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UniProtKB - P96284 (PKS15_MYCTU)
Protein
Putative inactive phenolphthiocerol synthesis polyketide synthase type I Pks15
Gene
pks15
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
Caution
M.bovis (strains ATCC BAA-935 / AF2122/97 and BCG / Pasteur 1173P2) and M.marinum (strain ATCC BAA-535 / M) have a single fused pks15/1 ORF, but M.tuberculosis (strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh) have 2 separate ORFs. This is due to the natural deletion of a single base, a guanine, that causes a frameshift and thus the two ORFs, pks15 and pks1, instead of pks15/1. This frameshift led to the inactivation of Pks15/1, which in turn caused the inability of these strains to elongate the putative p-hydroxybenzoic acid precursor and thus to produce phenolphthiocerol derivatives.Curated
GO - Molecular functioni
- 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: InterPro
GO - Biological processi
- fatty acid biosynthetic process Source: InterPro
- glycolipid biosynthetic process Source: MTBBASE
Enzyme and pathway databases
BRENDAi | 2.3.1.261, 3445 |
Names & Taxonomyi
Protein namesi | Recommended name: Putative inactive phenolphthiocerol synthesis polyketide synthase type I Pks15 |
Gene namesi | Name:pks15 Ordered Locus Names:Rv2947c |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv2947c |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000406363 | 1 – 496 | Putative inactive phenolphthiocerol synthesis polyketide synthase type I Pks15Add BLAST | 496 |
Proteomic databases
PaxDbi | P96284 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 42 – 471 | Beta-ketoacyl synthaseBy similarityAdd BLAST | 430 | |
Regioni | 474 – 496 | DisorderedSequence analysisAdd BLAST | 23 |
Phylogenomic databases
eggNOGi | COG3321, Bacteria |
InParanoidi | P96284 |
OMAi | MLNDKDF |
PhylomeDBi | P96284 |
Family and domain databases
Gene3Di | 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR032821, PKS_assoc IPR020841, PKS_Beta-ketoAc_synthase_dom IPR036299, Polyketide_synth_docking_sf IPR016039, Thiolase-like |
Pfami | View protein in Pfam PF16197, KAsynt_C_assoc, 1 hit PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit |
SMARTi | View protein in SMART SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF101173, SSF101173, 1 hit SSF53901, SSF53901, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit |
i Sequence
Sequence statusi: Complete.
P96284-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIEEQRTMSV EGADQQSEKL FHYLKKVAVE LDETRARLRE YEQRATEPVA
60 70 80 90 100
VVGIGCRFPG GVDGPDGLWD VVSAGRDVVS EFPTDRGWDV EGLYDPDPDA
110 120 130 140 150
EGKTYTRWGA FLDDATGFDA GFFGIAPSEV LAMDPQQRLM LEVSWEALEH
160 170 180 190 200
AGIDPLSLRG SATGVYTGIF AASYGNRDTG GLQGYGLTGT SISVASGRVS
210 220 230 240 250
YVLGLQGPAV SVDTACSSSL VAIHWAMSSL RSGECDLALA GGVTVMGLPS
260 270 280 290 300
IFVGFSRQRG LAADGRCKAF AAAADGTGWG EGAGVVVLER LSDARRLGHS
310 320 330 340 350
VLAVVRGSAV NQDGASNGLT APNGLAQQRV IQVALANAGL SAADVDVVEA
360 370 380 390 400
HGTATTLGDP IEAQALLSTY GQGGPAEQPL WVGSIKSNMG HTQAAAGVAG
410 420 430 440 450
VIKMVQAMRH GVMPATLHVD EPSPRVDWTS GAVSVLTEAR EWSVDGRPRR
460 470 480 490
AAVSSFGISG TNAHLILEEA PVPAPAEAPV EASESTGGRG RRWCRG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP45751.1 |
PIRi | H70668 |
RefSeqi | NP_217463.1, NC_000962.3 WP_009936729.1, NC_000962.3 |
Genome annotation databases
GeneIDi | 887291 |
KEGGi | mtu:Rv2947c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP45751.1 |
PIRi | H70668 |
RefSeqi | NP_217463.1, NC_000962.3 WP_009936729.1, NC_000962.3 |
3D structure databases
AlphaFoldDBi | P96284 |
SMRi | P96284 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 83332.Rv2947c |
Proteomic databases
PaxDbi | P96284 |
Protocols and materials databases
DNASUi | 887291 |
Genome annotation databases
GeneIDi | 887291 |
KEGGi | mtu:Rv2947c |
Organism-specific databases
TubercuListi | Rv2947c |
Phylogenomic databases
eggNOGi | COG3321, Bacteria |
InParanoidi | P96284 |
OMAi | MLNDKDF |
PhylomeDBi | P96284 |
Enzyme and pathway databases
BRENDAi | 2.3.1.261, 3445 |
Family and domain databases
Gene3Di | 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR032821, PKS_assoc IPR020841, PKS_Beta-ketoAc_synthase_dom IPR036299, Polyketide_synth_docking_sf IPR016039, Thiolase-like |
Pfami | View protein in Pfam PF16197, KAsynt_C_assoc, 1 hit PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit |
SMARTi | View protein in SMART SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF101173, SSF101173, 1 hit SSF53901, SSF53901, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PKS15_MYCTU | |
Accessioni | P96284Primary (citable) accession number: P96284 Secondary accession number(s): L0TBC2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 5, 2011 |
Last sequence update: | July 1, 1997 | |
Last modified: | May 25, 2022 | |
This is version 128 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |