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Entry version 129 (12 Aug 2020)
Sequence version 1 (01 May 1997)
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Protein

Transcriptional regulator MtlR

Gene

mtlR

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Positively regulates the expression of the mtlAFD operon involved in the uptake and catabolism of mannitol.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

The regulatory activity of MtlR is modulated by phosphorylation and dephosphorylation of the various MtlR domains. It becomes activated via phosphoryl group transfer from PEP, EI and HPr on the two conserved histidine residues in the PRD 2 domain, whereas phosphorylation of the EIIA-like domain on His-599 by the PTS EIIB-Mtl domain of MtlA inactivates MtlR (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Kinase, Transferase
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
BSUB:BSU04160-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcriptional regulator MtlR
Alternative name(s):
Mannitol operon transcriptional activator
Short name:
Mtl operon transcriptional activator
Including the following 2 domains:
Putative phosphotransferase enzyme IIB component (EC:2.7.1.197)
Alternative name(s):
Putative PTS system EIIB component
Putative phosphotransferase enzyme IIA component
Alternative name(s):
Putative PTS system EIIA component
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mtlR
Synonyms:ydaA
Ordered Locus Names:BSU04160
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacillus subtilis (strain 168)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri224308 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001570 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Cells lacking this gene cannot grow on either mannitol or glucitol as sole carbon source.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003760811 – 694Transcriptional regulator MtlRAdd BLAST694

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei230Phosphohistidine; by HPrPROSITE-ProRule annotation1
Modified residuei289Phosphohistidine; by HPrPROSITE-ProRule annotation1
Modified residuei342Phosphohistidine; by HPrPROSITE-ProRule annotation1
Modified residuei399Phosphohistidine; by HPrPROSITE-ProRule annotation1
Modified residuei419Phosphocysteine; by EIIASequence analysis1
Modified residuei599Phosphohistidine; by EIIBPROSITE-ProRule annotation1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P96574

PRoteomics IDEntifications database

More...
PRIDEi
P96574

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by mannitol or glucitol.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
224308.BSU04160

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P96574

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini195 – 300PRD 1PROSITE-ProRule annotationAdd BLAST106
Domaini305 – 410PRD 2PROSITE-ProRule annotationAdd BLAST106
Domaini413 – 502PTS EIIB type-2PROSITE-ProRule annotationAdd BLAST90
Domaini536 – 683PTS EIIA type-2PROSITE-ProRule annotationAdd BLAST148

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG3711, Bacteria

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P96574

KEGG Orthology (KO)

