Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P96086 (TRI_THEAC)

Entry version 141 (17 Jun 2020)
Sequence version 1 (01 May 1997)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Tricorn protease

Gene

tri

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Tricorn degrades oligopeptides (probably derived from the proteasome) and channels the products to F1, F2 and F3 proteases, which then catalyze the terminal degradation step, yielding free amino acids.

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Optimum pH is 8.5-8.8.

Temperature dependencei

Optimum temperature is 65 degrees Celsius.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei746Charge relay system2 Publications1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei936Substrate specificity switch1 Publication1
Active sitei965Nucleophile2 Publications1
Sitei966Transition state stabilizer; via amide nitrogen2 Publications1
Active sitei1023Charge relay system1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		TACI273075:G1GT7-1625-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.4.21.B34 6324

Protein family/group databases

MEROPS protease database

More...MEROPSi		S41.005

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tricorn protease (EC:3.4.21.-1 Publication)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tri
Ordered Locus Names:Ta1490
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri273075 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiArchaea › Euryarchaeota › Diaforarchaea group › Thermoplasmata › Thermoplasmatales › Thermoplasmataceae › Thermoplasma ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001024 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi131 – 132RR → EE: Decreased catalytic activity towards protein substrates. Retains 10% of wild-type activity towards casein and about 30% towards oxidized insulin beta chain. However, there is no change in the activity for a tripeptide substrate. 2 Publications2
Mutagenesisi184L → C: Both peptidolytic and proteolytic activities doubled, probably due to the increase of the diameter of the channel for product exit. Retains less than 50% of wild-type activity after modification of the thiol group by maleimide, which decreases the diameter of the exit channel and impairs product exit from the catalytic chamber. 2 Publications1
Mutagenesisi414R → C: Retains 50% of wild-type activity after modification of the thiol group by maleimide, which decreases the diameter of the access channel and impairs substrate access to the active site. Decreased catalytic activity towards fluorogenic substrate and insulin beta chain prior to any modification or oxidation, probably due to the decrease of the diameter of the substrate access channel. Further decreased catalytic activity towards these substrates after modification with fluorescein-5-maleimide or oxidation by oxidized glutathione; when associated with C-643. 2 Publications1
Mutagenesisi643A → C: Decreased catalytic activity towards fluorogenic substrate and insulin beta chain prior to any modification or oxidation. Further decreased catalytic activity towards these substrates after modification with fluorescein-5-maleimide or oxidation by oxidized glutathione; when associated with C-414. 1 Publication1
Mutagenesisi746H → A: Loss of catalytic activity. 1 Publication1
Mutagenesisi965S → A: Loss of catalytic activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002071971 – 1071Tricorn proteaseAdd BLAST1071

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		P96086

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the Tricorn proteolytic complex. Assembles to form a hexameric toroid, 20 copies of which may then assemble to form an icosahedral supermolecule of 14.6 MDa.

4 Publications

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		273075.Ta1490

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11071
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P96086

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P96086

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni39 – 310Six-bladed beta propeller1 PublicationAdd BLAST272
Regioni131 – 132Binds the substrate's C-terminus2 Publications2
Regioni326 – 675Seven-bladed beta propeller1 PublicationAdd BLAST350
Regioni679 – 745C-1; helical bundle1 PublicationAdd BLAST67
Regioni761 – 855PDZ-like1 PublicationAdd BLAST95
Regioni856 – 1061C-2; alpha-beta sandwich1 PublicationAdd BLAST206
Regioni916 – 918Substrate binding2 Publications3
Regioni993 – 995Substrate binding1 Publication3

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

It is thought that substrate reaches the active site through the seven-bladed beta propeller channel, while products exit via the six-bladed beta propeller channel.3 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S41B family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		arCOG03384 Archaea
ENOG4102TDY Archaea
COG0793 LUCA
COG4946 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005503_1_0_2

KEGG Orthology (KO)

