The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - P96692 (MHQN_BACSU)
Protein
Putative NAD(P)H nitroreductase MhqN
Gene
mhqN
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Putative nitroreductase that may contribute to the degradation of aromatic compounds.
CuratedCofactori
FMNBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 193 | FMN1 Publication | 1 | |
Binding sitei | 196 | FMN1 Publication | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 11 – 13 | FMN1 Publication | 3 | |
Nucleotide bindingi | 68 – 70 | FMN1 Publication | 3 | |
Nucleotide bindingi | 157 – 158 | FMN1 Publication | 2 |
GO - Molecular functioni
- oxidoreductase activity Source: GO_Central
GO - Biological processi
- aromatic compound catabolic process Source: UniProtKB-KW
- response to toxic substance Source: UniProtKB-KW
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Aromatic hydrocarbons catabolism, Detoxification |
Ligand | Flavoprotein, FMN, NAD, NADP |
Enzyme and pathway databases
BioCyci | BSUB:BSU05480-MONOMER |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:mhqN Synonyms:ydfN Ordered Locus Names:BSU05480 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 2 Publications
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000072717 | 1 – 206 | Putative NAD(P)H nitroreductase MhqNAdd BLAST | 206 |
Proteomic databases
PaxDbi | P96692 |
Expressioni
Inductioni
Repressed by MhqR. Strongly induced by stress due to exposure to 2-methylhydroquinone (2-MHQ) and less strongly induced after diamide or catechol stress. Not induced by oxidative stress due to hydrogen peroxide or methylglyoxal.2 Publications
Interactioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
STRINGi | 224308.BSU05480 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P96692 |
SMRi | P96692 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P96692 |
Family & Domainsi
Sequence similaritiesi
Belongs to the nitroreductase family.Curated
Phylogenomic databases
eggNOGi | COG0778, Bacteria |
InParanoidi | P96692 |
OMAi | AFNLQHT |
PhylomeDBi | P96692 |
Family and domain databases
Gene3Di | 3.40.109.10, 1 hit |
InterProi | View protein in InterPro IPR029479, Nitroreductase IPR000415, Nitroreductase-like |
Pfami | View protein in Pfam PF00881, Nitroreductase, 1 hit |
SUPFAMi | SSF55469, SSF55469, 1 hit |
i Sequence
Sequence statusi: Complete.
P96692-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEFTHLVNE RRSASNFLSG HPITKEDLNE MFELVALAPS AFNLQHTKYV
60 70 80 90 100
TVLDQDVKEK LKQAANGQYK VVSSSAVLLV LGDKQAYQQA ADIYEGLKVL
110 120 130 140 150
GILNKQEYDH MVQDTVSFYE NRGEQFKRDE AIRNASLSAM MFMLSAKEKG
160 170 180 190 200
WDTCPMIGFD AEAVKRILNI DDQFEVVMMI TIGKEKTESR RPRGYRKPVN
EFVEYM
Sequence cautioni
The sequence BAA19382 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB001488 Genomic DNA Translation: BAA19382.1 Different initiation. AL009126 Genomic DNA Translation: CAB12355.1 |
PIRi | D69781 |
RefSeqi | NP_388429.1, NC_000964.3 WP_003244392.1, NZ_JNCM01000031.1 |
Genome annotation databases
EnsemblBacteriai | CAB12355; CAB12355; BSU_05480 |
GeneIDi | 939899 |
KEGGi | bsu:BSU05480 |
PATRICi | fig|224308.179.peg.588 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB001488 Genomic DNA Translation: BAA19382.1 Different initiation. AL009126 Genomic DNA Translation: CAB12355.1 |
PIRi | D69781 |
RefSeqi | NP_388429.1, NC_000964.3 WP_003244392.1, NZ_JNCM01000031.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3BEM | X-ray | 1.65 | A/B | 1-206 | [»] | |
AlphaFoldDBi | P96692 | |||||
SMRi | P96692 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 224308.BSU05480 |
Proteomic databases
PaxDbi | P96692 |
Genome annotation databases
EnsemblBacteriai | CAB12355; CAB12355; BSU_05480 |
GeneIDi | 939899 |
KEGGi | bsu:BSU05480 |
PATRICi | fig|224308.179.peg.588 |
Phylogenomic databases
eggNOGi | COG0778, Bacteria |
InParanoidi | P96692 |
OMAi | AFNLQHT |
PhylomeDBi | P96692 |
Enzyme and pathway databases
BioCyci | BSUB:BSU05480-MONOMER |
Miscellaneous databases
EvolutionaryTracei | P96692 |
Family and domain databases
Gene3Di | 3.40.109.10, 1 hit |
InterProi | View protein in InterPro IPR029479, Nitroreductase IPR000415, Nitroreductase-like |
Pfami | View protein in Pfam PF00881, Nitroreductase, 1 hit |
SUPFAMi | SSF55469, SSF55469, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MHQN_BACSU | |
Accessioni | P96692Primary (citable) accession number: P96692 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | July 15, 1999 | |
Last modified: | May 25, 2022 | |
This is version 115 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families