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UniProtKB - P95608 (CATB_RHOOP)
Protein
Muconate cycloisomerase 1
Gene
catB
Organism
Rhodococcus opacus (Nocardia opaca)
Status
Functioni
Catalytic activityi
- EC:5.5.1.1By similarity
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 169 | By similarity | 1 | |
Active sitei | 169 | Proton acceptorBy similarity | 1 | |
Metal bindingi | 198 | ManganeseBy similarity | 1 | |
Metal bindingi | 224 | ManganeseBy similarity | 1 | |
Metal bindingi | 249 | ManganeseBy similarity | 1 | |
Active sitei | 327 | Proton donorBy similarity | 1 |
GO - Molecular functioni
- chloromuconate cycloisomerase activity Source: InterPro
- manganese ion binding Source: InterPro
- muconate cycloisomerase activity Source: UniProtKB-EC
GO - Biological processi
- aromatic compound catabolic process Source: UniProtKB-KW
- cellular amino acid catabolic process Source: InterPro
Keywordsi
Molecular function | Isomerase |
Biological process | Aromatic hydrocarbons catabolism |
Ligand | Manganese, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Muconate cycloisomerase 1 (EC:5.5.1.1By similarity)Alternative name(s): Cis,cis-muconate lactonizing enzyme I Short name: MLE Muconate cycloisomerase I |
Gene namesi | Name:catB |
Organismi | Rhodococcus opacus (Nocardia opaca) |
Taxonomic identifieri | 37919 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Nocardiaceae › Rhodococcus |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000171252 | 1 – 373 | Muconate cycloisomerase 1Add BLAST | 373 |
Proteomic databases
PRIDEi | P95608 |
Family & Domainsi
Sequence similaritiesi
Belongs to the mandelate racemase/muconate lactonizing enzyme family.Curated
Phylogenomic databases
eggNOGi | COG4948, Bacteria |
Family and domain databases
CDDi | cd03318, MLE, 1 hit |
Gene3Di | 3.20.20.120, 1 hit 3.30.390.10, 1 hit |
InterProi | View protein in InterPro IPR013370, Chloromuconate_cycloisomerase IPR036849, Enolase-like_C_sf IPR029017, Enolase-like_N IPR029065, Enolase_C-like IPR018110, Mandel_Rmase/mucon_lact_enz_CS IPR013342, Mandelate_racemase_C IPR013341, Mandelate_racemase_N_dom |
Pfami | View protein in Pfam PF13378, MR_MLE_C, 1 hit PF02746, MR_MLE_N, 1 hit |
SFLDi | SFLDG01258, (chloro)muconate_cycloisomeras, 1 hit |
SMARTi | View protein in SMART SM00922, MR_MLE, 1 hit |
SUPFAMi | SSF51604, SSF51604, 1 hit SSF54826, SSF54826, 1 hit |
TIGRFAMsi | TIGR02534, mucon_cyclo, 1 hit |
PROSITEi | View protein in PROSITE PS00908, MR_MLE_1, 1 hit PS00909, MR_MLE_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P95608-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTDLSIVSVE TTILDVPLVR PHKFATTSMT AQPLLLVAVT TAGGVTGYGE
60 70 80 90 100
GVVPGGPWWG GESVETMQAI VERYIVPVLL GRGVDEITGI MPDIERVVAN
110 120 130 140 150
ARFAKAAVDV ALHDAWARSL GVPVHTLLGG AFRKSVDVTW ALGAAPAEEI
160 170 180 190 200
IEEALDLVES KRHFSFKLKM GALDPAVDTA RVVQIAQALQ GKAGVRIDVN
210 220 230 240 250
ARWDRLTALK YVPRLVEGGV ELIEQPTPGE QLEVLAELNR LVPVPVMADE
260 270 280 290 300
SVQTPHDALE VARRGAADVI ALKTTKCGGL QKSREVVAIA KAAGIACHGA
310 320 330 340 350
TSIEGPIGTA ASIHFACAEP GIDFGTELFG PLLFSEELLQ EPIRYADGQV
360 370
FLPEGPGLGV ELNMDAVKTW TRN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X99622 Genomic DNA Translation: CAA67934.1 |
RefSeqi | WP_065492182.1, NZ_CP009111.1 |
Genome annotation databases
GeneIDi | 66788846 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X99622 Genomic DNA Translation: CAA67934.1 |
RefSeqi | WP_065492182.1, NZ_CP009111.1 |
3D structure databases
AlphaFoldDBi | P95608 |
SMRi | P95608 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 37919.EP51_30990 |
Proteomic databases
PRIDEi | P95608 |
Genome annotation databases
GeneIDi | 66788846 |
Phylogenomic databases
eggNOGi | COG4948, Bacteria |
Family and domain databases
CDDi | cd03318, MLE, 1 hit |
Gene3Di | 3.20.20.120, 1 hit 3.30.390.10, 1 hit |
InterProi | View protein in InterPro IPR013370, Chloromuconate_cycloisomerase IPR036849, Enolase-like_C_sf IPR029017, Enolase-like_N IPR029065, Enolase_C-like IPR018110, Mandel_Rmase/mucon_lact_enz_CS IPR013342, Mandelate_racemase_C IPR013341, Mandelate_racemase_N_dom |
Pfami | View protein in Pfam PF13378, MR_MLE_C, 1 hit PF02746, MR_MLE_N, 1 hit |
SFLDi | SFLDG01258, (chloro)muconate_cycloisomeras, 1 hit |
SMARTi | View protein in SMART SM00922, MR_MLE, 1 hit |
SUPFAMi | SSF51604, SSF51604, 1 hit SSF54826, SSF54826, 1 hit |
TIGRFAMsi | TIGR02534, mucon_cyclo, 1 hit |
PROSITEi | View protein in PROSITE PS00908, MR_MLE_1, 1 hit PS00909, MR_MLE_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CATB_RHOOP | |
Accessioni | P95608Primary (citable) accession number: P95608 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | May 1, 1997 | |
Last modified: | May 25, 2022 | |
This is version 90 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families