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UniProtKB - P96084 (PIP_THEAC)
Protein
Proline iminopeptidase
Gene
pip
Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Functioni
Cleaves H-Pro-AMC as well as a wide spectrum of amino acid substrates and several peptide substrates without a proline at the N-terminus. Proteases F1, F2 and F3 degrade oligopeptides produced by Tricorn (themselves probably produced by the proteasome) yielding free amino acids.
Catalytic activityi
- Release of N-terminal proline from a peptide. EC:3.4.11.5
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 105 | Nucleophile | 1 | |
Active sitei | 244 | By similarity | 1 | |
Active sitei | 271 | Proton donor | 1 |
GO - Molecular functioni
- aminopeptidase activity Source: UniProtKB-KW
Keywordsi
Molecular function | Aminopeptidase, Hydrolase, Protease |
Protein family/group databases
ESTHERi | theac-pip, Proline_iminopeptidase |
MEROPSi | S33.005 |
Names & Taxonomyi
Protein namesi | Recommended name: Proline iminopeptidase (EC:3.4.11.5)Short name: PIP Alternative name(s): Prolyl aminopeptidase Short name: PAP Tricorn protease-interacting factor F1 |
Gene namesi | Name:pip Ordered Locus Names:Ta0830 |
Organismi | Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) |
Taxonomic identifieri | 273075 [NCBI] |
Taxonomic lineagei | Archaea › Candidatus Thermoplasmatota › Thermoplasmata › Thermoplasmatales › Thermoplasmataceae › Thermoplasma › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080851 | 1 – 293 | Proline iminopeptidaseAdd BLAST | 293 |
Interactioni
Subunit structurei
Part of the tricorn proteolytic complex.
Protein-protein interaction databases
STRINGi | 273075.Ta0830 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P96084 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P96084 |
Family & Domainsi
Sequence similaritiesi
Belongs to the peptidase S33 family.Curated
Phylogenomic databases
eggNOGi | arCOG01648, Archaea |
HOGENOMi | CLU_020336_15_1_2 |
OMAi | TWYRVTG |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR000073, AB_hydrolase_1 IPR022742, Hydrolase_4 IPR002410, Peptidase_S33 IPR005945, Pro_imino_pep |
Pfami | View protein in Pfam PF12146, Hydrolase_4, 1 hit |
PIRSFi | PIRSF005539, Pept_S33_TRI_F1, 1 hit |
PRINTSi | PR00111, ABHYDROLASE PR00793, PROAMNOPTASE |
SUPFAMi | SSF53474, SSF53474, 1 hit |
TIGRFAMsi | TIGR01250, pro_imino_pep_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P96084-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDQECIENYA KVNGIYIYYK LCKAPEEKAK LMTMHGGPGM SHDYLLSLRD
60 70 80 90 100
MTKEGITVLF YDQFGCGRSE EPDQSKFTID YGVEEAEALR SKLFGNEKVF
110 120 130 140 150
LMGSSYGGAL ALAYAVKYQD HLKGLIVSGG LSSVPLTVKE MNRLIDELPA
160 170 180 190 200
KYRDAIKKYG SSGSYENPEY QEAVNYFYHQ HLLRSEDWPP EVLKSLEYAE
210 220 230 240 250
RRNVYRIMNG PNEFTITGTI KDWDITDKIS AIKIPTLITV GEYDEVTPNV
260 270 280 290
ARVIHEKIAG SELHVFRDCS HLTMWEDREG YNKLLSDFIL KHL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U72710 Genomic DNA Translation: AAC44636.1 AL445065 Genomic DNA Translation: CAC11959.1 |
PIRi | T37465 |
Genome annotation databases
EnsemblBacteriai | CAC11959; CAC11959; CAC11959 |
KEGGi | tac:Ta0830 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U72710 Genomic DNA Translation: AAC44636.1 AL445065 Genomic DNA Translation: CAC11959.1 |
PIRi | T37465 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1MT3 | X-ray | 2.00 | A | 1-293 | [»] | |
1MTZ | X-ray | 1.80 | A | 1-293 | [»] | |
1MU0 | X-ray | 2.40 | A | 1-293 | [»] | |
1XQV | X-ray | 2.30 | A | 1-293 | [»] | |
1XQW | X-ray | 2.00 | A | 1-293 | [»] | |
1XQX | X-ray | 2.10 | A | 1-293 | [»] | |
1XQY | X-ray | 3.20 | A | 1-293 | [»] | |
1XRL | X-ray | 1.82 | A | 1-293 | [»] | |
1XRM | X-ray | 2.70 | A | 1-293 | [»] | |
1XRN | X-ray | 2.80 | A | 1-293 | [»] | |
1XRO | X-ray | 1.80 | A | 1-293 | [»] | |
1XRP | X-ray | 2.30 | A | 1-293 | [»] | |
1XRQ | X-ray | 2.80 | A | 1-293 | [»] | |
1XRR | X-ray | 2.40 | A | 1-293 | [»] | |
SMRi | P96084 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 273075.Ta0830 |
Protein family/group databases
ESTHERi | theac-pip, Proline_iminopeptidase |
MEROPSi | S33.005 |
Genome annotation databases
EnsemblBacteriai | CAC11959; CAC11959; CAC11959 |
KEGGi | tac:Ta0830 |
Phylogenomic databases
eggNOGi | arCOG01648, Archaea |
HOGENOMi | CLU_020336_15_1_2 |
OMAi | TWYRVTG |
Miscellaneous databases
EvolutionaryTracei | P96084 |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR000073, AB_hydrolase_1 IPR022742, Hydrolase_4 IPR002410, Peptidase_S33 IPR005945, Pro_imino_pep |
Pfami | View protein in Pfam PF12146, Hydrolase_4, 1 hit |
PIRSFi | PIRSF005539, Pept_S33_TRI_F1, 1 hit |
PRINTSi | PR00111, ABHYDROLASE PR00793, PROAMNOPTASE |
SUPFAMi | SSF53474, SSF53474, 1 hit |
TIGRFAMsi | TIGR01250, pro_imino_pep_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PIP_THEAC | |
Accessioni | P96084Primary (citable) accession number: P96084 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 134 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families