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Protein

Aspartate carbamoyltransferase

Gene

pyrB

Organism
Thermus aquaticus
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes (S)-dihydroorotate from bicarbonate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Carbamoyl-phosphate synthase small chain (carA), Carbamoyl-phosphate synthase large chain (carB)
  2. Aspartate carbamoyltransferase (pyrB), Aspartate carbamoyltransferase (pyrB)
  3. Dihydroorotase (pyrC), Dihydroorotase (pyrC)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-dihydroorotate from bicarbonate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayi
UPA00070;UER00116

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate carbamoyltransferase (EC:2.1.3.2)
Alternative name(s):
Aspartate transcarbamylase
Short name:
ATCase
Gene namesi
Name:pyrB
OrganismiThermus aquaticus
Taxonomic identifieri271 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001132191 – 301Aspartate carbamoyltransferaseAdd BLAST301

Proteomic databases

PRIDEiP96079

Structurei

3D structure databases

ProteinModelPortaliP96079
SMRiP96079
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATCase/OTCase family.Curated

Family and domain databases

Gene3Di3.40.50.1370, 3 hits
HAMAPiMF_00001 Asp_carb_tr, 1 hit
InterProiView protein in InterPro
IPR006132 Asp/Orn_carbamoyltranf_P-bd
IPR006130 Asp/Orn_carbamoylTrfase
IPR036901 Asp/Orn_carbamoylTrfase_sf
IPR002082 Asp_carbamoyltransf
IPR006131 Asp_carbamoyltransf_Asp/Orn-bd
PANTHERiPTHR11405:SF16 PTHR11405:SF16, 1 hit
PfamiView protein in Pfam
PF00185 OTCace, 1 hit
PF02729 OTCace_N, 1 hit
PRINTSiPR00100 AOTCASE
PR00101 ATCASE
SUPFAMiSSF53671 SSF53671, 1 hit
TIGRFAMsiTIGR00670 asp_carb_tr, 1 hit
PROSITEiView protein in PROSITE
PS00097 CARBAMOYLTRANSFERASE, 1 hit

Sequencei

Sequence statusi: Complete.

P96079-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRHLLDFQGW TRPEVESLLD TARVMREVLE RPVKKVPALQ GFTVATVFFE
60 70 80 90 100
PSTRTRISFE LAARRMSADV VSFAAQTSSL QKGESYKDTL LTLEAMGVDA
110 120 130 140 150
YVIRADSAGV PHQATRWVKG AVINGGDGRR AHPTQALLDA YTLLEALGTL
160 170 180 190 200
EGKKVAIVGD ILHSRVARSN AELLPLLGAQ VFCAGPPSLL PQSLPGAHLT
210 220 230 240 250
PRLEEALEEA DAVMVLRLQK ERMEAGLVHL EDYIARYQVT EKRLALAKPQ
260 270 280 290 300
APLLHPGPMN RDVELEGTLA DSARSLVNRQ VQNGVAVRMA VLYHLLVGKG

R
Length:301
Mass (Da):32,949
Last modified:May 1, 1997 - v1
Checksum:i4A517D776A55E92B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09536 Genomic DNA Translation: CAA70729.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09536 Genomic DNA Translation: CAA70729.1

3D structure databases

ProteinModelPortaliP96079
SMRiP96079
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP96079

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayi
UPA00070;UER00116

Family and domain databases

Gene3Di3.40.50.1370, 3 hits
HAMAPiMF_00001 Asp_carb_tr, 1 hit
InterProiView protein in InterPro
IPR006132 Asp/Orn_carbamoyltranf_P-bd
IPR006130 Asp/Orn_carbamoylTrfase
IPR036901 Asp/Orn_carbamoylTrfase_sf
IPR002082 Asp_carbamoyltransf
IPR006131 Asp_carbamoyltransf_Asp/Orn-bd
PANTHERiPTHR11405:SF16 PTHR11405:SF16, 1 hit
PfamiView protein in Pfam
PF00185 OTCace, 1 hit
PF02729 OTCace_N, 1 hit
PRINTSiPR00100 AOTCASE
PR00101 ATCASE
SUPFAMiSSF53671 SSF53671, 1 hit
TIGRFAMsiTIGR00670 asp_carb_tr, 1 hit
PROSITEiView protein in PROSITE
PS00097 CARBAMOYLTRANSFERASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPYRB_THEAQ
AccessioniPrimary (citable) accession number: P96079
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1997
Last modified: October 10, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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