More...KOi		K08676

Identification of Orthologs from Complete Genome Data

More...OMAi		YLHVPDM

Database of Orthologous Groups

More...OrthoDBi		456at2157

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.130.10.10, 1 hit
2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029045 ClpP/crotonase-like_dom_sf
IPR011659 PD40
IPR036034 PDZ_sf
IPR005151 Tail-specific_protease
IPR028204 Tricorn_C1
IPR029414 Tricorn_PDZ
IPR012393 Tricorn_protease
IPR015943 WD40/YVTN_repeat-like_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR43253 PTHR43253, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07676 PD40, 1 hit
PF03572 Peptidase_S41, 1 hit
PF14684 Tricorn_C1, 1 hit
PF14685 Tricorn_PDZ, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF036421 Tricorn_protease, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00245 TSPc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50156 SSF50156, 1 hit
SSF52096 SSF52096, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P96086-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSLMSFGSC QWIDQGRFSR SLYRNFKTFK LHEMHGLCMP NLLLNPDIHG 
        60         70         80         90        100
DRIIFVCCDD LWEHDLKSGS TRKIVSNLGV INNARFFPDG RKIAIRVMRG 
       110        120        130        140        150
SSLNTADLYF YNGENGEIKR ITYFSGKSTG RRMFTDVAGF DPDGNLIIST 
       160        170        180        190        200
DAMQPFSSMT CLYRVENDGI NFVPLNLGPA THILFADGRR VIGRNTFELP 
       210        220        230        240        250
HWKGYRGGTR GKIWIEVNSG AFKKIVDMST HVSSPVIVGH RIYFITDIDG 
       260        270        280        290        300
FGQIYSTDLD GKDLRKHTSF TDYYPRHLNT DGRRILFSKG GSIYIFNPDT 
       310        320        330        340        350
EKIEKIEIGD LESPEDRIIS IPSKFAEDFS PLDGDLIAFV SRGQAFIQDV 
       360        370        380        390        400
SGTYVLKVPE PLRIRYVRRG GDTKVAFIHG TREGDFLGIY DYRTGKAEKF 
       410        420        430        440        450
EENLGNVFAM GVDRNGKFAV VANDRFEIMT VDLETGKPTV IERSREAMIT 
       460        470        480        490        500
DFTISDNSRF IAYGFPLKHG ETDGYVMQAI HVYDMEGRKI FAATTENSHD 
       510        520        530        540        550
YAPAFDADSK NLYYLSYRSL DPSPDRVVLN FSFEVVSKPF VIPLIPGSPN 
       560        570        580        590        600
PTKLVPRSMT SEAGEYDLND MYKRSSPINV DPGDYRMIIP LESSILIYSV 
       610        620        630        640        650
PVHGEFAAYY QGAPEKGVLL KYDVKTRKVT EVKNNLTDLR LSADRKTVMV 
       660        670        680        690        700
RKDDGKIYTF PLEKPEDERT VETDKRPLVS SIHEEFLQMY DEAWKLARDN 
       710        720        730        740        750
YWNEAVAKEI SERIYEKYRN LVPLCKTRYD LSNVIVEMQG EYRTSHSYEM 
       760        770        780        790        800
GGTFTDKDPF RSGRIACDFK LDGDHYVVAK AYAGDYSNEG EKSPIFEYGI 
       810        820        830        840        850
DPTGYLIEDI DGETVGAGSN IYRVLSEKAG TSARIRLSGK GGDKRDLMID 
       860        870        880        890        900
ILDDDRFIRY RSWVEANRRY VHERSKGTIG YIHIPDMGMM GLNEFYRLFI 
       910        920        930        940        950
NESSYQGLIV DVRFNGGGFV SQLIIEKLMN KRIGYDNPRR GTLSPYPTNS 
       960        970        980        990       1000
VRGKIIAITN EYAGSDGDIF SFSFKKLGLG KLIGTRTWGG VVGITPKRRL 
      1010       1020       1030       1040       1050
IDGTVLTQPE FAFWFRDAGF GVENYGVDPD VEIEYAPHDY LSGKDPQIDY 
      1060       1070 
AIDALIEELR NWNEELPQRP S
Length:1,071
Mass (Da):121,623
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD8C5579436870710
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U72850 Genomic DNA Translation: AAC44621.1
AL445067 Genomic DNA Translation: CAC12608.1

Protein sequence database of the Protein Information Resource

More...PIRi		T43255

NCBI Reference Sequences

More...RefSeqi		WP_010901890.1, NC_002578.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		CAC12608; CAC12608; CAC12608

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1456939

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		tac:Ta1490

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72850 Genomic DNA Translation: AAC44621.1
AL445067 Genomic DNA Translation: CAC12608.1
PIRiT43255
RefSeqiWP_010901890.1, NC_002578.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K32X-ray2.00A/B/C/D/E/F27-1071[»]
1N6DX-ray2.80A/B/C/D/E/F1-1071[»]
1N6EX-ray2.60A/C/E/G/I/K1-1071[»]
1N6FX-ray2.70A/B/C/D/E/F1-1071[»]
SMRiP96086
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi273075.Ta1490

Protein family/group databases

MEROPSiS41.005

Proteomic databases

PRIDEiP96086

Genome annotation databases

EnsemblBacteriaiCAC12608; CAC12608; CAC12608
GeneIDi1456939
KEGGitac:Ta1490

Phylogenomic databases

eggNOGiarCOG03384 Archaea
ENOG4102TDY Archaea
COG0793 LUCA
COG4946 LUCA
HOGENOMiCLU_005503_1_0_2
KOiK08676
OMAiYLHVPDM
OrthoDBi456at2157

Enzyme and pathway databases

BioCyciTACI273075:G1GT7-1625-MONOMER
BRENDAi3.4.21.B34 6324

Miscellaneous databases

EvolutionaryTraceiP96086

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR029045 ClpP/crotonase-like_dom_sf
IPR011659 PD40
IPR036034 PDZ_sf
IPR005151 Tail-specific_protease
IPR028204 Tricorn_C1
IPR029414 Tricorn_PDZ
IPR012393 Tricorn_protease
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR43253 PTHR43253, 1 hit
PfamiView protein in Pfam
PF07676 PD40, 1 hit
PF03572 Peptidase_S41, 1 hit
PF14684 Tricorn_C1, 1 hit
PF14685 Tricorn_PDZ, 1 hit
PIRSFiPIRSF036421 Tricorn_protease, 1 hit
SMARTiView protein in SMART
SM00245 TSPc, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
SSF52096 SSF52096, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRI_THEAC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P96086
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1997
Last modified: June 17, 2020
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Peptidase families
    Classification of peptidase families and list of entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again