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UniProtKB - P96128 (DER_TREPA)

Entry version 129 (02 Dec 2020)
Sequence version 1 (01 May 1997)
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Protein

GTPase Der

Gene

der

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GTPase that plays an essential role in the late steps of ribosome biogenesis.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi27 – 34GTP 1UniRule annotation8
Nucleotide bindingi74 – 78GTP 1UniRule annotation5
Nucleotide bindingi141 – 144GTP 1UniRule annotation4
Nucleotide bindingi204 – 211GTP 2UniRule annotation8
Nucleotide bindingi251 – 255GTP 2UniRule annotation5
Nucleotide bindingi316 – 319GTP 2UniRule annotation4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processRibosome biogenesis
LigandGTP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GTPase DerUniRule annotation
Alternative name(s):
GTP-binding protein EngAUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:derUniRule annotation
Synonyms:engA
Ordered Locus Names:TP_0689
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTreponema pallidum (strain Nichols)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri243276 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Treponema ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000811 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001790661 – 460GTPase DerAdd BLAST460

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with the 50S ribosomal subunit.

UniRule annotation

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		243276.TPANIC_0689

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P96128

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 187EngA-type G 1Add BLAST167
Domaini198 – 373EngA-type G 2Add BLAST176
Domaini374 – 457KH-likeUniRule annotationAdd BLAST84

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG1160, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_016077_6_1_12

Identification of Orthologs from Complete Genome Data

More...OMAi		GVTEQDQ

Database of Orthologous Groups

More...OrthoDBi		263682at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.300.20, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_00195, GTPase_Der, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR031166, G_ENGA
IPR016484, GTP-bd_EngA
IPR006073, GTP_binding_domain
IPR032859, KH_dom-like
IPR015946, KH_dom-like_a/b
IPR027417, P-loop_NTPase
IPR005225, Small_GTP-bd_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14714, KH_dom-like, 1 hit
PF01926, MMR_HSR1, 2 hits

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF006485, GTP-binding_EngA, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00326, GTP1OBG

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 2 hits

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR03594, GTPase_EngA, 1 hit
TIGR00231, small_GTP, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51712, G_ENGA, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P96128-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKGQDVILCD GGRHFSYKVL PRVVIVGRPN VGKSTLFNRL LGRRRSITSN 
        60         70         80         90        100
TSGVTRDSIE ETVILRGFPL RLVDTSGFTV FSEKKASRQH IDTLVLEQTY 
       110        120        130        140        150
KSIQCADKIL LVLDGTCESA EDEEVIQYLR PYWGKLIAAV NKTEGGEEVH 
       160        170        180        190        200
YNYARYGFST LICVSAEHGR NIDALERAII QNLFSVDERR ELPKDDVVRL 
       210        220        230        240        250
AIVGKPNTGK STLMNYLMRR TVSLVCDRAG TTRDVVTGHV EFKQYKFIIA 
       260        270        280        290        300
DTAGIRKRQK VYESIEYYSV IRAISILNAV DIVLYIVDAR DGFSEQDKKI 
       310        320        330        340        350
VSQISKRNLG VIFLLNKWDL LEGSTSLIAK KKRDVRTAFG KMNFVPVVPV 
       360        370        380        390        400
SAKTGHGISD ALHCVCKIFA QLNTKVETSA LNTALKDWVT SYPPPRKYGH 
       410        420        430        440        450
VSLKYLVQVS VRPIEFLLFA NRPDRIPENY VRFLQNRIRE DLGLDSIPVK 
       460
LTIRKNCRKR
Length:460
Mass (Da):52,121
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA2E191853D520A78
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U70661 Genomic DNA Translation: AAB38705.1
AE000520 Genomic DNA Translation: AAC65658.1

Protein sequence database of the Protein Information Resource

More...PIRi		F71292

NCBI Reference Sequences

More...RefSeqi		WP_010882134.1, NC_021490.2

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC65658; AAC65658; TP_0689

Database of genes from NCBI RefSeq genomes

More...GeneIDi		34331513

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		tpa:TP_0689

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70661 Genomic DNA Translation: AAB38705.1
AE000520 Genomic DNA Translation: AAC65658.1
PIRiF71292
RefSeqiWP_010882134.1, NC_021490.2

3D structure databases

SMRiP96128
ModBaseiSearch...

Protein-protein interaction databases

STRINGi243276.TPANIC_0689

Genome annotation databases

EnsemblBacteriaiAAC65658; AAC65658; TP_0689
GeneIDi34331513
KEGGitpa:TP_0689

Phylogenomic databases

eggNOGiCOG1160, Bacteria
HOGENOMiCLU_016077_6_1_12
OMAiGVTEQDQ
OrthoDBi263682at2

Family and domain databases

Gene3Di3.30.300.20, 1 hit
HAMAPiMF_00195, GTPase_Der, 1 hit
InterProiView protein in InterPro
IPR031166, G_ENGA
IPR016484, GTP-bd_EngA
IPR006073, GTP_binding_domain
IPR032859, KH_dom-like
IPR015946, KH_dom-like_a/b
IPR027417, P-loop_NTPase
IPR005225, Small_GTP-bd_dom
PfamiView protein in Pfam
PF14714, KH_dom-like, 1 hit
PF01926, MMR_HSR1, 2 hits
PIRSFiPIRSF006485, GTP-binding_EngA, 1 hit
PRINTSiPR00326, GTP1OBG
SUPFAMiSSF52540, SSF52540, 2 hits
TIGRFAMsiTIGR03594, GTPase_EngA, 1 hit
TIGR00231, small_GTP, 2 hits
PROSITEiView protein in PROSITE
PS51712, G_ENGA, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDER_TREPA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P96128
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1997
Last modified: December 2, 2020
This is version 129 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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