translation: CFR70556.1
CNDE01000112 Genomic DNA Translation: CKO59071.1
CNCN01000641 Genomic DNA Translation: CKP10639.1
CNFT01000015 Genomic DNA Translation: CKQ78858.1
CNFU01000021 Genomic DNA Translation: CKQ87600.1
CNFV01000036 Genomic DNA Translation: CKR01504.1
CIEA01000003 Genomic DNA Translation: CKR48822.1
CNFQ01000391 Genomic DNA Translation: CKR65024.1
CNGE01000247 Genomic DNA Translation: CKS30465.1
CNFW01000776 Genomic DNA Translation: CKS78101.1
CNIS01000097 Genomic DNA Translation: CKU61699.1
CHDS01000008 Genomic DNA Translation: CNG38495.1
CQGE01000081 Genomic DNA Translation: CNN34369.1
CQPV01000326 Genomic DNA Translation: CNV01275.1
CQPW01000576 Genomic DNA Translation: CNV31784.1
CQQC01000704 Genomic DNA Translation: CNV35207.1
CQPL01000840 Genomic DNA Translation: CNV41656.1
CHEE01000065 Genomic DNA Translation: COU88458.1
CSAE01000060 Genomic DNA Translation: COV22312.1
CSAJ01000059 Genomic DNA Translation: COV69504.1
CSAD01000337 Genomic DNA Translation: COV77753.1
CHKL01000094 Genomic DNA Translation: COW00783.1
CSAM01000322 Genomic DNA Translation: COW73073.1
QSXG01002186 Genomic DNA Translation: REM95595.1
FPPU01000019 Genomic DNA Translation: SGD58374.1
FPTZ01000012 Genomic DNA Translation: SGH80404.1
FPXX01000004 Genomic DNA Translation: SGL55972.1
SMOE01000098 Genomic DNA Translation: TFB18717.1
SZTS01000004 Genomic DNA Translation: TKR42044.1
PIRiE70612
RefSeqiWP_003403259.1, NZ_VOVY01000009.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4FN7X-ray1.25A/B/C1-231[»]
4FN8X-ray1.83A1-231[»]
4FNBX-ray1.80A1-231[»]
4FNDX-ray1.85A1-231[»]
4HC8X-ray2.51A/B1-231[»]
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...
PDBe-KBiSearch...

Genome annotation databases

EnsemblBacteriaiAMC44950; AMC44950; RN05_0674
CFE40188; CFE40188; ERS007681_02414
CFE51655; CFE51655; ERS007688_01951
CFR70556; CFR70556; ERS007657_00900
CKO59071; CKO59071; ERS024213_00694
CKP10639; CKP10639; ERS024276_02425
CKQ78858; CKQ78858; ERS027659_00137
CKQ87600; CKQ87600; ERS027661_00216
CKR01504; CKR01504; ERS027656_00425
CKR65024; CKR65024; ERS027652_01958
CKS30465; CKS30465; ERS027646_01620
CKS78101; CKS78101; ERS027644_03488
CKU61699; CKU61699; ERS031537_00908
CNG38495; CNG38495; ERS124361_00834
CNN34369; CNN34369; ERS023446_03043
CNV01275; CNV01275; ERS007663_02226
CNV31784; CNV31784; ERS007665_02614
CNV35207; CNV35207; ERS007661_02140
CNV41656; CNV41656; ERS007670_03220
CNZ12841; CNZ12841; ERS013471_03607
COU88458; COU88458; ERS007672_00578
COV22312; COV22312; ERS007703_00864
COV69504; COV69504; ERS007720_00743
COV77753; COV77753; ERS007679_02442
COW00783; COW00783; ERS007741_01193
COW73073; COW73073; ERS007722_03326
CRH15305; CRH15305; BN1303_03080
CRH16313; CRH16313; BN1213_03749
PATRICifig|1773.206.peg.2858

Phylogenomic databases

eggNOGiCOG1024 LUCA
HOGENOMiHOG000043437

Family and domain databases

InterProiView protein in InterPro
IPR029045 ClpP/crotonase-like_dom_sf
IPR001753 Enoyl-CoA_hydra/iso
PfamiView protein in Pfam
PF00378 ECH_1, 1 hit
SUPFAMiSSF52096 SSF52096, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP96907_MYCTX
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P96907
Secondary accession number(s): F2GMS9
, P96922, Q79FY2, Q7D9I3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: August 1, 1998
Last modified: November 13, 2019
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported
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