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Protein

ADP-dependent (S)-NAD(P)H-hydrate dehydratase

Gene

nnrD

Organism
Streptococcus thermophilus
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.UniRule annotation

Catalytic activityi

ADP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine-dinucleotide = AMP + phosphate + NADH.UniRule annotation
ADP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine-dinucleotide phosphate = AMP + phosphate + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei100NAD(P)HX; via amide nitrogenUniRule annotation1
Binding sitei217NAD(P)HXUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi188 – 192ADPUniRule annotation5
Nucleotide bindingi207 – 216ADPUniRule annotation10

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-dependent (S)-NAD(P)H-hydrate dehydrataseUniRule annotation (EC:4.2.1.136UniRule annotation)
Alternative name(s):
ADP-dependent NAD(P)HX dehydrataseUniRule annotation
Gene namesi
Name:nnrDUniRule annotation
OrganismiStreptococcus thermophilus
Taxonomic identifieri1308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001190501 – 278ADP-dependent (S)-NAD(P)H-hydrate dehydrataseAdd BLAST278

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP96051
SMRiP96051
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 276YjeF C-terminalUniRule annotationAdd BLAST273

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni152 – 158NAD(P)HXUniRule annotation7

Sequence similaritiesi

Belongs to the NnrD/CARKD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DR1 Bacteria
COG0063 LUCA

Family and domain databases

CDDicd01171 YXKO-related, 1 hit
Gene3Di3.40.1190.20, 1 hit
HAMAPiMF_01965 NADHX_dehydratase, 1 hit
InterProiView protein in InterPro
IPR017953 Carbohydrate_kinase_pred_CS
IPR000631 CARKD
IPR029056 Ribokinase-like
PfamiView protein in Pfam
PF01256 Carb_kinase, 1 hit
SUPFAMiSSF53613 SSF53613, 1 hit
TIGRFAMsiTIGR00196 yjeF_cterm, 1 hit
PROSITEiView protein in PROSITE
PS01049 YJEF_C_1, 1 hit
PS01050 YJEF_C_2, 1 hit
PS51383 YJEF_C_3, 1 hit

Sequencei

Sequence statusi: Complete.

P96051-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVDDDLVRQ VIRPRLRGSH KGSYGRVLLV GGLYPYGGAI IMAAIACVNS
60 70 80 90 100
GAGLVTVATD RENIIALHAH LPEAMAFDLR ETERFLDKLR AADVILIGSG
110 120 130 140 150
LGEEETADWA LELVLANIRS NQNLVVDGSA LNLLAKKNQS SLPKCHLILT
160 170 180 190 200
PHQKEWERLS GLAISEQSVS NTQRALEEFQ SGTILVAKSH KTAVYQGAEV
210 220 230 240 250
THLEVGGPYQ ATGGMGDTLA GMVAGFLAQF ASTDSYKAVI VATWLHSAIA
260 270
DNIAENAYVV LPTRISKAIP SWMKKLSL
Length:278
Mass (Da):29,912
Last modified:May 1, 1997 - v1
Checksum:iD392FBCB1BE70CD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58210 Genomic DNA Translation: AAC44613.1

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58210 Genomic DNA Translation: AAC44613.1

3D structure databases

ProteinModelPortaliP96051
SMRiP96051
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105DR1 Bacteria
COG0063 LUCA

Family and domain databases

CDDicd01171 YXKO-related, 1 hit
Gene3Di3.40.1190.20, 1 hit
HAMAPiMF_01965 NADHX_dehydratase, 1 hit
InterProiView protein in InterPro
IPR017953 Carbohydrate_kinase_pred_CS
IPR000631 CARKD
IPR029056 Ribokinase-like
PfamiView protein in Pfam
PF01256 Carb_kinase, 1 hit
SUPFAMiSSF53613 SSF53613, 1 hit
TIGRFAMsiTIGR00196 yjeF_cterm, 1 hit
PROSITEiView protein in PROSITE
PS01049 YJEF_C_1, 1 hit
PS01050 YJEF_C_2, 1 hit
PS51383 YJEF_C_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNNRD_STRTR
AccessioniPrimary (citable) accession number: P96051
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: October 10, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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