UniProtKB - P96847 (AVTA_MYCTU)
Protein
Valine--pyruvate aminotransferase
Gene
aspB
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
Catalytic activityi
- EC:2.6.1.661 Publication
Cofactori
pyridoxal 5'-phosphate1 Publication
GO - Molecular functioni
- pyridoxal phosphate binding Source: InterPro
- valine-pyruvate transaminase activity Source: UniProtKB-EC
GO - Biological processi
- biosynthetic process Source: InterPro
Keywordsi
Molecular function | Aminotransferase, Transferase |
Ligand | Pyridoxal phosphate |
Names & Taxonomyi
Protein namesi | Recommended name: Valine--pyruvate aminotransferaseCurated (EC:2.6.1.661 Publication)Alternative name(s): Alanine--valine transaminaseCurated |
Gene namesi | Name:aspB1 Publication Ordered Locus Names:Rv3565Imported |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv3565 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000450668 | 1 – 388 | Valine--pyruvate aminotransferaseAdd BLAST | 388 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 234 | N6-(pyridoxal phosphate)lysine1 Publication | 1 |
Proteomic databases
PaxDbi | P96847 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P96847 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.Curated
Phylogenomic databases
eggNOGi | COG0436, Bacteria |
OMAi | HVRFAYT |
Family and domain databases
Gene3Di | 3.40.640.10, 1 hit |
InterProi | View protein in InterPro IPR004839, Aminotransferase_I/II IPR004838, NHTrfase_class1_PyrdxlP-BS IPR015424, PyrdxlP-dep_Trfase IPR015421, PyrdxlP-dep_Trfase_major |
Pfami | View protein in Pfam PF00155, Aminotran_1_2, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
PROSITEi | View protein in PROSITE PS00105, AA_TRANSFER_CLASS_1, 1 hit |
i Sequence
Sequence statusi: Complete.
P96847-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTDRVALRAG VPPFYVMDVW LAAAERQRTH GDLVNLSAGQ PSAGAPEPVR
60 70 80 90 100
AAAAAALHLN QLGYSVALGI PELRDAIAAD YQRRHGITVE PDAVVITTGS
110 120 130 140 150
SGGFLLAFLA CFDAGDRVAM ASPGYPCYRN ILSALGCEVV EIPCGPQTRF
160 170 180 190 200
QPTAQMLAEI DPPLRGVVVA SPANPTGTVI PPEELAAIAS WCDASDVRLI
210 220 230 240 250
SDEVYHGLVY QGAPQTSCAW QTSRNAVVVN SFSKYYAMTG WRLGWLLVPT
260 270 280 290 300
VLRRAVDCLT GNFTICPPVL SQIAAVSAFT PEATAEADGN LASYAINRSL
310 320 330 340 350
LLDGLRRIGI DRLAPTDGAF YVYADVSDFT SDSLAFCSKL LADTGVAIAP
360 370 380
GIDFDTARGG SFVRISFAGP SGDIEEALRR IGSWLPSQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP46387.1 |
RefSeqi | NP_218082.1, NC_000962.3 WP_003419356.1, NZ_NVQJ01000014.1 |
Genome annotation databases
EnsemblBacteriai | AIR16355; AIR16355; LH57_19440 CCP46387; CCP46387; Rv3565 |
GeneIDi | 23490161 888305 |
KEGGi | mtu:Rv3565 mtv:RVBD_3565 |
PATRICi | fig|83332.111.peg.3970 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP46387.1 |
RefSeqi | NP_218082.1, NC_000962.3 WP_003419356.1, NZ_NVQJ01000014.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5YHV | X-ray | 2.70 | A/B/C/D | 1-388 | [»] | |
SMRi | P96847 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 83332.Rv3565 |
Proteomic databases
PaxDbi | P96847 |
Genome annotation databases
EnsemblBacteriai | AIR16355; AIR16355; LH57_19440 CCP46387; CCP46387; Rv3565 |
GeneIDi | 23490161 888305 |
KEGGi | mtu:Rv3565 mtv:RVBD_3565 |
PATRICi | fig|83332.111.peg.3970 |
Organism-specific databases
TubercuListi | Rv3565 |
Phylogenomic databases
eggNOGi | COG0436, Bacteria |
OMAi | HVRFAYT |
Family and domain databases
Gene3Di | 3.40.640.10, 1 hit |
InterProi | View protein in InterPro IPR004839, Aminotransferase_I/II IPR004838, NHTrfase_class1_PyrdxlP-BS IPR015424, PyrdxlP-dep_Trfase IPR015421, PyrdxlP-dep_Trfase_major |
Pfami | View protein in Pfam PF00155, Aminotran_1_2, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
PROSITEi | View protein in PROSITE PS00105, AA_TRANSFER_CLASS_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AVTA_MYCTU | |
Accessioni | P96847Primary (citable) accession number: P96847 Secondary accession number(s): F2GJR1, I6Y3W0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 12, 2020 |
Last sequence update: | July 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 133 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families