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Entry version 123 (11 Dec 2019)
Sequence version 2 (01 Jun 2001)
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Protein

Valine--tRNA ligase

Gene

valS

Organism
Thermus thermophilus
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+Note: Binds 2 Zn2+ ions per subunit.

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.7 µM for tRNA(Val)1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei50Val-AMP intermediate adenyl group1
    Binding sitei53Val-AMP intermediate phosphate group1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi176Zinc 11
    Metal bindingi179Zinc 11
    Metal bindingi344Zinc 11
    Metal bindingi347Zinc 11
    Metal bindingi417Zinc 21
    Metal bindingi420Zinc 21
    Metal bindingi438Zinc 21
    Metal bindingi441Zinc 21
    Binding sitei531ATPBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionAminoacyl-tRNA synthetase, Ligase
    Biological processProtein biosynthesis
    LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    6.1.1.9 2305

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Valine--tRNA ligase (EC:6.1.1.9)
    Alternative name(s):
    Valyl-tRNA synthetase
    Short name:
    ValRS
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:valS
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiThermus thermophilus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri274 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    GO - Cellular componenti

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi216R → A: Decrease in posttransfer editing activity. No change in aminoacylation activity. 1 Publication1
    Mutagenesisi264F → A: Decrease in posttransfer editing activity. No change in aminoacylation activity. 1 Publication1
    Mutagenesisi270K → A: Strong decrease in posttransfer editing activity. Slight decrease in Val-tRNA(Val) formation, which could be due to deacylation of the synthesized Val-tRNA(Val). 1 Publication1
    Mutagenesisi272T → A: Decrease in posttransfer editing activity. No change in aminoacylation activity. 1 Publication1
    Mutagenesisi276D → A: No change in aminoacylation and posttransfer editing activities. 1 Publication1
    Mutagenesisi279D → A: Strong decrease in posttransfer editing activity. No change in aminoacylation activity. 1 Publication1
    Mutagenesisi818R → A: Increase in Km for tRNA(Val), without change in Kcat; when associated with A-843. 1 Publication1
    Mutagenesisi843R → A: Increase in Km for tRNA(Val), without change in Kcat; when associated with A-818. 1 Publication1

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001062401 – 862Valine--tRNA ligaseAdd BLAST862

    Proteomic databases

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P96142

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Monomer.

    3 Publications

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei81Interaction with valine in the Val-AMP intermediate1
    Sitei570Interaction with tRNA1

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1862
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P96142

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    P96142

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni41 – 53Interaction with valine in the Val-AMP intermediateAdd BLAST13
    Regioni261 – 279Interaction with the Thr-AMP intermediateAdd BLAST19
    Regioni487 – 491Interaction with AMP in the Val-AMP intermediate5
    Regioni518 – 521Interaction with AMP in the Val-AMP intermediate4
    Regioni576 – 587Interaction with tRNAAdd BLAST12
    Regioni646 – 651Interaction with tRNA6
    Regioni815 – 847Interaction with tRNAAdd BLAST33

    Coiled coil

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili802 – 862Sequence analysisAdd BLAST61

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi44 – 53'HIGH' region10
    Motifi528 – 532'KMSKS' region5

    <p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.
    The C-terminal coiled-coil domain is crucial for aminoacylation activity.

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG4105CA4 Bacteria
    COG0525 LUCA

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd07962 Anticodon_Ia_Val, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.10.287.380, 1 hit
    3.40.50.620, 1 hit
    3.90.740.10, 1 hit

    HAMAP database of protein families

    More...
    HAMAPi
    MF_02004 Val_tRNA_synth_type1, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR001412 aa-tRNA-synth_I_CS
    IPR002300 aa-tRNA-synth_Ia
    IPR033705 Anticodon_Ia_Val
    IPR013155 M/V/L/I-tRNA-synth_anticd-bd
    IPR014729 Rossmann-like_a/b/a_fold
    IPR010978 tRNA-bd_arm
    IPR009080 tRNAsynth_Ia_anticodon-bd
    IPR037118 Val-tRNA_synth_C_sf
    IPR019499 Val-tRNA_synth_tRNA-bd
    IPR009008 Val/Leu/Ile-tRNA-synth_edit
    IPR002303 Valyl-tRNA_ligase

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF08264 Anticodon_1, 1 hit
    PF00133 tRNA-synt_1, 1 hit
    PF10458 Val_tRNA-synt_C, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00986 TRNASYNTHVAL

