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Protein

Holo-[acyl-carrier-protein] synthase

Gene

acpS

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of fatty acid acyl-carrier-protein ACP. Also modifies the D-alanyl carrier protein but fails to recognize PCP and AcpK, an acyl carrier protein of secondary metabolism.1 Publication

Catalytic activityi

CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein].UniRule annotation1 Publication

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi8Magnesium1
Metal bindingi58Magnesium1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciBSUB:BSU04620-MONOMER
SABIO-RKiP96618

Names & Taxonomyi

Protein namesi
Recommended name:
Holo-[acyl-carrier-protein] synthaseUniRule annotation (EC:2.7.8.7UniRule annotation)
Short name:
Holo-ACP synthaseUniRule annotation
Alternative name(s):
4'-phosphopantetheinyl transferase AcpSUniRule annotation
Gene namesi
Name:acpSUniRule annotation
Synonyms:ydcB
Ordered Locus Names:BSU04620
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2I → A: 6% of wild-type activity. 1 Publication1
Mutagenesisi5I → R: Loss of activity; no trimer formation. 1 Publication1
Mutagenesisi113Q → E: 14% of wild-type activity. 1 Publication1
Mutagenesisi113Q → R: Loss of activity; no trimer formation. 1 Publication1

Chemistry databases

ChEMBLiCHEMBL4734
DrugBankiDB01992 Coenzyme A

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001756131 – 121Holo-[acyl-carrier-protein] synthaseAdd BLAST121

Proteomic databases

PaxDbiP96618
PRIDEiP96618

Interactioni

Subunit structurei

Homotrimer.1 Publication

Protein-protein interaction databases

IntActiP96618, 1 interactor
STRINGi224308.Bsubs1_010100002618

Chemistry databases

BindingDBiP96618

Structurei

Secondary structure

1121
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP96618
SMRiP96618
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP96618

Family & Domainsi

Sequence similaritiesi

Belongs to the P-Pant transferase superfamily. AcpS family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41082V8 Bacteria
COG0736 LUCA
HOGENOMiHOG000014315
InParanoidiP96618
KOiK00997
OMAiDERHYAV
PhylomeDBiP96618

Family and domain databases

Gene3Di3.90.470.20, 1 hit
HAMAPiMF_00101 AcpS, 1 hit
InterProiView protein in InterPro
IPR008278 4-PPantetheinyl_Trfase_dom
IPR037143 4-PPantetheinyl_Trfase_dom_sf
IPR002582 ACPS
IPR004568 Ppantetheine-prot_Trfase_dom
PANTHERiPTHR45198 PTHR45198, 1 hit
PfamiView protein in Pfam
PF01648 ACPS, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD004282 PPantethiene-prot_Trfase, 1 hit
SUPFAMiSSF56214 SSF56214, 1 hit
TIGRFAMsiTIGR00516 acpS, 1 hit
TIGR00556 pantethn_trn, 1 hit

Sequencei

Sequence statusi: Complete.

P96618-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIYGIGLDIT ELKRIASMAG RQKRFAERIL TRSELDQYYE LSEKRKNEFL
60 70 80 90 100
AGRFAAKEAF SKAFGTGIGR QLSFQDIEIR KDQNGKPYII CTKLSQAAVH
110 120
VSITHTKEYA AAQVVIERLS S
Length:121
Mass (Da):13,718
Last modified:May 1, 1997 - v1
Checksum:i6C10401DA7116701
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001488 Genomic DNA Translation: BAA19299.1
AL009126 Genomic DNA Translation: CAB12269.1
PIRiH69772
RefSeqiNP_388343.1, NC_000964.3
WP_003234281.1, NZ_JNCM01000031.1

Genome annotation databases

EnsemblBacteriaiCAB12269; CAB12269; BSU04620
GeneIDi938194
KEGGibsu:BSU04620
PATRICifig|224308.179.peg.490

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001488 Genomic DNA Translation: BAA19299.1
AL009126 Genomic DNA Translation: CAB12269.1
PIRiH69772
RefSeqiNP_388343.1, NC_000964.3
WP_003234281.1, NZ_JNCM01000031.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F7LX-ray1.50A1-121[»]
1F7TX-ray1.80A/B/C/D/E/F2-121[»]
1F80X-ray2.30A/B/C2-121[»]
ProteinModelPortaliP96618
SMRiP96618
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP96618, 1 interactor
STRINGi224308.Bsubs1_010100002618

Chemistry databases

BindingDBiP96618
ChEMBLiCHEMBL4734
DrugBankiDB01992 Coenzyme A

Proteomic databases

PaxDbiP96618
PRIDEiP96618

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB12269; CAB12269; BSU04620
GeneIDi938194
KEGGibsu:BSU04620
PATRICifig|224308.179.peg.490

Phylogenomic databases

eggNOGiENOG41082V8 Bacteria
COG0736 LUCA
HOGENOMiHOG000014315
InParanoidiP96618
KOiK00997
OMAiDERHYAV
PhylomeDBiP96618

Enzyme and pathway databases

BioCyciBSUB:BSU04620-MONOMER
SABIO-RKiP96618

Miscellaneous databases

EvolutionaryTraceiP96618

Family and domain databases

Gene3Di3.90.470.20, 1 hit
HAMAPiMF_00101 AcpS, 1 hit
InterProiView protein in InterPro
IPR008278 4-PPantetheinyl_Trfase_dom
IPR037143 4-PPantetheinyl_Trfase_dom_sf
IPR002582 ACPS
IPR004568 Ppantetheine-prot_Trfase_dom
PANTHERiPTHR45198 PTHR45198, 1 hit
PfamiView protein in Pfam
PF01648 ACPS, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD004282 PPantethiene-prot_Trfase, 1 hit
SUPFAMiSSF56214 SSF56214, 1 hit
TIGRFAMsiTIGR00516 acpS, 1 hit
TIGR00556 pantethn_trn, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACPS_BACSU
AccessioniPrimary (citable) accession number: P96618
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1997
Last modified: October 10, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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