More...
KOi
K03483

Identification of Orthologs from Complete Genome Data

More...
OMAi
YMTAREQ

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P96574

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 2 hits
3.40.930.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013196, HTH_11
IPR007737, Mga_HTH
IPR011608, PRD
IPR036634, PRD_sf
IPR016152, PTrfase/Anion_transptr
IPR002178, PTS_EIIA_type-2_dom
IPR036095, PTS_EIIB-like_sf
IPR013011, PTS_EIIB_2
IPR003501, PTS_EIIB_2/3
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08279, HTH_11, 1 hit
PF05043, Mga, 1 hit
PF00874, PRD, 2 hits
PF00359, PTS_EIIA_2, 1 hit
PF02302, PTS_IIB, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785, SSF46785, 2 hits
SSF52794, SSF52794, 1 hit
SSF55804, SSF55804, 1 hit
SSF63520, SSF63520, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51372, PRD_2, 2 hits
PS51094, PTS_EIIA_TYPE_2, 1 hit
PS51099, PTS_EIIB_TYPE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P96574-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYMTAREQKL LKHLLLQNRY ITVTELAELM QVSTRTIHRE LKSIKPLMET
60 70 80 90 100
VGLTLDKQPG KGLKAVGSPE GKQKLLTDLS YEQHEYSADE RKLLILCSLL
110 120 130 140 150
ESQEPVKLYT LAHDLQVTNA TVSYDLDELE KWISPFGLTL IRKRGFGIQL
160 170 180 190 200
IGPENAKRKI VGNLIVNRLD IQMFLEAVEL NIKGKTDSSE KMFGVVSKGE
210 220 230 240 250
LLKMERILFQ LKEKIAFSLS DSSYIALVVH LTYAIERIKL GETITMEQNE
260 270 280 290 300
LEELMNAKEY SSALEIAGEL ERAFGVTIPE AEVGYITIHL RSANRKYKTE
310 320 330 340 350
YKAQEIELET ALQTKRLIAF ISDKIRMDLT KNYSLYEGLI AHLEPAVSRI
360 370 380 390 400
KENIEIYNPM KEQIKRDYFL LYMAIEEGVE KYFPGMSFSD DEIAFIVLHF
410 420 430 440 450
GSALEIKKEE AKVKALVVCS SGIGSSKMLA SRLKKELPEI ESFDMSSLIE
460 470 480 490 500
LKGKDVQAYD MIVSTVPIPY ENIDYIMVSP LLNEEDANQV KQYIKRKIPL
510 520 530 540 550
ILNKKRSSKE EAQQADVPDM LEAAESIGRY MEVIQDVLRH FTLAQLKTNP
560 570 580 590 600
DHSMLLLELF QQLKKDGLIR DPEKAAVCLA EREKQGGLGI PGTNMALYHL
610 620 630 640 650
KNDEIVLPFF KMFDLSTPYE VDGMDGNTLR MTRILVMMAP GSLSAEGSEI
660 670 680 690
LSAISSAIIE SGESMAGFQE EGGQELYQRL NRIFFTWMKE KNIL
Length:694
Mass (Da):78,853
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i540D906A19318343
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB001488 Genomic DNA Translation: BAA19254.1
AL009126 Genomic DNA Translation: CAB12223.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A69768

NCBI Reference Sequences

More...
RefSeqi
NP_388297.1, NC_000964.3
WP_003246695.1, NZ_JNCM01000031.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CAB12223; CAB12223; BSU04160

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
938253

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bsu:BSU04160

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|224308.179.peg.442

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001488 Genomic DNA Translation: BAA19254.1
AL009126 Genomic DNA Translation: CAB12223.1
PIRiA69768
RefSeqiNP_388297.1, NC_000964.3
WP_003246695.1, NZ_JNCM01000031.1

3D structure databases

SMRiP96574
ModBaseiSearch...

Protein-protein interaction databases

STRINGi224308.BSU04160

Proteomic databases

PaxDbiP96574
PRIDEiP96574

Genome annotation databases

EnsemblBacteriaiCAB12223; CAB12223; BSU04160
GeneIDi938253
KEGGibsu:BSU04160
PATRICifig|224308.179.peg.442

Phylogenomic databases

eggNOGiCOG3711, Bacteria
InParanoidiP96574
KOiK03483
OMAiYMTAREQ
PhylomeDBiP96574

Enzyme and pathway databases

BioCyciBSUB:BSU04160-MONOMER

Family and domain databases

Gene3Di1.10.10.10, 2 hits
3.40.930.10, 1 hit
InterProiView protein in InterPro
IPR013196, HTH_11
IPR007737, Mga_HTH
IPR011608, PRD
IPR036634, PRD_sf
IPR016152, PTrfase/Anion_transptr
IPR002178, PTS_EIIA_type-2_dom
IPR036095, PTS_EIIB-like_sf
IPR013011, PTS_EIIB_2
IPR003501, PTS_EIIB_2/3
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
PfamiView protein in Pfam
PF08279, HTH_11, 1 hit
PF05043, Mga, 1 hit
PF00874, PRD, 2 hits
PF00359, PTS_EIIA_2, 1 hit
PF02302, PTS_IIB, 1 hit
SUPFAMiSSF46785, SSF46785, 2 hits
SSF52794, SSF52794, 1 hit
SSF55804, SSF55804, 1 hit
SSF63520, SSF63520, 2 hits
PROSITEiView protein in PROSITE
PS51372, PRD_2, 2 hits
PS51094, PTS_EIIA_TYPE_2, 1 hit
PS51099, PTS_EIIB_TYPE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMTLR_BACSU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P96574
Secondary accession number(s): Q797N1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: May 1, 1997
Last modified: August 12, 2020
This is version 129 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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