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF46589 SSF46589, 1 hit
    SSF47323 SSF47323, 1 hit
    SSF50677 SSF50677, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00422 valS, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00178 AA_TRNA_LIGASE_I, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    P96142-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MDLPKAYDPK SVEPKWAEKW AKNPFVANPK SGKPPFVIFM PPPNVTGSLH
    60 70 80 90 100
    MGHALDNSLQ DALIRYKRMR GFEAVWLPGT DHAGIATQVV VERLLLKEGK
    110 120 130 140 150
    TRHDLGREKF LERVWQWKEE SGGTILKQLK RLGASADWSR EAFTMDEKRS
    160 170 180 190 200
    RAVRYAFSRY YHEGLAYRAP RLVNWCPRCE TTLSDLEVET EPTPGKLYTL
    210 220 230 240 250
    RYEVEGGGFI EIATVRPETV FADQAIAVHP EDERYRHLLG KRARIPLTEV
    260 270 280 290 300
    WIPILADPAV EKDFGTGALK VTPAHDPLDY EIGERHGLKP VSVINLEGRM
    310 320 330 340 350
    EGERVPEALR GLDRFEARRK AVELFREAGH LVKEEDYTIA LATCSRCGTP
    360 370 380 390 400
    IEYAIFPQWW LRMRPLAEEV LKGLRRGDIA FVPERWKKVN MDWLENVKDW
    410 420 430 440 450
    NISRQLWWGH QIPAWYCEDC QAVNVPRPER YLEDPTSCEA CGSPRLKRDE
    460 470 480 490 500
    DVFDTWFSSA LWPLSTLGWP EETEDLKAFY PGDVLVTGYD ILFLWVSRME
    510 520 530 540 550
    VSGYHFMGER PFKTVLLHGL VLDEKGQKMS KSKGNVIDPL EMVERYGADA
    560 570 580 590 600
    LRFALIYLAT GGQDIRLDLR WLEMARNFAN KLYNAARFVL LSREGFQAKE
    610 620 630 640 650
    DTPTLADRFM RSRLSRGVEE ITALYEALDL AQAAREVYEL VWSEFCDWYL
    660 670 680 690 700
    EAAKPALKAG NAHTLRTLEE VLAVLLKLLH PMMPFLTSEL YQALTGKEEL
    710 720 730 740 750
    ALEAWPEPGG RDEEAERAFE ALKQAVTAVR ALKAEAGLPP AQEVRVYLEG
    760 770 780 790 800
    ETAPVEENLE VFRFLSRADL LPERPAKALV KAMPRVTARM PLEGLLDVEE
    810 820 830 840 850
    WRRRQEKRLK ELLALAERSQ RKLASPGFRE KAPKEVVEAE EARLKENLEQ
    860
    AERIREALSQ IG
    Length:862
    Mass (Da):98,775
    Last modified:June 1, 2001 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i90504DC65780942F
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AB080140 Genomic DNA Translation: BAB85225.1

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB080140 Genomic DNA Translation: BAB85225.1

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1GAXX-ray2.90A/B1-862[»]
    1IVSX-ray2.90A/B1-862[»]
    1IYWX-ray4.00A/B1-862[»]
    1WK9X-ray1.75A193-337[»]
    1WKAX-ray1.70A193-338[»]
    SMRiP96142
    ModBaseiSearch...
    PDBe-KBiSearch...

    Proteomic databases

    PRIDEiP96142

    Phylogenomic databases

    eggNOGiENOG4105CA4 Bacteria
    COG0525 LUCA

    Enzyme and pathway databases

    BRENDAi6.1.1.9 2305

    Miscellaneous databases

    EvolutionaryTraceiP96142

    Family and domain databases

    CDDicd07962 Anticodon_Ia_Val, 1 hit
    Gene3Di1.10.287.380, 1 hit
    3.40.50.620, 1 hit
    3.90.740.10, 1 hit
    HAMAPiMF_02004 Val_tRNA_synth_type1, 1 hit
    InterProiView protein in InterPro
    IPR001412 aa-tRNA-synth_I_CS
    IPR002300 aa-tRNA-synth_Ia
    IPR033705 Anticodon_Ia_Val
    IPR013155 M/V/L/I-tRNA-synth_anticd-bd
    IPR014729 Rossmann-like_a/b/a_fold
    IPR010978 tRNA-bd_arm
    IPR009080 tRNAsynth_Ia_anticodon-bd
    IPR037118 Val-tRNA_synth_C_sf
    IPR019499 Val-tRNA_synth_tRNA-bd
    IPR009008 Val/Leu/Ile-tRNA-synth_edit
    IPR002303 Valyl-tRNA_ligase
    PfamiView protein in Pfam
    PF08264 Anticodon_1, 1 hit
    PF00133 tRNA-synt_1, 1 hit
    PF10458 Val_tRNA-synt_C, 1 hit
    PRINTSiPR00986 TRNASYNTHVAL
    SUPFAMiSSF46589 SSF46589, 1 hit
    SSF47323 SSF47323, 1 hit
    SSF50677 SSF50677, 1 hit
    TIGRFAMsiTIGR00422 valS, 1 hit
    PROSITEiView protein in PROSITE
    PS00178 AA_TRNA_LIGASE_I, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYV_THETH
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P96142
    Secondary accession number(s): Q54A82
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: June 1, 2001
    Last modified: December 11, 2019
    This is version 123 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
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